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不可测混杂下因果效应估计的近端平衡方法AI 解读

Estimating causal effects from observational data is central to science and policy, but the effects are not identified when confounders are unmeasured. Proximal causal inference addresses this problem with proxies of the unmeasured confounders. However, existing proxy-based approaches either designate proxy roles and solve an inverse problem, which is ill-posed and hard to estimate with high-dimensional proxies, or use a latent-variable model, which assumes that the learned…

受约束分类与政策学习AI 解读

Modern machine learning approaches to classification, including AdaBoost, support vector machines, and deep neural networks, utilize surrogate loss techniques to circumvent the computational complexity of minimizing empirical classification risk. These techniques are also useful for causal policy learning problems, since estimation of individualized treatment rules can be cast as a weighted (cost-sensitive) classification problem. Consistency of the surrogate loss approaches…

离散选择面板模型中平均效应的界AI 解读

In discrete choice panel data, estimation of average effects is crucial for quantifying the effect of covariates, and for policy evaluation and counterfactual analysis. However, in short panels with individual-specific effects, challenges arise due to partial identification and the incidental parameter problem. In particular, estimating the sharp identified set of average effects becomes impractical when covariates have large support sets, such as when they are continuous.…

含时间趋势试验中的估计目标与估计方法AI 解读

In platform trials, model-based approaches typically estimate treatment effects conditional on calendar time. However, scientific and regulatory interest often lies in treatment effects defined for a target population spanning multiple enrollment periods, requiring explicit consideration of how effects should be averaged across time. This raises two fundamental challenges. The first is the definition of the appropriate target estimand when combining data across multiple…

随机实验的一般设计型框架与估计器AI 解读

We describe a widely applicable design-based framework for drawing causal inference in randomized experiments. Causal effects are defined as linear functionals evaluated at unit-level potential outcome functions. Assumptions about the potential outcome functions are encoded as function spaces. This makes the framework expressive, allowing experimenters to formulate and investigate a wide range of causal questions that previously could not be investigated with design-based…

最优配置与曲面下体积AI 解读

This paper develops a framework for estimation and inference on the volumes of sets that are projections of critical function sets, focusing particularly on the convex body beneath the optimal receiver operating characteristic (ROC) surface. Specifically, we propose a volume calculation method that first uses an Aumann expectation representation and then applies Minkowski mixed volumes. Using this framework, we show that the population volume under the ROC surface (VUS) is…

贝叶斯神经网络辅助多处理混合治愈生存模型：儿科肿瘤应用AI 解读

Estimating covariate-conditional treatment effects in multi-arm oncology studies is complicated when treatment arms have common distributional features and a non-negligible fraction of patients achieve long-term remission. We propose a joint mixture cure model with covariate-dependent mixtures of log-normal kernels with treatment-specific inclusions. Both linear and neural-network-assisted non-linear covariate links are proposed. Specifically, the susceptible survival…

持续在线实验：动态处理下的序贯检验与错误发现率控制AI 解读

Generative AI has dramatically accelerated the rate at which new treatments---from novel pharmaceuticals to online marketing campaigns---can be conceived and deployed. As a result, modern experimentation platforms often run continuously, with treatments added as they are ready and removed when they underperform. We formalize this "Always-On" experimental setting, in which treatments can be dynamically generated, added to, and removed from a running experiment, and study the…

插补就够了：平均处理效应估计的双稳健、半参数有效性与自动协变量平衡AI 解读

Imputation-based causal estimation is typically viewed as relying exclusively on an outcome model, in contrast to augmented inverse-probability weighting, whose consistency is protected by fitting two nuisance models. This paper argues that this view can be misleading by highlighting a hidden dual weighting structure in least-squares sieve regression imputation. Although only outcome regressions are explicitly fitted, the resulting imputation estimator admits an exact…

时变协变量下交错双重差分处理效应的双重稳健估计AI 解读

With staggered adoption, difference-in-differences (DiD) analyses define the average treatment effect on the treated (ATT) at the group-period level and aggregate it into groupwise, periodwise, dynamic, and overall effects. We study a period-by-period version of conditional parallel trends, with covariates unaffected by treatment while allowing covariates to shift the trends in untreated potential outcomes. We propose an augmented inverse probability weighting (AIPW)…

目标试验模拟中的时间划分AI 解读

In target trial emulation, the treatment strategies that patients follow are inferred from the treatments they actually receive in routine care. However, in most settings, the outcome may preclude the observation of planned treatment, giving rise to immortal time bias through misclassification of treatment strategy, while markers of treatment response may influence subsequent treatment decisions, giving rise to time-varying confounding. A key step toward unbiased treatment…

数据驱动亚组发现后标准试验估计量的推断AI 解读

Data-driven subgroup identification is increasingly used in clinical trials, yet the effect reported for a discovered subgroup is typically the standard analysis: a Cox or generalized-linear-model treatment coefficient fitted within that subgroup. Selection by an effect-driven rule --- rewarding large estimated effects subject to screening and size criteria --- inflates the reported coefficient: a winner's curse invalidating naive intervals whether or not the identifier's…

