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The Confounder Trap: Treatment-Encoding Representations in Causal Inference with Text

混杂变量陷阱:文本因果推断中编码处理的表示

Estimating causal effects of linguistic properties from observational text is difficult because the same document can contain both the treatment of interest and the non-treatment textual attributes needed for adjustment. Existing approaches often learn representations from the full text to capture latent confounding, but when treatment status is itself encoded by words in the text, these representations can directly encode treatment. This creates a confounder trap: richer…

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Causal Inference with High-Dimensional Treatments

高维处理下的因果推断

In this work, we consider causal inference in various high-dimensional treatment settings, including for single multi-valued treatments and vector treatments with binary or continuous components, when the number of treatments can be comparable to or even larger than the number of observations. These settings bring unique challenges: first, the treatment effects of interest are represented by a high-dimensional vector rather than a scalar; second, positivity violations are…

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On the magnitude, sign and ranking of recanting-twin path-specific effects

Recanting-twin 路径特定效应的大小、符号与排序

The framework of recanting twin path-specific effects has recently been propose to address the issue of intermediate confounding in causal mediation analysis, enabling the decomposition of the average treatment effect into identifiable fine-grained path-specific effects (PSEs). An open question, however, is the extent to which recanting-twin PSEs reflect the direction and relative magnitude of their corresponding natural PSEs. In this paper, we systematically characterize…

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Identification and Estimation of Demand Models with Endogenous Product Entry and Exit

产品内生进入与退出下需求模型的识别和估计

Firms introduce products in markets where they anticipate stronger demand, using information unobserved by researchers. This creates endogenous selection in demand estimation. In differentiated-product oligopolies, multidimensional demand unobservables and strategic entry can render the ordinary propensity score insufficient for selection correction. Existing approaches either restrict firms' information at entry or jointly estimate demand, pricing, and entry under strong…

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Beyond Parallel Trends in Staggered Difference-in-Differences: Identification under Higher-Order Parallelism

超越错位实施双重差分的平行趋势:高阶平行性下的识别

In difference-in-differences designs, the parallel trends assumption requires that the outcome gap between treated and control units would have remained flat absent treatment. Pre-treatment event studies frequently reject this flat-gap requirement. Existing responses include parametric trend controls and bounds on the treatment effect under assumptions about the magnitude of the violation. This paper shows that point identification of cohort-specific and aggregate treatment…

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Longitudinal Outcomes Truncated by Death: Causal Estimands and Bayesian Estimators

被死亡截断的纵向结局:因果估计目标与贝叶斯估计

In randomized controlled trials with longitudinal outcomes, death before the end of follow-up poses a fundamental challenge: after death, the outcome is no longer a real-valued measurement. This complicates the definition and interpretation of causal estimands, particularly when treatment may affect both survival and longitudinal outcomes. We review existing estimands for longitudinal outcomes truncated by death and clarify the assumptions required for their identification…

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Demonstration Experiments

示证型实验

Adaptive experiments are used extensively in online platforms, healthcare and biotechnology, and the social sciences. Often, the primary goal is not to precisely estimate a treatment effect but to demonstrate that at least one candidate intervention yields a positive effect, for some subpopulation and on some measured outcome. We formalize this objective as testing the global null in a threshold bandit framework, and develop two inference procedures that are valid under…

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Robust Two-Sample Inference under Serial Dependence

序列相关下的稳健双样本推断

We propose robust inference for two-sample comparison with time-series data under serial dependence and heterogeneous long-run variances. Standardizing with orthonormal-basis (series HAR) projections, we develop two-sample t-tests and, for joint hypotheses on a vector of means, a series HAR Wald statistic. Because the increasing-K chi-square limit tends to over-reject, we propose Welch-type fixed-K t- and F-approximations with adjusted degrees of freedom. We further develop…

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Covariate-Adaptive Sample Size Re-estimation for Population-Standardized Historical Control Designs in Single-Arm Trials

