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Sensitivity analysis for contamination in egocentric-network randomized trials with interference

存在干扰的自我中心网络随机试验:污染敏感性分析

Egocentric-Network Randomized Trials (ENRTs) are increasingly used to estimate causal effects under interference when measuring complete sociocentric network data is infeasible. ENRTs rely on egocentric network sampling, where a set of egos is first sampled, and each ego recruits a subset of its neighbors as alters. Treatments are then randomized across egos. While the observed ego-networks are disjoint by design, the underlying population network may contain edges…

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Model Risk in Machine-Learning Distributional IV Estimation

机器学习分布型工具变量估计中的模型风险

We study model risk in machine-learning estimation of the Distributional Instrumental Variable Local Average Treatment Effect (D-IV-LATE), the distributional IV effect for the subpopulation induced into treatment by the instrument. The contribution is not a new neural causal estimand. We implement a reduced-form orthogonal level-score DML estimator for the covariate-adjusted D-IV-LATE target and use it to ask how much the nuisance learner matters for distributional IV…

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Semiparametric Difference-in-Differences Estimation With Missing Not at Random Data: A Shadow Variable Approach

非随机缺失数据下的半参数双重差分:影子变量方法

This paper considers a semiparametric difference-in-differences (DID) framework for identifying and estimating treatment effects on the treated (ATT) when outcomes are missing not at random (MNAR), and a fully observed shadow variable is available. The shadow variable is assumed to be associated with the outcome evolution but independent of the missingness process, conditional on covariates and the possibly unobserved outcome evolution. We establish the identification…

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Treatment Allocation under Uncertain Costs

成本不确定时的处理分配

We consider the problem of learning how to optimally allocate treatments whose cost is uncertain and can vary with pre-treatment covariates. This setting may arise in medicine if we need to prioritize access to a scarce resource that different patients would use for different amounts of time, or in marketing if we want to target discounts whose cost to the company depends on how much the discounts are used. Here, we show that the optimal treatment allocation rule under…

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Adaptive Estimation of Aggregated Values of Conditional Linear Programs

条件线性规划聚合值的自适应估计

We develop a covariate-assisted approach to partially identified parameters that are solutions to an under-identified system of linear equations with known coefficients. Examples include bounds on treatment effects, models of unemployment with state dependence, choice-theoretic models of IV, and random utility models. The boundary (i.e., support function) of the proposed identified set is represented as an average of intersections of regression functions, aggregated over the…

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Beyond Additivity: Causal Discovery in Location-Scale Noise Models with Hidden Variables

超越加性:含隐藏变量的位置—尺度噪声模型因果发现

We study causal discovery from observational data when some variables are hidden and the data-generating process follows a location-scale noise model (LSNM). Existing methods that handle hidden confounders typically assume additive noise, but in practice, causes often modulate not just the mean but also the variance of their effects. We prove that acyclic directed mixed graphs (ADMGs) satisfying a bow-free condition are identifiable under LSNM with hidden variables,…

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A Structural Matrix Autoregressive Model for the Joint Dynamics of Volume, Volatility, and Returns

交易量、波动率与收益联合动态的结构矩阵自回归模型

This paper proposes a Structural Matrix Autoregressive (SMAR) model for the joint analysis of asset returns, realized volatility, and trading volume in a large-dimensional setting. This framework simultaneously captures dynamic spillovers across financial variables and cross-sectional dependence across assets while preserving a parsimonious parameterization relative to conventional vector autoregressive models. The model is estimated on daily data for the constituents of the…

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Synthesizing Evidence: Data-Pooling as a Tool for Treatment Selection in Online Experiments

综合证据:利用在线实验数据汇集选择处理方案

Randomized experiments are the gold standard for causal inference but face significant challenges in business applications, including limited traffic allocation, the need for heterogeneous treatment effect estimation, and the complexity of managing overlapping experiments. These factors lead to high variability in treatment effect estimates, making data-driven policy roll out difficult. To address these issues, we introduce the data pooling treatment roll-out (DPTR)…

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Generalizing causal effects with noncompliance: Application to deep canvassing experiments

