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改进非参数回归与回归不连续设计的统计推断AI 解读

Nonparametric regression and regression-discontinuity designs suffer from smoothing bias that distorts conventional confidence intervals. Solutions based on robust bias correction (RBC) are now central to the economist's toolbox. In this paper, we establish a novel connection between RBC methods and bootstrap prepivoting. Revisiting RBC through the lens of bootstrapping allows us to develop a novel bias correction procedure which delivers improved nonparametric inference.…

因果可解释性的估计与推断AI 解读

Understanding how much each variable contributes to an outcome is a central question across disciplines. A causal view of explainability is favorable for its ability in uncovering underlying mechanisms and generalizing to new contexts. Based on a family of causal explainability quantities, we develop methods for their estimation and inference. In particular, we construct a one-step correction estimator using semi-parametric efficiency theory, which explicitly leverages the…

用贝叶斯层级可调随机分区识别自适应富集试验中的治疗效应异质性AI 解读

Treatment effect heterogeneity refers to the systematic variation in treatment effects across subgroups. There is an increasing need for clinical trials that aim to investigate treatment effect heterogeneity and estimate subgroup-specific responses. While several statistical methods have been proposed to address this problem, existing partitioning-based methods often depend on auxiliary analysis, overlook model uncertainty, or impose inflexible borrowing strength. We propose…

利用外部对照开展试验近端学习：HIV 预防案例AI 解读

With the advent of effective pre-exposure prophylaxis agents, active-controlled HIV prevention trials have become a common study design. Nevertheless, estimating absolute efficacy relative to a placebo remains important. In this paper, we introduce a novel application of proximal causal inference methods to estimate the counterfactual cumulative HIV incidence under placebo for participants in an active-controlled trial of cabotegravir, using external control data from a…

连续处理的异质性响应：基于聚类的因果框架AI 解读

When treatments are non-randomly assigned, continuous, and yield heterogeneous effects at the same intensity, causal identification becomes particularly challenging. In such contexts, existing approaches often fail to provide policy-relevant estimates of the relationship between treatment intensity and outcomes, especially in the presence of limited common support. To fill this gap, we introduce the Clustered Dose-Response Function (Cl-DRF), a novel estimator designed to…

从大语言模型中提取因果关系假说AI 解读

Large language models (LLMs) are trained on enormous amounts of data and encode knowledge in their parameters. We propose a pipeline to elicit causal relationships from LLMs. Specifically, (i) we sample many documents from LLMs on a given topic, (ii) we extract an event list from from each document, (iii) we group events that appear across documents into canonical events, (iv) we construct a binary indicator vector for each document over canonical events, and (v) we estimate…

回归不连续设计中直接估计条件平均处理效应的贝叶斯加性回归树AI 解读

Regression discontinuity designs (RDD) are widely used for causal inference. In many empirical applications, treatment effects vary substantially with covariates, and ignoring such heterogeneity can lead to misleading conclusions, which motivates flexible modeling of heterogeneous treatment effects in RDD. To this end, we propose a Bayesian nonparametric approach to estimating heterogeneous treatment effects based on Bayesian Additive Regression Trees (BART). The key feature…

一般混杂下线性非高斯因果模型的参数识别AI 解读

Linear non-Gaussian causal models postulate that each random variable is a linear function of parent variables and non-Gaussian exogenous error terms. We study identification of the linear coefficients when such models contain latent variables. Our focus is on the commonly studied acyclic setting, where each model corresponds to a directed acyclic graph (DAG). For this case, prior literature has demonstrated that connections to overcomplete independent component analysis…

用于因果推断的可控生成式沙盒AI 解读

Method validation and study design in causal inference rely on synthetic data with known counterfactuals. Existing simulators trade off distributional realism, the ability to capture mixed-type and multimodal tabular data, against causal controllability, including explicit control over overlap, unmeasured confounding, and treatment effect heterogeneity. We introduce CausalMix, a variational generative framework that closes this gap by coupling a mixture of Gaussian latent…

从观察数据估计广告视觉属性效应：生成图像辅助的双重机器学习AI 解读

Digital advertising increasingly relies on visual content, yet marketers lack rigorous methods for understanding how specific visual attributes causally affect consumer engagement. This paper addresses a fundamental methodological challenge: estimating causal effects when the treatment, such as a model's skin tone, is an attribute embedded within the image itself. Standard approaches like Double Machine Learning (DML) fail in this setting because vision encoders entangle…

通过设计型市场进行干扰下的因果推断AI 解读

In auction and matching markets, estimating the welfare effects of demand-side treatments is challenging because of spillovers through the mechanism. We develop a quasi-experimental approach that avoids parametric assumptions typically imposed by structural methods. For a class of strategy-proof "cutoff" mechanisms, we propose an estimator that runs a weighted and perturbed version of the mechanism on data from a single market. The estimator is semi-parametrically efficient,…

利用结局一致配对信息改进条件 Logistic 回归及其软件实现AI 解读

We develop an improvement to conditional logistic regression (CLR) in the setting where the parameter of interest is the additive effect of binary treatment effect on log-odds of the positive level in the binary response. Our improvement is simply to use information learned above the nuisance control covariates found in the concordant response pairs' observations (which is usually discarded) to create an informative prior on their coefficients. This prior is then used in the…

