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In this paper, we develop bootstrap methods for factor-augmented regressions with potentially weak common components, allowing signal eigenvalues to diverge at heterogeneous rates $N^{α_k}$, where $0<α_k\leq1$, $k=1,\ldots,r$. The regression estimator targets a rotation of the latent parameter vector that may be data dependent, while factor estimation can induce asymptotic bias. The proposed procedure directly constructs the rotation-specific target in the bootstrap world,…

使用生成模型检验条件分布相等AI 解读

Conditional distribution equality testing is a core problem with applications in causal inference, model diagnostics, and transfer learning. Existing methods often lose power when the conditioning variable is high-dimensional. We propose a new test that leverages generative models to compare conditional distributions using both observed data and synthetic samples. A sample-splitting and studentization scheme is introduced to control estimation error. Under the null, the test…

Factor models for longitudinal data, where policy adoption is unconfounded with respect to a low-dimensional set of latent factor loadings, have become increasingly popular for causal inference. Most existing approaches, however, rely on a causal finite-sample approach or computationally intensive methods, limiting their applicability and external validity. In this paper, we propose a novel method for panel causal inference within a super-population framework, based on…

预期高安慰剂反应时安慰剂对照随机试验的因果效应估计AI 解读

In placebo-controlled randomized clinical trials (RCTs), the placebo response significantly modifies treatment effects and diminishes the intention-to-treat (ITT) treatment effect, $Δ_{ITT}$. This study presents a novel two-stage framework for estimating the standardized causal treatment effect, $Δ_{STD}$, among the ITT population, under the assumption that their placebo responses are similar to the levels of self-administering medication at home. The first stage employs a…

Normality pre-tests on reduced-form innovations cannot detect whether two or more underlying structural shocks are Gaussian, and hence cannot detect a failure of identification in non-Gaussian SVARs. We propose a bootstrap-based approach that reveals such a failure. Under the null of valid identification and certain regularity conditions, the conditional bootstrap distribution of the maximum likelihood estimator of the impact matrix is asymptotically normal, so the…

Understanding associations between paired high-dimensional longitudinal datasets is a fundamental yet challenging problem arising across scientific domains, including longitudinal multi-omic studies. The difficulty stems from the complex, time-varying cross-covariance structure coupled with high dimensionality, which complicates both model formulation and statistical estimation for association discovery. To address these challenges, we propose a new framework called…

结合 model-X knockoffs 与 p 值的高维线性模型 FDR 控制AI 解读

We propose a novel multiple testing methodology for controlling the false discovery rate (FDR) in high-dimensional linear models that integrates model-X knockoff techniques with debiased penalized regression estimators. At the foundation of our methodology, we construct and study two sets of naturally paired high-dimensional test statistics and the associated $p$-values for evaluating the same null hypotheses. The first set is shown to be asymptotically mutually independent,…

Principal stratification (PS) is a commonly used approach for understanding the mechanisms through which a treatment affects an outcome. The goal of this work is to extend the PS framework to studies with continuous treatments, which introduces a number of both challenges and opportunities in terms of defining causal effects and performing inference. This manuscript provides multiple key methodological contributions: 1) we introduce principal causal estimands for continuous…

基于广义逆距离权重的GNAR模型改进多元时间序列预测AI 解读

Many multivariate time series arise on networks where relationships between variables depend on physical or more general distances. Standard vector autoregressive models struggle in such settings due to their quadratic parameter growth, while generalised network autoregressive (GNAR) models offer a parsimonious alternative by explicitly incorporating network structures. Existing GNAR formulations assume fixed weights, typically uniform or reciprocal distances, which may not…

多元Lévy自适应B样条回归AI 解读

We propose Multivariate Lévy Adaptive B-Spline Regression (MLABS), a Bayesian nonparametric regression model designed to capture nonlinear effects, interactions, and locally varying features of multivariate functions. MLABS represents the regression function as a random sum of low-order tensor-product B-spline basis functions under a finite Lévy random measure prior. The resulting representation adapts to the complexity and local structure of the regression function while…

Background: Generalized Odds (Gen Odds) provide summaries for ordinal outcomes without requiring the proportional odds assumption. However, conventional Gen Odds compares independently drawn treatment and control outcomes and targets a population-level contrast rather than an individual-level contrast. We developed an individual-level causal formulation of Gen Odds and examined its identification. Methods: We defined the Causal Gen Odds using the joint distribution of…

We develop a semiparametric continuous time inferential framework for testing cumulative treatment effects, including both immediate and carryover effects. The latent state process is modeled by an ordinary differential equation (ODE) whose drift depends on state and treatment, while the observed data are noisy measurements of this latent state at irregular, multi resolution time points. We define the average treatment effect (ATE) as the difference of expected cumulative…

