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比例高维下尺度混合误差的贝叶斯DAG结构学习与收缩协方差估计AI 解读

We propose a unified Bayesian framework namely robust DAG-Cholesky horseshoe (R-DACH) for joint directed acyclic graph (DAG) structure learning and precision matrix estimation in the high-dimensional proportional asymptotic regime $p/n \to c \in (0,\infty)$, under the scale mixture of normal errors. The construction places a global-local horseshoe-type prior directly on the strictly lower-triangular entries of the modified Cholesky factor of the DAG-Markov precision matrix,…

聚类数据中的结构学习AI 解读

Recent algorithmic advances have made directed acyclic graph (DAG) structure learning scalable for causal discovery. Yet, the currently available techniques assume a completely homogeneous population, precluding their application to clustered data where cluster-specific variations (e.g., patient-specific effects) are common. We address this issue by introducing a new approach that estimates a global structure while accounting for local cluster-level effects. The key idea is…

模型不确定性下因果效应的稳健加权三角验证AI 解读

A fundamental challenge in causal inference with observational data is correct specification of a causal model. When there is model uncertainty, analysts may seek to use estimates from multiple candidate models that rely on distinct, and possibly partially overlapping, sets of identifying assumptions to infer the causal effect, a process known as triangulation. Principled methods for triangulation, however, remain underdeveloped. Here, we develop a framework for causal…

农药风险评估中的等效性检验：设计、分析与解释AI 解读

Harmful pesticide effects exceeding specific protection goals (SPG) may go undetected in underpowered experimental designs. Regulatory honeybee field studies have consistently failed to reach the statistical power required under European Food Safety Authority (EFSA) guidance, which may have caused approval of high-risk substances. Therefore, EFSA advised a shift from testing the null hypothesis of 'no effect' to equivalence testing. Under this approach, a pesticide is…

用多重插补调整元分析中的结局报告偏倚AI 解读

Background: Outcome reporting bias (ORB) occurs when study outcomes are selectively reported based on their results. ORB potentially undermines the credibility and validity of meta-analyses and contributes to research waste by distorting overall treatment effects. ORB can be viewed as a missing data problem in which unreported study outcomes introduce bias. Despite the serious implications ORB poses, it remains an underrecognized issue, with only a few adjustment methods…

面向时间序列的双重机器学习AI 解读

We modify the Double Machine Learning estimator to broaden its applicability to macroeconomic time-series settings. A deterministic cross-fitting step, termed Reverse Cross-Fitting, leverages the time-reversibility of stationary series to improve sample utilization and efficiency. We detail and prove the conditions under which the estimator is asymptotically valid. We then demonstrate, through simulations, that its performance remains valid in realistic finite samples and is…

暴露或结局罕见时哪种正则化倾向得分与双稳健方法校准最佳？基于代理混杂调整的plasmode研究AI 解读

Purpose. Confounding adjustment in health-care database studies screens large proxy libraries where events per variable are low, straining standard propensity score (PS) methods, and many regularized variable-selection strategies exist (outcome-adaptive LASSO [OAL], group LASSO/GLiDeR, highly adaptive LASSO [HAL]). Yet few comparisons have varied exposure prevalence within such a selection menu, and none pairs it with doubly robust estimation, compute accounting, and a…

未观测混杂下的政策学习：稳健且有效的方法AI 解读

This paper develops a robust and efficient method for policy learning from observational data in the presence of unobserved confounding, complementing existing instrumental variable (IV) based approaches. We employ the marginal sensitivity model (MSM) to relax the commonly used yet restrictive unconfoundedness assumption by introducing a sensitivity parameter that captures the extent of selection bias induced by unobserved confounders. Building on this framework, we consider…

阶梯楔形集群随机试验中的模型稳健标准化AI 解读

Stepped-wedge cluster-randomized trials (SW-CRTs) are widely used in healthcare and implementation science, enabling all clusters to receive the intervention through a staggered rollout. Traditional model-based methods, including generalized estimating equations and mixed models, yield estimates that depend on implicit weighting schemes and parametric assumptions, and therefore may target ambiguous estimands under model misspecification. In this article, we propose a…

行为健康个案研究的因果推断AI 解读

We present a framework for causal inference in behavioral health case studies -- and observational N=1 settings more generally -- under unmeasured confounding. The framework rests on a class of causal estimands, termed $Ω$ estimands, defined as contrasts of functions of an outcome variable's support rather than its distribution. Because such estimands do not depend on how probability is distributed over supports, they are insensitive to the confounding that limits other…

通过混合分布学习处理分类未观测混杂的因果推断AI 解读

Unobserved confounding is a fundamental challenge for estimating causal effects. To address unobserved confounding, recent literature has turned to two different approaches -- proxy variables and the use of multiple treatments. The first approach, commonly referred to as proximal causal inference, requires proxies to be assigned to specific asymmetric roles: treatment-inducing proxies (negative control exposures), variables that act as common causes of the treatment and…

