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Blind Targeting: Personalization under Third-Party Privacy Constraints

盲式定向:第三方隐私约束下的个性化

Major advertising platforms recently increased privacy protections by limiting advertisers' access to individual-level data. Instead of providing access to granular raw data, the platforms only allow a limited number of aggregate queries to a dataset, which is further protected by adding differentially private noise. This paper studies whether and how advertisers can design effective targeting policies within these restrictive privacy preserving data environments. To achieve…

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Practical considerations for Gaussian Process modeling for causal inference quasi-experimental studies with panel data

面板数据准实验因果推断中高斯过程建模的实践考量

Estimating causal effects in quasi-experiments with spatio-temporal panel data often requires adjusting for unmeasured confounding that varies across space and time. Gaussian Processes (GPs) offer a flexible, nonparametric modeling approach that can account for such complex dependencies through carefully chosen covariance kernels. In this paper, we provide a practical and interpretable framework for applying GPs to causal inference in panel data settings. We demonstrate how…

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Inverse Probability Weighting for Recurrent Event Models

重复事件模型中的逆概率加权

Recurrent events are common and important clinical trial endpoints in many disease areas, e.g., cardiovascular hospitalizations in heart failure, relapses in multiple sclerosis, or exacerbations in asthma. During a trial, patients may experience intercurrent events, that is, events after treatment assignment which affect the interpretation or existence of the outcome of interest. In many settings, a treatment effect in the scenario in which the intercurrent event would not…

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Consistent Labeling Across Group Assignments: Variance Reduction in Conditional Average Treatment Effect Estimation

跨组分配的一致标记:降低条件平均治疗效应估计方差

Numerous algorithms have been developed for Conditional Average Treatment Effect (CATE) estimation. In this paper, we first highlight a common issue where many algorithms exhibit inconsistent learning behavior for the same instance across different group assignments. We introduce a metric to quantify and visualize this inconsistency. Next, we present a theoretical analysis showing that this inconsistency indeed contributes to higher test errors and cannot be resolved through…

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A New and Efficient Debiased Estimation of General Treatment Models by Balanced Neural Networks Weighting

平衡神经网络加权下的一般治疗模型去偏高效估计

Estimation and inference of treatment effects under unconfounded treatment assignments often suffer from bias and the `curse of dimensionality' due to the nonparametric estimation of nuisance parameters for high-dimensional confounders. Although debiased state-of-the-art methods have been proposed for binary treatments under particular treatment models, they can be unstable for small sample sizes. Moreover, directly extending them to general treatment models can lead to…

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On relation between separable indirect effect, natural indirect effect, and interventional indirect effect

可分离、自然与干预间接效应之间的关系

Recently, the separable indirect effect (SIE) has gained attention due to its identifiability without requiring the untestable cross-world assumption necessary for the natural indirect effect (NIE). This article systematically compares the causal assumptions underlying the SIE, NIE, and interventional indirect effect (IIE) and evaluates their feasibility for mediational interpretation using the mediation null criterion, with a particular focus on the SIE. We demonstrate…

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Causal Inference with Outcomes Truncated by Death and Missing Not at Random

死亡截断与非随机缺失结局下的因果推断

In clinical trials, principal stratification analysis is commonly employed to address the issue of truncation by death, where a subject dies before the outcome can be measured. However, in practice, many survivor outcomes may remain uncollected or be missing not at random, posing a challenge to standard principal stratification analyses. In this paper, we explore the identification, estimation, and bounds of the average treatment effect within a subpopulation of individuals…

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Treatment Effect Heterogeneity in Regression Discontinuity Designs

断点回归设计中的处理效应异质性

Empirical studies using Regression Discontinuity (RD) designs often explore heterogeneous treatment effects based on pretreatment covariates, even though no formal statistical methods exist for such analyses. This has led to the widespread use of ad hoc approaches in applications. Motivated by common empirical practice, we develop a unified, theoretically grounded framework for RD heterogeneity analysis. We show that a fully interacted local linear (in functional parameters)…

