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The martingale Z-test

鞅 Z 检验

We describe a statistical test for association of two autocorrelated time series, one of which generated randomly at each time point from a known but possibly history-dependent distribution. The null hypothesis is that at each time point, the two variables are independent, conditional on history until that time point. We define a test statistic that is a martingale under the null hypothesis and describe an asymptotic test for it based on the martingale central limit theorem.…

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Individualized treatment effect was predicted best by modeling baseline risk in interaction with treatment assignment

通过基线风险与治疗分配交互预测个体化治疗效应

Objective: To compare different risk-based methods for optimal prediction of treatment effects. Methods: We simulated RCT data using diverse assumptions for the average treatment effect, a baseline prognostic index of risk (PI), the shape of its interaction with treatment (none, linear, quadratic or non-monotonic), and the magnitude of treatment-related harms (none or constant independent of the PI). We predicted absolute benefit using: models with a constant relative…

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The Role of Placebo Samples in Observational Studies

安慰剂样本在观察性研究中的作用

In an observational study, it is common to leverage known null effect to detect bias. One such strategy is to set aside a placebo sample -- a subset of data immune from the hypothesized cause-and-effect relationship. Existence of an effect in the placebo sample raises concern of unmeasured confounding bias while absence of it corroborates the causal conclusion. This paper establishes a formal framework for using a placebo sample to detect and remove bias. We state…

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A Comparison of Methods for Adaptive Experimentation

自适应实验方法的比较

We use a simulation study to compare three methods for adaptive experimentation: Thompson sampling, Tempered Thompson sampling, and Exploration sampling. We gauge the performance of each in terms of social welfare and estimation accuracy, and as a function of the number of experimental waves. We further construct a set of novel "hybrid" loss measures to identify which methods are optimal for researchers pursuing a combination of experimental aims. Our main results are: 1)…

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Counterfactual Inference of Second Opinions

专家第二意见的反事实推断

Automated decision support systems that are able to infer second opinions from experts can potentially facilitate a more efficient allocation of resources; they can help decide when and from whom to seek a second opinion. In this paper, we look at the design of this type of support systems from the perspective of counterfactual inference. We focus on a multiclass classification setting and first show that, if experts make predictions on their own, the underlying causal…

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Bounds for the chi-square approximation of Friedman's statistic by Stein's method

利用 Stein 方法界定 Friedman 统计量的卡方近似误差

Friedman's chi-square test is a non-parametric statistical test for $r\geq2$ treatments across $n\ge1$ trials to assess the null hypothesis that there is no treatment effect. We use Stein's method with an exchangeable pair coupling to derive an explicit bound on the distance between the distribution of Friedman's statistic and its limiting chi-square distribution, measured using smooth test functions. Our bound is of the optimal order $n^{-1}$, and also has an optimal…

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Efficient estimation of modified treatment policy effects based on the generalized propensity score

基于广义倾向得分的修正处理政策效应有效估计

Continuous treatments have posed a significant challenge for causal inference, both in the formulation and identification of scientifically meaningful effects and in their robust estimation. Traditionally, focus has been placed on techniques applicable to binary or categorical treatments with few levels, allowing for the application of propensity score-based methodology with relative ease. Efforts to accommodate continuous treatments introduced the generalized propensity…

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Causal discovery under a confounder blanket

混杂覆盖条件下的因果发现

Inferring causal relationships from observational data is rarely straightforward, but the problem is especially difficult in high dimensions. For these applications, causal discovery algorithms typically require parametric restrictions or extreme sparsity constraints. We relax these assumptions and focus on an important but more specialized problem, namely recovering the causal order among a subgraph of variables known to descend from some (possibly large) set of confounding…

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On Well-posedness and Minimax Optimal Rates of Nonparametric Q-function Estimation in Off-policy Evaluation

