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时间序列高斯链图模型AI 解读

Time series graphical models have recently received considerable attention for characterizing (conditional) dependence structures in multivariate time series. In many applications, the multivariate series exhibit variable-partitioned blockwise dependence, with distinct patterns within and across blocks. In this paper, we introduce a new class of time series Gaussian chain graph models that represent contemporaneous and lagged causal relations via directed edges across…

因果基础模型的干预时间序列先验AI 解读

Prior-data fitted networks (PFNs) have emerged as powerful foundation models for tabular causal inference, yet their extension to time series remains limited by the absence of synthetic data generators that provide interventional targets. Existing time series benchmarks generate observational data with ground-truth causal graphs but lack the interventional data required for training causal foundation models. To address this, we propose \textbf{CausalTimePrior}, a principled…

非参数倾向得分估计的局部平衡校准AI 解读

The propensity score is widely used for causal inference in observational studies, but common parametric estimators can produce biased and inefficient effect estimates when model assumptions are violated. Nonparametric approaches reduce sensitivity to misspecification but often yield unstable weights and inadequate covariate balance. We propose Local Balance with Calibration, implemented by Neural Networks, a weighting method that combines flexible function approximation…

平均处理效应的高效协作学习AI 解读

In response to the growing need for generating real-world evidence from multi-site collaborative studies, we introduce an efficient collaborative learning approach to evaluate average treatment effect (ECO-ATE) in a multi-site setting under data sharing constraints. Specifically, ECO-ATE operates in a federated manner, using individual-level data from a user-defined target population and summary statistics from other source populations, to construct efficient estimator for…

用加权控制效应处理中介分析的正值性违背：既往抗原暴露人群的免疫保护关联应用AI 解读

Causal mediation analysis has become an important and increasingly used framework for evaluating candidate immune response biomarkers in vaccine research. A controlled effects approach has been proposed to estimate controlled risk curves under a counterfactual scenario in which the entire study population is vaccinated and their post-vaccination immune responses are set to a range of fixed levels. This framework performs well when the study population is antigenically naïve,…

营销增益建模中元学习器与因果森林的异质性处理效应大规模比较AI 解读

Estimating Conditional Average Treatment Effects (CATE) at the individual level is central to precision marketing, yet systematic benchmarking of uplift modeling methods at industrial scale remains limited. We present UpliftBench, an empirical evaluation of four CATE estimators: S-Learner, T-Learner, X-Learner (all with LightGBM base learners), and Causal Forest (EconML), applied to the Criteo Uplift v2.1 dataset comprising 13.98 million customer records. The near-random…

不依赖生产率动态设定的生产函数非参数识别与估计AI 解读

Production function estimates underpin the measurement of firm-level markups, allocative efficiency, and the productivity effects of policy interventions. Since Olley and Pakes (1996), every major proxy variable estimator has identified the production function through a first-order Markov assumption on unobserved productivity; I show that misspecification of this assumption generates persistent upward bias in the materials elasticity that propagates into overestimated…

充分原因框架下的死亡截断AI 解读

The sufficient cause framework has been used for decades to improve our understanding of both basic and more complex causal concepts in epidemiology, such as mediation and interaction. Here, we make use of this framework to provide a description of truncation by death, in which the outcome of interest is undefined for individuals who die before the time of assessment at the end of follow-up. We explain the non-causal nature of the crude estimand that compares outcomes by…

结合目标学习推断的在线元层级自适应设计：代理结局的评价与利用AI 解读

Adaptive designs are increasingly used in clinical trials and online experiments to improve participant outcomes by dynamically updating treatment allocation as data accumulate. In practice, experimenters often consider multiple candidate designs, each with distinct trade-offs. However, typically only one design is implemented at a time, leaving benefits and costs of alternative designs unobserved and unquantified. To address this, we propose a novel meta-level adaptive…

涉及半连续暴露的因果推断：两阶段估计AI 解读

Methods for causal inference are well developed for binary and continuous exposures, but in many settings, the exposure has a substantial mass at zero-such exposures are called semi-continuous. We propose a general causal framework for such semi-continuous exposures, together with a novel two-stage estimation strategy. A two-part propensity structure is introduced for the semi-continuous exposure, with one component for exposure status (exposed vs unexposed) and another for…

不让任何人受损：具有遗憾厌恶的政策定向AI 解读

While the importance of personalized policymaking is widely recognized, fully personalized implementation remains rare in practice, often due to legal, fairness or cost concerns. We study the problem of policy targeting for a regret-averse planner when training data gives a rich set of observables while the assignment rules can only depend on its subset. Our regret-averse criterion reflects a planner's concern about regret inequality across the population. This, in general,…

弱识别下的置信集：理论与实践AI 解读

We develop new methods for constructing confidence sets and intervals in linear instrumental variables (IV) models based on tests that remain valid under weak identification and under heteroskedastic, autocorrelated, or clustered errors. In practice, researchers typically recover such sets by grid search, a procedure that can miss parts of the confidence region, truncate unbounded sets, and deliver misleading inference. We replace grid inversion with exact and…

