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网络成员身份误分类下自我中心网络随机试验的因果溢出效应推断AI 解读

To leverage peer influence and increase population behavioral changes, behavioral interventions often rely on peer-based strategies. A common study design that assesses such strategies is the egocentric-network randomized trial (ENRT), in which those receiving the intervention are encouraged to disseminate information to their peers. The Average Spillover Effect (ASpE) measures the impact of the intervention on participants who do not receive it, but whose outcomes may be…

论 d 分离的不易出现AI 解读

Causal discovery aims to recover a causal graph from data generated by it; constraint based methods do so by searching for a d-separating conditioning set of nodes in the graph via an oracle. In this paper, we provide analytic evidence that on large graphs, d-separation is a rare phenomenon, even when guaranteed to exist, unless the graph is extremely sparse. We then provide an analytic average case analysis of the PC Algorithm for causal discovery, as well as a variant of…

比较两个生存函数多项特征的同时推断程序AI 解读

Survival time is the primary endpoint of many randomized controlled trials, and a treatment effect is typically quantified by the hazard ratio under the assumption of proportional hazards. Awareness is increasing that in many settings this assumption is a-priori violated, e.g. due to delayed onset of drug effect. In these cases, interpretation of the hazard ratio estimate is ambiguous and statistical inference for alternative parameters to quantify a treatment effect is…

稀有结局下的政策学习AI 解读

Machine learning (ML) estimates of conditional average treatment effects (CATE) can guide policy decisions, either by allowing targeting of individuals with beneficial CATE estimates, or as inputs to decision trees that optimise overall outcomes. There is limited information available regarding how well these algorithms perform in real-world policy evaluation scenarios. Using synthetic data, we compare the finite sample performance of different policy learning algorithms,…

因果推断入门课程AI 解读

I developed the lecture notes based on my ``Causal Inference'' course at the University of California Berkeley over the past seven years. Since half of the students were undergraduates, my lecture notes only required basic knowledge of probability theory, statistical inference, and linear and logistic regressions.

深度神经网络引导的点估计集成学习AI 解读

In modern statistics, interests shift from pursuing the uniformly minimum variance unbiased estimator to reducing mean squared error (MSE) or residual squared error. Shrinkage based estimation and regression methods offer better prediction accuracy and improved interpretation. However, the characterization of such optimal statistics in terms of minimizing MSE remains open and challenging in many problems, for example estimating treatment effect in adaptive clinical trials…

不要求解唯一性的近端因果推断AI 解读

We consider identification and inference about a counterfactual outcome mean when there is unmeasured confounding using tools from proximal causal inference (Miao et al. [2018], Tchetgen Tchetgen et al. [2020]). Proximal causal inference requires existence of solutions to at least one of two integral equations. We motivate the existence of solutions to the integral equations from proximal causal inference by demonstrating that, assuming the existence of a solution to one of…

CausalGPS：连续暴露因果推断的 R 软件包AI 解读

Quantifying the causal effects of continuous exposures on outcomes of interest is critical for social, economic, health, and medical research. However, most existing software packages focus on binary exposures. We develop the CausalGPS R package that implements a collection of algorithms to provide algorithmic solutions for causal inference with continuous exposures. CausalGPS implements a causal inference workflow, with algorithms based on generalized propensity scores…

利用协变量辅助构造工具变量因果效应界AI 解读

When an exposure of interest is confounded by unmeasured factors, an instrumental variable (IV) can be used to identify and estimate certain causal contrasts. Identification of the marginal average treatment effect (ATE) from IVs relies on strong untestable structural assumptions. When one is unwilling to assert such structure, IVs can nonetheless be used to construct bounds on the ATE. Famously, Balke and Pearl (1997) proved tight bounds on the ATE for a binary outcome, in…

多终点优效性与非劣效性同时检验的直接方法AI 解读

Simultaneous tests of superiority and non-inferiority hypotheses on multiple endpoints are often performed in clinical trials to demonstrate that a new treatment is superior over a control on at least one endpoint and non-inferior on the remaining endpoints. Existing methods tackle this problem by testing the superiority and non-inferiority hypotheses separately and control the Type I error rate each at $α$ level. In this paper we propose a unified approach to testing the…

算法决策中的动态选择AI 解读

This paper identifies and addresses dynamic selection problems in online learning algorithms with endogenous data. In a contextual multi-armed bandit model, a novel bias (self-fulfilling bias) arises because the endogeneity of the data influences the choices of decisions, affecting the distribution of future data to be collected and analyzed. We propose an instrumental-variable-based algorithm to correct for the bias. It obtains true parameter values and attains low…

观察性研究中基于风险比的因果效应边际敏感性模型AI 解读

In observational studies, the identification of causal estimands depends on the no unmeasured confounding (NUC) assumption. As this assumption is not testable from observed data, sensitivity analysis plays an important role in observational studies to investigate the impact of unmeasured confounding on the causal conclusions. In this paper, we proposed a risk-ratio-based sensitivity analysis framework by introducing a modified marginal sensitivity model for observational…

