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Local Learning for Covariate Selection in Nonparametric Causal Effect Estimation with Latent Variables

存在潜变量时非参数因果效应估计的局部协变量选择

Estimating causal effects from nonexperimental data is a fundamental problem in many fields of science. A key component of this task is selecting an appropriate set of covariates for confounding adjustment to avoid bias. Most existing methods for covariate selection often assume the absence of latent variables and rely on learning the global network structure among variables. However, identifying the global structure can be unnecessary and inefficient, especially when our…

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Bridging Stratification and Regression Adjustment: Batch-Adaptive Stratification with Post-Design Adjustment in Randomized Experiments

连接分层与回归调整:随机实验中的批次自适应分层与设计后调整

To increase statistical efficiency in a randomized experiment, researchers often use stratification (i.e., blocking) in the design stage. However, conventional practices of stratification fail to exploit valuable information about the predictive relationship between covariates and potential outcomes. In this paper, I introduce an adaptive stratification procedure for increasing statistical efficiency when some information is available about the relationship between…

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Unifying regression-based and design-based causal inference in time-series experiments

统一时间序列实验中的回归式与设计式因果推断

Time-series experiments, also called switchback experiments or N-of-1 trials, play increasingly important roles in modern applications in medical and industrial areas. Under the potential outcomes framework, recent research has studied time-series experiments from the design-based perspective, relying solely on the randomness in the design to drive the statistical inference. Focusing on simpler statistical methods, we examine the design-based properties of regression-based…

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Efficiently Learning Synthetic Control Models for High-dimensional Disaggregated Data

高维细分数据中合成控制模型的高效学习

The Synthetic Control method (SC) has become a valuable tool for estimating causal effects. Originally designed for single-treated unit scenarios, it has recently found applications in high-dimensional disaggregated settings with multiple treated units. However, challenges in practical implementation and computational efficiency arise in such scenarios. To tackle these challenges, we propose a novel approach that integrates the Multivariate Square-root Lasso method into the…

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Differentiable Structure Learning and Causal Discovery for General Binary Data

一般二元数据的可微结构学习与因果发现

Existing methods for differentiable structure learning in discrete data typically assume that the data are generated from specific structural equation models. However, these assumptions may not align with the true data-generating process, which limits the general applicability of such methods. Furthermore, current approaches often ignore the complex dependence structure inherent in discrete data and consider only linear effects. We propose a differentiable structure learning…

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Beyond the Average: Distributional Causal Inference under Imperfect Compliance

超越平均效应:不完全依从下的分布因果推断

We study the estimation of distributional treatment effects in randomized experiments with imperfect compliance. When participants do not adhere to their assigned treatments, we leverage treatment assignment as an instrumental variable to identify the local distributional treatment effect-the difference in outcome distributions between treatment and control groups for the subpopulation of compliers. We propose a regression-adjusted estimator based on a distribution…

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A Capture-Recapture Approach to Enhance Treatment Effect Evaluation in an Observational Cohort

利用捕获—再捕获方法改进观察队列中的处理效应评估

We extend recently proposed design-based capture-recapture (CRC) methods for prevalence estimation among registry participants, in order to enhance treatment effect evaluation among a trial-eligible target population. The so-called ``anchor stream design" for CRC analysis integrates an observational study cohort with a randomized trial involving a small representative study sample, and enhances the generalizability and transportability of CRC findings. We show that a novel…

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TERRA: A Transformer-Enabled Recursive R-learner for Longitudinal Heterogeneous Treatment Effect Estimation

TERRA:用于纵向异质性处理效应估计的 Transformer 递归 R 学习器

Accurately estimating heterogeneous treatment effects (HTE) in longitudinal settings is essential for personalized decision-making across healthcare, public policy, education, and digital marketing. However, time-varying interventions introduce many unique challenges, such as carryover effects, time-varying heterogeneity, and post-treatment bias, which are not addressed by standard HTE methods. To address these challenges, we introduce TERRA (Transformer-Enabled Recursive…

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Dual-Channel Technology Diffusion: Spatial Decay and Network Contagion in Supply Chain Networks

