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Doubly Robust Criterion for Causal Inference

因果推断中的双重稳健模型选择准则

The semiparametric estimation approach, which includes inverse-probability-weighted and doubly robust estimation using propensity scores, is a standard tool in causal inference, and it is rapidly being extended in various directions. On the other hand, although model selection is indispensable in statistical analysis, an information criterion for selecting an appropriate regression structure has just started to be developed. In this paper, based on the original definition of…

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Orthogonal Series Estimation for the Ratio of Conditional Expectation Functions

条件期望函数之比的正交级数估计

In various fields of data science, researchers are often interested in estimating the ratio of conditional expectation functions (CEFR). Specifically in causal inference problems, it is sometimes natural to consider ratio-based treatment effects, such as odds ratios and hazard ratios, and even difference-based treatment effects are identified as CEFR in some empirically relevant settings. This chapter develops the general framework for estimation and inference on CEFR, which…

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DeepMed: Semiparametric Causal Mediation Analysis with Debiased Deep Learning

DeepMed:利用去偏深度学习开展半参数因果中介分析

Causal mediation analysis can unpack the black box of causality and is therefore a powerful tool for disentangling causal pathways in biomedical and social sciences, and also for evaluating machine learning fairness. To reduce bias for estimating Natural Direct and Indirect Effects in mediation analysis, we propose a new method called DeepMed that uses deep neural networks (DNNs) to cross-fit the infinite-dimensional nuisance functions in the efficient influence functions.…

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Causal Modelling of Heavy-Tailed Variables and Confounders with Application to River Flow

重尾变量与混杂因素的因果建模:河流流量应用

Confounding variables are a recurrent challenge for causal discovery and inference. In many situations, complex causal mechanisms only manifest themselves in extreme events, or take simpler forms in the extremes. Stimulated by data on extreme river flows and precipitation, we introduce a new causal discovery methodology for heavy-tailed variables that allows the effect of a known potential confounder to be almost entirely removed when the variables have comparable tails, and…

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Offline Reinforcement Learning for Human-Guided Human-Machine Interaction with Private Information

存在私人信息的人类引导人机交互中的离线强化学习

Motivated by the human-machine interaction such as training chatbots for improving customer satisfaction, we study human-guided human-machine interaction involving private information. We model this interaction as a two-player turn-based game, where one player (Alice, a human) guides the other player (Bob, a machine) towards a common goal. Specifically, we focus on offline reinforcement learning (RL) in this game, where the goal is to find a policy pair for Alice and Bob…

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Proximal Learning for Individualized Treatment Regimes Under Unmeasured Confounding

未测量混杂下个体化处理规则的近端学习

Data-driven individualized decision making has recently received increasing research interests. Most existing methods rely on the assumption of no unmeasured confounding, which unfortunately cannot be ensured in practice especially in observational studies. Motivated by the recent proposed proximal causal inference, we develop several proximal learning approaches to estimating optimal individualized treatment regimes (ITRs) in the presence of unmeasured confounding. In…

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Debiased machine learning for estimating the causal effect of urban traffic on pedestrian crossing behaviour

利用去偏机器学习估计城市交通对行人过街行为的因果效应

Before the transition of AVs to urban roads and subsequently unprecedented changes in traffic conditions, evaluation of transportation policies and futuristic road design related to pedestrian crossing behavior is of vital importance. Recent studies analyzed the non-causal impact of various variables on pedestrian waiting time in the presence of AVs. However, we mainly investigate the causal effect of traffic density on pedestrian waiting time. We develop a Double/Debiased…

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Interpretability and causal discovery of the machine learning models to predict the production of CBM wells after hydraulic fracturing

水力压裂后煤层气井产量预测模型的可解释性与因果发现

Machine learning approaches are widely studied in the production prediction of CBM wells after hydraulic fracturing, but merely used in practice due to the low generalization ability and the lack of interpretability. A novel methodology is proposed in this article to discover the latent causality from observed data, which is aimed at finding an indirect way to interpret the machine learning results. Based on the theory of causal discovery, a causal graph is derived with…

