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DAG-CLIP：存在潜变量时的有向无环图学习框架AI 解读

Learning directed acyclic graphs (DAGs) to uncover causal mechanisms has attracted substantial attention in machine learning. While most existing methods focus exclusively on observed variables, many variables of substantive interest are latent constructs defined by statistical measurement models. Such constructs are particularly common in the social and behavioral sciences. In this paper, we propose a general statistical framework for DAG learning when some or all nodes of…

以模型平均替代处理前趋势检验AI 解读

We study difference-in-differences (DID) estimation of average treatment effects on the treated when the researcher is uncertain about which pre-treatment periods satisfy the parallel trends assumption. Roth (2022) shows that pre-trend testing can induce bias, complementing the statistical literature on post-selection inference. We propose the model averaged difference-in-differences (MADID) estimator, a weighted average of the candidate $2\times2$ DID estimators. The…

通过正交化自适应估计发现存在混杂的时间序列因果滞后结构AI 解读

Finding which variables cause which others in multivariate time series, and at what lags, is central to science and policy, yet existing methods force a choice between flexible confounder adjustment, data-driven lag selection, and inference that controls the false discovery rate (FDR). ORACLE-VARX does all three in one pipeline. First, double/debiased machine learning (DML) removes nonlinear confounder effects from the outcomes and the lagged series. Second, adaptive causal…

二元结果混合对照试验的稳健估计与推断：非小细胞肺癌案例AI 解读

Hybrid controlled trials (HCTs), which augment randomized controlled trials (RCTs) with external controls (ECs), are increasingly receiving attention as a way to address limited power, slow accrual, and ethical concerns in clinical research. However, borrowing from ECs raises critical statistical challenges in estimation and inference, especially for binary outcomes where hidden bias is harder to detect and estimands such as risk difference, risk ratio, and odds ratio are of…

跨度之外共同冲击下的合成控制：诊断、暴露平衡与修正AI 解读

Synthetic control relies on pre-treatment fit to balance the unobserved factors that drive untreated outcomes. The argument fails when an observed common shock, such as a commodity price, moves with the latent factors before treatment and departs from them afterwards and pre-treatment fit then says almost nothing about the synthetic unit's exposure to the shock. I derive a period-specific bound that links the post-treatment bias of any weighting estimator to pre-treatment…

删失随机试验中限制平均生存时间处理获益排序的直接学习AI 解读

In precision medicine, treatment decisions often depend more on identifying which patients are most likely to benefit from treatment than on accurately estimating benefit for every patient. However, existing methods estimate patient-specific treatment effects and derive patient rankings as a secondary step. We propose a direct ranking approach for conditional RMST treatment benefit in randomized trials with right-censored outcomes. We first construct a censoring-adjusted…

利用辅助事件信息进行删失结局的因果推断AI 解读

Clinical trials with survival endpoints lose information when participants are censored before death is observed. We develop target-preserving estimators that use posttreatment disease history, such as recurrence or progression, to recover information lost to censoring for marginal survival and restricted mean survival effects. The difficulty is that the intermediate event is downstream of treatment: naive adjustment can change the causal estimand, and the useful information…

暴露与结局关系非线性时，两样本孟德尔随机化估计什么？AI 解读

Two-sample Mendelian randomization with summary statistics has become a popular MR design in Epidemiology. Its ratio estimate has an average causal effect interpretation only under strong untestable assumptions including linearity. We derive what the per-variant ratio, and the pooled and robust estimators built from it, estimate when a continuous exposure has a nonlinear effect, under two conditions on how genetic variation and unmeasured factors shape exposure: no…

协变量密度有界条件下期望条件协方差的极小极大估计AI 解读

In many scientific studies, evaluating the association between two responses requires adjusting for shared covariates. The expected conditional covariance measures this adjusted association and is used in conditional independence testing and treatment effect estimation. Researchers often estimate it using fitted conditional means, but removing the bias caused by the estimation errors of these conditional means remains a difficult task. This difficulty can increase when the…

控制政策与经济体制的非线性财政乘数AI 解读

A new form of the fiscal multiplier suited to data expressed as gross growth rates is proposed, together with a structural vector autoregression that isolates discretionary fiscal policy from regime and rule-based components. Because cumulating growth-rate responses over a horizon involves a product rather than a sum, the proposed multiplier is multiplicative: both numerator and denominator are polynomials in the size of the fiscal impulse, so the multiplier varies…

稀疏依赖下二元配置概率的对抗估计AI 解读

We consider the problem of estimating binary configuration probabilities, which is common in operations management applications, including product bundling, advertising, etc. Existing approaches typically model each assortment as a category and apply multinomial models to estimate the choice probabilities; while computationally convenient, these methods do not exploit independence structures in the joint distribution and may therefore be statistically inefficient when the…

匹配三重差分：协变量调整框架AI 解读

A common empirical strategy in triple-differences (DDD) is to include either covariate trends or covariate levels to a three-way fixed effects (3WFE) regression. This strategy is typically motivated by the conditional parallel gaps assumption which assumes that deviations from parallel trends are similar among units with comparable observed covariates. We formally study both 3WFE specifications and show that, in general, neither consistently estimates the average treatment…