单臂试验总体标准化历史对照设计的协变量自适应样本量重估

Externally controlled single-arm trials are increasingly considered when randomized controls are infeasible, but baseline imbalance between the active-arm trial and historical controls complicates both estimation and sample size planning. We propose a population-standardized design framework in which the target estimand is defined for the actually enrolled active-arm population and historical-control outcomes are standardized to that population through a pre-specified…

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Spectral Truncation in Synthetic Control

合成控制中的谱截断

Synthetic control (SC) matches a treated unit's pre-treatment trajectory to a weighted combination of donor units. We study Spectral SC, which instead matches the treated unit in coordinates defined by the leading temporal singular vectors of the donor panel, and a hybrid estimator that places separately tunable weight on retained and discarded directions, nesting raw-path SC and truncated Spectral SC as endpoints. We prove that the family reduces exactly to raw-path SC at…

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The positivity assumption in causal mediation analyses? Checked!

因果中介分析中的正值性假设检查

Causal mediation analyses are increasingly used in psychological sciences. Among the required assumptions, positivity is unfortunately seldom mentioned, likely due to the lack of tools for checking it. Mediational positivity is more complex than positivity in standard, non-mediated exposure effect analysis, because it requires positivity for both the exposure and the mediator, and because the specific form of the positivity assumption depends on the mediation estimand of…

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Bayesian Nonparametric Causal Inference for Quantile Residual Life: An Application to Alzheimer's Disease

剩余生存时间分位数的贝叶斯非参数因果推断:阿尔茨海默病应用

In Alzheimer's disease research, a clinically important question is how much longer individuals would remain dementia-free beyond a given time under different baseline amyloid statuses. We address this question using observational data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) treating baseline amyloid status as the exposure. Estimation is challenging because amyloid status is confounded, time to dementia onset is heterogeneous and heavily right censored,…

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Causal-TS: A Python Library for Causal Discovery in High-Dimensional and Nonstationary Time Series

Causal-TS:高维与非平稳时间序列因果发现的 Python 库

We describe Causal-TS, an open-source Python library for causal discovery in high-dimensional and nonstationary multivariate time series. Causal-TS provides four specialized algorithms-CDNOTS, CDNOTS+, CEDAR, and GRACE-along with wrappers for GES, Granger, LASSO-VAR, and LGES, all sharing a unified conditional independence (CI) test layer with GPU acceleration via PyTorch. A regime discovery pipeline detects structural breaks via pluggable changepoint detectors and runs…

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Variance for Estimation and Prediction in Linear Mixed Effects Models Under MAR

随机缺失下线性混合效应模型的估计与预测方差

In linear mixed effects models (LMM), inference on fixed effects typically relies on either the generalized least squares (GLS) variance estimator obtained by assuming that the variance parameters are known, or on the Kenward-Roger method with a small-sample bias adjustment. A simulation study shows that both approaches can underestimate the variance of the treatment effect and inflate the type I error rate in large clinical trials under missing at random (MAR) mechanisms,…

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Decomposition of Spillover Effects Under Misspecification: Pseudo-true Estimands and a Local-Global Extension

误设下溢出效应的分解:伪真估计目标与局部—全局扩展

To measure spillovers, researchers often summarize who else was treated with a simple measure, such as the share of treated neighbors. We study what the researcher estimates when that summary is misspecified. We show that the researcher estimates the best approximation to the true policy effect among all functionals of the chosen summary, and that the usual direct and spillover estimates are exactly the components of this approximation. Under a monotonicity restriction, the…

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Locally Robust Kernel Specification Tests for Conditional Moment Restrictions

条件矩限制的局部稳健核设定检验

We develop kernel-based specification tests for semiparametric conditional moment models with high-dimensional nuisance parameters, extending existing conditional moment tests---which typically require asymptotically linear nuisance estimators---to accommodate modern machine-learning methods. The proposed locally robust kernel tests combine Neyman-orthogonal moments, cross-fitting, and reproducing kernel Hilbert space methods, yielding inference that is first-order…

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Inference on counterfactual distributions using martingale posteriors

