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Riesz Regression As Direct Density Ratio Estimation

将 Riesz 回归理解为直接密度比估计

This study clarifies the relationship between Riesz regression [Chernozhukov et al., 2021] and density ratio estimation (DRE) in causal inference problems, such as average treatment effect estimation. We first show that the Riesz representer can be written as a signed density ratio and then demonstrate that the Riesz regression objective coincides with the least-squares importance fitting criterion [Kanamori et al., 2009]. Although Riesz regression applies to a broad class…

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An Improved Inference for IV Regressions

工具变量回归的改进推断:结合低维与多工具变量检验

Empirical instrumental variables (IV) studies often report separate results based on low-dimensional instruments and many base instruments. This paper proposes a combination test that integrates these commonly reported statistics. The test linearly combines a cluster-robust Wald statistic based on low-dimensional IVs with leave-one-cluster-out Lagrangian Multiplier (LM) and Anderson-Rubin (AR) statistics constructed from many IVs. We establish joint asymptotic normality and…

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Optimal Design under Interference, Homophily, and Robustness Trade-offs

干扰、同质性与稳健性权衡下的最优实验设计

To minimize the mean squared error (MSE) in global average treatment effect (GATE) estimation under network interference, a popular approach is to use a cluster-randomized design. However, in the presence of homophily, which is common in social networks, cluster randomization can instead increase the MSE. We develop a novel potential outcomes model that accounts for interference, homophily, and heterogeneous variation. In this setting, we establish a framework for optimizing…

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Consistent Bayesian causal discovery for structural equation models with equal error variances

等误差方差结构方程模型的一致贝叶斯因果发现

We consider the problem of recovering the true causal structure among a set of variables, generated by a linear acyclic structural equation model (SEM) with the error terms being independent, not necessarily Gaussian, and having equal variances. It is well-known that the true underlying directed acyclic graph (DAG) encoding the causal structure is uniquely identifiable under this assumption. Interestingly, in this setting, it further holds that the sum of minimum expected…

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Cost-Aware Optimized Front-Door Experimental Design

考虑成本的最优前门实验设计

Causal effect estimation often succeeds cost-constrained sequential data collection. This work considers multivariate linear front-door models with arbitrary unobserved confounding on treatment and response. We optimize the experimental design by balancing the statistical efficiency and measurement costs through partial data. The full-data efficient influence function for the causal effect is derived, together with the geometry of all observed-data influence functions. This…

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Learning about Treatment Effects with Prior Studies: A Bayesian Model Averaging Approach

利用既有研究学习处理效应:贝叶斯模型平均方法

We establish concentration rates for estimation of treatment effects in experiments that incorporate prior sources of information -- such as past pilots, related studies, or expert assessments -- whose external validity is uncertain. Each source is modeled as a Gaussian prior with its own mean and precision, and sources are combined using Bayesian model averaging (BMA), allowing data from the new experiment to update posterior weights. To capture empirically relevant…

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On the Number of Conditional Independence Tests in Constraint-based Causal Discovery

基于约束的因果发现所需条件独立检验数量

Learning causal relations from observational data is a fundamental problem with wide-ranging applications across many fields. Constraint-based methods infer the underlying causal structure by performing conditional independence tests. However, existing algorithms such as the prominent PC algorithm need to perform a large number of independence tests, which in the worst case is exponential in the maximum degree of the causal graph. Despite extensive research, it remains…

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Rethinking the Win Ratio: A Causal Framework for Hierarchical Outcome Analysis

重新审视胜率比:层级结局分析的因果框架

Quantifying causal effects in the presence of complex and multivariate outcomes remains a key challenge in treatment evaluation. For hierarchical multivariate outcomes, the FDA recommends the Win Ratio and Generalized Pairwise Comparisons approaches \citep{Pocock2011winratio,Buyse2010}. However, commonly used estimators can yield treatment recommendations that target a population-level estimand (the probability that a randomly sampled patient under treatment fares better…