拓扑因果效应AI 解读

Estimating causal effects is particularly challenging when outcomes arise in complex, non-Euclidean spaces, where conventional methods often fail to capture meaningful structural variation. We develop a framework for topological causal inference that defines treatment effects through differences in the topological structure of potential outcomes, summarized by power-weighted silhouette functions of persistence diagrams. We develop an efficient, doubly robust estimator in a…

含处理与协变量交互项的两阶段最小二乘及处理效应异质性AI 解读

Treatment effect heterogeneity with respect to covariates is common in instrumental variable (IV) analyses. An intuitive approach, which we call the interacted two-stage least squares (2sls), is to postulate a working linear model of the outcome on the treatment, covariates, and treatment-covariate interactions, and instrument it using the IV, covariates, and IV-covariate interactions. We clarify the causal interpretation of the interacted 2sls under the local average…

异质性处理效应变量重要性的目标学习AI 解读

Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different population subgroups. While much of treatment effect heterogeneity analysis focuses on the conditional average treatment effect, an alternative parameter that captures treatment effect heterogeneity is the variance of treatment effect across different covariate groups. One can also derive variable importance parameters that measure…

DoFlow：用于时间序列干预与反事实预测的流生成模型AI 解读

Time-series forecasting increasingly demands not only accurate observational predictions but also causal forecasting under interventional and counterfactual queries in multivariate systems. We present DoFlow, a flow-based generative model defined over a causal Directed Acyclic Graph (DAG) that delivers coherent observational and interventional predictions, as well as counterfactuals through the natural encoding-decoding mechanism of continuous normalizing flows (CNFs). We…

工具变量回归中的弱工具稳健子向量推断：LM 检验与 AR 置信集性质AI 解读

We propose a weak-instrument-robust subvector Lagrange multiplier test for instrumental variables regression. We show that it is asymptotically size-correct under a technical condition or as the number of instruments grows to infinity. This is the first weak-instrument-robust subvector test for instrumental variables regression to recover the degrees of freedom of the commonly used non-weak-instrument-robust Wald test. Additionally, we provide a closed-form solution for…

如何解释净生存率：实际估计目标与通常理解的差异AI 解读

Net survival is conventionally defined as ``survival if cancer were the only possible cause of death'', an estimand corresponding to cancer-specific mortality alone. The Pohar Perme estimator targets this by removing general population other-cause mortality from observed total mortality, but achieves it only when cancer patients experience the same other-cause mortality as the general population. However, cancer patients often experience elevated other-cause mortality due to…

何时校正均值回归反而不如不校正AI 解读

The ubiquitous regression to the mean (RTM) effect complicates statistical inference regarding the relationship between baseline levels of a biological variable and its subsequent change. We demonstrate that common RTM correction methods are problematic: the Berry et al. method, popularized by Kelly & Price in The American Naturalist, is unreliable for hypothesis testing or effect-size estimation, leading to systematic bias and inflated error rates. Conversely, while the…

用于因果中介与溢出效应的网络结构方程模型AI 解读

Social network interference induces complex dependencies where a unit's outcome is influenced not only by its own exposure and mediator but also by those of connected neighbors. In such settings, a significant challenge lies in distinguishing direct exposure effects from interference-driven spillover effects, and further separating these from indirect effects mediated by intermediate variables. To address this, we propose a theoretical framework utilizing structural…

隐藏在眼前：不可折叠性如何使网络元分析的处理效应产生偏差AI 解读

Network meta-analysis (NMA) is widely used to compare multiple interventions simultaneously by synthesizing direct and indirect evidence. The general fixed or random effects contrast-based NMA model can be applied to different outcomes and data structures by opting for either an arm-based or contrast-based likelihood depending on the data available. Depending on the outcome and link-function, we estimate either collapsible or non-collapsible effect measures. Using an…

重症监护中的锚回归域泛化与域适应AI 解读

The performance of predictive models in clinical settings often degrades when deployed in new hospitals due to distribution shifts. This paper presents a large-scale study of causality-inspired domain generalization on heterogeneous multi-center intensive care unit (ICU) data. We apply anchor regression and introduce anchor boosting, a novel, tree-based nonlinear extension, to a large dataset comprising 400,000 patients from nine distinct ICU databases. We find that anchor…

估计长期处理效应的替代指标指数法：敏感性分析AI 解读

This paper develops a sensitivity analysis of the surrogacy assumption for the surrogate index approach in Athey et al. [2025b]. We introduce "Weighted Surrogate Indices (WSIs)," the analog of the surrogate index under the surrogacy assumption. We show that under comparability, the ATE on WSI identifies the ATE on the long-term outcome when a copula of the treatment and the long-term outcome conditional on baseline covariates and surrogates is known. When the copula is…

自遮蔽非随机缺失混杂变量下的因果推断：分层偏移插补倾向估计AI 解读

In observational studies, causal inference becomes difficult when confounders are missing-not-at-random (MNAR), particularly where the missingness depends on the confounder's own unreported value (self-masking). Existing methods for handling MNAR confounders often rely on strong, unverifiable assumptions, leading to biased estimates. We propose a simple approach with Stratified Delta-Imputed Propensity Estimator (SDIPE) in the presence of self-masking confounders. SDIPE…