存在不依从时的因果效应推广:深度游说实验应用

Standard approaches in generalizability often focus on generalizing the intent-to-treat (ITT). However, in practice, a more policy-relevant quantity is the generalized impact of an intervention across compliers. While instrumental variable (IV) methods are commonly used to estimate the complier average causal effect (CACE) within samples, standard approaches cannot be applied to a target population with a different distribution from the study sample. This paper makes several…

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Confounder-robust causal discovery and inference in Perturb-seq using proxy and instrumental variables

利用代理变量与工具变量处理 Perturb-seq 中的未观测混杂

Emerging single-cell technologies that combine CRISPR-based genetic perturbations with single-cell RNA sequencing, such as Perturb-seq, offer unprecedented opportunities to uncover cause-and-effect relationships among genes. Nonetheless, Perturb-seq experiments are subject to unobserved factors that, if not properly handled, can severely bias the inferred causal relationships between genes. These latent factors may arise not only from intrinsic molecular features of the…

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Inference on the TSLS Estimand with Weak Instruments and Treatment Effect Heterogeneity

弱工具变量与处理效应异质性下对两阶段最小二乘目标量的推断

Traditional inference on the coefficient in an instrumental variables regression does not retain size when the instrument set is weak. With constant treatment effects or one instrument, the Anderson and Rubin (1949) AR test, the Klieibergen (2002)-Moreira (2003) LM test, and the Moreira CLR test provide robust alternatives which retain validity. Under treatment effect heterogeneity, no valid inference procedure exists in the overidentified setting. This paper develops the…

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A General Framework for Design-Based Treatment Effect Estimation in Paired Cluster-Randomized Experiments

配对整群随机实验中基于设计的处理效应估计框架

Paired cluster-randomized experiments (pCRTs) are common in education program impact evaluation trials. Although common, there is surprisingly no clear consensus regarding how to analyze this randomization design to estimate average treatment effects. Variance estimation is also complicated due to the dependency created through pairing clusters. Therefore, we aim to provide an intuitive and practical comparison between different estimation strategies for pCRTs to inform…

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Testing identification in mediation and dynamic treatment models

中介模型与动态处理模型中的识别检验

We propose a test for the identification of causal effects in mediation and dynamic treatment models that is based on two sets of observed variables, namely covariates to be controlled for and suspected instruments, building on the test by Huber and Kueck (2022) for single treatment models. We consider models with a sequential assignment of a treatment and a mediator to assess the direct treatment effect (net of the mediator), the indirect treatment effect (via the…

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Testing Full Mediation of Treatment Effects and the Identifiability of Causal Mechanisms

处理效应完全中介与因果机制可识别性的检验

In causal analysis, understanding the causal mechanisms through which an intervention or treatment affects an outcome is often of central interest. We propose a test to evaluate (i) whether the causal effect of a treatment that is randomly assigned conditional on covariates is fully mediated by, or operates exclusively through, observed intermediate outcomes (referred to as mediators or surrogate outcomes), and (ii) whether the various causal mechanisms operating through…

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CausalAlpha: A Real-Time Geopolitical Risk Index from OSINT Channels for Causal Discovery in Financial Markets

CausalAlpha:基于开源情报的实时地缘政治风险指数与金融因果发现

We introduce CausalAlpha, an open-source framework that constructs a high-frequency Geopolitical Risk (GPR) index from Telegram OSINT channels using natural language processing, and applies causal discovery methods to identify the directed causal structure between geopolitical uncertainty and financial market variables. Unlike standard sentiment indices or Granger-causality approaches, CausalAlpha employs the Peter-Clark (PC) algorithm to recover the directed acyclic graph…

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Causal inference of Plackett-Burman designs in applications

Plackett–Burman 设计应用中的因果推断

Driven by four applications of Plackett-Burman (PB) designs, this paper proposes a causal inference framework based on potential outcomes. First, we define the causal effects of the PB designs under finite populations. The Neymanian estimator of causal effects is then obtained, including the estimated variance and covariance. Furthermore, we conduct a sharp null-hypothesis test and construct the Fisherian interval using an algorithm. Finally, the proposed methods are…

