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高维数据下协变量特定处理效应的模型辅助推断AI 解读

Covariate-specific treatment effects (CSTEs) represent heterogeneous treatment effects across subpopulations defined by certain selected covariates. In this article, we consider marginal structural models where CSTEs are linearly represented using a set of basis functions of the selected covariates. We develop a new approach in high-dimensional settings to obtain not only doubly robust point estimators of CSTEs, but also model-assisted confidence intervals, which are valid…

贝叶斯不确定性导向试验设计运行特征的近似AI 解读

Bayesian response adaptive clinical trials are currently evaluating experimental therapies for several diseases. Adaptive decisions, such as pre-planned variations of the randomization probabilities, attempt to accelerate the development of new treatments. The design of response adaptive trials, in most cases, requires time consuming simulation studies to describe operating characteristics, such as type I/II error rates, across plausible scenarios. We investigate large…

中断时间序列设计中的模型选择后推断：加州攻击性武器禁令评估AI 解读

There have been many claims in the media and a bit of respectable research about the causes of variation in firearm sales. The challenges for causal inference can be quite daunting. This paper reports an analysis of daily handgun sales in California from 1996 through 2018 using an interrupted time series design and analysis. The design was introduced to social scientists in 1963 by Campbell and Stanley, analysis methods were proposed by Box and Tiao in 1975, and more recent…

用于临床离散度计数数据分析的灵活贝叶斯非混杂空间模型AI 解读

In employing spatial regression models for counts, we usually meet two issues. First, ignoring the inherent collinearity between covariates and the spatial effect would lead to causal inferences. Second, real count data usually reveal over or under-dispersion where the classical Poisson model is not appropriate to use. We propose a flexible Bayesian hierarchical modeling approach by joining non-confounding spatial methodology and a newly reconsidered dispersed count modeling…

反事实与合成控制的精确稳健共形推断AI 解读

We introduce new inference procedures for counterfactual and synthetic control methods for policy evaluation. We recast the causal inference problem as a counterfactual prediction and a structural breaks testing problem. This allows us to exploit insights from conformal prediction and structural breaks testing to develop permutation inference procedures that accommodate modern high-dimensional estimators, are valid under weak and easy-to-verify conditions, and are provably…

通过贝叶斯优化改进自适应无缝试验设计AI 解读

We propose to use Bayesian optimization (BO) to improve the efficiency of the design selection process in clinical trials. BO is a method to optimize expensive black-box functions, by using a regression as a surrogate to guide the search. In clinical trials, planning test procedures and sample sizes is a crucial task. A common goal is to maximize the test power, given a set of treatments, corresponding effect sizes, and a total number of samples. From a wide range of…

分布无关的条件独立检验及其因果发现应用AI 解读

This paper is concerned with test of the conditional independence. We first establish an equivalence between the conditional independence and the mutual independence. Based on the equivalence, we propose an index to measure the conditional dependence by quantifying the mutual dependence among the transformed variables. The proposed index has several appealing properties. (a) It is distribution free since the limiting null distribution of the proposed index does not depend on…

配对随机实验中分位数处理效应的自助法推断AI 解读

This paper examines methods of inference concerning quantile treatment effects (QTEs) in randomized experiments with matched-pairs designs (MPDs). Standard multiplier bootstrap inference fails to capture the negative dependence of observations within each pair and is therefore conservative. Analytical inference involves estimating multiple functional quantities that require several tuning parameters. Instead, this paper proposes two bootstrap methods that can consistently…

用于识别非线性模型因果效应的积分方程AI 解读

When the causal relationship between X and Y is specified by a structural equation, the causal effect of X on Y is the expected rate of change of Y with respect to changes in X, when all other variables are kept fixed. This causal effect is not identifiable from the distribution of (X,Y). We give conditions under which this causal effect is identified as the solution of an integral equation based on the distributions of (X,Z) and (Y,Z), where Z is an instrumental variable.

零利率下限下的识别AI 解读

I show that the Zero Lower Bound (ZLB) on interest rates can be used to identify the causal effects of monetary policy. Identification depends on the extent to which the ZLB limits the efficacy of monetary policy. I propose a simple way to test the efficacy of unconventional policies, modelled via a `shadow rate'. I apply this method to U.S. monetary policy using a three-equation SVAR model of inflation, unemployment and the federal funds rate. I reject the null hypothesis…

群组人群中传染病干预效应的因果识别AI 解读

Causal identification of treatment effects for infectious disease outcomes in interconnected populations is challenging because infection outcomes may be transmissible to others, and treatment given to one individual may affect others' outcomes. Contagion, or transmissibility of outcomes, complicates standard conceptions of treatment interference in which an intervention delivered to one individual can affect outcomes of others. Several statistical frameworks have been…

利用电子健康记录稳健估计异质性处理效应AI 解读

Estimation of heterogeneous treatment effects is an essential component of precision medicine. Model and algorithm-based methods have been developed within the causal inference framework to achieve valid estimation and inference. Existing methods such as the A-learner, R-learner, modified covariates method (with and without efficiency augmentation), inverse propensity score weighting, and augmented inverse propensity score weighting have been proposed mostly under the square…

