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潜在结果模型中外生性假设的选择AI 解读

There are many kinds of exogeneity assumptions. How should researchers choose among them? When exogeneity is imposed on an unobservable like a potential outcome, we argue that the form of exogeneity should be chosen based on the kind of selection on unobservables it allows. Consequently, researchers can assess the plausibility of any exogeneity assumption by studying the distributions of treatment given the unobservables that are consistent with that assumption. We use this…

观察性研究中限制平均生存时间边际因果效应的匹配设计AI 解读

Investigating the causal relationship between exposure and the time-to-event outcome is an important topic in biomedical research. Previous literature has discussed the potential issues of using the hazard ratio as a marginal causal effect measure due to its noncollapsibility property. In this paper, we advocate using the restricted mean survival time (RMST) difference as the marginal causal effect measure, which is collapsible and has a simple interpretation as the…

具有连续共同主要终点的集群随机试验功效分析AI 解读

Pragmatic trials evaluating health care interventions often adopt cluster randomization due to scientific or logistical considerations. Previous reviews have shown that co-primary endpoints are common in pragmatic trials but infrequently recognized in sample size or power calculations. While methods for power analysis based on $K$ ($K\geq 2$) binary co-primary endpoints are available for CRTs, to our knowledge, methods for continuous co-primary endpoints are not yet…

因果可解释元分析中的系统性数据缺失AI 解读

Causally interpretable meta-analysis combines information from a collection of randomized controlled trials to estimate treatment effects in a target population in which experimentation may not be possible but covariate information can be collected from a simple random sample. In such analyses, a key practical challenge is systematically missing data when some baseline covariates are not collected in all trials. Here, we provide identification results for potential…

分布偏移下的统计检验AI 解读

In this work, we introduce statistical testing under distributional shifts. We are interested in the hypothesis $P^* \in H_0$ for a target distribution $P^*$, but observe data from a different distribution $Q^*$. We assume that $P^*$ is related to $Q^*$ through a known shift $τ$ and formally introduce hypothesis testing in this setting. We propose a general testing procedure that first resamples from the observed data to construct an auxiliary data set and then applies an…

带约束的条件矩限制模型AI 解读

Shape restrictions have played a central role in economics as both testable implications of theory and sufficient conditions for obtaining informative counterfactual predictions. In this paper we provide a general procedure for inference under shape restrictions in identified and partially identified models defined by conditional moment restrictions. Our test statistics and proposed inference methods are based on the minimum of the generalized method of moments (GMM)…

边际反事实生存曲线的近端因果推断AI 解读

Contrasting marginal counterfactual survival curves across treatment arms is an effective and popular approach for inferring the causal effect of an intervention on a right-censored time-to-event outcome. A key challenge to drawing such inferences in observational settings is the possible existence of unmeasured confounding, which may invalidate most commonly used methods that assume no hidden confounding bias. In this paper, rather than making the standard no unmeasured…

个体治疗效应的敏感性分析：稳健共形推断方法AI 解读

We propose a model-free framework for sensitivity analysis of individual treatment effects (ITEs), building upon ideas from conformal inference. For any unit, our procedure reports the $Γ$-value, a number which quantifies the minimum strength of confounding needed to explain away the evidence for ITE. Our approach rests on the reliable predictive inference of counterfactuals and ITEs in situations where the training data is confounded. Under the marginal sensitivity model of…

利用条件随机森林高效优化成本有效的个体化治疗规则AI 解读

Evidence from observational studies has become increasingly important for supporting healthcare policy making via cost-effectiveness (CE) analyses. Similar as in comparative effectiveness studies, health economic evaluations that consider subject-level heterogeneity produce individualized treatment rules (ITRs) that are often more cost-effective than one-size-fits-all treatment. Thus, it is of great interest to develop statistical tools for learning such a cost-effective ITR…

结局延迟随机临床试验期中监测的组序贯方法AI 解读

The primary analysis in two-arm clinical trials usually involves inference on a scalar treatment effect parameter; e.g., depending on the outcome, the difference of treatment-specific means, risk difference, risk ratio, or odds ratio. Most clinical trials are monitored for the possibility of early stopping. Because ordinarily the outcome on any given subject can be ascertained only after some time lag, at the time of an interim analysis, among the subjects already enrolled,…

平均因果效应熵平衡估计量的大样本性质AI 解读

Weighting methods are used in observational studies to adjust for covariate imbalances between treatment and control groups. Entropy balancing (EB) is an alternative to inverse probability weighting with an estimated propensity score. The EB weights are constructed to satisfy balance constraints and optimized towards stability. We describe large sample properties of EB estimators of the average causal treatment effect, based on the Kullback-Leibler and quadratic Rényi…

模型误设下的边际处理效应AI 解读

This paper studies the implication of a fraction of the population not responding to the instrument when selecting into treatment. We show that, in general, the presence of non-responders biases the Marginal Treatment Effect (MTE) curve and many of its functionals. Yet, we show that, when the propensity score is fully supported on the unit interval, it is still possible to restore identification of the MTE curve and its functionals with an appropriate re-weighting.