重尾齐次结构因果模型AI 解读

We consider causal discovery in structural causal models driven by heavy-tailed noise, where extremes carry important information about causal direction. We introduce the Heavy-Tailed Homogeneous Structural Causal Model (HT-HSCM), a unified framework that generalizes heavy-tailed linear and max-linear models. We demonstrate that causal tail coefficients identify the complete ancestral partial order of the underlying directed acyclic graph. We also formulate a recursive…

链式法则下的因果归因：统一自然选择、学习、经济学及其他学科AI 解读

Analysis often splits change into components. For example, how much of the observed variance is caused by genes or environment? In many cases, the split is ultimately made by the logic of the chain rule, which divides the difference of a product into two terms. Each term quantifies the partial difference associated with change in one component while holding the other component constant. The chain rule is of course widely known. However, this article argues that its deep…

含停药后恢复随访者的连续终点临床试验处理效应估计AI 解读

The estimand framework provides guidance on handling intercurrent events, such as treatment discontinuation, in the analysis of clinical trial responses. Under ICH E9(R1), the treatment policy (TP) strategy incorporates post-discontinuation data to reflect treatment effects in real-world practice. However, many existing approaches focus primarily on imputing missing endpoint values for lost-to-follow-up subjects and do not explicitly model completers, retrieved dropouts…

贝叶斯层级不变预测AI 解读

We propose Bayesian Hierarchical Invariant Prediction (BHIP) reframing Invariant Causal Prediction (ICP) through the lens of Hierarchical Bayes. We leverage the hierarchical structure to explicitly test invariance of causal mechanisms under heterogeneous data, resulting in improved computational scalability for a larger number of predictors compared to ICP. Moreover, given its Bayesian nature BHIP enables the use of prior information. We evaluate BHIP on both synthetic and…

面向政策制定者的处理效应同质性非参数检验AI 解读

Recent work has focused on nonparametric estimation of conditional treatment effects, but inference has remained relatively unexplored. We propose a class of nonparametric tests for both quantitative and qualitative treatment effect heterogeneity. The tests can incorporate a variety of structured assumptions on the conditional average treatment effect, allow for both continuous and discrete covariates, and do not require sample splitting to obtain a tractable asymptotic null…

部分函数型动态后门扩散因果模型AI 解读

Causal inference in spatio-temporal settings is critically hindered by unmeasured confounders with complex spatio-temporal dynamics and the prevalence of multi-resolution data. While diffusion models present a promising avenue for estimating structural causal models, existing approaches are limited by assumptions of causal sufficiency or static confounding, failing to capture the region-specific, temporally dependent nature of real-world latent variables or to directly…

因果空间中因果效应的细粒度分析AI 解读

The notion of causal effect is fundamental across many scientific disciplines. Traditionally, quantitative researchers have studied causal effects at the level of variables; for example, how a certain drug dose (W) causally affects a patient's blood pressure (Y). However, in many modern data domains, the raw variables-such as pixels in an image or tokens in a language model-do not have the semantic structure needed to formulate meaningful causal questions. In this paper, we…

非线性工具变量估计量的遗漏变量偏差量化AI 解读

We develop a framework for quantifying omitted variable bias (OVB) in nonlinear instrumental variable (IV) estimators, including the local average treatment effect (LATE), the LATE for the treated (LATT), and the partially linear IV model (PLIVM). Extending sensitivity analysis beyond linear settings, we derive bias decompositions, establish partial identification bounds, and construct OVB-adjusted confidence intervals. We estimate OVB bounds and conduct inference using…

含潜变量的多层断点回归模型AI 解读

Regression discontinuity (RD) analysis with latent variables as introduced by Morell et al. (2025), offers a useful augmentation of the conventional RD by incorporating measurement model. This approach is particularly relevant in education research, where noisy proxy (e.g., observed test score) of underlying latent construct is adopted for the running variable. This extension enables extrapolation of average treatment effect (ATE) away from the cutoff score and assessment of…

通过基于模拟的推断改进因果评估的生成方法AI 解读

Generating synthetic datasets that accurately reflect real-world observational data is critical for evaluating causal estimators, but it remains a challenging task. Existing generative methods offer a solution by producing synthetic datasets anchored in the observed data (source data) while allowing variation in key parameters such as the treatment effect and amount of confounding bias. However, it is often unclear which generative methods to use and which values of…

生存结局的非参数断点回归设计AI 解读

Quasi-experimental evaluations are central for generating real-world causal evidence and complementing insights from randomized trials. The regression discontinuity design (RDD) is a quasi-experimental design that can be used to estimate the causal effect of treatments that are assigned based on a running variable crossing a threshold. Such threshold-based rules are ubiquitous in healthcare, where predictive and prognostic biomarkers frequently guide treatment decisions.…

随机对照试验中存在竞争性伴发事件的处理效应估计AI 解读

The analysis of randomized controlled trials is often complicated by intercurrent events (IEs) -- events that occur after treatment initiation and affect either the interpretation or existence of outcome measurements. Examples include treatment discontinuation or the use of additional medications. In two recent clinical trials for systemic lupus erythematosus with complications of IEs, we classify the IEs into two broad categories: effect-informative (e.g., treatment…