格兰杰因果：综述与近期进展AI 解读

Introduced more than a half century ago, Granger causality has become a popular tool for analyzing time series data in many application domains, from economics and finance to genomics and neuroscience. Despite this popularity, the validity of this notion for inferring causal relationships among time series has remained the topic of continuous debate. Moreover, while the original definition was general, limitations in computational tools have primarily limited the…

SDRcausal：基于充分降维的因果推断 R 软件包AI 解读

SDRcausal is a package that implements sufficient dimension reduction methods for causal inference as proposed in Ghosh, Ma, and de Luna (2021). The package implements (augmented) inverse probability weighting and outcome regression (imputation) estimators of an average treatment effect (ATE) parameter. Nuisance models, both treatment assignment probability given the covariates (propensity score) and outcome regression models, are fitted by using semiparametric locally…

不确定的近邻：用于因果推断的贝叶斯倾向得分匹配AI 解读

We compare the performance of standard nearest-neighbor propensity score matching with that of an analogous Bayesian propensity score matching procedure. We show that the Bayesian approach makes better use of available information, as it makes less arbitrary decisions about which observations to drop and which ones to keep in the matched sample. We conduct a simulation study to evaluate the performance of standard and Bayesian nearest-neighbor matching when matching is done…

存在未观测混杂时利用差值分数估计兄弟姐妹溢出效应AI 解读

A growing area of research in epidemiology is the identification of health-related sibling spillover effects, or the effect of one individual's exposure on their sibling's outcome. The health and health care of family members may be inextricably confounded by unobserved factors, rendering identification of spillover effects within families particularly challenging. We demonstrate a gain-score regression method for identifying exposure-to-outcome spillover effects within…

病例对照研究中的因果效应识别AI 解读

Case-control designs are an important tool in contrasting the effects of well-defined treatments. In this paper, we reconsider classical concepts, assumptions and principles and explore when the results of case-control studies can be endowed a causal interpretation. Our focus is on identification of target causal quantities, or estimands. We cover various estimands relating to intention-to-treat or per-protocol effects for popular sampling schemes (case-base, survivor, and…

高维辅助参数下一致有效因果推断的成本与收益AI 解读

Important advances have recently been achieved in developing procedures yielding uniformly valid inference for a low dimensional causal parameter when high-dimensional nuisance models must be estimated. In this paper, we review the literature on uniformly valid causal inference and discuss the costs and benefits of using uniformly valid inference procedures. Naive estimation strategies based on regularisation, machine learning, or a preliminary model selection stage for the…

竞争风险模型中处理内生性的非参数工具变量方法AI 解读

This paper discusses endogenous treatment models with duration outcomes, competing risks and random right censoring. The endogeneity issue is solved using a discrete instrumental variable. We show that the competing risks model generates a non-parametric quantile instrumental regression problem. The cause-specific cumulative incidence, the cause-specific hazard and the subdistribution hazard can be recovered from the regression function. A distinguishing feature of the model…

利用外部数据估计未来临床试验中协变量调整的效率增益AI 解读

We present a general framework for using existing data to estimate the efficiency gain from using a covariate-adjusted estimator of a marginal treatment effect in a future randomized trial. We describe conditions under which it is possible to define a mapping from the distribution that generated the existing external data to the relative efficiency of a covariate-adjusted estimator compared to an unadjusted estimator. Under conditions, these relative efficiencies approximate…

利用广义随机森林排序事件时间结果的平均处理效应AI 解读

In this paper we present a data-adaptive estimation procedure for estimation of average treatment effects in a time-to-event setting based on generalized random forests. In these kinds of settings, the definition of causal effect parameters are complicated by competing risks; here we distinguish between treatment effects on the crude and the net probabilities, respectively. To handle right-censoring, and to switch between crude and net probabilities, we propose a two-step…

弱工具变量：传统两阶段最小二乘的局限与替代估计量AI 解读

Instrumental variables estimation has gained considerable traction in recent decades as a tool for causal inference, particularly amongst empirical researchers. This paper makes three contributions. First, we provide a detailed theoretical discussion on the properties of the standard two-stage least squares estimator in the presence of weak instruments and introduce and derive two alternative estimators. Second, we conduct Monte-Carlo simulations to compare the finite-sample…

双边市场实验中的干扰、偏差与方差：平台实验设计指引AI 解读

Two-sided marketplace platforms often run experiments to test the effect of an intervention before launching it platform-wide. A typical approach is to randomize individuals into the treatment group, which receives the intervention, and the control group, which does not. The platform then compares the performance in the two groups to estimate the effect if the intervention were launched to everyone. We focus on two common experiment types, where the platform randomizes…

多中心试验中的中心特定因果推断AI 解读

In multicenter randomized trials, when effect modifiers have a different distribution across centers, comparisons between treatment groups that average over centers may not apply to any of the populations underlying the individual centers. Here, we describe methods for reinterpreting the evidence produced by a multicenter trial in the context of the population underlying each center. We describe how to identify center-specific effects under identifiability conditions that…