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开发数字干预的微随机试验：实验设计与数据分析考量AI 解读

Just-in-time adaptive interventions (JITAIs) are time-varying adaptive interventions that use frequent opportunities for the intervention to be adapted--weekly, daily, or even many times a day. The micro-randomized trial (MRT) has emerged for use in informing the construction of JITAIs. MRTs can be used to address research questions about whether and under what circumstances JITAI components are effective, with the ultimate objective of developing effective and efficient…

政策选择与最优臂识别：探索抽样的渐近分析AI 解读

We consider the "policy choice" problem -- otherwise known as best arm identification in the bandit literature -- proposed by Kasy and Sautmann (2021) for adaptive experimental design. Theorem 1 of Kasy and Sautmann (2021) provides three asymptotic results that give theoretical guarantees for exploration sampling developed for this setting. We first show that the proof of Theorem 1 (1) has technical issues, and the proof and statement of Theorem 1 (2) are incorrect. We then…

倾向得分分析中的选择后推断AI 解读

Selective inference (post-selection inference) is a methodology that has attracted much attention in recent years in the fields of statistics and machine learning. Naive inference based on data that are also used for model selection tends to show an overestimation, and so the selective inference conditions the event that the model was selected. In this paper, we develop selective inference in propensity score analysis with a semiparametric approach, which has become a…

利用多重插补估计依从者的治疗效应AI 解读

Randomized controlled trials are considered the gold standard to evaluate the treatment effect (estimand) for efficacy and safety. According to the recent International Council on Harmonisation (ICH)-E9 addendum (R1), intercurrent events (ICEs) need to be considered when defining an estimand, and principal stratum is one of the five strategies to handle ICEs. Qu et al. (2020, Statistics in Biopharmaceutical Research 12:1-18) proposed estimators for the adherer average causal…

异质系数、控制变量与多重处理效应的识别AI 解读

Multidimensional heterogeneity and endogeneity are important features of models with multiple treatments. We consider a heterogeneous coefficients model where the outcome is a linear combination of dummy treatment variables, with each variable representing a different kind of treatment. We use control variables to give necessary and sufficient conditions for identification of average treatment effects. With mutually exclusive treatments we find that, provided the…

通过虚拟 VAR 建模解析因果关系AI 解读

In modeling multivariate time series for either forecast or policy analysis, it would be beneficial to have figured out the cause-effect relations within the data. Regression analysis, however, is generally for correlation relation, and very few researches have focused on variance analysis for causality discovery. We first set up an equilibrium for the cause-effect relations using a fictitious vector autoregressive model. In the equilibrium, long-run relations are identified…

合成控制为何有偏及其修正：放松与惩罚合成控制AI 解读

This paper extends the literature on the theoretical properties of synthetic controls to the case of non-linear generative models, showing that the synthetic control estimator is generally biased in such settings. I derive a lower bound for the bias, showing that the only component of it that is affected by the choice of synthetic control is the weighted sum of pairwise differences between the treated unit and the untreated units in the synthetic control. To address this…

回归折点设计中的优化推断AI 解读

We propose a method to remedy finite sample coverage problems and improve upon the efficiency of commonly employed procedures for the construction of nonparametric confidence intervals in regression kink designs. The proposed interval is centered at the half-length optimal, numerically obtained linear minimax estimator over distributions with Lipschitz constrained conditional mean function. Its construction ensures excellent finite sample coverage and length properties which…

多协变量调整随机化下最优个体化治疗策略的灵活推断AI 解读

To maximize clinical benefit, clinicians routinely tailor treatment to the individual characteristics of each patient, where individualized treatment rules are needed and are of significant research interest to statisticians. In the covariate-adjusted randomization clinical trial with many covariates, we model the treatment effect with an unspecified function of a single index of the covariates and leave the baseline response completely arbitrary. We devise a class of…

影响下的随机对照试验：协变量因素与图网络干扰AI 解读

Randomized controlled trials are not only the golden standard in medicine and vaccine trials but have spread to many other disciplines like behavioral economics, making it an important interdisciplinary tool for scientists. When designing randomized controlled trials, how to assign participants to treatments becomes a key issue. In particular in the presence of covariate factors, the assignment can significantly influence statistical properties and thereby the quality of the…

利用连续工具变量对非随机缺失数据进行非参数扫描AI 解读

This article introduces a new instrumental variable approach for estimating unknown population parameters with data having nonrandom missing values. With coarse and discrete instruments, Shao and Wang (2016) proposed a semiparametric method that uses the added information to identify the tilting parameter from the missing data propensity model. A naive application of this idea to continuous instruments through arbitrary discretizations is apt to be inefficient, and maybe…

面向情境感知人脸迁移的因果表征学习AI 解读

Human face synthesis involves transferring knowledge about the identity and identity-dependent face shape (IDFS) of a human face to target face images where the context (e.g., facial expressions, head poses, and other background factors) may change dramatically. Human faces are non-rigid, so facial expression leads to deformation of face shape, and head pose also affects the face observed in 2D images. A key challenge in face transfer is to match the face with unobserved new…

