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Adaptive sample splitting for randomization tests

随机化检验的自适应样本分割

Randomization tests are widely used to generate finite-sample valid $p$-values for causal inference on experimental data. However, when applied to subgroup analysis, these tests may lack power due to small subgroup sizes. Incorporating a shared estimator of the conditional average treatment effect (CATE) can substantially improve power across subgroups but requires sample splitting to preserve validity. To this end, we quantify each unit's contribution to estimation and…

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Decomposition and Interpretation of Treatment Effects in Settings with Delayed Outcomes

结果延迟实现时治疗效应的分解与解释

This paper studies settings where the analyst is interested in identifying and estimating the average \emph{direct} causal effect of a binary treatment on an outcome. We consider a setup in which the outcome realization does not get immediately realized after the treatment assignment, a feature that is ubiquitous in empirical settings. The period between the treatment and the realization of the outcome allows other observed actions to occur and affect the outcome. In this…

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Deciphering interventional dynamical causality from non-intervention complex systems

从非干预复杂系统中解析干预型动力因果关系

Detecting and quantifying causality is a focal topic in the fields of science, engineering, and interdisciplinary studies. However, causal studies on non-intervention systems attract much attention but remain extremely challenging. Delay-embedding technique provides a promising approach. In this study, we propose a framework named Interventional Dynamical Causality (IntDC) in contrast to the traditional Constructive Dynamical Causality (ConDC). ConDC, including Granger…

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Generalized Optimal Transport

广义最优传输

Many causal and structural parameters in economics can be identified and estimated by computing the value of an optimization program over all distributions consistent with the model and the data. Existing tools apply when the data is discrete, or when only disjoint marginals of the distribution are identified, which is restrictive in many applications. We develop a general framework that yields sharp bounds on a linear functional of the unknown true distribution under i) an…

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Estimating invertible processes in Hilbert spaces, with applications to functional ARMA processes

Hilbert 空间可逆过程的估计及其函数型 ARMA 应用

Invertible processes are central to functional time series analysis, making the estimation of their defining operators a key problem. While asymptotic error bounds have been established for specific ARMA models on $L^2[0,1]$, a general theoretical framework has not yet been considered. This paper fills in this gap by deriving consistent estimators for the operators characterizing the invertible representation of a functional time series with white noise innovations in a…

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Misspecifications in structural equation modeling: The choice of latent variables, causal-formative constructs or composites

结构方程建模中构念类型选择的误设问题

Empirical research in many social disciplines involves constructs that are not directly observable, such as behaviors. To model them, constructs must be operationalized using their relations with indicators. Structural equation modeling (SEM) is the primary approach for this purpose. In SEM, three types of constructs are distinguished: latent variables, causal-formative constructs, and composites. To estimate the parameters of the different models, various estimators have…

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Regional Price Dynamics and Market Integration in the U.S. Beef Industry: An Econometric Analysis

美国牛肉业的区域价格动态与市场整合

The United States, a leading global producer and consumer of beef, continues to face substantial challenges in achieving price harmonization across its regional markets. This paper evaluates the validity of the Law of One Price (LOP) in the U.S. beef industry and investigates causal relationships among regional price dynamics. Through a series of econometric tests, we establish that regional price series are integrated of order one, displaying non-stationarity in levels and…

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Causal Inference for Circular Data

圆周数据的因果推断

In causal inference, a fundamental task is to estimate the effect resulting from a specific treatment, which is often handled with inverse probability weighting. Despite an abundance of attention to the advancement of this task, most articles have focused on linear data rather than circular data, which are measured in angles. In this article, we extend the causal inference framework to accommodate circular data. Specifically, two new treatment effects, average direction…

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Evaluating the effect of different non-informative prior specifications on the Bayesian proportional odds model in randomised controlled trials: a simulation study

