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因果推断的拓扑视角AI 解读

This paper presents a topological learning-theoretic perspective on causal inference by introducing a series of topologies defined on general spaces of structural causal models (SCMs). As an illustration of the framework we prove a topological causal hierarchy theorem, showing that substantive assumption-free causal inference is possible only in a meager set of SCMs. Thanks to a known correspondence between open sets in the weak topology and statistically verifiable…

时间模式的因果推断AI 解读

Complex dynamical systems are prevalent in many scientific disciplines. In the analysis of such systems two aspects are of particular interest: 1) the temporal patterns along which they evolve and 2) the underlying causal mechanisms. Time-series representations like discrete Fourier and wavelet transforms have been widely applied in order to obtain insights on the temporal structure of complex dynamical systems. Questions of cause and effect can be formalized in the causal…

交叉试验中因果处理效应的无偏与高效估计AI 解读

We introduce causal inference reasoning to cross-over trials, with a focus on Thorough QT (TQT) studies. For such trials, we propose different sets of assumptions and consider their impact on the modelling strategy and estimation procedure. We show that unbiased estimates of a causal treatment effect are obtained by a G-computation approach in combination with weighted least squares predictions from a working regression model. Only a few natural requirements on the working…

无需调参的最优倾向得分匹配方法AI 解读

Propensity score matching (PSM) is a pseudo-experimental method that uses statistical techniques to construct an artificial control group by matching each treated unit with one or more untreated units of similar characteristics. To date, the problem of determining the optimal number of matches per unit, which plays an important role in PSM, has not been adequately addressed. We propose a tuning-parameter-free PSM method based on the nonparametric maximum-likelihood…

因果分解分析的敏感性分析：评估对遗漏变量偏误的稳健性AI 解读

A key objective of decomposition analysis is to identify a factor (the 'mediator') contributing to disparities in an outcome between social groups. In decomposition analysis, a scholarly interest often centers on estimating how much the disparity (e.g., health disparities between Black women and White men) would be reduced/remain if we set the mediator (e.g., education) distribution of one social group equal to another. However, causally identifying disparity reduction and…

识别患者个体层面的疾病根源AI 解读

Complex diseases are caused by a multitude of factors that may differ between patients. As a result, hypothesis tests comparing all patients to all healthy controls can detect many significant variables with inconsequential effect sizes. A few highly predictive root causes may nevertheless generate disease within each patient. In this paper, we define patient-specific root causes as variables subject to exogenous "shocks" which go on to perturb an otherwise healthy system…

重复截面中连续处理的非参数双重差分AI 解读

This paper studies the identification of causal effects of a continuous treatment using a new difference-in-difference strategy. Our approach allows for endogeneity of the treatment, and employs repeated cross-sections. It requires an exogenous change over time which affects the treatment in a heterogeneous way, stationarity of the distribution of unobservables and a rank invariance condition on the time trend. On the other hand, we do not impose any functional form…

用高维渐近理论解释处理效应估计器的实际差异AI 解读

We revisit the classical causal inference problem of estimating the average treatment effect in the presence of fully observed confounding variables using two-stage semiparametric methods. In existing theoretical studies of methods such as G-computation, inverse propensity weighting (IPW), and two common doubly robust estimators -- augmented IPW (AIPW) and targeted maximum likelihood estimation (TMLE) -- they are either bias-dominated, or have similar asymptotic statistical…

did2s：两阶段双重差分方法与 R 软件包AI 解读

Recent work has highlighted the difficulties of estimating difference-in-differences models when treatment timing occurs at different times for different units. This article introduces the R package did2s which implements the estimator introduced in Gardner (2021). The article provides an approachable review of the underlying econometric theory and introduces the syntax for the function did2s. Further, the package introduces a function, event_study, that provides a common…

利用似然比评分序贯学习因果图的拓扑排序AI 解读

Causal discovery, the learning of causality in a data mining scenario, has been of strong scientific and theoretical interest as a starting point to identify "what causes what?" Contingent on assumptions and a proper learning algorithm, it is sometimes possible to identify and accurately estimate a causal directed acyclic graph (DAG), as opposed to a Markov equivalence class of graphs that gives ambiguity of causal directions. The focus of this paper is in highlighting the…

高维数据的 Bootstrap 方法AI 解读

This article reviews recent progress in high-dimensional bootstrap. We first review high-dimensional central limit theorems for distributions of sample mean vectors over the rectangles, bootstrap consistency results in high dimensions, and key techniques used to establish those results. We then review selected applications of high-dimensional bootstrap: construction of simultaneous confidence sets for high-dimensional vector parameters, multiple hypothesis testing via…

多维连续处理的因果效应估计AI 解读

Causal inference is widely used in various fields, such as biology, psychology and economics, etc. In observational studies, we need to balance the covariates before estimating causal effect. This study extends the one-dimensional entropy balancing method to multiple dimensions to balance the covariates. Both parametric and nonparametric methods are proposed to estimate the causal effect of multivariate continuous treatments and theoretical properties of the two estimations…

