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结合贝叶斯非参数与半参数校正的因果中介分析案例AI 解读

We propose a Bayesian nonparametric approach using a truncated Enriched Dirichlet Process mixture (EDPM) model to estimate natural direct (NDE) and indirect (NIE) effects in causal mediation analyses in the presence of post-treatment confounders. We introduce an efficient cluster reallocation Metropolis-Hasting algorithm to improve mixing in the blocked Gibbs sampler. We implement a one-step posterior correction based on the efficient influence function for our setting. This…

遗漏协变量的比例风险模型内生选择偏差：模拟证据与替代方法AI 解读

In time-to-event analysis, the hazard ratio (HR) derived from the Cox proportional hazards (PH) model is the most commonly used and widely reported measure for assessing treatment effects. However, hazard ratios are non-collapsible due to their inherent conditioning on survival up to each time point. As a result, they are subject to built-in selection bias in the presence of unmeasured heterogeneity arising from omitted important covariates, even when these covariates are…

高维离散协变量下的因果推断AI 解读

When estimating causal effects from observational studies, researchers often need to adjust for many covariates to deconfound the non-causal relationship between exposure and outcome, among which many covariates are discrete. The behavior of commonly used estimators in the presence of many discrete covariates is not well understood since their properties are often analyzed under structural assumptions including sparsity and smoothness, which do not apply in discrete…

评估扩大筛查与改善结局策略总效应的因果框架AI 解读

For many health conditions, there are highly efficacious treatment and prevention products. Maximizing their impact requires strategies that improve the reach of health screening in order to establish who could benefit. For example, HIV prevention strategies aim to expand risk screening and to improve uptake of pre-exposure prophylaxis (PrEP) among those experiencing risk. Often, these strategies induce changes at the group-level (e.g., health clinics or communities) and are…

组成型处理因果推断中的核函数平衡方法AI 解读

We study causal effect estimation with compositional treatments, where the exposure lies on a simplex and the estimand is defined over compositions rather than scalar or binary values. By considering a projection of the average potential outcome onto the treatment space, a kernel-based covariate functional balancing approach is adopted for weight construction. The weights are obtained by directly minimizing a worst-case balancing error over a reproducing kernel Hilbert space…

冉阿让的警探有理由怀疑吗？持续时间结果的边际处理效应AI 解读

We identify the distributional and quantile marginal treatment effect functions when the outcome is right-censored. Our method requires a conditionally exogenous instrument and random censoring. We propose asymptotically consistent semi-parametric estimators and valid inferential procedures for the target functions. To illustrate, we evaluate the effect of alternative sentences (fines and community service vs. no punishment) on recidivism in Brazil. Our results highlight…

分布型结局的 Wasserstein 政策学习AI 解读

Offline policy learning has received growing attention in causal inference. The primary objective is to learn a policy (individualized treatment rule) as a mapping from covariates to treatment that maximizes the empirical welfare defined as the mean of scalar-valued potential outcomes. In this paper, we study offline policy learning with distribution-valued outcomes, where each potential outcome is a probability measure on $\mathbb{R}$ and the reward is defined through a…

贝叶斯替代混杂变量的收缩先验AI 解读

Multi-cause observational studies contain information about unmeasured confounding through the dependence structure among causes. However, literal imputation of the unobserved confounder is often more complex than learning a lower-dimensional substitute score that preserves the shared assignment variation needed for stable causal adjustment. The deconfounder (Wang and Blei, 2019) and related substitute confounder methods exploit this idea, but flexible assignment models can…

以估计目标为中心的 AUC 推广与跨研究比较AI 解读

The area under the ROC curve (AUC) is the standard measure of a biomarker's discriminatory accuracy; however, AUC is rarely treated as a population-specific estimand. When validation cohorts differ from the intended target population in case mix, Naïve AUC estimates can mislead both generalization and cross-study comparison. We develop an estimand-focused framework that anchors biomarker AUC inference to a prespecified target population, aligning with the ICH E9(R1) estimand…

通过反事实归因分摊两个风险因素的因果责任AI 解读

Unlike traditional causal inference, which prospectively evaluates the effects of causes, apportioning causal responsibility requires a retrospective assessment to deduce the causes of an outcome that has already occurred. This paper proposes a quantitative framework for apportioning causal responsibility between two binary risk factors that jointly contribute to a realized adverse outcome. Ideally, knowing the individual's latent causal type, defined by the potential…

分布工具变量方法AI 解读

The instrumental variable (IV) approach is commonly used to infer causal effects in the presence of unmeasured confounding. Existing methods typically aim to estimate the mean causal effects, whereas a few other methods focus on quantile treatment effects. The aim of this work is to estimate the entire interventional distribution. We propose a method called Distributional Instrumental Variable (DIV), which uses generative modelling in a nonlinear IV setting. We establish…

改进抽签分配：最优分配规则的有效估计AI 解读

Scarce opportunities are often allocated by lotteries. We study how to improve such allocations by estimating optimal assignment rules that maximize welfare net of a Kullback--Leibler penalty for departing from the benchmark randomization. The framework covers discrete, continuous, and mixed treatments. Regret is asymptotically quadratic in the estimation error, so inefficient estimation raises the mean of limiting regret, not merely its dispersion. We show that inverse…

