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Connections as treatment: causal inference with edge interventions in networks

以连接为处理:网络边干预的因果推断

Causal inference has traditionally focused on interventions at the unit level. In many applications, however, the central question concerns the causal effects of connections between units, such as transportation links, social relationships, or collaborative ties. We develop a causal framework for edge interventions in networks, where treatments correspond to the presence or absence of edges. Our framework defines causal estimands under stochastic interventions on the network…

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Experiment-selector cross-validated targeted maximum likelihood estimator for hybrid RCT-external data studies

用于随机试验与外部数据混合研究的实验选择交叉验证 TMLE

Augmenting a randomized controlled trial (RCT) with external data may increase power at the risk of introducing bias. To select and analyze the experiment (RCT alone or combined with external data) with the optimal bias-variance tradeoff, we develop a novel experiment-selector cross-validated targeted maximum likelihood estimator for randomized-external data studies (ES-CVTMLE). This estimator utilizes two estimates of bias to determine whether to integrate external data…

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Dimension-reduced outcome-weighted learning for estimating individualized treatment regimes in observational studies

观察研究中估计个体化治疗规则的降维结局加权学习

Individualized treatment regimes (ITRs) aim to improve clinical outcomes by assigning treatment based on patient-specific characteristics. However, existing methods often struggle with high-dimensional covariates, limiting accuracy, interpretability, and real-world applicability. We propose a novel sufficient dimension reduction approach that directly targets the contrast between potential outcomes and identifies a low-dimensional subspace of the covariates capturing…

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Identifying Causal Effects in Information Provision Experiments

信息提供实验中的因果效应识别

Standard estimators in information provision experiments place more weight on individuals who update their beliefs more in response to new information. This paper shows that, in practice, these individuals who update the most have the weakest causal effects of beliefs on outcomes. Standard estimators therefore understate these causal effects. I propose an alternative local least squares (LLS) estimator that recovers a representative unweighted average effect in a broad class…

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Long-Term Causal Inference with Many Noisy Proxies

利用大量含噪代理变量进行长期因果推断

We propose a method for estimating long-term treatment effects with many short-term proxy outcomes: a central challenge when experimenting on digital platforms. We formalize this challenge as a latent variable problem where observed proxies are noisy measures of a low-dimensional set of unobserved surrogates that mediate treatment effects. Through theoretical analysis and simulations, we demonstrate that regularized regression methods substantially outperform naive proxy…

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The resource theory of causal influence and knowledge of causal influence

因果影响及其知识状态的资源理论

Understanding and quantifying causal relationships between variables is essential for reasoning about the physical world. In this work, we develop a resource-theoretic framework to do so. Here, we focus on the simplest nontrivial setting -- two variables that are causally ordered, meaning that the first has the potential to influence the second, without hidden confounding. First, we introduce the resource theory that directly quantifies causal influence of a functional…

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Estimating optimal interpretable individualized treatment regimes from a classification perspective using adaptive LASSO

从分类视角利用自适应 LASSO 估计可解释的最优个体化治疗规则

Real-world data (RWD) gains growing interests to provide a representative sample of the population for selecting the optimal treatment options. However, existing complex black box methods for estimating individualized treatment rules (ITR) from RWD have problems in interpretability and convergence. Providing an interpretable and sparse ITR can be used to overcome the limitation of existing methods. We developed an algorithm using Adaptive LASSO to predict optimal…

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Semiparametric causal mediation analysis of cluster-randomized trials for indirect and spillover effects

集群随机试验中间接效应与溢出效应的半参数因果中介分析

In cluster-randomized trials (CRTs), there is emerging interest in exploring the causal mechanism in which a cluster-level treatment affects the outcome through an intermediate outcome. The majority of existing causal mediation methods are applicable to independent data and only a few exceptions have considered assessing causal mediation in CRTs, all of which heavily depend on parametric assumptions. In this article, we develop a formal semiparametric efficiency theory to…