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Out-of-sample scoring and automatic selection of causal estimators

因果估计量的样本外评分与自动选择

Recently, many causal estimators for Conditional Average Treatment Effect (CATE) and instrumental variable (IV) problems have been published and open sourced, allowing to estimate granular impact of both randomized treatments (such as A/B tests) and of user choices on the outcomes of interest. However, the practical application of such models has ben hampered by the lack of a valid way to score the performance of such models out of sample, in order to select the best one for…

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Combinatorial Causal Bandits

组合因果多臂老虎机

In combinatorial causal bandits (CCB), the learning agent chooses at most $K$ variables in each round to intervene, collects feedback from the observed variables, with the goal of minimizing expected regret on the target variable $Y$. We study under the context of binary generalized linear models (BGLMs) with a succinct parametric representation of the causal models. We present the algorithm BGLM-OFU for Markovian BGLMs (i.e. no hidden variables) based on the maximum…

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Prognostic Covariate Adjustment for Binary Outcomes Using Stratification

利用分层对二元结局进行预后协变量调整

Covariate adjustment and methods of incorporating historical data in randomized clinical trials (RCTs) each provide opportunities to increase trial power. We unite these approaches for the analysis of RCTs with binary outcomes based on the Cochran-Mantel-Haenszel (CMH) test for marginal risk ratio (RR). In PROCOVA-CMH, subjects are stratified on a single prognostic covariate reflective of their predicted outcome on the control treatment (e.g. placebo). This prognostic score…

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All models are wrong, but which are useful? Comparing parametric and nonparametric estimation of causal effects in finite samples

模型皆有误,何者有用?有限样本中参数与非参数因果效应估计的比较

There is a long-standing debate in the statistical, epidemiological and econometric fields as to whether nonparametric estimation that uses data-adaptive methods, like machine learning algorithms in model fitting, confer any meaningful advantage over simpler, parametric approaches in real-world, finite sample estimation of causal effects. We address the question: when trying to estimate the effect of a treatment on an outcome, across a universe of reasonable data…

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Detecting causal covariates for extreme dependence structures

极端依赖结构的因果协变量发现

Determining the causes of extreme events is a fundamental question in many scientific fields. An important aspect when modelling multivariate extremes is the tail dependence. In application, the extreme dependence structure may significantly depend on covariates. As for the general case of modelling including covariates, only some of the covariates are causal. In this paper, we propose a methodology to discover the causal covariates explaining the tail dependence structure…

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Dyadic double/debiased machine learning for analyzing determinants of free trade agreements

用于分析自由贸易协定决定因素的二元组双重去偏机器学习

This paper presents novel methods and theories for estimation and inference about parameters in econometric models using machine learning for nuisance parameters estimation when data are dyadic. We propose a dyadic cross fitting method to remove over-fitting biases under arbitrary dyadic dependence. Together with the use of Neyman orthogonal scores, this novel cross fitting method enables root-$n$ consistent estimation and inference robustly against dyadic dependence. We…

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Measuring covariate balance in weighted propensity score analyses by the weighted z-difference

用加权 z 差衡量倾向得分加权分析的协变量平衡

Propensity score (PS) methods have been increasingly used in recent years when assessing treatment effects in nonrandomized studies. In terms of statistical methods, a number of new PS weighting methods were developed, and it was shown that they can outperform PS matching in efficiency of treatment effect estimation in different simulation settings. For assessing balance of covariates in treatment groups, PS weighting methods commonly use the weighted standardized…

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Robust Estimation of Average Treatment Effects from Panel Data

面板数据平均治疗效应的稳健估计

In order to evaluate the impact of a policy intervention on a group of units over time, it is important to correctly estimate the average treatment effect (ATE) measure. Due to lack of robustness of the existing procedures of estimating ATE from panel data, in this paper, we introduce a robust estimator of the ATE and the subsequent inference procedures using the popular approach of minimum density power divergence inference. Asymptotic properties of the proposed ATE…