离策略评估中非参数 Q 函数估计的适定性与极小极大最优速率

We study the off-policy evaluation (OPE) problem in an infinite-horizon Markov decision process with continuous states and actions. We recast the $Q$-function estimation into a special form of the nonparametric instrumental variables (NPIV) estimation problem. We first show that under one mild condition the NPIV formulation of $Q$-function estimation is well-posed in the sense of $L^2$-measure of ill-posedness with respect to the data generating distribution, bypassing a…

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Improving Data-driven Heterogeneous Treatment Effect Estimation Under Structure Uncertainty

因果结构不确定时改进数据驱动的异质处理效应估计

Estimating how a treatment affects units individually, known as heterogeneous treatment effect (HTE) estimation, is an essential part of decision-making and policy implementation. The accumulation of large amounts of data in many domains, such as healthcare and e-commerce, has led to increased interest in developing data-driven algorithms for estimating heterogeneous effects from observational and experimental data. However, these methods often make strong assumptions about…

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A Causal Research Pipeline and Tutorial for Psychologists and Social Scientists

面向心理学与社会科学的因果研究流程及教程

Causality is a fundamental part of the scientific endeavour to understand the world. Unfortunately, causality is still taboo in much of psychology and social science. Motivated by a growing number of recommendations for the importance of adopting causal approaches to research, we reformulate the typical approach to research in psychology to harmonize inevitably causal theories with the rest of the research pipeline. We present a new process which begins with the…

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Empirical Decomposition of the IV-OLS Gap with Heterogeneous and Nonlinear Effects

异质与非线性效应下 IV 与 OLS 差距的经验分解

This study proposes an econometric framework to interpret and empirically decompose the difference between IV and OLS estimates given by a linear regression model when the true causal effects of the treatment are nonlinear in treatment levels and heterogeneous across covariates. I show that the IV-OLS coefficient gap consists of three estimable components: the difference in weights on the covariates, the difference in weights on the treatment levels, and the difference in…

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Do forecasts of bankruptcy cause bankruptcy? A machine learning sensitivity analysis

破产预测会导致破产吗?机器学习敏感性分析

It is widely speculated that auditors' public forecasts of bankruptcy are, at least in part, self-fulfilling prophecies in the sense that they might actually cause bankruptcies that would not have otherwise occurred. This conjecture is hard to prove, however, because the strong association between bankruptcies and bankruptcy forecasts could simply indicate that auditors are skillful forecasters with unique access to highly predictive covariates. In this paper, we investigate…

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Nonparametric identification of causal effects in clustered observational studies with differential selection

差异性选择下聚类观察研究因果效应的非参数识别

The clustered observational study (COS) design is the observational study counterpart to the clustered randomized trial. In a COS, a treatment is assigned to intact groups, and all units within the group are exposed to the treatment. However, the treatment is non-randomly assigned. COSs are common in both education and health services research. In education, treatments may be given to all students within some schools but withheld from all students in other schools. In health…

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Addressing Extreme Propensity Scores in Estimating Counterfactual Survival Functions via the Overlap Weights

利用重叠权重处理反事实生存函数估计中的极端倾向得分

The inverse probability weighting approach is popular for evaluating treatment effects in observational studies, but extreme propensity scores could bias the estimator and induce excessive variance. Recently, the overlap weighting approach has been proposed to alleviate this problem, which smoothly down-weighs the subjects with extreme propensity scores. Although advantages of overlap weighting have been extensively demonstrated in literature with continuous and binary…

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Two-Way Fixed Effects and Differences-in-Differences with Heterogeneous Treatment Effects: A Survey

异质处理效应下的双向固定效应与双重差分:文献综述

Linear regressions with period and group fixed effects are widely used to estimate policies' effects: 26 of the 100 most cited papers published by the American Economic Review from 2015 to 2019 estimate such regressions. It has recently been shown that those regressions may produce misleading estimates, if the policy's effect is heterogeneous between groups or over time, as is often the case. This survey reviews a fast-growing literature that documents this issue, and that…