基于二次型的重随机化统一框架AI 解读

When designing a randomized experiment, one way to ensure treatment and control groups exhibit similar covariate distributions is to randomize treatment until some prespecified level of covariate balance is satisfied; this strategy is known as rerandomization. Most rerandomization methods utilize balance metrics based on a quadratic form $\mathbf{v}^T \mathbf{A} \mathbf{v}$, where $\mathbf{v}$ is a vector of covariate mean differences and $\mathbf{A}$ is a positive…

主分层下异质性处理效应的双重交叉拟合去偏机器学习AI 解读

Principal stratification provides a foundational framework for causal inference with intermediate outcomes by defining causal effects within subpopulations, yet existing work has largely focused on average effects across strata rather than treatment effect heterogeneity within strata. Such within-stratum heterogeneity informs individualized treatment decisions but the associated methods are sparse. We address this gap by studying the identification and estimation of the…

正视溢出：实验中的空间效应AI 解读

Interventions delivered in space generate effects that spill over between experimental units. We develop a framework for spatial experiments in which causal estimands, inclduing direct, indirect, total, and dose--response effects, are linear functionals of a spillover kernel. Under cluster randomisation with a fixed exposure set size, the data identify the shape of the kernel but not its level: the level is aliased with the intercept and direct effect, at any sample size and…

因果归因中必要性概率的统计推断AI 解读

To answer questions of "causes of effects", the probability of necessity was previously introduced for assessing whether an observed outcome was caused by an earlier treatment. However, statistical inference for the probability of necessity is understudied due to several difficulties, which hinder its application in practice. The evaluation of the probability of necessity involves the joint distribution of potential outcomes, and thus it is generally not point identified and…

兼容机器学习的处理效应异质性综合检验AI 解读

This study proposes a formal, computationally efficient nonparametric omnibus test for treatment-effect heterogeneity that is compatible with a broad class of estimators, including modern machine-learning methods. The test is designed for settings in which identification can rely on high-dimensional controls while heterogeneity is assessed with respect to a low-dimensional subset of covariates. We derive the test statistic's asymptotic null distribution and develop a…

半参数效率理论：概率分布空间上的微分学AI 解读

Semiparametric efficiency theory provides the mathematical foundation for influence-function-based estimation, including one-step estimators, targeted minimum loss estimators, and many modern inferential methods used in causal inference and missing data analysis. Despite its widespread use, the theory is often presented through a collection of technical constructions whose geometric meaning remains opaque. As a result, influence functions are often derived and applied…

利用随机算法生成的数据估计因果效应AI 解读

Recommendation systems and chatbots present content to users, typically using stochastic algorithms that select the content based on user characteristics or context. Examples of content include chat responses, videos, or items available for purchase. Scientists and application developers are often interested in whether characteristics of content increase outcomes such as user engagement. Estimates of such causal effects may guide content providers to generate content that…

二元结局处理效应的最优实验设计与稳健推断AI 解读

We study randomized experiments with binary outcomes under Neyman's nonparametric model, where covariate measurements are fixed but potential outcomes are random. In this setting we derive the exact variance of the difference-in-means estimator and characterize designs that minimize it. We show that any balanced design satisfying a covariate-balance condition is asymptotically optimal, and we prove that a broad class of blocking designs satisfies this condition under mild…

营销干预中贝叶斯因果影响模型的敏感性与早期检测AI 解读

Marketing systems frequently undergo operational changes that may affect performance, making timely detection of adverse effects essential for decision making. While Bayesian Causal Impact models are widely used to estimate the causal effects of interventions, their ability to support early operational monitoring remains less explored. This paper proposes a simulation based framework to evaluate the sensitivity and detection capabilities of Bayesian causal impact analysis…

线性回归中的潜在权重与隐含因果设计AI 解读

Applied researchers routinely use linear regression to estimate causal effects, justified by quasi-experimental treatment variation, while leaving assumptions on treatment assignment implicit. We formalize a minimal criterion for quasi-experimental interpretation -- that the regression estimates some contrast of potential outcomes under the true assignment process, regardless of potential outcomes -- and characterize its implications for arbitrary regressions. This criterion…

通过部分信息分解剖析频域格兰杰因果AI 解读

Granger causality (GC), a popular statistical method for the inference of directional influences between time series measured from a complex network, is sensitive to high-order (non-pairwise) interactions which fundamentally shape the collective network dynamics. This work introduces Partial Decomposition of Granger Causality (PDGC), a tool eliciting redundant and synergistic causal interactions in the pattern of information flow between the subsystems of physiological…

复发事件结局的双重稳健方法：降压治疗对急性肾损伤的因果效应AI 解读

Evaluating the average causal effects of treatment strategies on recurrent event outcomes, such as heart attacks or renal failure, is important in clinical and medical research. However, the analysis becomes increasingly complex as multiple interacting factors are considered within a longitudinal setting. In this paper, we use advanced methodologies to estimate the average causal effects of standard versus intensive blood pressure-lowering therapies on acute kidney injury…

极端事件中的格兰杰因果关系AI 解读

We introduce a rigorous mathematical framework for Granger causality in extremes, designed to identify causal links from extreme events in time series. Granger causality plays a pivotal role in uncovering directional relationships among time-varying variables. While this notion gains heightened importance during extreme and highly volatile periods, state-of-the-art methods primarily focus on causality within the body of the distribution, often overlooking causal mechanisms…