处理改变服务人群时聚类随机试验的依从者平均因果效应估计AI 解读

RCTs sometimes test interventions that aim to improve existing services targeted to a subset of individuals identified after randomization. Accordingly, the treatment could affect the composition of service recipients and the offered services. With such bias, intention-to-treat estimates using data on service recipients and nonrecipients may be difficult to interpret. This article develops causal estimands and inverse probability weighting (IPW) estimators for complier…

因果概率树的主动学习AI 解读

The past two decades have seen a growing interest in combining causal information, commonly represented using causal graphs, with machine learning models. Probability trees provide a simple yet powerful alternative representation of causal information. They enable both computation of intervention and counterfactuals, and are strictly more general, since they allow context-dependent causal dependencies. Here we present a Bayesian method for learning probability trees from a…

处理右删失的多处理二元结局逆概率加权回归因果估计AI 解读

Comparative effectiveness research often involves evaluating the differences in the risks of an event of interest between two or more treatments using observational data. Often, the post-treatment outcome of interest is whether the event happens within a pre-specified time window, which leads to a binary outcome. One source of bias for estimating the causal treatment effect is the presence of confounders, which are usually controlled using propensity score-based methods. An…

用监督机器学习开展观察性科学的因果发现AI 解读

Causal inference can estimate causal effects, but unless data are collected experimentally, statistical analyses must rely on pre-specified causal models. Causal discovery algorithms are empirical methods for constructing such causal models from data. Several asymptotically correct methods already exist, but they generally struggle on smaller samples. Moreover, most methods focus on very sparse causal models, which may not always be a realistic representation of real-life…

稳健异质优势比：估计未购买商品的价格敏感性AI 解读

Problem definition: Mining for heterogeneous responses to an intervention is a crucial step for data-driven operations, for instance to personalize treatment or pricing. We investigate how to estimate price sensitivity from transaction-level data. In causal inference terms, we estimate heterogeneous treatment effects when (a) the response to treatment (here, whether a customer buys a product) is binary, and (b) treatment assignments are partially observed (here, full…

利用平台工具变量因果估计推荐系统的位置偏差AI 解读

Information retrieval systems, such as online marketplaces, news feeds, and search engines, are ubiquitous in today's digital society. They facilitate information discovery by ranking retrieved items on predicted relevance, i.e. likelihood of interaction (click, share) between users and items. Typically modeled using past interactions, such rankings have a major drawback: interaction depends on the attention items receive. A highly-relevant item placed outside a user's…

用于因果推断的最优传输权重AI 解读

Imbalance in covariate distributions leads to biased estimates of causal effects. Weighting methods attempt to correct this imbalance but rely on specifying models for the treatment assignment mechanism, which is unknown in observational studies. This leaves researchers to choose the proper weighting method and the appropriate covariate functions for these models without knowing the correct combination to achieve distributional balance. In response to these difficulties, we…

多层级研究中更高效的双重稳健非参数处理效应估计量AI 解读

When studying treatment effects in multilevel studies, investigators commonly use (semi-)parametric estimators, which make strong parametric assumptions about the outcome, the treatment, and/or the correlation structure between study units in a cluster. We propose a novel estimator of treatment effects that does not make such assumptions. Specifically, the new estimator is shown to be doubly robust, asymptotically Normal, and often more efficient than existing estimators,…

个体患者数据有限时相容间接治疗比较的参数化 G 计算AI 解读

Population adjustment methods such as matching-adjusted indirect comparison (MAIC) are increasingly used to compare marginal treatment effects when there are cross-trial differences in effect modifiers and limited patient-level data. MAIC is based on propensity score weighting, which is sensitive to poor covariate overlap and cannot extrapolate beyond the observed covariate space. Current outcome regression-based alternatives can extrapolate but target a conditional…

中间混杂与单调性约束下自然中介效应的高效灵活估计AI 解读

Natural direct and indirect effects are mediational estimands that decompose the average treatment effect and describe how outcomes would be affected by contrasting levels of a treatment through changes induced in mediator values (in the case of the indirect effect) or not through induced changes in the mediator values (in the case of the direct effect). Natural direct and indirect effects are not generally point-identifiable in the presence of a treatment-induced…

未知软干预下贝叶斯因果推断的干预型高斯等价评分AI 解读

Describing the causal relations governing a system is a fundamental task in many scientific fields, ideally addressed by experimental studies. However, obtaining data under intervention scenarios may not always be feasible, while discovering causal relations from purely observational data is notoriously challenging. In certain settings, such as genomics, we may have data from heterogeneous study conditions, with soft (partial) interventions only pertaining to a subset of the…

具有高维协变量的断点回归设计推断AI 解读

We study regression discontinuity designs in which many predetermined covariates, possibly much more than the number of observations, can be used to increase the precision of treatment effect estimates. We consider a two-step estimator which first selects a small number of "important" covariates through a localized Lasso-type procedure, and then, in a second step, estimates the treatment effect by including the selected covariates linearly into the usual local linear…