非信息先验对随机试验中贝叶斯比例优势模型的影响

Background: Ordinal outcomes combine multiple distinct ordered patient states into a single endpoint and are commonly analysed using proportional odds (PO) models in clinical trials. When using a Bayesian approach, it is not obvious what the influence of a 'non-informative' prior is in the analysis of a fixed design or on early stopping decisions in adaptive designs. Methods: This study compares different non-informative prior specifications for the Bayesian PO model in the…

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A Framework for Covariate-Adjusted Bivariate Causal Discovery

协变量调整的二元因果发现框架

Ascertaining causal direction from observational data is a fundamental challenge in scientific inquiry. Of particular interest is the problem of covariate-adjusted bivariate causal discovery, i.e., determining the causal direction between X and Y in the presence of Z. While unadjusted bivariate causal discovery has seen significant advances (Hoyer et al., 2008; Ni, 2022), there is a lack of methodology dealing with real-world bivariate relationships, which are often…

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Nonparametric regression for cost-effectiveness analyses with observational data -- a tutorial

观察数据成本效果分析中的非参数回归:教程

Healthcare decision-making often requires selecting among treatment options under budget constraints, particularly when one option is more effective but also more costly. Cost-effectiveness analysis (CEA) provides a framework for evaluating whether the health benefits of a treatment justify its additional costs. A key component of CEA is the estimation of treatment effects on both health outcomes and costs, which becomes challenging when using observational data, due to…

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Identifying Socially Disruptive Policies

社会关系扰动政策的识别

Social disruption occurs when a policy creates or destroys many network connections between agents. It is a costly side effect of many interventions and so a growing empirical literature recommends measuring and accounting for social disruption when evaluating the welfare impact of a policy. However, there is currently little work characterizing what can actually be learned about social disruption from data in practice. In this paper, we consider the problem of identifying…

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From Observations to Causations: A GNN-based Probabilistic Prediction Framework for Causal Discovery

从观察到因果:基于图神经网络的概率化因果发现框架

Causal discovery from observational data is challenging, especially with large datasets and complex relationships. Traditional methods often struggle with scalability and capturing global structural information. To overcome these limitations, we introduce a novel graph neural network (GNN)-based probabilistic framework that learns a probability distribution over the entire space of causal graphs, unlike methods that output a single deterministic graph. Our framework…

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Causal Inference when Intervention Units and Outcome Units Differ

干预单位与结果单位不同时的因果推断

We study causal inference in settings characterized by interference with a bipartite structure. There are two distinct sets of units: intervention units to which an intervention can be applied and outcome units on which the outcome of interest can be measured. Outcome units may be affected by interventions on some, but not all, intervention units, as captured by a bipartite graph. Examples of this setting can be found in analyses of the impact of pollution abatement in…

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The Effect of Alcohol intake on Brain White Matter Microstructural Integrity: A New Causal Inference Framework for Incomplete Phenomic Data

饮酒对脑白质微结构完整性的影响:不完整表型数据的因果推断框架

Although substance use, such as alcohol intake, is known to be associated with cognitive decline during aging, its direct influence on the central nervous system remains incompletely understood. In this study, we investigate the influence of alcohol intake frequency on reduction of brain white matter microstructural integrity in the fornix, a brain region considered a promising marker of age-related microstructural degeneration, using a large UK Biobank (UKB) cohort with…

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Adaptive Proximal Causal Inference with Some Invalid Proxies

含部分无效代理变量的自适应近端因果推断

Proximal causal inference (PCI) is a recently proposed framework to identify and estimate the causal effect of an exposure on an outcome in the presence of hidden confounders, using observed proxies. Specifically, PCI relies on two types of proxies: a treatment-inducing confounding proxy, related to the outcome only through its association with unmeasured confounders (given treatment and covariates), and an outcome-inducing confounding proxy, related to the treatment only…

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Inference with weights: Residualization produces short, valid intervals for varying estimands and varying resampling processes