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Cumulative Marginal Mean Model for Assessing Sequential Effects Using Digital Health Data

利用数字健康数据评估序贯效应的累积边际均值模型

Mobile health (mHealth) leverages digital technologies, such as mobile phones, to capture objective, frequent, and real-world digital phenotypes from individuals, enabling the delivery of tailored interventions to accommodate substantial between-subject and temporal heterogeneity. However, evaluating heterogeneous treatment effects (HTEs) using digital phenotype data is challenging because treatments are delivered dynamically over time and may generate carryover effects that…

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Double machine learning to estimate the effects of multiple treatments and their interactions

用双重机器学习估计多种处理及其交互效应

Causal inference literature has extensively focused on binary treatments, with relatively fewer methods developed for multi-valued treatments. In particular, methods for multiple simultaneously assigned treatments remain understudied despite their practical importance. This paper introduces two settings: (1) estimating the effects of multiple treatments of different types (binary, categorical, and continuous) and the effects of treatment interactions, and (2) estimating the…

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Sequential Transport for Causal Mediation Analysis

用于因果中介分析的序贯传输

We propose sequential transport (ST), a distributional framework for mediation analysis that combines optimal transport (OT) with a mediator directed acyclic graph (DAG). Instead of relying on cross-world counterfactual assumptions, ST constructs unit-level mediator counterfactuals by minimally transporting each mediator, either marginally or conditionally, toward its distribution under an alternative treatment while preserving the causal dependencies encoded by the DAG. For…

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Correcting for Missing Data When Evaluating Surrogate Markers in a Clinical Trial

临床试验替代标志物评价中的缺失数据校正

Evaluating treatment effects is critical in clinical trials but sometimes involves lengthy, invasive, or costly follow-up procedures. In these cases, surrogate markers, which provide intermediate measures of the long-term treatment effect, allow clinicians to obtain results faster and more efficiently than would have otherwise been possible. Prior to adoption, it is vital that the utility of surrogate markers (i.e., their ability to capture the treatment effect on the…

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The Structural Bite: A Methodological Framework for Minimum Wage Studies using Spanish Administrative Data

结构性冲击强度:利用西班牙行政数据研究最低工资的方法框架

We study the employment effects of the 22% increase in the Spanish minimum wage in 2019, focusing on young workers. Using census-grade administrative tax data covering the universe of formal wage bills and employment (Models 190/390 linked to personal income tax records), we construct several measures of treatment intensity, including two structurally grounded bite indicators based on the incidence of young minimum-wage workers and the implied increase in the wage bill…

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Variance reduction combining pre-experiment and in-experiment data

结合实验前与实验中数据降低处理效应估计方差

Online controlled experiments (A/B testing) are fundamental to data-driven decision-making in many companies. Improving the sensitivity of these experiments under fixed sample size constraints requires reducing the variance of the average treatment effect (ATE) estimator. Existing variance reduction techniques such as CUPED and CUPAC use pre-experiment data, but their effectiveness depends on how predictive those data are for outcomes measured during the experiment.…

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Multi-Domain Empirical Bayes for Linearly-Mixed Causal Representations

线性混合因果表征的多域经验贝叶斯学习

Causal representation learning (CRL) aims to learn low-dimensional causal latent variables from high-dimensional observations. While identifiability has been extensively studied for CRL, estimation has been less explored. In this paper, we explore the use of empirical Bayes (EB) to estimate causal representations. In particular, we consider the problem of learning from data from multiple domains, where differences between domains are modeled by interventions in a shared…

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Evaluating A/B Testing Methodologies via Sample Splitting: Theory and Practice

通过样本分割评估 A/B 测试方法:理论与实践

We develop a theoretical framework for sample splitting in A/B testing environments, where data for each test are partitioned into two splits to measure methodological performance when the true impacts of tests are unobserved. We show that sample-split estimators are generally biased for full-sample performance but consistently estimate sample-split analogues of it. We derive their asymptotic distributions, construct valid confidence intervals, and characterize the…