可微希尔伯特空间值参数的一步估计AI 解读

We present estimators for smooth Hilbert-valued parameters, where smoothness is characterized by a pathwise differentiability condition. When the parameter space is a reproducing kernel Hilbert space, we provide a means to obtain efficient, root-n rate estimators and corresponding confidence sets. These estimators correspond to generalizations of cross-fitted one-step estimators based on Hilbert-valued efficient influence functions. We give theoretical guarantees even when…

预算约束下组合治疗的最优个体化规则AI 解读

The individualized treatment rule (ITR), which recommends an optimal treatment based on individual characteristics, has drawn considerable interest from many areas such as precision medicine, personalized education, and personalized marketing. Existing ITR estimation methods mainly adopt one of two or more treatments. However, a combination of multiple treatments could be more powerful in various areas. In this paper, we propose a novel Double Encoder Model (DEM) to estimate…

批次自适应实验中的双重机器学习与实验设计AI 解读

We consider an experiment with at least two stages or batches and $O(N)$ subjects per batch. First, we propose a semiparametric treatment effect estimator that efficiently pools information across the batches, and show it asymptotically dominates alternatives that aggregate single batch estimates. Then, we consider the design problem of learning propensity scores for assigning treatment in the later batches of the experiment to maximize the asymptotic precision of this…

从自激与互激时间序列中发现因果图AI 解读

We present a generalized linear structural causal model, coupled with a novel data-adaptive linear regularization, to recover causal directed acyclic graphs (DAGs) from time series. By leveraging a recently developed stochastic monotone Variational Inequality (VI) formulation, we cast the causal discovery problem as a general convex optimization. Furthermore, we develop a non-asymptotic recovery guarantee and quantifiable uncertainty by solving a linear program to establish…

竞争风险观察研究中平均处理效应的重抽样置信区间与置信带AI 解读

The g-formula can be used to estimate the treatment effect while accounting for confounding bias in observational studies. With regard to time-to-event endpoints, possibly subject to competing risks, the construction of valid pointwise confidence intervals and time-simultaneous confidence bands for the causal risk difference is complicated, however. A convenient solution is to approximate the asymptotic distribution of the corresponding stochastic process by means of…

协变量漂移下基于加权共形p值的无模型选择性推断AI 解读

This paper introduces novel weighted conformal p-values and methods for model-free selective inference. The problem is as follows: given test units with covariates $X$ and missing responses $Y$, how do we select units for which the responses $Y$ are larger than user-specified values while controlling the proportion of false positives? Can we achieve this without any modeling assumptions on the data and without any restriction on the model for predicting the responses? Last,…

利用深度生存剂量反应函数推荐连续治疗AI 解读

We propose a general formulation for continuous treatment recommendation problems in settings with clinical survival data, which we call the Deep Survival Dose Response Function (DeepSDRF). That is, we consider the problem of learning the conditional average dose response (CADR) function solely from historical data in which observed factors (confounders) affect both observed treatment and time-to-event outcomes. The estimated treatment effect from DeepSDRF enables us to…

分期推行处理的最优实验设计AI 解读

In this paper, we study the design and analysis of experiments conducted on a set of units over multiple time periods where the starting time of the treatment may vary by unit. The design problem involves selecting an initial treatment time for each unit in order to most precisely estimate both the instantaneous and cumulative effects of the treatment. We first consider non-adaptive experiments, where all treatment assignment decisions are made prior to the start of the…

哪些模型有用？迈向统一的贝叶斯模型分类体系AI 解读

Probabilistic (Bayesian) modeling has experienced a surge of applications in almost all quantitative sciences and industrial areas. This development is driven by a combination of several factors, including better probabilistic estimation algorithms, flexible software, increased computing power, and a growing awareness of the benefits of probabilistic learning. However, a principled Bayesian model building workflow is far from complete and many challenges remain. To aid…

以深度学习时间序列因果推断量化北极放大的成因AI 解读

The warming of the Arctic, also known as Arctic amplification, is led by several atmospheric and oceanic drivers. However, the details of its underlying thermodynamic causes are still unknown. Inferring the causal effects of atmospheric processes on sea ice melt using fixed treatment effect strategies leads to unrealistic counterfactual estimations. Such models are also prone to bias due to time-varying confoundedness. Further, the complex non-linearity in Earth science data…

随机试验中高效处理效应推断的加权预后协变量调整AI 解读

A crucial task for a randomized controlled trial (RCT) is to specify a statistical method that can yield an efficient estimator and powerful test for the treatment effect. A novel and effective strategy to obtain efficient and powerful treatment effect inferences is to incorporate predictions from generative artificial intelligence (AI) algorithms into covariate adjustment for the regression analysis of a RCT. Training a generative AI algorithm on historical control data…

结构线性模型中非高斯维数的稳健估计AI 解读

Statistical identification of possibly non-fundamental SVARMA models requires structural errors: (i) to be an i.i.d process, (ii) to be mutually independent across components, and (iii) each of them must be non-Gaussian distributed. Hence, provided the first two requisites, it is crucial to evaluate the non-Gaussian identification condition. We address this problem by relating the non-Gaussian dimension of structural errors vector to the rank of a matrix built from the…