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Ordinal Causal Discovery

有序数据的因果结构发现

Causal discovery for purely observational, categorical data is a long-standing challenging problem. Unlike continuous data, the vast majority of existing methods for categorical data focus on inferring the Markov equivalence class only, which leaves the direction of some causal relationships undetermined. This paper proposes an identifiable ordinal causal discovery method that exploits the ordinal information contained in many real-world applications to uniquely identify the…

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Instrumental variable estimation of dynamic treatment effects on a duration outcome

持续时间结局上动态治疗效应的工具变量估计

This paper considers identification and estimation of the causal effect of the time Z until a subject is treated on a survival outcome T. The treatment is not randomly assigned, T is randomly right censored by a random variable C and the time to treatment Z is right censored by min(T,C). The endogeneity issue is treated using an instrumental variable explaining Z and independent of the error term of the model. We study identification in a fully nonparametric framework. We…

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Improving uplift model evaluation on RCT data

改进随机对照试验数据中的增益模型评估

Estimating treatment effects is one of the most challenging and important tasks of data analysts. In many applications, like online marketing and personalized medicine, treatment needs to be allocated to the individuals where it yields a high positive treatment effect. Uplift models help select the right individuals for treatment and maximize the overall treatment effect (uplift). A major challenge in uplift modeling concerns model evaluation. Previous literature suggests…

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Tree-based exploratory identification of predictive biomarkers in observational data

基于树的观察性数据预测性生物标志物探索识别

The idea of "stratified medicine" is an important driver of methodological research on the identification of predictive biomarkers. Most methods proposed so far for this purpose have been developed for the use on randomized data only. However, especially for rare cancers, data from clinical registries or observational studies might be the only available data source. For such data, methods for an unbiased estimation of the average treatment effect are well established.…

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On sample size determination for restricted mean survival time-based tests in randomized clinical trials

随机临床试验中基于限制平均生存时间检验的样本量确定

Restricted mean survival time (RMST) is gaining attention as a measure to quantify the treatment effect on survival outcomes in randomized clinical trials. Several methods to determine sample size based on the RMST-based tests have been proposed. However, to the best of our knowledge, there is no discussion about the power and sample size regarding the augmented version of RMST-based tests, which utilize baseline covariates for a gain in estimation efficiency and in power…

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Nonparametric estimators of interventional (transported) direct and indirect effects that accommodate multiple mediators and multiple intermediate confounders

容许多个中介与多个中间混杂因素的干预型及可迁移直接、间接效应非参数估计

Mediation analysis is appealing for its ability to improve understanding of the mechanistic drivers of causal effects, but real-world data complexities challenge its successful implementation, including: 1) the existence of post-exposure variables that also affect mediators and outcomes (thus, confounding the mediator-outcome relationship), that may also be 2) multivariate, and 3) the existence of multivariate mediators. Interventional direct and indirect effects (IDE/IIE)…

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One Instrument to Rule Them All: The Bias and Coverage of Just-ID IV

一个工具变量统领全局:恰好识别工具变量估计的偏差与覆盖率

We revisit the finite-sample behavior of single-variable just-identified instrumental variables (just-ID IV) estimators, arguing that in most microeconometric applications, the usual inference strategies are likely reliable. Three widely-cited applications are used to explain why this is so. We then consider pretesting strategies of the form $t_{1}>c$, where $t_{1}$ is the first-stage $t$-statistic, and the first-stage sign is given. Although pervasive in empirical practice,…

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The finite sample performance of instrumental variable-based estimators of the Local Average Treatment Effect when controlling for covariates

控制协变量时工具变量局部平均处理效应估计量的有限样本表现

This paper investigates the finite sample performance of a range of parametric, semi-parametric, and non-parametric instrumental variable estimators when controlling for a fixed set of covariates to evaluate the local average treatment effect. Our simulation designs are based on empirical labor market data from the US and vary in several dimensions, including effect heterogeneity, instrument selectivity, instrument strength, outcome distribution, and sample size. Among the…

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