论文检索

破解孟德尔随机化的赢家诅咒：再随机化逆方差加权估计量AI 解读

Developments in genome-wide association studies and the increasing availability of summary genetic association data have made the application of two-sample Mendelian Randomization (MR) with summary data increasingly popular. Conventional two-sample MR methods often employ the same sample for selecting relevant genetic variants and for constructing final causal estimates. Such a practice often leads to biased causal effect estimates due to the well known "winner's curse"…

存在隐藏混杂时的连续时间处理效应估计AI 解读

Estimating treatment effects plays a crucial role in causal inference, having many real-world applications like policy analysis and decision making. Nevertheless, estimating treatment effects in the longitudinal setting in the presence of hidden confounders remains an extremely challenging problem. Recently, there is a growing body of work attempting to obtain unbiased ITE estimates from time-dynamic observational data by ignoring the possible existence of hidden…

面向健康公平的新因果分解框架AI 解读

Causal decomposition has provided a powerful tool to analyze health disparity problems, by assessing the proportion of disparity caused by each mediator. However, most of these methods lack \emph{policy implications}, as they fail to account for all sources of disparities caused by the mediator. Besides, their estimations \emph{pre-specified} some covariates set (\emph{a.k.a}, admissible set) for the strong ignorability condition to hold, which can be problematic as some…

合成控制的识别与推断：近端因果推断框架AI 解读

Synthetic control (SC) methods are commonly used to estimate the treatment effect on a single treated unit in panel data settings. An SC is a weighted average of control units built to match the treated unit, with weights typically estimated by regressing (summaries of) pre-treatment outcomes and measured covariates of the treated unit to those of the control units. However, it has been established that in the absence of a good fit, such regression estimator will generally…

平均因果效应识别假设的比较：稳健性与半参数效率AI 解读

Semiparametric inference on average causal effects from observational data is based on assumptions yielding identification of the effects. In practice, several distinct identifying assumptions may be plausible; an analyst has to make a delicate choice between these models. In this paper, we study three identifying assumptions based on the potential outcome framework: the back-door assumption, which uses pre-treatment covariates, the front-door assumption, which uses…

图模型的 Lauritzen–Chen 似然AI 解读

Graphical models such as Markov random fields (MRFs) that are associated with undirected graphs, and Bayesian networks (BNs) that are associated with directed acyclic graphs, have proven to be a very popular approach for reasoning under uncertainty, prediction problems and causal inference. Parametric MRF likelihoods are well-studied for Gaussian and categorical data. However, in more complicated parametric and semi-parametric settings, likelihoods specified via clique…

基于单样本 Mantel–Haenszel 方法的篮式试验频率学派分析AI 解读

Recent substantial advances of molecular targeted oncology drug development is requiring new paradigms for early-phase clinical trial methodologies to enable us to evaluate efficacy of several subtypes simultaneously and efficiently. The concept of the basket trial is getting of much attention to realize this requirement borrowing information across subtypes, which are called baskets. Bayesian approach is a natural approach to this end and indeed the majority of the existing…

具有因果解释的元分析：明确的因果效应与两个案例AI 解读

Meta-analysis is commonly used to combine results from multiple clinical trials, but traditional meta-analysis methods do not refer explicitly to a population of individuals to whom the results apply and it is not clear how to use their results to assess a treatment's effect for a population of interest. We describe recently-introduced causally-interpretable meta-analysis methods and apply their treatment effect estimators to two individual-participant data sets. These…

图像混杂偏差下的因果效应估计及非洲贫困应用AI 解读

Observational studies of causal effects require adjustment for confounding factors. In the tabular setting, where these factors are well-defined, separate random variables, the effect of confounding is well understood. However, in public policy, ecology, and in medicine, decisions are often made in non-tabular settings, informed by patterns or objects detected in images (e.g., maps, satellite or tomography imagery). Using such imagery for causal inference presents an…

非可分三角模型中个体处理效应的统计推断AI 解读

In nonseparable triangular models with a binary endogenous treatment and a binary instrumental variable, Vuong and Xu (2017) established identification results for individual treatment effects (ITEs) under the rank invariance assumption. Using their approach, Feng, Vuong, and Xu (2019) proposed a uniformly consistent kernel estimator for the density of the ITE that utilizes estimated ITEs. In this paper, we establish the asymptotic normality of the density estimator of Feng,…

CUTS：从不规则时间序列中进行神经网络因果发现AI 解读

Causal discovery from time-series data has been a central task in machine learning. Recently, Granger causality inference is gaining momentum due to its good explainability and high compatibility with emerging deep neural networks. However, most existing methods assume structured input data and degenerate greatly when encountering data with randomly missing entries or non-uniform sampling frequencies, which hampers their applications in real scenarios. To address this issue,…

合成双重差分估计的 Stata 实现AI 解读

In this paper, we describe a computational implementation of the Synthetic difference-in-differences (SDID) estimator of Arkhangelsky et al. (2021) for Stata. Synthetic difference-in-differences can be used in a wide class of circumstances where treatment effects on some particular policy or event are desired, and repeated observations on treated and untreated units are available over time. We lay out the theory underlying SDID, both when there is a single treatment adoption…