技术扩散的双通道机制:供应链网络中的空间衰减与网络传播

This paper develops a dual-channel framework for analyzing technology diffusion that integrates spatial decay mechanisms from continuous functional analysis with network contagion dynamics from spectral graph theory. Building on our previous studies, which establish Navier-Stokes-based approaches to spatial treatment effects and financial network fragility, we demonstrate that technology adoption spreads simultaneously through both geographic proximity and supply chain…

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Causal Effect Estimation with TMLE: Handling Missing Data and Near-Violations of Positivity

TMLE 因果效应估计:缺失数据与近正值性违背

We evaluate the performance of targeted maximum likelihood estimation (TMLE) for estimating the average treatment effect in missing data scenarios under varying levels of positivity violations. We employ model- and design-based simulations, with the latter using undersmoothed highly adaptive lasso on the 'WASH Benefits Bangladesh' dataset to mimic real-world complexities. Five missingness-directed acyclic graphs are considered, capturing common missing data mechanisms in…

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Estimating the Impact of the Bitcoin Halving on Its Price Using Synthetic Control

利用合成控制估计比特币减半对价格的影响

The third Bitcoin halving that took place in May 2020 cut down the mining reward from 12.5 to 6.25 BTC per block and thus slowed down the rate of issuance of new Bitcoins, making it more scarce. The fourth and most recent halving happened in April 2024, cutting the block reward further to 3.125 BTC. If the demand did not decrease simultaneously after these halvings, then the neoclassical economic theory posits that the price of Bitcoin should have increased due to the…

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Optimal Nuisance Function Tuning for Estimating a Doubly Robust Functional under Proportional Asymptotics

比例渐近下双重稳健泛函估计的最优干扰函数调参

In this paper, we explore the asymptotically optimal tuning parameter choice in ridge regression for estimating nuisance functions of a statistical functional that has recently gained prominence in conditional independence testing and causal inference. Given a sample of size $n$, we study estimators of the Expected Conditional Covariance (ECC) between variables $Y$ and $A$ given a high-dimensional covariate $X \in \mathbb{R}^p$. Under linear regression models for $Y$ and $A$…

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Leveraging semantic similarity for experimentation with AI-generated treatments

利用语义相似性开展人工智能生成处理的实验

Large Language Models (LLMs) enable a new form of digital experimentation where treatments combine human and model-generated content in increasingly sophisticated ways. The main methodological challenge in this setting is representing these high-dimensional treatments without losing their semantic meaning or rendering analysis intractable. Here, we address this problem by focusing on learning low-dimensional representations that capture the underlying structure of such…

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Sensitivity Analysis when Generalizing Causal Effects from Multiple Studies to a Target Population: Motivation from the ECHO Program

多研究因果效应推广至目标人群的敏感性分析:ECHO 项目的启发

Unobserved effect modifiers can induce bias when generalizing causal effect estimates to target populations. In this work, we extend a sensitivity analysis framework assessing the robustness of study results to unobserved effect modification that adapts to various generalizability scenarios, including multiple (conditionally) randomized trials, observational studies, or combinations thereof. This framework is interpretable and does not rely on distributional or functional…

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Handling Missing Responses under Cluster Dependence with Applications to Language Model Evaluation

簇依赖下缺失响应的处理及其在语言模型评估中的应用

Human annotations play a crucial role in evaluating the performance of GenAI models. Two common challenges in practice, however, are missing annotations (the response variable of interest) and cluster dependence among human-AI interactions (e.g., questions asked by the same user may be highly correlated). Reliable inference must address both these issues to achieve unbiased estimation and appropriately quantify uncertainty when estimating average scores from human…

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SCMD: A Kernel-Based Distance for Structural Causal Models to Quantify Transferability Across Environments

SCMD:量化跨环境可迁移性的结构因果模型核距离

Out-of-distribution generalization is key to building models that remain reliable across diverse environments. Recent causality-based methods address this challenge by learning invariant causal relationships in the underlying data-generating process. Yet, measuring how causal structures differ across environments, and the resulting generalization difficulty, remains difficult. To tackle this challenge, we propose the Structural Causal Model Distance (SCMD), a principled…

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On Multiple Robustness of Proximal Dynamic Treatment Regimes