利用鞅后验推断反事实分布

Causal inference is often focused on average effects, which can hide important aspects of the effect distributions. Here we consider the entire posterior effects distribution by estimating full counterfactual outcome distributions. We propose a methodology for inference on counterfactual distributions which builds upon the martingale posterior framework of Fong et al. (2023). This provides a highly flexible approach to estimating densities, distribution functions, and…

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Learning Where to Look: Delaunay Matching for Policy Choice and Data Collection

学会到哪里寻找数据:用于政策选择与数据收集的 Delaunay 匹配

This paper studies data-driven policy choices from a geometric perspective. A sample from a donor population fully exposed to an innovation informs a policymaker (PM) on whether to innovate groups in a target population where the innovation was not introduced. Any wrong decision must be compensated from a finite budget and the PM seeks an estimator of the innovation's effect that guarantees an affordable compensation cost. I focus on matching estimators with positive weights…

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Simulation-Free Bayesian Power and Sample Size Calculations for Bayes Factors in Single-Arm Phase II Trials with Binary Endpoints

二元终点单臂二期试验中贝叶斯因子功效与样本量的免模拟计算

Bayes factors provide a coherent Bayesian measure of evidence for competing hypotheses and have recently been used as the basis for single-arm phase II trial designs with binary endpoints. In contrast to classical power analyses based on test statistics and p-values, Bayes-factor based sample size calculations target high probabilities of obtaining compelling evidence either for a relevant treatment effect or for the null hypothesis, given pre-specified Bayes-factor…

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MOCA: A Transformer-based Modular Causal Inference Framework with One-way Cross-attention and Cutting Feedback

MOCA:采用单向交叉注意力与反馈切断的模块化因果推断框架

Causal effect estimation from observational data requires careful adjustment for confounding. Classical estimators such as inverse probability weighting and augmented inverse probability weighting can perform well under favorable model specification but may become unstable in complex settings. Machine-learning and representation-learning methods provide greater flexibility, but joint optimization may allow outcome information to alter treatment representations and compromise…

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Joint Model for Mediation Analysis with Causally Related Longitudinal and Recurrent Event Mediators for Survival Outcome

生存结局中具有因果关联的纵向与复发事件中介的联合模型

Recurrent events and repeated measures are commonly encountered in clinical longitudinal studies, often holding strong associations with patient outcomes. Although joint models for repeated measures, recurrent events, and a terminal event have been developed to account for their correlation, limited methodologies exist to examine causal mediation mechanisms involving multiple types of mediators, especially when mediators are causally related. This study addresses this gap by…

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Causal Inference under Interference with Learned Exposure Mappings

使用学习所得暴露映射开展存在干扰的因果推断

Exposure mappings are often assumed to be known in causal spillover analyses. In environmental settings, however, they are typically induced by transport processes that are not directly observed and must instead be learned from pollution data. We study how uncertainty in learned transport processes propagates into exposure mappings and downstream spillover inference under interference. We compare mechanistic transport models with modern operator-learning approaches,…

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A Bayesian Additive Regression Tree Model for Learning Conditional Average Treatment Effects in Regression Discontinuity Designs

利用贝叶斯加性回归树估计断点回归中的条件平均处理效应

This paper develops an effective Bayesian approach to conditional average treatment effect (CATE) estimation in regression discontinuity designs (RDD), an increasingly prevalent form of quasi-experiment that facilitates causal inference. Earlier Bayesian approaches do not easily accommodate CATE estimation while recent frequentist approaches to this problem assume a known basis expansion, a steep model specification requirement that our approach avoids. The new model is a…

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Towards Optimal Estimators for Randomized Control Trials

迈向随机对照试验的最优估计量

Randomized controlled trials (RCTs) are fundamental tools for causal inference across technology companies, pharmaceutical research, and federal agencies. While the standard difference-in-means estimator provides unbiased treatment effect estimates, it often lacks precision, particularly when treatment effects are heterogeneous or outcomes exhibit heavy-tailed distributions. Although numerous precision-enhancing methods exist---from covariate adjustment techniques to…

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