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Causality-Encoded Diffusion Models for Interventional Sampling and Edge Inference

用于干预抽样与边推断的因果编码扩散模型

Standard diffusion models are flexible estimators of complex distributions, but they do not encode causal structures and therefore do not by themselves support causal analysis. We propose a causality-encoded diffusion framework that incorporates a known directed acyclic graph by training conditional diffusion models consistent with the graph factorisation. The resulting sampler approximately recovers the observational distribution and enables interventional sampling by…

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A Riesz Representer Perspective on Targeted Learning

从 Riesz 表示元视角理解目标学习

As research in causal inference has sought to address more complex scientific questions, the number of specialized estimands in the field has proliferated. Recognition that many of these estimands share a common linear form has generated interest in simplifying estimation procedures using Riesz representers. In this work, we construct a targeted minimum loss-based estimation procedure for nested linear functionals, leveraging Riesz representers of a general recursive form.…

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Estimator-Aligned Prospective Sample Size Determination for Designs Using Inverse Probability of Treatment Weighting

与估计量匹配的逆概率处理加权前瞻性样本量设计

In observational studies, accurately characterizing variance is critical for sample size determination, yet unaccounted-for variability from propensity score estimation and the resulting weights limit the accuracy of standard variance approximations for design. Existing approaches often rely on heuristics or randomized controlled trial (RCT) formulas that treat weights as fixed, potentially misaligning prospective design with the causal estimator used at analysis. We propose…

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Causal Discovery in Multivariate Extremes via Tail Asymmetry

利用尾部不对称性发现多元极端事件的因果结构

Causal discovery in multivariate extremes is challenging because extreme observations are sparse, dependent, and often affected by latent common shocks. Existing approaches focus on undirected extremal dependence, require prior graph restriction, and do not scale beyond small systems. We introduce tail-induced asymmetry as a principle for causal directionality in heavy-tailed systems, where extreme events propagate asymmetrically so that forward tail prediction is…

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Nonparametric Point Identification of Treatment Effect Distributions via Rank Stickiness

通过秩黏性非参数点识别处理效应分布

Treatment effect distributions are not identified without restrictions on the joint distribution of potential outcomes. Existing approaches either impose rank preservation -- a strong assumption -- or derive partial identification bounds that are often wide. We show that a single scalar parameter, rank stickiness, suffices for nonparametric point identification while permitting rank violations. The identified joint distribution -- the coupling that maximizes average rank…

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balnet: Pathwise Estimation of Covariate Balancing Propensity Scores

balnet:协变量平衡倾向得分的路径估计

We present balnet, an R package for scalable pathwise estimation of covariate balancing propensity scores via logistic covariate balancing loss functions. Regularization paths are computed with Yang and Hastie (2024)'s generic elastic net solver, supporting convex losses with non-smooth penalties, as well as group penalties and feature-specific penalty factors. For lasso penalization, balnet computes a regularization path of balancing weights from the largest observed…

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A Functional-Class Meta-Analytic Framework for Quantifying Surrogate Resilience

量化替代终点韧性的函数类元分析框架

A surrogate marker is a biomarker or other physical measurement used to replace a primary outcome in clinical trials to evaluate a treatment effect when the primary outcome of interest is costly, invasive, or takes a long time to observe. However, replacing a primary outcome with a surrogate can lead to the "surrogate paradox," in which a treatment appears beneficial based on the surrogate but is actually harmful with respect to the primary outcome. In this paper, we propose…

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Early Detection of Latent Microstructure Regimes in Limit Order Books

限价订单簿潜在微观结构状态的早期检测

Limit order books can transition rapidly from stable to stressed conditions, yet standard early-warning signals such as order flow imbalance and short-term volatility are inherently reactive. We formalise this limitation via a three-regime causal data-generating process (stable $\to$ latent build-up $\to$ stress) in which a latent deterioration phase creates a prediction window prior to observable stress. Under mild assumptions on temporal drift and regime persistence, we…

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Data Integration for Estimating Subgroup-Specific Conditional Average Treatment Effects (CATEs) Using Coarsened External Information in Randomized Trials