近端动态治疗策略的多重稳健性

Dynamic treatment regimes are sequential decision rules that adapt treatment according to individual time-varying characteristics and outcomes to achieve optimal effects, with applications in precision medicine, personalized recommendations, and dynamic marketing. Estimating optimal dynamic treatment regimes via sequential randomized trials might face costly and ethical hurdles, often necessitating the use of historical observational data. In this work, we utilize proximal…

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Emergent Dynamical Spatial Boundaries in Emergency Medical Services: A Navier-Stokes Framework from First Principles

急救医疗服务中涌现的动态空间边界:从基本原理出发的 Navier–Stokes 框架

Emergency medical services (EMS) response times are critical determinants of patient survival, yet existing approaches to spatial coverage analysis rely on discrete distance buffers or ad-hoc geographic information system (GIS) isochrones without theoretical foundation. This paper derives continuous spatial boundaries for emergency response from first principles using fluid dynamics (Navier-Stokes equations), demonstrating that response effectiveness decays exponentially…

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Dynamic Spatial Treatment Effects as Continuous Functionals: Theory and Evidence from Healthcare Access

作为连续泛函的动态空间处理效应:医疗可及性的理论与证据

I develop a continuous functional framework for spatial treatment effects grounded in Navier-Stokes partial differential equations. Rather than discrete treatment parameters, the framework characterizes treatment intensity as continuous functions $τ(\mathbf{x}, t)$ over space-time, enabling rigorous analysis of boundary evolution, spatial gradients, and cumulative exposure. Empirical validation using 32,520 U.S. ZIP codes demonstrates exponential spatial decay for healthcare…

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Network Contagion Dynamics in European Banking: A Navier-Stokes Framework for Systemic Risk Assessment

欧洲银行网络传染动态:基于 Navier–Stokes 的系统性风险评估框架

This paper develops a continuous functional framework for analyzing contagion dynamics in financial networks, extending the Navier-Stokes-based approach to network-structured spatial processes. We model financial distress propagation as a diffusion process on weighted networks, deriving a network diffusion equation from first principles that predicts contagion decay depends on the network's algebraic connectivity through the relation $κ= \sqrt{λ_2/D}$, where $λ_2$ is the…

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Treatment Effect Learning Under Sequential Randomization

序贯随机化下的处理效应学习

Sequential treatment assignments in online experiments lead to complex dependency structures, often rendering identification, estimation and inference over treatments a challenge. Treatments in one session (e.g., a user logging on) can have an effect that persists into subsequent sessions, leading to cumulative effects on outcomes measured at a later stage. This can render standard methods for identification and inference trivially misspecified. We propose T-Learners layered…

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Assessing treatment effects in observational data with missing confounders: A comparative study of practical doubly-robust and traditional missing data methods

混杂变量缺失时的处理效应评估:双重稳健与传统缺失数据方法比较

In pharmacoepidemiology, safety and effectiveness are frequently evaluated using readily available administrative and electronic health records data. In these settings, detailed confounder data are often not available in all data sources and therefore missing on a subset of individuals. Multiple imputation (MI) and inverse-probability weighting (IPW) are go-to analytical methods to handle missing data and are dominant in the biomedical literature. Doubly-robust methods,…

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A Multi-Layer Machine Learning and Econometric Pipeline for Forecasting Market Risk: Evidence from Cryptoasset Liquidity Spillovers

预测市场风险的多层机器学习与计量流程:加密资产流动性溢出证据

We study whether liquidity and volatility proxies of a core set of cryptoassets generate spillovers that forecast market-wide risk. Our empirical framework integrates three statistical layers: (A) interactions between core liquidity and returns, (B) principal-component relations linking liquidity and returns, and (C) volatility-factor projections that capture cross-sectional volatility crowding. The analysis is complemented by vector autoregression impulse responses and…

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Leveraging external data in the analysis of randomized controlled trials: a comparative analysis

随机对照试验分析中利用外部数据的方法比较

The use of patient-level information from previous studies, registries, and other external datasets can support the analysis of single-arm and randomized controlled trials to evaluate and test experimental treatments. However, the integration of external data in the analysis of clinical trials can also compromise the scientific validity of the results due to selection bias, study-to-study differences, unmeasured confounding, and other distortion mechanisms. Therefore,…

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