将伴发事件下的随机临床试验问题转化为目标估计量AI 解读

Intercurrent (post-treatment) events occur frequently in randomized trials, and investigators often express interest in treatment effects that suitably take account of these events. A naive conditioning on intercurrent events does not have a straight-forward causal interpretation, and the practical relevance of other commonly used approaches is debated. In this work, we discuss how to formulate and choose an estimand, beyond the marginal intention to treat effect, from the…

兼顾连锁不平衡与特异性多效性的两样本稳健贝叶斯孟德尔随机化AI 解读

Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome of interest. Despite wide uses of various popular two-sample MR methods based on genome-wide association study summary level data, however, those methods could suffer from potential power loss or/and biased inference when the chosen genetic variants are in linkage disequilibrium (LD), and also have…

用于异质性处理效应估计的收缩贝叶斯因果森林AI 解读

This paper develops a sparsity-inducing version of Bayesian Causal Forests, a recently proposed nonparametric causal regression model that employs Bayesian Additive Regression Trees and is specifically designed to estimate heterogeneous treatment effects using observational data. The sparsity-inducing component we introduce is motivated by empirical studies where not all the available covariates are relevant, leading to different degrees of sparsity underlying the surfaces…

线性模型中可扩展的干预目标估计AI 解读

This paper considers the problem of estimating the unknown intervention targets in a causal directed acyclic graph from observational and interventional data. The focus is on soft interventions in linear structural equation models (SEMs). Current approaches to causal structure learning either work with known intervention targets or use hypothesis testing to discover the unknown intervention targets even for linear SEMs. This severely limits their scalability and sample…

处理效应随暴露时间变化时的阶梯楔形整群随机试验分析AI 解读

Stepped wedge cluster randomized controlled trials are typically analyzed using models that assume the full effect of the treatment is achieved instantaneously. We provide an analytical framework for scenarios in which the treatment effect varies as a function of exposure time (time since the start of treatment) and define the "effect curve" as the magnitude of the treatment effect on the linear predictor scale as a function of exposure time. The "time-averaged treatment…

结合神经网络预测的归一化增广逆概率加权AI 解读

The estimation of Average Treatment Effect (ATE) as a causal parameter is carried out in two steps, where in the first step, the treatment and outcome are modeled to incorporate the potential confounders, and in the second step, the predictions are inserted into the ATE estimators such as the Augmented Inverse Probability Weighting (AIPW) estimator. Due to the concerns regarding the nonlinear or unknown relationships between confounders and the treatment and outcome, there…

单向混合模型中汇总数据与个体患者数据的高效整合AI 解读

Often both Aggregate Data (AD) studies and Individual Patient Data (IPD) studies are available for specific treatments. Combining these two sources of data could improve the overall meta-analytic estimates of treatment effects. Moreover, often for some studies with AD, the associated IPD maybe available, albeit at some extra effort or cost to the analyst. We propose a method for combining treatment effects across trials when the response is from the exponential family of…

警惕模拟有向无环图：因果发现基准可能容易被取巧AI 解读

Simulated DAG models may exhibit properties that, perhaps inadvertently, render their structure identifiable and unexpectedly affect structure learning algorithms. Here, we show that marginal variance tends to increase along the causal order for generically sampled additive noise models. We introduce varsortability as a measure of the agreement between the order of increasing marginal variance and the causal order. For commonly sampled graphs and model parameters, we show…

随机缺失样本选择下用于因果推断的广义核岭回归AI 解读

I propose kernel ridge regression estimators for nonparametric dose response curves and semiparametric treatment effects in the setting where an analyst has access to a selected sample rather than a random sample; only for select observations, the outcome is observed. I assume selection is as good as random conditional on treatment and a sufficiently rich set of observed covariates, where the covariates are allowed to cause treatment or be caused by treatment -- an extension…

评估兄弟姐妹固定效应模型中的结局间干扰AI 解读

Sibling fixed effects (FE) models are useful for estimating causal treatment effects while offsetting unobserved sibling-invariant confounding. However, treatment estimates are biased if an individual's outcome affects their sibling's outcome. We propose a robustness test for assessing the presence of outcome-to-outcome interference in linear two-sibling FE models. We regress a gain-score--the difference between siblings' continuous outcomes--on both siblings' treatments and…

定性处理效应的在线序贯检验AI 解读

Tech companies (e.g., Google or Facebook) often use randomized online experiments and/or A/B testing primarily based on the average treatment effects to compare their new product with an old one. However, it is also critically important to detect qualitative treatment effects such that the new one may significantly outperform the existing one only under some specific circumstances. The aim of this paper is to develop a powerful testing procedure to efficiently detect such…

混合尺度数据的因果中介与敏感性分析AI 解读

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential ignorability to attain non-parametric identification, Imai et al. (2010) proposed a flexible approach to measuring mediation effects, focusing on parametric and semiparametric normal/Bernoulli models for the outcome and mediator. Less attention…