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Learning and Testing Exposure Mappings of Interference using Graph Convolutional Autoencoder

利用图卷积自编码器学习并检验干扰的暴露映射

Interference or spillover effects arise when an individual's outcome (e.g., health) is influenced not only by their own treatment (e.g., vaccination) but also by the treatment of others, creating challenges for evaluating treatment effects. Exposure mappings provide a framework to study such interference by explicitly modeling how the treatment statuses of contacts within an individual's network affect their outcome. Most existing research relies on a priori exposure…

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The Curious Case of Aid and Conflict: Causal Evidence from Panel Econometrics and Composite Indices

援助与冲突的复杂关系:面板计量与综合指数的证据

This paper examines the relationship between Official Development Assistance (ODA) and conflict in the ten largest aid-receiving African countries between 2009 and 2023. Using Ordinary Least Squares, Principal Component Analysis, and Ridge (L2) regression, the study assesses whether conflict, proxied by political stability, governance indicators, and macroeconomic conditions, systematically influences aid inflows. Results reveal a nuanced relationship. Pooled regressions…

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Event Studies with Feedback

存在反馈的事件研究

Event studies often conflate direct treatment effects with indirect effects operating through endogenous covariate adjustment. We develop a dynamic panel event study framework that separates these effects. The framework allows for persistent outcomes and treatment effects and for covariates that respond to past outcomes and treatment exposure. Under sequential exogeneity and homogeneous feedback, we establish point identification of common parameters governing outcome and…

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Epsilon-Minimax Solutions of Statistical Decision Problems

统计决策问题的 ε 极小极大解

A decision rule is epsilon-minimax if it is minimax up to an additive factor epsilon. We present an algorithm for provably obtaining epsilon-minimax solutions for a class of statistical decision problems. In particular, we are interested in problems where the statistician chooses randomly among I decision rules. The minimax solution of these problems admits a convex programming representation over the (I-1)-simplex. Our suggested algorithm is a well-known mirror subgradient…

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Revealing the Truth: Calculating True Values in Causal Inference Simulation Studies via Gaussian Quadrature

用高斯求积计算因果推断模拟研究中的真实目标值

Simulation studies are used to understand the properties of statistical methods. A key luxury in many simulation studies is knowledge of the true value (i.e. the estimand) being targeted. With this oracle knowledge in-hand, the researcher conducting the simulation study can assess across repeated realizations of the data how well a given method recovers the truth. In causal inference simulation studies, the truth is rarely a simple parameter of the statistical model chosen…

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Avoiding the Price of Adaptivity: Inference in Linear Contextual Bandits via Stability

避免适应性的代价:基于稳定性的线性情境赌博机推断

Statistical inference in contextual bandits is challenging due to the adaptive, non-i.i.d. nature of the data. A growing body of work shows that classical least-squares inference can fail under adaptive sampling, and that valid confidence intervals for linear functionals typically require an inflation of order $\sqrt{d \log T}$. This phenomenon -- often termed the price of adaptivity -- reflects the intrinsic difficulty of reliable inference under general contextual bandit…

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Uncovering Treatment Effect Heterogeneity in Pragmatic Gerontology Trials

揭示实用性老年医学试验中的处理效应异质性

Detecting heterogeneity in treatment response enriches the interpretation of gerontologic trials. In aging research, estimating the effect of the intervention on clinically meaningful outcomes faces analytical challenges when it is truncated by death. For example, in the Whole Systems Demonstrator trial, a large cluster-randomized study evaluating telecare among older adults, the overall effect of the intervention on quality of life was found to be null. However, this…

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Causal Invariance Learning via Efficient Nonconvex Optimization

通过高效非凸优化学习因果不变性

Identifying the causal relationship among variables from observational data is an important yet challenging task. This work focuses on identifying the direct causes of an outcome and estimating their magnitude, i.e., learning the causal outcome model. Data from multiple environments provide valuable opportunities to uncover causality by exploiting the invariance principle that the causal outcome model holds across heterogeneous environments. Based on the invariance…

