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通过机器学习与二次推断函数优化阶梯楔形设计的估计精度AI 解读

Stepped-wedge designs are increasingly used in randomized experiments to accommodate logistical and ethical constraints by staggering treatment roll-out over time. Despite their popularity, existing analytical methods largely rely on parametric models with linear covariate adjustment and prespecified correlation structures, which may limit achievable precision in practice. We propose a new class of estimators for the causal average treatment effect in stepped-wedge designs…

广义预测驱动推断及其在二分类器评估中的应用AI 解读

In the partially-observed outcome setting, a recent set of proposals known as "prediction-powered inference" (PPI) involve (i) applying a pre-trained machine learning model to predict the response, and then (ii) using these predictions to obtain an estimator of the parameter of interest with asymptotic variance no greater than that which would be obtained using only the labeled observations. While existing PPI proposals consider estimators arising from M-estimation, in this…

因果推断中系统识别与联合分析多重偏差的路线图AI 解读

Observational studies examining causal effects rely on unverifiable assumptions, the violation of which can induce multiple biases. Quantitative bias analysis (QBA) methods examine the sensitivity of findings to such violations, generally, by producing estimates under alternative assumptions, incorporating external information. Although substantial guidance exists for implementing QBA, there is limited guidance on how to systematically determine the assumptions underlying a…

矩阵时间序列的逐模态加性因子模型AI 解读

We introduce a Modewise Additive Factor Model (MAFM) for matrix-valued time series that captures row-specific and column-specific latent effects through an additive structure, offering greater flexibility than multiplicative frameworks such as Tucker and CP factor models. In MAFM, each observation decomposes into a row-factor component, a column-factor component, and noise, allowing distinct sources of variation along different modes to be modeled separately. We develop a…

结局优劣排序概率的双重稳健估计及其耐多药菌研究应用AI 解读

In observational studies, adjusting for confounders is required if a treatment comparison is planned. A crude comparison of the primary endpoint without covariate adjustment will suffer from biases, and the addition of regression models could improve precision by incorporating imbalanced covariates and thus help make correct inference. Desirability of outcome ranking (DOOR) is a patient-centric benefit-risk evaluation methodology designed for randomized clinical trials.…

张量列结构下协方差估计的无维界AI 解读

We consider a problem of covariance estimation from a sample of i.i.d. high-dimensional random vectors. To avoid the curse of dimensionality, we impose an additional assumption on the structure of the covariance matrix $Σ$. To be more precise, we study the case when $Σ$ can be approximated by a sum of double Kronecker products of smaller matrices in a tensor train (TT) format. Our setup naturally extends widely known Kronecker sum and CANDECOMP/PARAFAC models but admits…

斯勒茨基对称性的非参数可检验性AI 解读

Economic theory implies strong limitations on what types of consumption behavior are considered rational. Rationality implies that the Slutsky matrix, which captures the substitution effects of compensated price changes on demand for different goods, is symmetric and negative semi-definite. While empirically informed versions of negative semi-definiteness have been shown to be nonparametrically testable, the analogous question for Slutsky symmetry has remained open.…

长程相依气候时间序列早期预警信号的贝叶斯识别AI 解读

Detecting early warning signals in climatic time series is essential for anticipating critical transitions and tipping points. Common statistical indicators include increased variance and lag-one autocorrelation prior to bifurcation points. However, these indicators are sensitive to observational noise, long-term mean trends, and long-memory dependence, all of which are prevalent in climatic time series. Such effects can easily obscure genuine signals or generate spurious…

基于常微分方程的非线性混合效应模型的变分自编码器推断AI 解读

We propose a variational autoencoder (VAE) approach for parameter estimation in nonlinear mixed-effects models based on ordinary differential equations (NLME-ODEs) using longitudinal data from multiple subjects. In moderate dimensions, likelihood-based inference via the stochastic approximation EM algorithm (SAEM) is widely used, but it relies on Markov Chain Monte-Carlo (MCMC) to approximate subject-specific posteriors. As model complexity increases or observations per…

通过元学习估计因果图不确定时的干预分布AI 解读

In scientific domains -- from biology to the social sciences -- many questions boil down to \textit{What effect will we observe if we intervene on a particular variable?} If the causal relationships (e.g.~a causal graph) are known, it is possible to estimate the intervention distributions. In the absence of this domain knowledge, the causal structure must be discovered from the available observational data. However, observational data are often compatible with multiple…

死亡截断下生活质量与生存的联合框架及去偏估计AI 解读

Evaluating quality-of-life (QoL) outcomes in populations with high mortality risk is complicated by truncation by death, since QoL is undefined for individuals who do not survive to the planned measurement time. We propose a framework that jointly models the distribution of QoL and survival without extrapolating QoL beyond death. Inspired by multistate formulations, we extend the joint characterization of binary health states and mortality to continuous QoL outcomes. Because…

秩相关系数的渐近推断AI 解读

Kendall's tau and Spearman's rho are widely used tools for measuring dependence. Surprisingly, when it comes to asymptotic inference for these rank correlations, some fundamental results and methods have not yet been developed, in particular for discrete random variables and in the time series case, and concerning variance estimation in general. Consequently, asymptotic confidence intervals are not available. We provide a comprehensive treatment of asymptotic inference for…

