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病例队列研究中基于匹配设计的限制平均生存时间因果效应估计AI 解读

In large observational studies, the case-cohort design is commonly used to reduce the cost associated with covariate measurement. For survival outcomes, literature has suggested that the restricted mean survival time (RMST) be a more appropriate marginal causal effect measure than the hazard ratio. In this paper, we develop a marginal causal effect estimation method for RMST difference under the stratified case-cohort design. We adjust for measured confounders using an…

基于 Copula 的处理效应双重稳健估计内生性修正AI 解读

Doubly Robust (DR) estimation of treatment effect relies on an untestable assumption that is the absence of unobserved confounding. This assumption is par- ticularly problematic in the context of healthcare research, where variables like pre- scription refill rates serve as proxies for unobserved behaviors such as medication adherence. These proxy variables are often endogenous, exhibiting correlation with the regression error term due to unmeasured confounding or…

均方误差最优的双重差分估计量AI 解读

This paper develops a difference-in-differences (DiD) estimation method that selects the optimal length of pre-trends by minimizing the mean squared error (MSE). Conventional DiD regression models, such as the two-way fixed effects model or the event study model, may suffer from accuracy and validity concerns. If the sample size is small, the estimator may have a larger variance. Also, pre-tests often lack power to detect violations of the parallel trends assumption as Roth…

个体处理效应无分布预测推断的不可能性AI 解读

Uncertainty quantification for individual treatment effects (ITEs) is a daunting challenge in causal inference. Motivated by recent advances in conformal prediction, several works aim to construct distribution-free prediction sets for ITEs with desired coverage under standard assumptions such as strong ignorability and overlap. In this paper, we show that such goals are fundamentally unattainable in the presence of continuous covariates. Specifically, we establish…

用于异质性处理效应可扩展推断的倾向得分拼接克里金AI 解读

Gaussian process-based models are attractive for estimating heterogeneous treatment effects (HTE), but their computational cost limits scalability in causal inference settings. In this work, we address this challenge by extending Patchwork Kriging into the causal inference framework. Our proposed method partitions the data according to the estimated propensity score and applies Patchwork Kriging to enforce continuity of HTE estimates across adjacent regions. By imposing…

PAIR-CI：不完整资料因果发现中的校准条件独立检验AI 解读

The standard constraint-based paradigm for causal discovery with incomplete data -- impute first, test second -- is frequently miscalibrated: any consistent conditional independence (CI) test rejects a true null with probability approaching 1 when imputation error induces spurious conditional dependence. We introduce PAIR-CI, a nonparametric CI test that restores calibration by integrating multiple imputation directly into the inferential procedure via a paired permutation…

通过量化对处理效应估计的影响改进偏差校正评价标准AI 解读

With the growing access to administrative health databases, retrospective studies have become crucial evidence for medical treatments. Yet, non-randomized studies frequently face selection biases, requiring mitigation strategies. Propensity score matching (PSM) addresses these biases by selecting comparable populations, allowing for analysis without further methodological constraints. However, PSM has several drawbacks. Different matching methods can produce significantly…

利用替代指标辅助缺失主要结局的高效跨总体分布与分位数处理效应估计AI 解读

We study target-population distributional and quantile treatment effects when a source study observes treatment and post-treatment surrogates for all source units but observes a long-run primary outcome only for a validation subset, while the target population contributes only baseline covariates. The target estimands are transported counterfactual distribution functions $ψ_a(y)=P(Y^a\le y\mid R=0)$, their quantiles $q_a(τ)$, and the quantile treatment effect $Δ(τ)=q_1(τ)-q_0(τ)$…

超越全局单调性的反事实可识别性：非单调三角结构因果模型AI 解读

Structural causal models provide a unified semantics for interventions and counterfactuals, but most identifiability results rely on restrictive assumptions like global monotonicity, which are often violated in embodied interaction, where the same exogenous perturbation can induce opposite responses under different contact contexts. We ask what structure still suffices once global monotonicity is dropped. We introduce non-monotone triangular structural causal models…

均值独立与线性条件下的因果发现AI 解读

Causal discovery methods such as LiNGAM identify causal structure from observational data by assuming mutually independent disturbances. This assumption is fragile: shared volatility, common scale effects, or other forms of dependence can cause the methods to recover the wrong causal order, even with infinite data. We introduce the Linear Mean-Independent Acyclic Model (LiMIAM), which replaces full independence with weaker one-sided mean-independence restrictions on the…

用于组成型微生物组中介变量边际中介分析的零膨胀贝塔混合模型AI 解读

The role of the microbiome in disease pathogenesis is an emerging field with strong evidence suggesting that dysbiosis is associated with precancerous and cancerous states. Microbiome data present substantial challenges for causal mediation analysis due to sparsity, compositional constraints, and latent heterogeneity. To address these issues, we propose a zero-inflated beta mixture (ZIBM) method for mediation analysis with compositional microbiome mediators. The proposed…

双重稳健的工具变量双重差分AI 解读

We study estimation of the local average treatment effect on the treated ($LATT$) in instrumented difference-in-differences (IDiD) designs with covariates and staggered instrument exposure. We derive the efficient influence function (EIF) of the target parameter in both panel and repeated cross-sections settings, allowing for two classes of control groups: never-exposed and not-yet-exposed. Building on the EIF, we construct doubly robust estimands and corresponding…