加权推断:不同估计目标与重抽样机制下的残差化区间

Weighting procedures are used in observational causal inference to adjust for covariate imbalance within the sample. Common practice for inference is to estimate robust standard errors from a weighted regression of outcome on treatment. However, it is well known that weighting can inflate variance estimates, sometimes significantly, leading to standard errors and confidence intervals that are overly conservative. We instead examine and recommend the use of robust standard…

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Comparing Causal Inference Methods for Point Exposures with Missing Confounders: A Simulation Study

混杂变量缺失时点暴露因果推断方法的模拟比较

Causal inference methods based on electronic health record (EHR) databases must simultaneously handle confounding and missing data. Vast scholarship exists aimed at addressing these two issues separately, but surprisingly few papers attempt to address them simultaneously. In practice, when faced with simultaneous missing data and confounding, analysts may proceed by first imputing missing data and subsequently using outcome regression or inverse-probability weighting (IPW)…

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Testing Sign Congruence Between Two Parameters

两个参数的符号一致性检验

We test the null hypothesis that two parameters $(μ_1,μ_2)$ have the same sign, assuming that (asymptotically) normal estimators $(\hatμ_1,\hatμ_2)$ are available. Examples of this problem include the analysis of heterogeneous treatment effects, causal interpretation of reduced-form estimands, meta-studies, and mediation analysis. A number of tests were recently proposed. We recommend a test that is simple and rejects more often than many of these recent proposals. Like all…

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Estimation of conditional average treatment effects on distributed confidential data

分布式保密数据上的条件平均处理效应估计

The estimation of conditional average treatment effects (CATEs) is an important topic in many scientific fields. CATEs can be estimated with high accuracy if data distributed across multiple parties are centralized. However, it is difficult to aggregate such data owing to confidentiality or privacy concerns. To address this issue, we propose data collaboration double machine learning, a method for estimating CATE models using privacy-preserving fusion data constructed from…

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A Liberating Framework from Truncation and Censoring, with Application to Learning Treatment Effects

摆脱截断与删失限制的学习框架及其处理效应应用

Time-to-event outcomes are often subject to left truncation and right censoring. While many survival analysis methods have been developed to handle truncation and censoring, majority of the past works require strong independence assumptions. We relax these stringent assumptions through leveraging covariate information together with orthogonal learning, and develop a liberating framework from left truncation and right censoring so that desirable properties like double…

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Cure Rate Joint Model for Time-to-Event Data and Longitudinal Tumor Burden with Potential Change Points

含潜在变点的生存时间与纵向肿瘤负荷治愈率联合模型

In non-small cell lung cancer (NSCLC) clinical trials, tumor burden (TB) is a key longitudinal biomarker for assessing treatment effects. Typically, standard-of-care (SOC) therapies and some novel interventions initially decrease TB; however, many patients subsequently experience an increase-indicating disease progression-while others show a continuous decline. In patients with an eventual TB increase, the change point marks the onset of progression and must occur before the…

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Good Controls Gone Bad: Difference-in-Differences with Covariates

好控制变量为何失效:含协变量的双重差分

This paper introduces the two-way common causal covariates (CCC) assumption, which is necessary to get an unbiased estimate of the ATT when using time-varying covariates in existing Difference-in-Differences methods. The two-way CCC assumption implies that the effect of the covariates remain the same between groups and across time periods. This assumption has been implied in previous literature, but has not been explicitly addressed. Through theoretical proofs and a Monte…

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Trek-Based Parameter Identification for Linear Causal Models With Arbitrarily Structured Latent Variables

任意结构潜变量下线性因果模型的 Trek 路径参数识别

We develop a criterion to certify whether causal effects are identifiable in linear structural equation models with latent variables. Linear structural equation models correspond to directed graphs whose nodes represent the random variables of interest and whose edges are weighted with linear coefficients that correspond to direct causal effects. In contrast to previous identification methods, we do not restrict ourselves to settings where the latent variables constitute…

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