随机分配回归变量的自助法推断：协方差过滤与边际重抽样的局限AI 解读

Random assignment can make ordinary least squares (OLS) inference insensitive to outcome dependence, yet iid resampling can still fail because assignment and resampling need not remove the same covariance terms. With binary treatment, the iid variance target differs from the sampling variance by exactly minus aggregate cross-unit covariance of treatment effects. Under a Gaussian first-order limit, positive covariance leads to over-rejection and negative covariance to…

We introduce a new formulation of structural causal models for extremes, called the extremal structural causal model (eSCM). Unlike conventional structural causal models, where randomness is governed by a probability distribution, eSCMs use an exponent measure, an infinite-mass law that naturally arises in the analysis of multivariate extremes. Central to this framework are activation variables, which abstract the single-big-jump principle, along with additional…

Comparing dependence structures between two related multivariate time series is of fundamental interest in many scientific applications, where changes may occur in both directed temporal interactions and contemporaneous connectivity. Modeling each time series by a vector autoregressive (VAR) model, we propose a new framework for estimation and inference of differential Granger causality (DiffGC) and differential network (DiffNet) structures in high dimensions. The proposed…

Instrumental variable (IV) methods mitigate bias from unobserved confounding in observational causal inference but rely on the availability of a valid instrument, which can often be difficult or infeasible to identify in practice. In this paper, we propose a representation learning approach that constructs instrumental representations from observed covariates, which could enable IV-based estimation even in the absence of an explicit instrument. Our model (ZNet) achieves this…

网络约束匹配与因果效应的随机化推断AI 解读

Matching is widely used to mimic randomized experiments by forming matched sets in which treated and control units differ only randomly with respect to observed covariates. However, when the study population consists of interconnected units from a single network or a small number of networks, matching solely on observed covariates may produce matched units that are more closely connected in the network than would occur by chance. This increased network proximity within…

随机实验中的 Neyman 式推断AI 解读

In his seminal 1923 work, Neyman studied the variance estimation problem for the difference-in-means estimator of the average treatment effect in completely randomized experiments. He proposed a variance estimator that is conservative in general and unbiased under homogeneous treatment effects. While widely used under complete randomization, there is no unique or natural way to extend this estimator to more complex designs. To this end, we show that Neyman's estimator can be…

共同监督树合成：随机试验中的可解释亚组识别与诚实处理效应推断AI 解读

Identifying patient subgroups with heterogeneous treatment effects is central to precision medicine, yet existing approaches face a tension. Black-box methods estimate individualized effects well but yield no interpretable subgroups, while tree-based methods produce explicit partitions but are unstable and less accurate in moderate-sample trials. We propose CausalSynthTree, a co-supervised method in which black-box causal estimators guide construction of an interpretable…

玻利维亚犯罪与暴力治理政策组合的路径依赖主体微观模拟AI 解读

This study develops a survey-calibrated, path-dependent agent-based microsimulation for evaluating crime and violence reduction policies in Bolivia. A synthetic population is constructed from the 2025 Household Survey and the fourth-quarter 2025 Continuous Employment Survey using official expansion weights and cross-survey donor matching. The model combines heterogeneous agents, place-based risk, criminal adaptation, institutional capacity, community organization, and…

高维因果外推中的风险校准平衡AI 解读

In observational causal inference, covariate balancing is widely used to reduce source-target covariate shift, but under weak overlap in high dimensions, stronger balance can induce concentrated weights and increase variance. Balance measures how well the target covariate distribution is represented, but does not by itself determine how reliably the counterfactual mean can be estimated. We develop risk-calibrated balancing for the average treatment effect on the treated,…

前门模型下因果效应的灵活非参数推断AI 解读

Evaluating causal treatment effects in observational studies requires addressing confounding. While the back-door criterion enables identification through adjustment for observed covariates, it fails in the presence of unmeasured confounding. The front-door criterion offers an alternative by leveraging variables that fully mediate the treatment effect and are unaffected by unmeasured confounders of the treatment-outcome pair. We develop novel one-step and targeted minimum…

使用 AI 学习表征的实用双重机器学习AI 解读

Text, images, and other rich covariates are increasingly compressed into AI-learned representations and then used as controls in causal analysis. We study when this approach is valid and develop a practical framework for causal inference with learned representations. For a broad class of estimands, an imperfect representation distorts the target causal parameter by the product of two representation errors: one in the outcome regression and one in the balancing weight (or…

非正则情形下的交叉拟合：基于局部性的正态性与推断AI 解读

Cross-fitting is routine in much of applied research. While conventional confidence intervals that ignore cross-fold dependence are asymptotically valid in several settings, they undercover in many applications that share a common form of nonregularity: from the classic cross-validation problem of testing whether a fitted model outperforms another, to testing for heterogeneous treatment effects with machine learning, to estimating the value of a potentially non-unique…