杠杆效应的整体多尺度推断：相依微观结构噪声下的效率AI 解读

This paper addresses the long-standing challenge of estimating the leverage effect from high-frequency data contaminated by dependent, non-Gaussian microstructure noise. We depart from the conventional reliance on pre-averaging or volatility "plug-in" methods by introducing a holistic multi-scale framework that operates directly on the leverage effect. We propose two novel estimators: the Subsampling-and-Averaging Leverage Effect (SALE) and the Multi-Scale Leverage Effect…

植被绿度驱动因素的空间变量选择：面向 MODIS 植被指数AI 解读

Understanding how environmental drivers relate to vegetation condition motivates spatially varying regression models, but estimating a separate coefficient surface for every predictor can yield noisy patterns and poor interpretability when many predictors are irrelevant. Motivated by MODIS vegetation index studies, we examine predictors from spectral bands, productivity and energy fluxes, observation geometry, and land surface characteristics. Because these relationships…

三重稳健面板估计量AI 解读

This paper studies estimation of causal effects in a panel data setting. We introduce a new estimator, the Triply RObust Panel (TROP) estimator, that combines (i) a flexible model for the potential outcomes based on a low-rank factor structure on top of a two-way-fixed effect specification, with (ii) unit weights intended to upweight units similar to the treated units and (iii) time weights intended to upweight time periods close to the treated time periods. We study the…

通过修正函数型处理策略估计函数型处理的因果效应AI 解读

Functional data are increasingly prevalent in biomedical research. While functional data analysis has been established for decades, causal inference with functional treatments remains largely unexplored. Existing methods typically focus on estimating the causal average dose response functional (ADRF), which requires strong positivity assumptions and offers limited interpretability. In this work, we target a new causal estimand, the modified functional treatment policy…

面向稳定因果中介分析的偏差针对性非参数平衡AI 解读

Influence function (IF)-based estimators are widely used in mediation analysis due to their modeling flexibility, but standard implementations require direct estimation of the distribution functions of the mediator and treatment variables. Since these functions appear in the denominator of IF-based estimators, they can induce significant instability, particularly with continuous mediators. In this work, we propose an alternative implementation of IF-based estimators for both…

作为生成回归变量的固定效应AI 解读

Many economic models feature moment conditions that involve latent variables. When the latent variables are individual fixed effects in an auxiliary panel data regression, we construct orthogonal moments that eliminate first-order bias induced by estimating the fixed effects. Machine Learning methods and Empirical Bayes methods can be used to improve the estimate of the nuisance parameters in the orthogonal moments. We establish a central limit theorem based on the…

评估协变量无法解释的因果效应异质性AI 解读

There has been considerable interest in estimating heterogeneous causal effects across individuals or subpopulations. Researchers often assess causal effect heterogeneity based on the subjects' covariates using the conditional average causal effect (CACE). However, substantial heterogeneity may persist even after accounting for the covariates. Existing work on causal effect heterogeneity unexplained by covariates mainly focused on binary treatment and outcome. In this paper,…

AMP框架下基于Lasso统计量的经验贝叶斯变量选择AI 解读

The Lasso is one of the most ubiquitous methods for variable selection in high-dimensional linear regression and has been studied extensively under different regimes. In a particular asymptotic setup entailing $n/p\to \text{constant}$, an i.i.d.~Gaussian $X$ matrix and linear sparsity, \citet{su2017false} analyzed the Lasso selection path and presented negative results, showing that maintaining small levels of the false discovery proportion comes at a substantial cost in…

循证决策价值的估计AI 解读

In an era of data abundance, statistical evidence is increasingly critical for business and policy decisions. Yet, organizations lack empirical tools to assess the value of evidence-based decision making (EBDM), optimize statistical precision, and balance the costs of evidence-gathering strategies against their benefits. To tackle these challenges, this article introduces an empirical framework to estimate the value of EBDM and evaluate the return on investment in…

临床试验治疗个性化的因果机器学习框架：溃疡性结肠炎应用AI 解读

Randomized controlled trials estimate average treatment effects, but treatment response heterogeneity motivates personalized approaches. A critical question is whether statistically detectable heterogeneity translates into improved treatment decisions -- these are distinct questions that can yield contradictory answers. We present a modular causal machine learning framework that evaluates each question separately: permutation importance identifies which features predict…

高维重尾局部平稳时间序列的稀疏学习：集中与预言不等式AI 解读

Sparse learning is ubiquitous in many machine learning tasks. It aims to regularize the goodness-of-fit objective by adding a penalty term to encode structural constraints on the model parameters. In this paper, we develop a flexible sparse learning framework tailored to high-dimensional heavy-tailed locally stationary time series (LSTS). The data-generating mechanism incorporates a regression function that changes smoothly over time and is observed under noise belonging to…

多元因果效应：贝叶斯因果回归因子模型AI 解读

The impact of wildfire smoke on air quality is a growing concern, contributing to air pollution through a complex mixture of chemical species with important implications for public health. While previous studies have primarily focused on its association with total particulate matter (PM2.5), the causal relationship between wildfire smoke and the chemical composition of PM2.5 remains largely unexplored. Exposure to these chemical mixtures plays a critical role in shaping…