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Causal Inference with Groupwise Matching

基于群组匹配的因果推断

This paper examines methods of causal inference based on groupwise matching when we observe multiple large groups of individuals over several periods. We formulate causal inference validity through a generalized matching condition, generalizing the parallel trend assumption in difference-in-differences designs. We show that difference-in-differences, synthetic control, and synthetic difference-in-differences designs are distinguished by the specific matching conditions that…

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Double Machine Learning for Static Panel Data with Instrumental Variables: New Method and Applications

静态面板工具变量模型的双重机器学习:方法与应用

Panel data methods are widely used in empirical analysis to address unobserved heterogeneity, but causal inference remains challenging when treatments are endogenous and confounding variables high-dimensional and potentially nonlinear. Standard instrumental variables (IV) estimators, such as two-stage least squares (2SLS), become unreliable when instrument validity requires flexibly conditioning on many covariates with potentially non-linear effects. This paper develops a…

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When are time series predictions causal? The potential system and dynamic causal effects

时间序列预测何时具有因果含义?潜在系统与动态因果效应

The potential system is a nonparametric time series model for assessing the causal impact of moving an assignment at time $t$ on an outcome at future time $t+h$, accounting for the presence of features. The potential system provides nonparametric content for, e.g., time series experiments, time series regression, local projection, impulse response functions and SVARs. It closes a gap between time series causality and nonparametric cross-sectional causal methods, and provides…

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Decoupling and randomization for double-indexed permutation statistics

双索引排列统计量的解耦与随机化

This paper introduces a version of decoupling and randomization to establish concentration inequalities for double-indexed permutation statistics. The results yield, among other applications, a new combinatorial Hanson-Wright inequality and a new combinatorial Bennett inequality. Several illustrative examples from rank-based statistics, graph-based statistics, and causal inference are also provided.

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Automatic Debiased Machine Learning for Smooth Functionals of Nonparametric M-Estimands

非参数 M 估计目标光滑泛函的自动去偏机器学习

We develop a unified framework for automatic debiased machine learning (autoDML) for inference on a broad class of statistical parameters. The framework applies to any smooth functional of a nonparametric M-estimand, defined as the minimizer of a population risk over an infinite-dimensional linear space. Examples include counterfactual regression, quantile, and survival functions, as well as conditional average treatment effects. Rather than requiring manual derivation of…

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A proxy-based approach for unmeasured confounding in electronic health records research

电子健康记录研究中处理未测混杂的代理变量方法

Electronic health records (EHR) are widely used to study clinical decisions, yet unmeasured confounding remains a persistent challenge. Proxy variables offer a potential solution. In EHR data, clinicians already record many such measurements (e.g., vitals), each revealing something about a patient's underlying health. Despite this, proxy-based methods are rarely used in practice. We introduce a new way to use proxies to adjust for unmeasured confounding. Our approach uses a…

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Synthetic Control Misconceptions: Recommendations for Practice

合成控制的常见误解与实践建议

To estimate the causal effect of an intervention, researchers need to identify a control group that represents what might have happened to the treatment group in the absence of that intervention. This is challenging without a randomized experiment and further complicated when few units (possibly only one) are treated. Nevertheless, when data are available on units over time, synthetic control (SC) methods provide an opportunity to construct a valid comparison by…

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PPI is the Difference Estimator: Recognizing the Survey Sampling Roots of Prediction-Powered Inference

PPI 即差值估计量:预测辅助推断的调查抽样根源

Prediction-powered inference (PPI) is a rapidly growing framework for combining machine learning predictions with a small set of gold-standard labels to conduct valid statistical inference. In this article, I argue that the core estimators underlying PPI are equivalent to well-established estimators from the survey sampling literature dating back to the 1970s. Specifically, the PPI estimator for a population mean is algebraically equivalent to the difference estimator of…

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