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DR-VIDAL -- Doubly Robust Variational Information-theoretic Deep Adversarial Learning for Counterfactual Prediction and Treatment Effect Estimation on Real World Data

DR-VIDAL:用于反事实预测与处理效应估计的双重稳健深度生成学习

Determining causal effects of interventions onto outcomes from real-world, observational (non-randomized) data, e.g., treatment repurposing using electronic health records, is challenging due to underlying bias. Causal deep learning has improved over traditional techniques for estimating individualized treatment effects (ITE). We present the Doubly Robust Variational Information-theoretic Deep Adversarial Learning (DR-VIDAL), a novel generative framework that combines two…

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Estimation of causal dose-response functions under data fusion

数据融合下因果剂量反应函数的估计

Estimating the causal dose-response function is challenging, particularly when data from a single source are insufficient to estimate responses precisely across all exposure levels. To overcome this limitation, we propose a data fusion framework that leverages multiple data sources that are partially aligned with the target distribution. Specifically, we derive a Neyman-orthogonal loss function tailored for estimating the dose-response function within data fusion settings.…

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Comparison of Simulation-Guided Design to Closed-Form Power Calculations in Planning a Cluster Randomized Trial with Covariate-Constrained Randomization: A Case Study in Rural Chad

协变量约束随机化的整群试验规划:模拟设计与闭式功效计算的乍得农村案例比较

Current practices for designing cluster-randomized trials (cRCTs) typically rely on closed-form formulas for power calculations. For cRCTs using covariate-constrained randomization, the utility of conventional calculations might be limited, particularly when data is nested. We compared simulation-based planning of a nested cRCT using covariate-constrained randomization to conventional power calculations using OptiMAx-Chad as a case study. OptiMAx-Chad will examine the impact…

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Towards Identifiability of Hierarchical Temporal Causal Representation Learning

分层时间因果表征学习的可识别性

Modeling hierarchical latent dynamics behind time series data is critical for capturing temporal dependencies across multiple levels of abstraction in real-world tasks. However, existing temporal causal representation learning methods fail to capture such dynamics, as they fail to recover the joint distribution of hierarchical latent variables from \textit{single-timestep observed variables}. Interestingly, we find that the joint distribution of hierarchical latent variables…

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Can We Validate Counterfactual Estimations in the Presence of General Network Interference?

一般网络干扰下能否验证反事实估计?

Randomized experiments have become a cornerstone of evidence-based decision-making in contexts ranging from online platforms to public health. However, in experimental settings with network interference, a unit's treatment can influence outcomes of other units, challenging both causal effect estimation and its validation. Classic validation approaches fail as outcomes are only observable under a single treatment scenario and exhibit complex correlation patterns due to…

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Copula Structural Equation Models for Mediation Pathway Analysis

中介路径分析中的 Copula 结构方程模型

Structural equation models (SEMs) are fundamental to causal mediation pathway discovery. However, traditional SEM approaches often rely on \emph{ad hoc} model specifications when handling complex data structures such as mixed data types or non-normal data in which Gaussian assumptions for errors are rather restrictive. The invocation of copula dependence modeling methods to extend the classical linear SEMs mitigates several of key technical limitations, offering greater…

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Choosing an analytic approach: Key study design considerations in state policy evaluation

如何选择分析方法:州级政策评估中的关键研究设计考量

This paper reviews and details methods for state policy evaluation to guide selection of a research approach based on evaluation setting and available data. We highlight key design considerations for an analysis, including treatment and control group selection, timing of policy adoption, expected effect heterogeneity, and data considerations. We then provide an overview of analytic approaches and differentiate between methods based on evaluation context, such as settings…

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COADVISE: Covariate Adjustment with Variable Selection in Randomized Controlled Trials

COADVISE:随机对照试验中结合变量选择的协变量调整

Adjusting for covariates in randomized controlled trials can enhance the credibility and efficiency of treatment effect estimation. However, handling numerous covariates and their complex (non-linear) transformations poses a challenge. Motivated by the case study of the Best Apnea Interventions for Research (BestAIR) trial data from the National Sleep Research Resource (NSRR), where the number of covariates (p=114) is comparable to the sample size (N=196), we propose a…