利用粗粒度外部信息估计随机试验的细分亚组处理效应

Randomized controlled trials (RCTs) are often underpowered to detect treatment heterogeneity in subgroups defined by cross-classifications of multiple covariates, due to sparse sample sizes in some strata. External RCT data can help, but typically provide treatment effect estimates at a coarser level (e.g., by sex or race) rather than for the finer subgroups of interest (e.g., race-by-sex). We propose a novel James-Stein (JS)-type estimator that borrows strength from such…

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A general nonparametric framework for testing hypotheses about function-valued parameters

函数值参数假设检验的一般非参数框架

We present a general nonparametric approach for testing whether a statistical parameter defined through conditional distributions is constant across the conditioning variables. Such hypotheses arise naturally in problems such as assessing treatment effect heterogeneity, conditional associational effects, and conditional mean dependence. Our framework studies function-valued parameters obtained by evaluating a smooth statistical functional on conditional probability…

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Constructing external comparator groups via transportability in mean or in effect measure

通过均值或效应尺度可迁移性构造外部对照组

Learning about causal effects in target populations and their subsets may be facilitated by combining information from multiple sources. One major class of study designs that combine information involves appending an index study with data from an external comparator, which may facilitate head-to-head comparisons of treatments initially studied in different populations. We delineate external comparator analyses under two distinct, but related, identification strategies. The…

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Recent Advances in Causal Analysis of the Stochastic Frontier Model

随机前沿模型因果分析的近期进展

Causal inference methods (instrumental variables, difference-in-differences, regression discontinuity, etc.) are primary tools used across many social science milieus. One area where their application has lagged however, is in the study of productivity and efficiency. A main reason for this is that the nature of the stochastic frontier model does not immediately lend itself to a causal framework when interest hinges on an error component of the model. This paper reviews the…

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From Clerks to Agentic-AI: How will Technology Change Labor Market in Finance?

从职员到智能体人工智能:技术将如何改变金融业劳动力市场?

Financial firms have gone through three major technological waves: computerization in the 1980s and 1990s, the rise of indexing and passive investing in the 2000s and 2010s, and the AI and automation wave from roughly 2015 to the present. This project studies how much labor is required to manage capital across those waves by tracking a simple productivity measure: assets under management per employee. Using a small panel of representative firms, we compare changes in AUM per…

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A Statistical Framework for Understanding Causal Effects that Vary by Treatment Initiation Time in EHR-based Studies

电子健康记录研究中随治疗启动时间变化的因果效应框架

Standard practice in electronic health record (EHR)-based studies evaluating the comparative effectiveness of bariatric surgery relative to no surgery is to estimate and report a constant treatment effect across calendar time. However, real-world treatment strategies can evolve, particularly when comparators include standard of care or surgical procedures where techniques may improve, making it clinically important to ascertain whether efficacy of bariatric surgery has…

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Beyond Coefficients: Forecast-Necessity Testing for Interpretable Causal Discovery in Nonlinear Time-Series Models

超越系数:非线性时间序列模型中可解释因果发现的预测必要性检验

Nonlinear machine-learning models are increasingly used to discover causal relationships in time-series data, yet the interpretation of their outputs remains poorly understood. In particular, causal scores produced by regularized neural autoregressive models are often treated as analogues of regression coefficients, leading to misleading claims of statistical significance. In this paper, we argue that causal relevance in nonlinear time-series models should be evaluated…

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Which Small-Sample Correction Should Be Used When Analyzing Stepped-Wedge Designs with Time-Varying Treatment Effects?

时变处理效应阶梯楔形设计应采用哪种小样本修正?