多处理实验中的响应自适应目标分配策略AI 解读

Response-adaptive randomization (RAR) in clinical trials aims to improve ethical and statistical efficiency by dynamically allocating patients to treatments based on observed outcomes. While RAR based on a target optimal allocation have been extensively studied for two-arms settings, their extension to multi-treatment experiments ($K \geq 2$) remains theoretically fragmented, with most existing methods focusing on specific algorithms or restricted target allocations. In this…

存在隐藏反悔见证变量时的近端中介分析AI 解读

Mediation analysis is essential for decomposing the causal effect of a treatment into direct and indirect pathways. However, many practical settings rely on the stringent assumption that recanting witnesses, defined as treatment-induced mediator-outcome confounders, are either absent or fully known a priori. Such a requirement is often untenable, especially when these variables remain unobservable due to measurement difficulties or privacy constraints. In this paper, we…

FoundCause：含潜在混杂的观测数据因果发现AI 解读

Causal discovery from observational data remains challenging due to the need to recover directed structure and latent confounding without interventions. We propose FoundCause, an amortized causal discovery model trained entirely on synthetic data that maps datasets directly to causal graphs in a single forward pass. By learning from large collections of simulated structural causal models, FoundCause captures transferable statistical patterns that generalize beyond individual…

暴露与结局均存在缺失时的因果推断AI 解读

Missing data are ubiquitous in public health research. When estimating causal effects, there are well-established methods to address bias to due missing outcomes. Commonly, causal estimands are defined under hypothetical interventions to "set" the exposure and to prevent missingness. We demonstrate how this framework can be extended to missing exposures. We further extend this framework to incorporate missingness on the baseline outcome, which induces missingness on the…

收敛网络干扰下的处理效应估计AI 解读

Under network interference, a unit's observed outcome depends on the treatment assignment of its neighboring units in an exposure graph. Existing design-based asymptotic theory typically considers local interference by restricting neighborhood sizes in the exposure graph. Such methods do not apply to dense exposure graphs, so prior work has often adopted a superpopulation approach instead, imposing regularity through random-graph models. In this paper, we introduce a notion…

成绩测量误差影响处理分配时的倾向得分调整AI 解读

U.S. state education agencies mark schools displaying achievement gaps between demographic subgroups as needing improvement. Some schools may have few students in these subgroups, such that average end-of-year test scores only noisily measure the average "true" score-the score one would expect if students took the test many times. This, in addition to the masking of small subgroup averages in publicly available assessment data, poses challenges for evaluating interventions…

基于半参数加速失效时间模型的贝叶斯联合建模AI 解读

Longitudinal clinical studies often collect repeated measurements of biomarkers or health-related quality of life together with a time-to-event outcome. These processes are intrinsically linked: longitudinal trajectories may predict event risk, while event occurrence, or its anticipation, can induce informative censoring of the longitudinal process. Joint models provide a principled framework for handling this dependence, but most existing formulations rely on proportional…

正依赖条件下有序结果因果效应的界限AI 解读

Defining and estimating causal effects for ordinal data is challenging. Standard average treatment effects are not appropriate for ordinal scales, and alternative estimands, such as the probabilities that the treatment outcome exceeds or does not worsen the control outcome, are generally not identifiable. Existing work provides sharp bounds for these quantities based only on marginal distributions. Motivated by a previous observation showing that bounds obtained under an…

原型发现问题的决策理论AI 解读

In the archetype discovery problem a researcher wants to summarize N heterogeneous policy effects of interest that vary over a discrete set of covariates. The goal is to partition the set of covariates into K<N groups -- the archetype sets -- and to provide a summary of the policy effects for each group. We use decision theory to show that, under a weighted mean-squared-error criterion, a procedure analogous to the Sorted Group Average Treatment Effects (GATES) solves the…

多重连续暴露的因果充分降维及其环境混合物应用AI 解读

Estimating causal effects with multivariate continuous exposures is challenging because causal exposure-response surfaces can be high-dimensional, complicating estimation and interpretation of joint exposure effects. Such settings arise in environmental epidemiology, where interest centers on the health effects of chemical and pollutant mixtures. We develop causal sufficient dimension reduction (CSDR), a semiparametric framework for representing causal exposure-response…

含同期效应与指数族噪声的可识别马尔可夫切换模型AI 解读

Temporal systems often exhibit non-stationary behaviour, such as seasonal climate variation or glucose fluctuations in patients with type-1 diabetes. One way to model non-stationarity is through discrete latent regimes, i.e., stationary segments of time. Such systems induce a Markov Switching Model (MSM), a class of Hidden Markov Models with autoregressive dependencies among latent regimes and observed variables. Identifying latent regimes is challenging in the presence of…

HSCI：高维比例风险模型下的 Neyman 正交因果推断AI 解读

Valid treatment effect inference in survival studies is fundamental yet challenging when the treatment assignments and outcomes are confounded by many baseline covariates. To this end, in this paper we propose a high-dimensional survival causal inference (HSCI) framework that delivers valid inference under a sparse high-dimensional Cox proportional hazards outcome model and a high-dimensional logistic propensity score working model. To mitigate the nuisance estimation bias,…