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处理后混杂下集群随机试验因果机制的贝叶斯非参数识别与估计AI 解读

Causal mediation analysis in cluster-randomized trials (CRTs) is essential for explaining how cluster-level interventions affect individual outcomes, yet it is complicated by interference, post-treatment confounding, and hierarchical covariate adjustment. We develop a Bayesian nonparametric framework that simultaneously accommodates interference and a post-treatment confounder that precedes the mediator. Identification is achieved through a multivariate Gaussian copula that…

面向异质时间动态变点问题的可逆跳跃 MCMC 扩展AI 解读

Detecting brief changes in time-series data remains a major challenge in fields where short-lived states carry meaning. In single-molecule localisation microscopy, this problem is particularly acute as fluorescent molecules used to tag protein oligomers display heterogenous photophysical behaviour that can complicate photobleach step analysis; a key step in resolving nanoscale protein organisation. Existing methods often require extensive filtering or prior calibration, and…

加权支持向量机的稀疏学习与类别概率估计AI 解读

Classification and probability estimation are fundamental tasks with broad applications across modern machine learning and data science, spanning fields such as biology, medicine, engineering, and computer science. Recent development of weighted Support Vector Machines (wSVMs) has demonstrated considerable promise in robustly and accurately predicting class probabilities and performing classification across a variety of problems (Wang et al., 2008). However, the existing…

极端分位数处理效应的尾部校准估计AI 解读

Extreme quantile treatment effects (eQTEs) measure the causal impact of a treatment on the tails of an outcome distribution and are central for studying rare, high-impact events. Standard QTE methods often fail in extreme regimes due to data sparsity, while existing eQTE methods rely on restrictive tail assumptions or on interior-quantile theory. We propose the Tail-Calibrated Inverse Estimating Equation (TIEE) framework, which combines information across quantile levels and…

含期中分析的平台试验如何纳入非同期对照AI 解读

The analysis of platform trials can be enhanced by utilizing non-concurrent controls. Since including this data might also introduce bias in the treatment effect estimators if time trends are present, methods for incorporating non-concurrent controls adjusting for time have been proposed. However, so far their behavior has not been systematically investigated in platform trials that include interim analyses. To evaluate the impact of an interim analysis in trials utilizing…

贝叶斯非线性回归中的总体稳健性AI 解读

Modern regression analyses are often undermined by covariate measurement error, misspecification of the regression model, and misspecification of the measurement error distribution. We present, to the best of our knowledge, the first Bayesian nonparametric learning framework targeting total robustness to all three challenges in general nonlinear regression. Our framework places a joint Dirichlet process prior on the latent covariate--response distribution and updates it with…

将 Riesz 回归理解为直接密度比估计AI 解读

This study clarifies the relationship between Riesz regression [Chernozhukov et al., 2021] and density ratio estimation (DRE) in causal inference problems, such as average treatment effect estimation. We first show that the Riesz representer can be written as a signed density ratio and then demonstrate that the Riesz regression objective coincides with the least-squares importance fitting criterion [Kanamori et al., 2009]. Although Riesz regression applies to a broad class…

对抗扰动下的精度矩阵估计AI 解读

Precision matrix estimation is a fundamental topic in multivariate statistics and modern machine learning. This paper proposes an adversarially perturbed precision matrix estimation framework, motivated by recent developments in adversarial training. The proposed framework is versatile for the precision matrix problem since, by adapting to different perturbation geometries, the proposed framework can not only recover the existing distributionally robust method but also…

依赖删失或竞争风险下的非参数回归AI 解读

Single-index models or time-to-event models are frequently applied in empirical research. These models are non-identifiable in presence of unknown (dependent) censoring or competing risks and do not give informative results in empirical analysis unless rather strong, non-testable restrictions hold. Little is known, whether the known robustness properties of the single-index model carry over to models with dependent censoring or competing risks. This paper shows that the…

DROP：图模型多任务学习中的分布鲁棒优化AI 解读

Gaussian Graphical Models (GGMs) are widely used to infer conditional dependence structures in high-dimensional data. However, standard precision matrix estimators are highly sensitive to data contamination, such as extreme outliers and heavy-tailed noise. In this paper, we propose DROP (Distributionally Robust Optimization), a robust estimation method formulated within a multi-task nodewise regression framework. The proposed estimator enforces structural sparsity while…

新闻发布后的熔断：高频市场价格发现与基本面定价AI 解读

This paper examines how regulatory interventions in high-frequency financial markets affect price discovery. We focus on Breaking news, where dynamic circuit breakers trigger trading halts immediately after the release of macroeconomic fundamentals. Within a high-frequency signal-in-noise model, we show that triggering rules complicate statistical inference for the price impact of news, rendering conventional non-parametric jump estimators inconsistent. Building on this…

Refactor 分析：因子模型与维度的预测评估AI 解读

Unidimensional factor models justify some of the most consequential summaries in science -- single scores, single ranks, and single leaderboards -- yet unidimensionality is usually assessed indirectly by fitting and evaluating models on images of the data (e.g., correlation matrices) rather than on the response matrix itself. We introduce Refactor analysis, a data-first evaluation paradigm that converts a one-factor solution into a rank-1 prediction of the original matrix by…