通过交叉代理平衡的近似因果推断AI 解读

Proximal causal inference identifies causal effects in the presence of unmeasured confounding by drawing on two sets of proxy variables. Identification typically utilizes bridge functions, defined as solutions to integral equations. However, the mechanism by which fitted bridge functions correct for confounding bias remains opaque, offering little to interpret, inspect or stress-test. We show that the defining equation of a treatment bridge function is already a balance…

最小设定扰动：以距证伪的距离衡量因果推断稳健性AI 解读

Empirical causal claims depend on many analyst decisions, from selecting covariates to choosing estimators. Existing robustness tools summarize how results vary across these choices, but, to the best of our knowledge, do not answer: \textbf{How many analyst decisions must change to reach a specification, which is a set of choices, whose confidence interval (CI) contains zero?} We introduce \emph{Minimum Specification Perturbation (MSP)}, the smallest number of changes. MSP…

何时能够进行奈曼正交推断？存在性与信息相关性AI 解读

Neyman-orthogonal moments underpin debiased and double machine learning, yet their existence and informativeness are typically presumed. We ask three questions: when do nontrivial orthogonal moments exist, which target directions contain first-order information, and does a proposed moment detect all such directions? Restricted local overidentification characterizes existence under attainability. Effective Fisher information determines relevance; its rank counts informative…

随时间刻画幸存者主层：识别、有效估计与敏感性分析AI 解读

Longitudinal studies with functional outcomes subject to truncation-by-death frequently report time-indexed survivor average causal effect estimates, defined among individuals who would survive regardless of treatment assignment. Because the survivor stratum can change over time, the resulting effect estimates may pertain to populations with different characteristics. We propose accompanying survivor average causal effect estimates with measures of covariate divergence…

小样本多协变量随机对照试验中的G计算AI 解读

In contemporary randomized controlled trials (RCTs), the number of patients is often small relative to the number of baseline covariates collected. In such settings, maximum likelihood estimators of conditional treatment effects in generalized linear models, along with their standard errors, may exhibit substantial bias. This study examines whether similar bias arises in G-computation estimators of marginal treatment effects, which are known for their robustness to model…

多控制变量下工资不平等界的去偏推断AI 解读

We study estimation and inference for a partially identified parameter whose identified set depends on a first-stage nuisance parameter that must itself be estimated. Combining the criterion-function approach with the theory of Neyman-orthogonal moments that underlies double/debiased machine learning, we propose a two-step procedure: the point-identified nuisance is estimated by flexible machine-learning methods, and the set-identified target is recovered as a level set of a…

不可观测异质性的去偏机器学习：高维面板与测量误差模型AI 解读

Developing robust inference for models with nonparametric Unobserved Heterogeneity (UH) is both important and challenging. We propose novel Debiased Machine Learning (DML) procedures for valid inference on functionals of UH, allowing for partial identification of multivariate target and high-dimensional nuisance parameters. Our main contribution is a full characterization of all relevant Neyman-orthogonal moments in models with nonparametric UH, where relevance means…

基于残差化 Walsh–Hadamard 得分的异质析因效应修饰因子去偏与同时推断AI 解读

In factorial randomized experiments with $K$ binary treatment components, we study which baseline covariates modify component main effects and interactions. We define effect-modifier cells $(j,S)$, $j\in[p]$ and $\emptyset\neq S\subseteq[K]$, through the coefficients $θ^\ast_{jS}$ of population linear projections of conditional Walsh--Hadamard contrasts $τ_{S}$ onto standardized covariates. Using baseline-robust direct scores, we develop frequentist inference for all $p(2^K-1)$…

全正编码下的 INSIDE 假设：解释与部分经验评估AI 解读

Mendelian randomisation (MR) implemented through instrumental variable (IV) analysis is a popular strategy for strengthening causal inference in observational studies. A key assumption for several MR estimators, including MR-Egger regression, is the INstrument Strength Independent of Direct Effect (INSIDE) assumption. However, there is no established empirical test for assessing the plausibility of this assumption. Moreover, INSIDE depends on how genetic variants are coded…

识别临床AI预测多重性中亚组脆弱性的统计框架AI 解读

AI models trained on the same data can disagree about patient risk, with disagreement potentially concentrated in clinically important subgroups. We propose V(S), a statistically grounded vulnerability index combining an observable lower-bound witness of model disagreement with clinical severity, and develop inference and multiplicity-adjustment procedures for auditing prespecified subgroups. We applied the framework to two large critical-care cohorts, MIMIC-IV (n = 65,078)…

交替处理实验中的随机化检验AI 解读

Switchback experiments assign an experimental unit, such as a market or a platform, to treatment or control over successive blocks of time. Inference can be challenging because these experiments often contain only a small number of randomized blocks, while outcomes may exhibit serial dependence, seasonality, and treatment effects that persist across periods. We develop a conditional randomization test for the null of no total treatment effect that is finite-sample valid…

本地收益大、净收益小：波多黎各首次行业进入的直接与溢出效应AI 解读

I study how first sizable industry entries reshape local and neighboring labor markets in Puerto Rico. Using over a decade of quarterly municipality--industry data (2014Q1--2025Q1), I identify ``first sizable entries'' as large, persistent jumps in establishments, covered employment, and wage bill, and treat these as shocks to local industry presence at the municipio--industry level. Methodologically, I combine staggered-adoption difference-in-differences estimators that are…