更精确的测量还是更大的样本？存在未观测异质性时的政策学习数据采集AI 解读

Empirical research shows that individuals' responses to treatments vary along latent characteristics, such as innate ability or motivation. Therefore, a policymaker seeking to maximize welfare may consider designing policies based on observed characteristics and estimated latent traits. I characterize how the estimates' precision affects the worst-case performance of policies deriving rate-sharp regret bounds for assignment rules that include or exclude them, highlighting…

序贯多次随机分配试验中评估动态治疗方案的纵向—生存联合框架AI 解读

Sequential multiple assignment randomized trials (SMARTs) provide a systematic framework for constructing and evaluating dynamic treatment regimens (DTRs). In clinical studies, longitudinal biomarkers are routinely collected to monitor disease progression and define treatment response. However, the integration of longitudinal biomarker data into survival analysis for DTR evaluation within a SMART remains unexplored. We propose a joint longitudinal-survival framework to…

利用仅调查可得协变量进行因果小区域估计AI 解读

Area-specific causal inference is important in many policy and survey applications, where the goal is to evaluate treatment effects for small geographic or demographic domains. Existing causal small area estimation methods, however, typically rely on a strong data requirement that treatment status is observed for all units in the population. This assumption is often unrealistic in practical survey settings, where both treatment and outcome variables are observed only for…

利用定向工具变量识别处理效应AI 解读

Multivalued treatments are commonplace in applications. We explore the use of discrete-valued instruments to control for selection bias in this setting. Our discussion revolves around the concept of targeting: which instruments target which treatments. It allows us to establish conditions under which counterfactual averages and treatment effects are point- or partially-identified for composite complier groups. We explore the additional identifying power of a positive…

时变行动下处理复发事件与半竞争事件的新型 g 计算算法AI 解读

Background: A core aspect of epidemiology is determining the impacts of potential public health interventions over time. With long follow-up periods, epidemiologists may need to consider semi-competing events, in which a terminal event, like death, precludes a non-terminal event, like hypertension. Time-varying confounding poses an additional challenge when studying time-varying interventions or actions. Existing methods do not simultaneously address semi- competing events…

利用 CV-TMLE 全局检验提高罕见病多组分终点研究的功效AI 解读

Rare disease trials face unique statistical challenges due to limited patient populations and heterogeneous clinical manifestations among patients. Multiple endpoints are often necessary to comprehensively capture treatment benefits. A global test is an approach for evaluating whether a treatment has any beneficial effect across multiple endpoints. We propose a new global test based on a weighted composite endpoint. The proposed global test employs shrinkage-based…

试验后推广实验的无先验样本量设计AI 解读

This paper studies sample-size design for finite-population test-and-roll experiments, where a decision-maker first conducts an experiment on $m$ units and then assigns the remaining $N-m$ units to the treatment that performs better in the experiment. We consider welfare-aware sample-size choice, which involves an exploration-exploitation tradeoff: larger experiments improve the rollout decision but impose welfare losses on experimental units assigned to the inferior…

相对稀疏性的自适应方差估计量AI 解读

An approach to inference for relative sparsity was developed in prior work, and an adaptive lasso asymptotic normality theorem was given there, but this theorem was not fully used when estimating the variance of the policy coefficients. Here, we develop a new coefficient variance estimator that fully uses this theorem and, in the process, takes into account the variable selection. This improves the uncertainty representation in the graphical selection diagrams, ultimately…

自适应采集数据下的核处理效应AI 解读

Adaptive experiments improve efficiency by adjusting treatment assignments based on past outcomes, but this adaptivity breaks the i.i.d.\ assumptions that underpin classical asymptotics. At the same time, many questions of interest are distributional, extending beyond average effects. Kernel treatment effects (KTE) provide a flexible framework by representing interventional outcome distributions in an RKHS and comparing them via kernel distances. We present the first…

利用无标签协变量的半监督处理效应估计与预测驱动因果推断AI 解读

This study investigates treatment effect estimation in the semi-supervised setting, also can be interpreted as prediction-powered inference. In our setting, we can use not only the standard triple of covariates, treatment indicator, and outcome, but also unlabeled auxiliary covariates. For this problem, we develop efficiency bounds and efficient estimators whose asymptotic variance aligns with the efficiency bound. In the analysis, we introduce two different data-generating…

设计、杯子与毯子：基于自由能原理的产品设计方法AI 解读

Classical design theory treats the type of an object as a given: the designer decides in advance that this will be a cup, then optimizes its parameters. This paper argues that object type is not a presupposition but an inference, something that can be determined from physical data and functional requirements jointly. We call this problem requirement-steered interface type inference and show that it is inexpressible within existing design frameworks. This paper makes two…

日志的有限证词：模型选择受混杂影响时的语言模型生成评估AI 解读

Offline evaluation of language models from usage logs is biased when model choice is confounded: the same user-side factors that influence which model is used can also influence how its output is judged, so raw comparisons of logged scores mix self-selected populations rather than estimating a common quantity of interest. A small randomized experiment can break this bias by overriding model choice, but in practice such experiments are scarce and costly. We study a…