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Dynamic Spatial Treatment Effect Boundaries: A Continuous Functional Framework from Navier-Stokes Equations

动态空间处理效应边界:源自纳维–斯托克斯方程的连续函数框架

I develop a comprehensive theoretical framework for dynamic spatial treatment effect boundaries using continuous functional definitions grounded in Navier-Stokes partial differential equations. Rather than discrete treatment effect estimators, the framework characterizes treatment intensity as a continuous function $τ(\mathbf{x}, t)$ over space-time, enabling rigorous analysis of propagation dynamics, boundary evolution, and cumulative exposure patterns. Building on exact…

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Nonparametric Identification of Spatial Treatment Effect Boundaries: Evidence from Bank Branch Consolidation

空间处理效应边界的非参数识别:银行网点整合的证据

I develop a nonparametric framework for identifying spatial boundaries of treatment effects without imposing parametric functional form restrictions. The method employs local linear regression with data-driven bandwidth selection to flexibly estimate spatial decay patterns and detect treatment effect boundaries. Monte Carlo simulations demonstrate that the nonparametric approach exhibits lower bias and correctly identifies the absence of boundaries when none exist, unlike…

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Nonparametric Identification and Estimation of Spatial Treatment Effect Boundaries: Evidence from 42 Million Pollution Observations

空间处理效应边界的非参数识别与估计:四千二百万条污染观测的证据

This paper develops a nonparametric framework for identifying and estimating spatial boundaries of treatment effects in settings with geographic spillovers. While atmospheric dispersion theory predicts exponential decay of pollution under idealized assumptions, these assumptions -- steady winds, homogeneous atmospheres, flat terrain -- are systematically violated in practice. I establish nonparametric identification of spatial boundaries under weak smoothness and…

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Spatial and Temporal Boundaries in Difference-in-Differences: A Framework from Navier-Stokes Equation

双重差分中的空间与时间边界:源自纳维–斯托克斯方程的框架

This paper develops a unified framework for identifying spatial and temporal boundaries of treatment effects in difference-in-differences designs. Starting from fundamental fluid dynamics equations (Navier-Stokes), we derive conditions under which treatment effects decay exponentially in space and time, enabling researchers to calculate explicit boundaries beyond which effects become undetectable. The framework encompasses both linear (pure diffusion) and nonlinear…

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Discovering Causal Relationships using Proxy Variables under Unmeasured Confounding

未观测混杂下利用代理变量发现因果关系

Inferring causal relationships between variable pairs in the observational study is crucial but challenging, due to the presence of unmeasured confounding. While previous methods employed the negative controls to adjust for the confounding bias, they were either restricted to the discrete setting (i.e., all variables are discrete) or relied on strong assumptions for identification. To address these problems, we develop a general nonparametric approach that accommodates both…

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A Double Machine Learning Approach to Combining Experimental and Observational Data

结合实验与观察数据的双重机器学习方法

Experimental and observational studies often lack validity due to untestable assumptions. We propose a double machine learning approach to combine experimental and observational studies, allowing practitioners to test for assumption violations and estimate treatment effects consistently. Our framework proposes a falsification test for external validity and ignorability under milder assumptions. We provide consistent treatment effect estimators even when one of the…

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On Quantile Treatment Effects, Rank Similarity,and Variation of Instrumental Variables

分位数处理效应、秩相似性与工具变量变异

This paper develops a nonparametric framework to identify and estimate distributional treatment effects under nonseparable endogeneity. We begin by revisiting the widely adopted \emph{rank similarity} (RS) assumption and characterizing it by the relationship it imposes between observed and counterfactual potential outcome distributions. The characterization highlights the restrictiveness of RS, motivating a weaker identifying condition. Under this alternative, we construct…

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Causal Inference in High-Dimensional Generalized Linear Models with Binary Outcomes

二元结果高维广义线性模型中的因果推断

This paper proposes a debiased estimator for causal effects in high-dimensional generalized linear models with binary outcomes and general link functions. The estimator augments a regularized regression plug-in with weights computed from a convex optimization problem that approximately balances link-derivative-weighted covariates and controls variance; it does not rely on estimated propensity scores. Under standard conditions, the estimator is $\sqrt{n}$-consistent and…