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MediEncoder: Nonlinear Representation Learning for High-Dimensional Causal Mediation Analysis

MediEncoder:高维因果中介分析的非线性表示学习

Causal mediation analysis decomposes a treatment effect into indirect pathways through mediators and direct pathways not operating through them. Modern biomedical studies often involve high-dimensional covariates and mediators that are noisy proxies for lower-dimensional latent biological processes. Existing methods typically rely on sparsity, linear factor models, or ignore the connection among variables in the learned representations, which can be restrictive when…

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Leveraging External Controls for Treatment Switching in Randomized Controlled Trials: A Weighted Causal Inference Framework for Overall Survival

利用外部对照调整随机试验中的治疗转换:总生存期的加权因果框架

In many oncology clinical trials where overall survival is a key endpoint, patients are permitted to switch from the control arm to the experimental treatment arm or other suitable therapies. Switching can occur for various reasons, including disease progression. This violates the causal guarantees of randomized treatment assignment, resulting in biased treatment effect estimates. Existing methods often require strong assumptions, complicated model specifications, or both.…

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Optimally taming biases in black-box models for efficient semiparametric estimation

优化控制黑箱模型偏差以实现有效半参数估计

Modern semiparametric estimation often relies on flexible black-box machine learning methods to estimate nuisance functions, raising a fundamental question: how do nuisance estimation errors propagate into inference for low-dimensional target parameters? The dominant paradigm, exemplified by double machine learning (DML), yields error bounds in which nuisance estimation errors enter multiplicatively. While widely adopted, it remains unclear whether this multiplicative-rate…

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Uncertainty quantification and multi-stage variable selection for personalized treatment regimes

个性化治疗方案的贝叶斯不确定性量化与多阶段变量选择

A dynamic treatment regime is a sequence of medical decisions that adapts to the evolving clinical status of a patient over time. To facilitate personalized care, it is crucial to assess the probability of each available treatment option being optimal for a specific patient, while also identifying the key prognostic factors that determine the optimal sequence of treatments. This task has become increasingly challenging due to the growing number of individual prognostic…

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On the Impossibility of Specification Testing of Interference Models Based on Exposure Mappings

基于暴露映射的干扰模型设定检验之不可能性

Researchers use interference models based on exposure mappings to facilitate estimation of causal effects in randomized experiments with interference. To test the veracity of such models, researchers can use specification tests that aim to detect departures from the stipulated model. However, existing tests suffer from poor power and are often unable to detect important model violations. The main result in this paper is to show that the specification testing problem for…

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Beyond Means: Topological Causal Effects under Persistent-Homology Ignorability

超越均值:持久同调可忽略性下的拓扑因果效应

Average treatment effects (ATE) and conditional average treatment effects (CATE) are foundational causal estimands, but they target changes in expected outcomes and can miss treatment-induced changes in the shape of outcome distributions. A canonical failure mode occurs when control outcomes are unimodal, treated outcomes become bimodal, and both distributions have the same mean. In such cases mean-based causal estimands are zero even though the geometry and topology of the…

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Semiparametric Bayesian Difference-in-Differences

半参数贝叶斯双重差分

This paper studies semiparametric Bayesian inference for the average treatment effect on the treated (ATT) within the difference-in-differences (DiD) research design. We propose two new Bayesian methods with frequentist validity. The first one is the semiparametric Bayesian outcome regression, where we place a Gaussian process prior on the conditional mean function of the control group. The second method is a doubly robust Bayesian procedure that adjusts the prior…

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LMT: A Bayesian Framework for Causal Discovery from Textual Alarm Records in Manufacturing Systems

LMT:从制造系统文本告警记录发现因果关系的贝叶斯框架

Textual event records, such as alarm logs, have become an increasingly common data source in engineering and manufacturing systems. Beyond identifying correlations or recurring patterns, engineers are often interested in understanding which types of events causally trigger or influence other events during system operation. Textual event descriptions may contain semantic clues about such causal relationships, and recent large language models (LLMs) provide a promising tool…

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