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Causal Inference with Treatment Measurement Error: A Nonparametric Instrumental Variable Approach

处理变量存在测量误差时的因果推断:非参数工具变量方法

We propose a kernel-based nonparametric estimator for the causal effect when the cause is corrupted by error. We do so by generalizing estimation in the instrumental variable setting. Despite significant work on regression with measurement error, additionally handling unobserved confounding in the continuous setting is non-trivial: we have seen little prior work. As a by-product of our investigation, we clarify a connection between mean embeddings and characteristic…

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Dynamic and heterogeneous treatment effects with abrupt changes

存在突变的动态异质性处理效应

From personalised medicine to targeted advertising, it is an inherent task to provide a sequence of decisions with historical covariates and outcome data. This requires understanding of both the dynamics and heterogeneity of treatment effects. In this paper, we are concerned with detecting abrupt changes in the treatment effects in terms of the conditional average treatment effect (CATE) in a sequential fashion. To be more specific, at each time point, we consider a…

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On the probability of invalidating a causal inference due to limited external validity

外部效度不足导致因果推断失效的概率

External validity is often questionable in empirical research, especially in randomized experiments due to the trade-off between internal validity and external validity. To quantify the robustness of external validity, one must first conceptualize the gap between a sample that is fully representative of the target population (i.e., the ideal sample) and the observed sample. Drawing on Frank & Min (2007) and Frank et al. (2013), I define such gap as the unobserved sample and…

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Rules Ensemble Method with Group Lasso for Heterogeneous Treatment Effect Estimation

用于异质性处理效应估计的组 Lasso 规则集成方法

The increasing scientific attention given to precision medicine based on real-world data has led many recent studies to clarify the relationships between treatment effects and patient characteristics. However, this is challenging because of ubiquitous heterogeneity in the treatment effect for individuals and the real-world data on their background being complex and noisy. Because of their flexibility, various heterogeneous treatment effect (HTE) machine learning (ML)…

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Identification and estimation of causal effects in the presence of confounded principal strata

主分层存在混杂时的因果效应识别与估计

The principal stratification has become a popular tool to address a broad class of causal inference questions, particularly in dealing with non-compliance and truncation-by-death problems. The causal effects within principal strata which are determined by joint potential values of the intermediate variable, also known as the principal causal effects, are often of interest in these studies. Analyses of principal causal effects from observed data in the literature mostly rely…

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Empirical Bayesian Approaches for Robust Constraint-based Causal Discovery under Insufficient Data

数据不足时稳健约束型因果发现的经验贝叶斯方法

Causal discovery is to learn cause-effect relationships among variables given observational data and is important for many applications. Existing causal discovery methods assume data sufficiency, which may not be the case in many real world datasets. As a result, many existing causal discovery methods can fail under limited data. In this work, we propose Bayesian-augmented frequentist independence tests to improve the performance of constraint-based causal discovery methods…

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Benchmarking Heterogeneous Treatment Effect Models through the Lens of Interpretability

从可解释性视角评测异质性处理效应模型

Estimating personalized effects of treatments is a complex, yet pervasive problem. To tackle it, recent developments in the machine learning (ML) literature on heterogeneous treatment effect estimation gave rise to many sophisticated, but opaque, tools: due to their flexibility, modularity and ability to learn constrained representations, neural networks in particular have become central to this literature. Unfortunately, the assets of such black boxes come at a cost: models…

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Optimality of Matched-Pair Designs in Randomized Controlled Trials

随机对照试验中匹配成对设计的最优性

In randomized controlled trials (RCTs), treatment is often assigned by stratified randomization. I show that among all stratified randomization schemes which treat all units with probability one half, a certain matched-pair design achieves the maximum statistical precision for estimating the average treatment effect (ATE). In an important special case, the optimal design pairs units according to the baseline outcome. In a simulation study based on datasets from 10 RCTs, this…

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