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利用协变量注释信息提高 Knockoff 变量选择的功效AI 解读

Genome-wide association studies (GWAS) often find association signals between many genetic variants and traits of interest in a genomic region. Functional annotations of these variants provide valuable prior information that helps prioritize biologically relevant variants and enhances the power to detect causal variants. However, due to substantial correlations among these variants, a critical question is how to rigorously control the false discovery rate while effectively…

基于组 Lasso 选择的高维中介分析AI 解读

Mediation analysis aims to identify and estimate the effect of an exposure on an outcome that is mediated through one or more intermediate variables. In the presence of multiple intermediate variables, two pertinent methodological questions arise: estimating mediated effects when mediators are correlated, and performing high-dimensional mediation analyses when the number of mediators exceeds the sample size. This paper presents a two-step procedure for high-dimensional…

一般线性泛函估计的尖锐结构无关下界AI 解读

We establish a general statistical optimality theory for estimation problems where the target parameter is a linear functional of an unknown nuisance component that must be estimated from data. This formulation covers many causal and predictive parameters and has applications to numerous disciplines. We adopt the structure-agnostic framework introduced by \citet{balakrishnan2023fundamental}, which poses no structural properties on the nuisance functions other than access to…

使用稳健 MAP 先验评估区域处理效应AI 解读

Bayesian dynamic borrowing has become an increasingly important tool for evaluating the consistency of regional treatment effects which is a key requirement for local regulatory approval of a new drug. It helps increase the precision of regional treatment effect estimate when regional and global data are similar, while guarding against potential bias when they differ. In practice, the two-component mixture prior, of which one mixture component utilizes the power prior to…

状态依赖局部投影何时成立，以及为何成立AI 解读

This paper studies state-dependent local projections (LPs). First, I establish a general characterization of their estimand: under minimal assumptions, state-dependent LPs recover weighted averages of causal effects. This holds for essentially all specifications used in practice. Second, I show that state-dependent LPs and VARs target different estimands and propose a simple VAR-based estimator whose probability limit equals the LP estimand. Third, in instrumental variable…

终末事件存在时复发事件处理效应的模型辅助因果推断AI 解读

This paper is motivated by evaluating the benefits of patients receiving mechanical circulatory support (MCS) devices in end-stage heart failure management inference, in which hypothesis testing for a treatment effect on the risk of recurrent events is challenged in the presence of terminal events. Existing methods based on cumulative frequency unreasonably disadvantage longer survivors as they tend to experience more recurrent events. The While-Alive-based (WA) test has…

普通病区患者安置优化：以工具变量因果森林降低死亡率AI 解读

Normal care units (NCU) placement affects health outcomes. NCUs in a hospital have different specialisations. There are patients that can potentially stay in multiple different NCUs. On a given day the NCUs are on different utilisation levels, which also affects health outcomes. Our approach uses instrumental variable causal forests, with emergency admission as an instrument, to estimate how the effect of NCU placement varies across patients and utilisation levels. The…

超越 P 值：将金融风险与遗憾指标引入学习型医疗系统的 AI 评价AI 解读

The increasing deployment of artificial intelligence (AI) in clinical settings challenges foundational assumptions underlying traditional frameworks of medical evidence. Classical statistical approaches, centered on randomized controlled trials, frequentist hypothesis testing, and static confidence intervals, were designed for fixed interventions evaluated under stable conditions. In contrast, AI-driven clinical systems learn continuously, adapt their behavior over time, and…

排序后的统计推断及其在经济流动性研究中的应用AI 解读

This paper considers the problem of inference after ranking. In our setting, we are interested in any population whose rank according to some random quantity, such as an estimated treatment effect, a measure of value-added, or benefit (net of cost), falls in a pre-specified range of values. As such, this framework generalizes the inference on winners setting previously considered in Andrews et al. (2023), in which a winner is understood to be the single population whose rank…

HOLOGRAPH：通过层论对齐大语言模型先验的主动因果发现AI 解读

Causal discovery from observational data remains fundamentally limited by identifiability constraints. Recent work has explored leveraging Large Language Models (LLMs) as sources of prior causal knowledge, but existing approaches rely on heuristic integration that lacks theoretical grounding. We introduce HOLOGRAPH, a framework that formalizes LLM-guided causal discovery through sheaf theory--representing local causal beliefs as sections of a presheaf over variable subsets.…

结合双重负向控制与图神经网络的双重差分：处理未观测网络混杂AI 解读

Estimating causal effects from observational network data faces dual challenges of network interference and unmeasured confounding. To address this, we propose a general Difference-in-Differences framework that integrates double negative controls (DNC) and graph neural networks (GNNs). Based on the modified parallel trends assumption and DNC, semiparametric identification of direct and indirect causal effects is established. We then propose doubly robust estimators.…

二部网络干扰下的公平政策学习：公平且具成本效益的环境政策AI 解读

Numerous studies have shown the harmful effects of airborne pollutants on human health. Vulnerable groups and communities often bear a disproportionately larger health burden due to exposure to airborne pollutants. Thus, there is a need to design policies that effectively reduce the public health burdens while ensuring cost-effective policy interventions. Designing policies that optimally benefit the population while ensuring equity between groups under cost constraints is a…