抵御混杂影响的稳健因果图表示学习AI 解读

The prevailing graph neural network models have achieved significant progress in graph representation learning. However, in this paper, we uncover an ever-overlooked phenomenon: the pre-trained graph representation learning model tested with full graphs underperforms the model tested with well-pruned graphs. This observation reveals that there exist confounders in graphs, which may interfere with the model learning semantic information, and current graph representation…

利用潜在多中介路径进行因果去混杂AI 解读

Causal effect estimation from observational data is one of the essential problems in causal inference. However, most estimation methods rely on the strong assumption that all confounders are observed, which is impractical and untestable in the real world. We develop a mediation analysis framework inferring the latent confounder for debiasing both direct and indirect causal effects. Specifically, we introduce generalized structural equation modeling that incorporates…

网络干扰下使用不依赖模型的协变量进行回归调整AI 解读

When estimating a Global Average Treatment Effect (GATE) under network interference, units can have widely different relationships to the treatment depending on a combination of the structure of their network neighborhood, the structure of the interference mechanism, and how the treatment was distributed in their neighborhood. In this work, we introduce a sequential procedure to generate and select graph- and treatment-based covariates for GATE estimation under regression…

用于处理效应推广的 Group LASSO 变量选择方法AI 解读

Often in public health, we are interested in the treatment effect of an intervention on a population that is systemically different from the experimental population the intervention was originally evaluated in. When treatment effect heterogeneity is present in a randomized controlled trial, generalizing the treatment effect from this experimental population to a target population of interest is a complex problem; it requires the characterization of both the treatment effect…

用半参数 G 计算估计依从性不可观测时的纵向因果效应AI 解读

Participant noncompliance, in which participants do not follow their assigned treatment protocol, often obscures the causal relationship between treatment and treatment effect in randomized trials. In the longitudinal setting, the G-computation algorithm can adjust for confounding to estimate causal effects. Typically, G-computation assumes that both 1) compliance is observed; and 2) the densities of the confounders can be correctly specified. We aim to develop a…

具有因果解释的随机效应元分析AI 解读

Recent work has made important contributions in the development of causally-interpretable meta-analysis. These methods transport treatment effects estimated in a collection of randomized trials to a target population of interest. Ideally, estimates targeted toward a specific population are more interpretable and relevant to policy-makers and clinicians. However, between-study heterogeneity not arising from differences in the distribution of treatment effect modifiers can…

整群随机试验中 p 值与置信区间的置换式多重检验校正AI 解读

In this article, we derive and compare methods to derive \textit{p}-values and sets of confidence intervals with strong control of the family-wise error rates and coverage for estimates of treatment effects in cluster randomised trials with multiple outcomes. There are few methods for \textit{p}-value corrections and deriving confidence intervals, limiting their application in this setting. We discuss the methods of Bonferroni, Holm, and Romano \& Wolf (2005) and adapt them…

隐私保护、通信高效且目标灵活的医院质量测量AI 解读

Integrating information from multiple data sources can enable more precise, timely, and generalizable decisions. However, it is challenging to make valid causal inferences using observational data from multiple data sources. For example, in healthcare, learning from electronic health records contained in different hospitals is desirable but difficult due to heterogeneity in patient case mix, differences in treatment guidelines, and data privacy regulations that preclude…

少量处理簇下双重差分推断的扩展AI 解读

In settings with few treated units, Difference-in-Differences (DID) estimators are not consistent, and are not generally asymptotically normal. This poses relevant challenges for inference. While there are inference methods that are valid in these settings, some of these alternatives are not readily available when there is variation in treatment timing and heterogeneous treatment effects; or for deriving uniform confidence bands for event-study plots. We present alternatives…

无需 Cookie 的隐私友好实验AI 解读

Consider two brands that want to jointly test alternate web experiences for their customers with an A/B test. Such collaborative tests are today enabled using \textit{third-party cookies}, where each brand has information on the identity of visitors to another website. With the imminent elimination of third-party cookies, such A/B tests will become untenable. We propose a two-stage experimental design, where the two brands only need to agree on high-level aggregate…

簇级有向无环图中的因果效应识别AI 解读

Reasoning about the effect of interventions and counterfactuals is a fundamental task found throughout the data sciences. A collection of principles, algorithms, and tools has been developed for performing such tasks in the last decades (Pearl, 2000). One of the pervasive requirements found throughout this literature is the articulation of assumptions, which commonly appear in the form of causal diagrams. Despite the power of this approach, there are significant settings…

mbsts 包：R 中的多变量贝叶斯结构时间序列模型AI 解读

The multivariate Bayesian structural time series (MBSTS) model is a general machine learning model that deals with inference and prediction for multiple correlated time series, where one also has the choice of using a different candidate pool of contemporaneous predictors for each target series. The MBSTS model has wide applications and is ideal for feature selection, time series forecasting, nowcasting, inferring causal impact, and others. This paper demonstrates how to use…