因果面板数据模型的矩阵补全方法AI 解读

In this paper we study methods for estimating causal effects in settings with panel data, where some units are exposed to a treatment during some periods and the goal is estimating counterfactual (untreated) outcomes for the treated unit/period combinations. We propose a class of matrix completion estimators that uses the observed elements of the matrix of control outcomes corresponding to untreated unit/periods to impute the "missing" elements of the control outcome matrix,…

Cox比例风险模型变点检测的信息准则AI 解读

The Cox proportional hazards model, commonly used in clinical trials, assumes proportional hazards. However, it does not hold when, for example, there is a delayed onset of the treatment effect. In such a situation, an acute change in the hazard ratio function is expected to exist. This paper considers the Cox model with change-points and derives AIC-type information criteria for detecting those change-points. The change-point model does not allow for conventional…

因果推断稀疏方法的信息准则AI 解读

For propensity score analysis and sparse estimation, we develop an information criterion for determining the regularization parameters needed in variable selection. First, for Gaussian distribution-based causal inference models, we extend Stein's unbiased risk estimation theory, which leads to a generalized Cp criterion that has almost no weakness in conventional sparse estimation, and derive an inverse-probability-weighted sparse estimation version of the criterion without…

Intact-VAE：未观测混杂下的处理效应估计AI 解读

NOTE: This preprint has a flawed theoretical formulation. Please avoid it and refer to the ICLR22 publication https://openreview.net/forum?id=q7n2RngwOM. Also, arXiv:2109.15062 contains some new ideas on unobserved Confounding. As an important problem of causal inference, we discuss the identification and estimation of treatment effects under unobserved confounding. Representing the confounder as a latent variable, we propose Intact-VAE, a new variant of variational…

利用条件独立性预先指定结构，优化数据收集与研究透明度AI 解读

Data collection and research methodology represents a critical part of the research pipeline. On the one hand, it is important that we collect data in a way that maximises the validity of what we are measuring, which may involve the use of long scales with many items. On the other hand, collecting a large number of items across multiple scales results in participant fatigue, and expensive and time consuming data collection. It is therefore important that we use the available…

含无效工具变量的半参数有效G估计AI 解读

The instrumental variable method is widely used in the health and social sciences for identification and estimation of causal effects in the presence of potentially unmeasured confounding. In order to improve efficiency, multiple instruments are routinely used, leading to concerns about bias due to possible violation of the instrumental variable assumptions. To address this concern, we introduce a new class of g-estimators that are guaranteed to remain consistent and…

不依从随机实验中二元结局的模型辅助依从者平均处理效应估计AI 解读

In randomized experiments, the actual treatments received by some experimental units may differ from their treatment assignments. This non-compliance issue often occurs in clinical trials, social experiments, and the applications of randomized experiments in many other fields. Under certain assumptions, the average treatment effect for the compliers is identifiable and equal to the ratio of the intention-to-treat effects of the potential outcomes to that of the potential…

因果推断中平均处理效应的抗异常值估计AI 解读

The inverse probability (IPW) and doubly robust (DR) estimators are often used to estimate the average causal effect (ATE), but are vulnerable to outliers. The IPW/DR median can be used for outlier-resistant estimation of the ATE, but the outlier resistance of the median is limited and it is not resistant enough for heavy contamination. We propose extensions of the IPW/DR estimators with density power weighting, which can eliminate the influence of outliers almost…

面向收缩估计的实验设计AI 解读

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the causal estimates from our trial toward causal estimates obtained from an observational study. We ask: how might we design the experiment to better complement the observational study in this setting? We propose using an estimator that shrinks…

非嵌套设计中将试验证据推广至目标人群：艾滋病临床试验应用AI 解读

Comparative effectiveness evidence from randomized trials may not be directly generalizable to a target population of substantive interest when, as in most cases, trial participants are not randomly sampled from the target population. Motivated by the need to generalize evidence from two trials conducted in the AIDS Clinical Trials Group (ACTG), we consider weighting, regression and doubly robust estimators to estimate the causal effects of HIV interventions in a specified…

马尔可夫范畴、因果理论与 do 演算AI 解读

We give a category-theoretic treatment of causal models that formalizes the syntax for causal reasoning over a directed acyclic graph (DAG) by associating a free Markov category with the DAG in a canonical way. This framework enables us to define and study important concepts in causal reasoning from an abstract and "purely causal" point of view, such as causal independence/separation, causal conditionals, and decomposition of intervention effects. Our results regarding these…

分布式锚回归AI 解读

Prediction models often fail if train and test data do not stem from the same distribution. Out-of-distribution (OOD) generalization to unseen, perturbed test data is a desirable but difficult-to-achieve property for prediction models and in general requires strong assumptions on the data generating process (DGP). In a causally inspired perspective on OOD generalization, the test data arise from a specific class of interventions on exogenous random variables of the DGP,…