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On the Asymptotics of the Minimax Linear Estimator

极小极大线性估计量的渐近性质

Many causal estimands, such as average treatment effects under unconfoundedness, can be written as continuous linear functionals of an unknown regression function. We study a weighting estimator that sets weights by a minimax procedure: solving a convex optimization problem that trades off worst-case conditional bias against variance. Despite its growing use, general root-$n$ theory for this method has been limited. This paper fills that gap. Under regularity conditions, we…

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Generative Quantile Bayesian Prediction

生成式分位数贝叶斯预测

Prediction is a central task of machine learning. Our goal is to solve large scale prediction problems using Generative Quantile Bayesian Prediction (GQBP).By directly learning predictive quantiles rather than densities we achieve a number of theoretical and practical advantages. We contrast our approach with state-of-the-art methods including conformal prediction, fiducial prediction and marginal likelihood. Our distinguishing feature of our method is the use of generative…

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Selecting the Best Arm in One-Shot Multi-Arm RCTs: The Asymptotic Minimax-Regret Decision Framework for the Best-Population Selection Problem

一次性多臂随机试验的最佳方案选择:渐近极小极大遗憾决策框架

We develop a frequentist decision-theoretic framework for selecting the best arm in one-shot, multi-arm randomized controlled trials (RCTs). Our approach characterizes the minimax-regret (MMR) optimal decision rule for any multivariate location family reward distribution with full support. We show that the MMR rule is deterministic, unique, and computationally tractable. We then specialize to the case of multivariate normal (MVN) rewards with an arbitrary covariance matrix,…

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Remote Auditing: Design-based Tests of Randomization, Selection, and Missingness with Broadly Accessible Satellite Imagery

遥感审计:利用卫星影像检验随机化、选择与缺失

Randomized controlled trials (RCTs) are the benchmark for causal inference, yet field implementation can drift from the registered design or, by chance, yield imbalances. We introduce a remote audit -- a preregistrable, design-based diagnostic that uses strictly pre-treatment, publicly available satellite imagery to test whether assignment is independent of local conditions. The audit implements a conditional randomization test that asks whether treatment is more predictable…

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Inference after discretizing time-varying unobserved heterogeneity

时变不可观测异质性离散化后的推断

Approximating time-varying unobserved heterogeneity by discrete types has become increasingly popular in economics. Yet, provably valid post-clustering inference for target parameters in models that do not impose an exact group structure is still lacking. This paper fills this gap in the leading case of a linear panel data model with nonseparable two-way unobserved heterogeneity. Building on insights from the double machine learning literature, we propose a simple inference…

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Safe Individualized Treatment Rules with Controllable Harm Rates

可控制伤害率的安全个体化处理规则

Estimating individualized treatment rules (ITRs) is crucial for tailoring interventions in precision medicine. Typical ITR estimation methods rely on conditional average treatment effects (CATEs) to guide treatment assignments. However, such methods overlook individual-level harm within covariate-specific subpopulations, potentially leading many individuals to experience worse outcomes under CATE-based ITRs. In this article, we aim to estimate ITRs that maximize the reward…

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Treatment Effects Inference with High-Dimensional Instruments and Control Variables

高维工具变量与控制变量下的处理效应推断

Obtaining valid treatment effect inference remains a challenging problem when dealing with numerous instruments and non-sparse control variables. In this paper, we propose a novel ridge regularization-based instrumental variables method for estimation and inference in the presence of both high-dimensional instrumental variables and high-dimensional control variables. These methods are applicable both with and without sparsity assumptions. To remove the estimation bias, we…

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Evaluating Policy Effects under Network Interference without Network Information: A Transfer Learning Approach

未知网络下的干扰政策效应评估:迁移学习方法

This paper develops a sensitivity analysis framework that transfers the average total treatment effect (ATTE) from source data with a fully observed network to target data whose network is completely unknown. The ATTE represents the average social impact of a policy that assigns the treatment to every individual in the dataset. We postulate a covariate-shift type assumption that both source and target datasets share the same conditional mean outcome. However, because the…

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