干扰、同质性与稳健性权衡下的最优实验设计AI 解读

To minimize the mean squared error (MSE) in global average treatment effect (GATE) estimation under network interference, a popular approach is to use a cluster-randomized design. However, in the presence of homophily, which is common in social networks, cluster randomization can instead increase the MSE. We develop a novel potential outcomes model that accounts for interference, homophily, and heterogeneous variation. In this setting, we establish a framework for optimizing…

函数型线性分位数回归的变量选择：识别日常体力活动模式与认知功能的关联AI 解读

Quantile regression is useful for characterizing the conditional distribution of a response variable and understanding heterogeneity in the covariate effects at different quantiles. The rise of high-dimensional physiological data in biomedical research through wearable and sensor devices underscores the need for effective variable selection methods for interpretable and accurate quantile regression, which can offer robust insights into heterogeneous and dynamic covariate…

用于组学数据的通路引导贝叶斯因子模型AI 解读

Interpreting RNA-sequencing data requires identifying coordinated gene expression patterns that correspond to biological pathways. Standard factor models provide useful dimension reduction but typically ignore existing pathway knowledge or incorporate it through restrictive assumptions, limiting interpretability, and reproducibility. Here, we develop Bayesian Analysis with gene-Sets Informed Latent space (BASIL), a scalable framework for analyzing transcriptomic data that…

三次与线性平滑样条的分位数回归AI 解读

Spline quantile regression (SQR) is a method introduced recently by Li and Megiddo (2026) for linear quantile regression where the regression coefficients are treated as smooth functions of the quantile level. With the coefficients represented by cubic splines with fixed knots on a given set of quantiles, the SQR method produces an estimate for the functional coefficients by solving a penalized quantile regression problem. The $\ell_1$-norm of the second derivatives of the…

球面上的变化区域检测AI 解读

While change point detection in time series data has been extensively studied, little attention has been given to its generalisation to data observed on spheres or other manifolds, where changes may occur within spatially complex regions with irregular boundaries, posing significant challenges. We propose a new class of estimators, namely, Change Region Identification and SeParation (CRISP), to locate changes in the mean function of a signal-plus-noise model defined on $d$-di…

考虑成本的最优前门实验设计AI 解读

Causal effect estimation often succeeds cost-constrained sequential data collection. This work considers multivariate linear front-door models with arbitrary unobserved confounding on treatment and response. We optimize the experimental design by balancing the statistical efficiency and measurement costs through partial data. The full-data efficient influence function for the causal effect is derived, together with the geometry of all observed-data influence functions. This…

移动聚合修正的自回归 Copula 时间序列模型AI 解读

Copula-based time series models can model univariate and stationary time series in a flexible way by decomposing the joint distribution of consecutive observations into a copula and the stationary distribution. Implicitly this approach assumes a finite Markov order. In reality a time series may not follow the Markov property. We modify the copula-based time series models by introducing a moving aggregate (MAG) part into the model updating equation. The functional form of the…

利用既有研究学习处理效应：贝叶斯模型平均方法AI 解读

We establish concentration rates for estimation of treatment effects in experiments that incorporate prior sources of information -- such as past pilots, related studies, or expert assessments -- whose external validity is uncertain. Each source is modeled as a Gaussian prior with its own mean and precision, and sources are combined using Bayesian model averaging (BMA), allowing data from the new experiment to update posterior weights. To capture empirically relevant…

重新审视胜率比：层级结局分析的因果框架AI 解读

Quantifying causal effects in the presence of complex and multivariate outcomes remains a key challenge in treatment evaluation. For hierarchical multivariate outcomes, the FDA recommends the Win Ratio and Generalized Pairwise Comparisons approaches \citep{Pocock2011winratio,Buyse2010}. However, commonly used estimators can yield treatment recommendations that target a population-level estimand (the probability that a randomly sampled patient under treatment fares better…

异方差测量误差下常微分方程模型的贝叶斯推断AI 解读

Ordinary differential equation (ODE) models are widely used to describe systems in many areas of science. To ensure these models provide accurate and interpretable representations of real-world dynamics, it is often necessary to infer parameters from data, which involves specifying the form of the ODE system as well as a statistical model describing the observational process. A popular and convenient choice for the error model is a Gaussian distribution with constant…

利用数字健康数据评估序贯效应的累积边际均值模型AI 解读

Mobile health (mHealth) leverages digital technologies, such as mobile phones, to capture objective, frequent, and real-world digital phenotypes from individuals, enabling the delivery of tailored interventions to accommodate substantial between-subject and temporal heterogeneity. However, evaluating heterogeneous treatment effects (HTEs) using digital phenotype data is challenging because treatments are delivered dynamically over time and may generate carryover effects that…

用双重机器学习估计多种处理及其交互效应AI 解读

Causal inference literature has extensively focused on binary treatments, with relatively fewer methods developed for multi-valued treatments. In particular, methods for multiple simultaneously assigned treatments remain understudied despite their practical importance. This paper introduces two settings: (1) estimating the effects of multiple treatments of different types (binary, categorical, and continuous) and the effects of treatment interactions, and (2) estimating the…