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Generalized coarsened confounding for causal effects: a large-sample framework

因果效应的广义粗化混杂调整:大样本框架

There has been widespread use of causal inference methods for the rigorous analysis of observational studies and to identify policy evaluations. In this article, we consider a class of generalized coarsened procedures for confounding. At a high level, these procedures can be viewed as performing a clustering of confounding variables, followed by treatment effect and attendant variance estimation using the confounder strata. In addition, we propose two new algorithms for…

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Quantum-enhanced causal discovery for a small number of samples

小样本下的量子增强因果发现

The discovery of causal relations from observed data has attracted significant interest from disciplines such as economics, social sciences, and biology. In practical applications, considerable knowledge of the underlying systems is often unavailable, and real data are usually associated with nonlinear causal structures, which makes the direct use of most conventional causality analysis methods difficult. This study proposes a novel quantum Peter-Clark (qPC) algorithm for…

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Nonparanormal Adjusted Marginal Inference

非正态变换模型下的协变量调整边际推断

Although treatment effects can be estimated from observed outcome distributions obtained from proper randomization in clinical trials, covariate adjustment is recommended to increase precision. For important treatment effects, such as odds or hazard ratios, conditioning on covariates in binary logistic or proportional hazards models changes the interpretation of the treatment effect and conditioning on different sets of covariates renders the resulting effect estimates…

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Bayesian analysis of the causal reference-based model for missing data in clinical trials

临床试验缺失数据的因果参照模型贝叶斯分析

The statistical analysis of clinical trials is often complicated by missing data. Patients sometimes experience intercurrent events (ICEs), which usually (although not always) lead to missing subsequent outcome measurements for such individuals. The reference-based imputation methods were proposed by Carpenter et al. (2013) and have been commonly adopted for handling missing data due to ICEs when estimating treatment policy strategy estimands. Conventionally, the variance…

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Shrinkage-Based Regressions with Many Related Treatments

针对多种相关处理的收缩回归

When using observational causal models, practitioners often want to disentangle the effects of many related, partially-overlapping treatments. Examples include estimating treatment effects of different marketing touchpoints, ordering different types of products, or signing up for different services. Common approaches that estimate separate treatment coefficients are too noisy for practical decision-making. We propose a computationally light model that uses a customized ridge…

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rdhte: Conditional Average Treatment Effects in RD Designs

rdhte:断点回归设计中的条件平均处理效应

Understanding causal heterogeneous treatment effects based on pretreatment covariates is a crucial aspect of empirical work. Building on Calonico, Cattaneo, Farrell, Palomba, and Titiunik (2025), this article discusses the software package rdhte for estimation and inference of heterogeneous treatment effects in sharp regression discontinuity (RD) designs. The package includes three main commands: rdhte conducts estimation and robust bias-corrected inference for heterogeneous…

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Nonparametric causal inference for optogenetics: sequential excursion effects for dynamic regimes

光遗传学的非参数因果推断:动态方案中的序贯偏离效应

Optogenetics is a powerful neuroscience technique for studying how neural circuit manipulation affects behavior. Standard analysis conventions discard information and severely limit the scope of the causal questions that can be probed. To address this gap, we 1) draw connections to the causal inference literature on sequentially randomized experiments, 2) propose a non-parametric framework for analyzing "open-loop" (static regime) optogenetics behavioral experiments, 3)…

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Bayesian estimation of causal effects from observational categorical data

基于观测分类数据的因果效应贝叶斯估计

We present a Bayesian procedure for estimation of pairwise intervention effects in a high-dimensional system of categorical variables. We assume that we have observational data generated from an unknown causal Bayesian network for which there are no latent confounders. Most of the existing methods developed for this setting assume that the underlying model is linear Gaussian, including the Bayesian IDA (BIDA) method that we build upon in this work. By combining a Bayesian…

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A Binary IV Model for Persuasion: Profiling Persuasion Types among Compliers