Stepped-wedge cluster randomized trials (SW-CRTs) evaluate interventions rolled out across clusters over time. Standard analyses typically use immediate-treatment (IT) models, which assume effects begin at crossover and remain constant thereafter. When effects vary with exposure duration, IT models may misrepresent target effects. Exposure-time indicator (ETI) models address this by allowing treatment effects to differ by time since exposure and by targeting the…

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Embarrassingly Causal: Causal Use of Associational Data in Magic The Gathering Drafts

显然存在因果关系的场景:万智牌轮抽中关联数据的因果使用

Observational data are often used to answer causal questions, yet the legitimacy of doing so is often argued to hinge on strong, domain supported assumptions about underlying causal structure with limited guidance on how much domain knowledge support should exist to justify including a causal edge of interest in a directed acyclic graph. We introduce the criterion of embarrassingly causal scenarios, where the existence of an exposure outcome relationship is so…

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Causal Meta-Analysis: Rethinking the Foundations of Evidence-Based Medicine

因果元分析:重新审视循证医学的基础

Meta-analysis, by synthesizing effect estimates from multiple studies conducted in diverse settings, stands at the top of the evidence hierarchy in clinical research. Yet, conventional approaches based on fixed- or random-effects models lack a causal framework, which may limit their interpretability and utility for public policy. Incorporating causal inference reframes meta-analysis as the estimation of well-defined causal effects on clearly specified populations, enabling a…

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Factor-Augmented Panel Regressions and Variance-Weighted Treatment Effects

因子增强面板回归与方差加权处理效应

We revisit panel regressions with unobserved heterogeneity through the lens of variance-weighted average treatment effects. Building on established results for cross-sectional OLS and one-way fixed effects panels, we show that two-way panel estimators with latent factors, specifically the principal components estimator of Greenaway-McGrevy, Han and Sul (2012) and the interactive fixed effects estimator of Bai (2009), also converge to interpretable estimands under fully…

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Causal inference for social network formation

社会网络形成的因果推断

This paper develops a framework for identification, estimation, and inference on the causal mechanisms driving endogenous social network formation. Identification is challenging because of unobserved confounders and reverse causality; inference is complicated by questions of equilibrium and sampling. We leverage repeated observations of a network over time and random variation in initial ties to address challenges to causal identification. Our design-based approach sidesteps…

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Partial identification of principal causal effects under violations of principal ignorability

主层可忽略性违反时主层因果效应的部分识别

Principal stratification is a general framework for studying causal mechanisms involving post-treatment variables. When estimating principal causal effects, the principal ignorability assumption is commonly invoked, which we study in detail in this manuscript. Our first key contribution is studying a commonly used strategy of using parametric models to jointly model the outcome and principal strata without requiring the principal ignorability assumption. We show that even if…

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Stable Transport Meta-Analysis for Heterogeneous Cardiovascular Trials: A Nuisance-Anchor Framework with a Sign-Stability Diagnostic

异质性心血管试验的稳定迁移元分析:干扰锚框架与符号稳定性诊断

Random-effects meta-analysis summarizes heterogeneous trials by estimating an average effect over the observed evidence base, which may not represent the clinically relevant target population. In cardiovascular medicine, treatment effects vary systematically across era, endpoint definitions, background therapy, and case-mix, making the historical average often misaligned with current decision-making. We propose stable transport meta-analysis (AMT-MA), a nuisance-anchor…

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Bootstrap consistency for general double/debiased machine learning estimators

一般双重/去偏机器学习估计量的自助法一致性

Double/debiased machine learning (DML) provides a general framework for inference with high-dimensional or otherwise complex nuisance parameters by combining Neyman-orthogonal scores with cross-fitting, thereby circumventing classical Donsker-type conditions in many modern machine-learning settings. Despite its strong empirical performance, bootstrap inference for DML estimators has received little theoretical justification. This is particularly noteworthy since bootstrap…

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Complier General Causal Effect in Randomized Controlled Trials with One-Sided Noncompliance

单侧不依从随机对照试验中的依从者一般因果效应

A randomized controlled trial (RCT) is widely regarded as the gold standard for assessing the causal effect of a treatment or intervention, assuming perfect implementation. In practice, however, randomization can be compromised for various reasons, such as one-sided noncompliance. In this paper, we first systematically study the likelihood-based identifiability in an RCT with one-sided noncompliance. This foundational analysis naturally gives rise to the complier general…

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