通过后验耦合实现贝叶斯双重稳健因果推断AI 解读

Bayesian doubly robust (DR) causal inference faces a fundamental dilemma: joint modeling of outcome and propensity score suffers from the feedback problem where outcome information contaminates propensity score estimation, while two-step inference sacrifices valid posterior distributions for computational convenience. We resolve this dilemma through posterior coupling via entropic tilting. Our framework constructs independent posteriors for propensity score and outcome…

多弱工具变量下的非参数工具变量推断AI 解读

We study inference on linear functionals in the nonparametric instrumental variable (NPIV) problem with a discretely-valued instrument under a many-weak-instruments asymptotic regime, where the number of instrument values grows with the sample size. A key motivating example is estimating long-term causal effects in a new experiment with only short-term outcomes, using past experiments to instrument for the effect of short- on long-term outcomes. Here, the assignment to a…

观测数据中有效且高效的两阶段潜在子组分析AI 解读

Subgroup analysis evaluates treatment effects across multiple sub-populations. When subgroups are defined by latent memberships inferred from imperfect measurements, the analysis typically involves two inter-connected models, a latent class model and a subgroup outcome model. The classical one-stage framework, which models the joint distribution of the two models, may be infeasible with observational data containing many confounders. The two-stage framework, which first…

连续处理下的双重差分AI 解读

This paper analyzes difference-in-differences designs with a continuous treatment. We show that treatment-on-the-treated-type parameters are identified under a parallel trends assumption analogous to the binary treatment case. However, comparing these parameters across treatments is challenging because parallel trends does not rule out selection bias. We discuss alternative, typically stronger, assumptions that eliminate selection bias. We further show that popular two-way…

文本因果推断中的处理信息泄漏：检测、蒸馏与敏感性分析AI 解读

Text-based causal inference increasingly employs textual data as proxies for unobserved confounders, yet this approach introduces a previously undertheorized source of bias: treatment leakage. Treatment leakage occurs when text intended to capture confounding information also contains signals predictive of treatment status, thereby inducing post-treatment bias in causal estimates. Critically, this problem can arise even when documents precede treatment assignment, as authors…

随机试验中有序结果透明总体汇总指标的模型辅助贝叶斯估计AI 解读

In randomized controlled trials, ordinal outcomes typically improve statistical efficiency over binary outcomes. The treatment effect on an ordinal outcome is usually described by the odds ratio from a proportional odds model, but this summary measure lacks transparency with respect to its emphasis on the components of the ordinal outcome when proportional odds is violated. We propose various summary measures for ordinal outcomes that are fully transparent in this regard,…

数据边界上的推断：用高斯过程处理模型依赖、重叠不足与外推AI 解读

Many inferential tasks involve fitting models to observed data and predicting outcomes at new covariate values, requiring interpolation or extrapolation. Conventional methods select a single best-fitting model, discarding fits that were similarly plausible in-sample but would yield sharply different predictions out-of-sample. Gaussian Processes (GPs) offer a principled alternative. Rather than committing to one conditional expectation function, GPs deliver a posterior…

弱工具变量下局部平均处理效应的外推AI 解读

To evaluate the effectiveness of a counterfactual policy, it is often necessary to extrapolate treatment effects on compliers to broader populations. This extrapolation relies on exogenous variation in instruments, which is often weak in practice. This limited variation leads to invalid confidence intervals that are typically too short and cannot be accurately detected by classical methods. For instance, the F-test may falsely conclude that the instruments are strong.…

TabMixNN：表格数据结构混合效应建模的统一深度学习框架AI 解读

We present TabMixNN, a flexible PyTorch-based deep learning framework that synthesizes classical mixed-effects modeling with modern neural network architectures for tabular data analysis. TabMixNN addresses the growing need for methods that can handle hierarchical data structures while supporting diverse outcome types including regression, classification, and multitask learning. The framework implements a modular three-stage architecture: (1) a mixed-effects encoder with…

概率建模足以开展因果推断AI 解读

Causal inference is a key research area in machine learning, yet confusion reigns over the tools needed to tackle it. There are prevalent claims in the machine learning literature that you need a bespoke causal framework or notation to answer causal questions. In this paper, we want to make it clear that you \emph{can} answer any causal inference question within the realm of probabilistic modelling and inference, without causal-specific tools or notation. Through concrete…

通过基函数投票稳健调整空间混杂AI 解读

Estimating effects of spatially structured exposures is complicated by unmeasured spatial confounders, which undermine identifiability in spatial linear regression models unless structural assumptions are imposed. We develop a general framework for effect estimation in spatial regression models that relaxes the commonly assumed requirement that exposures contain higher-frequency variation than confounders. We propose basis voting, a plurality-rule estimator - novel in the…

学校选择中的非参数处理效应识别AI 解读

This paper studies nonparametric identification and estimation of causal effects in centralized school assignment. In many centralized assignment algorithms, students face both lottery-driven variation and regression discontinuity- (RD) driven variation. We characterize the full set of identified atomic treatment effects (aTEs), defined as the conditional average treatment effect between a pair of schools given student characteristics. Atomic treatment effects are the…