说服研究中的二元工具变量模型:刻画服从者的说服类型

In an empirical study of persuasion, researchers often use a binary instrument to encourage individuals to consume information and take some action. We show that, with a binary Imbens-Angrist instrumental variable model and the monotone treatment response assumption, it is possible to identify the joint distribution of potential outcomes among compliers. This is necessary to identify the percentage of mobilised voters and their statistical characteristic defined by the…

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A Recipe for Causal Graph Regression: Confounding Effects Revisited

因果图回归的方法方案:重新审视混杂效应

Through recognizing causal subgraphs, causal graph learning (CGL) has risen to be a promising approach for improving the generalizability of graph neural networks under out-of-distribution (OOD) scenarios. However, the empirical successes of CGL techniques are mostly exemplified in classification settings, while regression tasks, a more challenging setting in graph learning, are overlooked. We thus devote this work to tackling causal graph regression (CGR); to this end we…

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Extrapolation in Regression Discontinuity Design Using Comonotonicity

利用共单调性外推断点回归中的因果效应

We present a novel approach for extrapolating causal effects away from the margin between treatment and non-treatment in sharp regression discontinuity designs with multiple covariates. Our methods apply both to settings in which treatment is a function of multiple observables and settings in which treatment is determined based on a single running variable. Our key identifying assumption is that conditional average treated and untreated potential outcomes are comonotonic:…

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Coarse Personalization

粗粒度个性化:联合分群与处理配置

With advances in estimating heterogeneous treatment effects, firms can personalize and target individuals at a granular level. However, feasibility constraints limit full personalization. In practice, firms choose segments of individuals and assign a treatment to each segment to maximize profits: We call this the coarse personalization problem. We propose a two-step solution that simultaneously makes segmentation and targeting decisions. First, the firm personalizes by…

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Bayesian regression discontinuity design with unknown cutoff

阈值未知时的贝叶斯断点回归设计

The regression discontinuity design (RDD) is a quasi-experimental approach used to estimate the causal effects of an intervention assigned based on a cutoff criterion. RDD exploits the idea that close to the cutoff units below and above are similar; hence, they can be meaningfully compared. Consequently, the causal effect can be estimated only locally at the cutoff point. This makes the cutoff point an essential element of RDD. However, the exact cutoff location may not…

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Fortified Proximal Causal Inference with Many Invalid Proxies

容许多个无效代理变量的强化近端因果推断

Causal inference from observational data often relies on the assumption of no unmeasured confounding, an assumption frequently violated in practice due to unobserved or poorly measured covariates. Proximal causal inference (PCI) offers a promising framework for addressing unmeasured confounding using a pair of outcome and treatment confounding proxies. However, existing PCI methods typically assume all specified proxies are valid, which may be unrealistic and is untestable…

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Penalized FCI for Causal Structure Learning in a Sparse DAG for Biomarker Discovery in Parkinson's Disease

用于帕金森病生物标志物发现的稀疏因果结构学习:惩罚化 FCI

Parkinson's disease (PD) is a progressive neurodegenerative disorder that lacks reliable early-stage biomarkers for diagnosis, prognosis, and therapeutic monitoring. While cerebrospinal fluid (CSF) biomarkers, such as alpha-synuclein seed amplification assays (alphaSyn-SAA), offer diagnostic potential, their clinical utility is limited by invasiveness and incomplete specificity. Plasma biomarkers provide a minimally invasive alternative, but their mechanistic role in PD…

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What Makes Treatment Effects Identifiable? Characterizations and Estimators Beyond Unconfoundedness

处理效应何以可识别?超越无混杂性的刻画与估计

Most of the widely used estimators of the average treatment effect (ATE) in causal inference rely on the assumptions of unconfoundedness and overlap. Unconfoundedness requires that the observed covariates account for all correlations between the outcome and treatment. Overlap requires the existence of randomness in treatment decisions for all individuals. Nevertheless, many types of studies frequently violate unconfoundedness or overlap, for instance, observational studies…

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