Joint-event forecasts combine an estimated dependence model with current marginal forecasts. Retaining historical transforms at the marginal fits available when each outcome arrived creates overlapping estimation errors. We derive their joint influence with the terminal estimates in a stable Vine Copula VAR with normal innovation margins and a fixed, correctly specified Gaussian or positive Clayton vine. An intercept identity and the stable VAR filter reduce the historical…

当处理发生溢出：时空因果效应估计的神经网络框架AI 解读

Real-world public health policies are often enacted by local jurisdictions, but their effects can ripple through connected populations. For causal evaluation, this creates a difficult spatiotemporal problem: intermittent policy updates create path-level treatments, and because spillover depends on neighboring treatment paths along with the focal-unit's own history, controlling time-varying confounding requires high-dimensional, multimodal information from both sources. To…

时空干扰下用于实验的聚类切换设计AI 解读

We consider experimentation in the presence of non-stationarity, inter-unit (spatial) interference, and carry-over effects (temporal interference), where we wish to estimate the global average treatment effect (GATE), the difference between average outcomes having exposed all units at all times to treatment or to control. We suppose spatial interference is described by a graph, where a unit's outcome depends on its neighborhood's treatments, and that temporal interference is…

We study inference for continuous linear functionals of solutions to ill-posed inverse problems, including Euclidean parameters arising in nonparametric instrumental variables, proximal causal inference, and shadow-variable models. Although pointwise root-$n$ inference is possible under standard conditions, we show that this need not translate into locally reliable inference. Under a model imposing only minimal regularity conditions, the target is Hellinger discontinuous…

We consider the joint estimation of change-point locations and the sparsity pattern of the variance-covariance matrix, which is assumed to evolve in a piecewise constant manner. By applying Group Fused LASSO and LASSO penalties to the squared Frobenius norm, we estimate both the covariance structure and the change points. Adaptive weights are incorporated into the penalty terms to enhance change-point detection and covariance estimation accuracy. We establish the conditions…

Motivation: Mediation analysis is an important tool for elucidating causal mechanisms in biomedical research and has recently gained increasing attention in microbiome studies. Motivated by a microbiome study of acute myeloid leukemia (AML) patients, we investigate whether the effect of induction chemotherapy intensity on infection status is mediated through gut microbial taxa. This problem poses substantial methodological challenges due to the high dimensionality, zero…

This article introduces a framework for evaluating statistical decisions under both prior ambiguity and likelihood misspecification. We begin with an ambiguity set - a frequentist model that pairs a possibly misspecified likelihood with every possible prior - and uniformly expand it by a Kullback-Leibler radius to accommodate likelihood misspecification. We show that optimal decisions under this framework are equivalent to minimax decisions with an exponentially tilted loss…

观测因果推断中不完全识别下的相对偏差AI 解读

To conduct causal inference in observational settings, researchers must rely on certain identifying assumptions. In practice, these assumptions are unlikely to hold exactly. This paper considers the bias of selection-on-observables, instrumental variables, and proximal inference estimates under violations of their identifying assumptions. We develop bias expressions for IV and proximal inference that show how violations of their respective assumptions are amplified by any…

While causal discovery methods have matured for complete data, such algorithms for handling missing values remain limited. We establish general sufficient conditions under which causal graphs remain identifiable (i.e., uniquely determined from the available data distribution) under various missingness categories, including Missing Not At Random, and provide a framework to extend correctness guarantees from causal discovery algorithms for complete data to missing data…

组间不平衡下的风险异质性稳健推断AI 解读

Population-level heterogeneity is ubiquitous in biomedical data, where differences across demographic or clinical subgroups can substantially alter risk patterns. For example, in intensive care unit (ICU) studies, the mortality risk associated with specific admission diagnoses can vary across ethnic groups. Existing approaches for detecting risk heterogeneity are often sensitive to baseline model misspecification and regularization bias, both of which commonly arise in…

Wigner 矩阵时间序列的相变监测AI 解读

We develop methodology and theory for the detection of a phase transition in a time-series of high-dimensional random matrices. In the model we study, at each time point \( t = 1,2,\ldots \), we observe a deformed Wigner matrix \( \mathbf{M}_t \), where the unobservable deformation represents a latent signal. This signal is detectable only in the supercritical regime, and our objective is to detect the transition to this regime in real time, as new matrix--valued…

I study randomization inference for dynamic causal effects in panels with many units and few periods when treatment is endogenous and an instrument is as good as randomly assigned only through the innovations of a first-order autoregressive assignment mechanism with unknown persistence. The persistence is a nuisance parameter in two senses: it determines which weighted average of heterogeneous causal effects the instrumented local projection estimand measures, and it governs…