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Causal Inference for Aggregated Treatment

聚合处理变量的因果推断

In this paper, we study causal inference when the treatment variable is an aggregation of multiple sub-treatment variables. Researchers often report marginal causal effects for the aggregated treatment, implicitly assuming that the target parameter corresponds to a well-defined average of sub-treatment effects. We show that, even in an ideal scenario for causal inference such as random assignment, the weights underlying this average have some key undesirable properties: they…

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On the estimation of inclusion probabilities for weighted analyses of nested case control studies

嵌套病例对照研究加权分析中的纳入概率估计

Nested case-control (NCC) studies are a widely adopted design in epidemiology to investigate exposure-disease relationships. This paper examines weighted analyses in NCC studies, focusing on two prominent weighting methods: Kaplan-Meier (KM) weights and Generalized Additive Model (GAM) weights. We consider three target estimands: log-hazard ratios, conditional survival, and associations between exposures. While KM- and GAM-weights are generally robust, we identify specific…

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Ill-Conditioned Orthogonal Scores in Double Machine Learning

双重机器学习中病态正交得分的误差放大

Double Machine Learning is often justified by nuisance-rate conditions, yet finite-sample reliability also depends on the conditioning of the orthogonal-score Jacobian. This conditioning is typically assumed rather than tracked. When residualized treatment variance is small, the Jacobian is ill-conditioned and small systematic nuisance errors can be amplified, so nominal confidence intervals may look precise yet systematically under-cover. Our main result is an exact…

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Improving operating characteristics of clinical trials by augmenting control arm using propensity score-weighted borrowing-by-parts power prior

利用倾向得分加权与分部借用幂先验增强临床试验对照组

Borrowing external data can improve estimation efficiency but may introduce bias when populations differ in covariate distributions or outcome variability. A proper balance needs to be maintained between the two datasets to justify the borrowing. We propose a propensity score weighting borrowing-by-parts power prior (PSW-BPP) that integrates causal covariate adjustment through propensity score weighting with a flexible Bayesian borrowing approach to address these challenges…

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Simple Inference on a Simplex-Valued Weight

单纯形约束权重的简便统计推断

In many applications, the parameter of interest involves a simplex-valued weight which is identified as a solution to an optimization problem. Examples include synthetic control methods with group-level weights and various methods of model averaging and forecast combinations. The simplex constraint on the weight poses a challenge in statistical inference due to the constraint potentially binding. In this paper, we propose a simple method of constructing a confidence set for…

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On estimands in target trial emulation

目标试验模拟中的目标估计量

The target trial framework enables causal inference from longitudinal observational data by emulating randomized trials initiated at multiple time points. Precision is often improved by pooling information across trials, with standard models typically assuming - among other things - a time-constant treatment effect. However, this obscures interpretation when the true treatment effect varies, which we argue to be likely as a result of relying on noncollapsible estimands. To…

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Time-Aware Synthetic Control

考虑时间结构的合成控制

The synthetic control (SC) framework is widely used for observational causal inference with time-series panel data. SC has been successful in diverse applications, but existing methods typically treat the ordering of pre-intervention time indices interchangeable. This invariance means they may not fully take advantage of temporal structure when strong trends are present. We propose Time-Aware Synthetic Control (TASC), which employs a state-space model with a constant trend…

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Sensitivity Analysis in Unconditional Quantile Effects

无条件分位数效应的敏感性分析

This paper proposes a framework to analyze the effects of counterfactual policies on the unconditional quantiles of an outcome variable. For a given counterfactual policy, we obtain identified sets for the effect of both marginal and global changes in the proportion of treated individuals. To conduct a sensitivity analysis, we introduce the quantile breakdown frontier, a curve that (i) indicates whether a sensitivity analysis is possible or not, and (ii) when a sensitivity…

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