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Disentangled Latent Representation Learning for Tackling the Confounding M-Bias Problem in Causal Inference

应对混杂与 M 偏差的解耦潜在表征学习

In causal inference, it is a fundamental task to estimate the causal effect from observational data. However, latent confounders pose major challenges in causal inference in observational data, for example, confounding bias and M-bias. Recent data-driven causal effect estimators tackle the confounding bias problem via balanced representation learning, but assume no M-bias in the system, thus they fail to handle the M-bias. In this paper, we identify a challenging and…

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Generalized difference-in-differences

广义双重差分

We propose a new method for estimating causal effects in longitudinal/panel data settings that we call generalized difference-in-differences. Our approach unifies two alternative approaches in these settings: ignorability estimators (e.g., synthetic controls) and difference-in-differences (DiD) estimators. We propose a new identifying assumption -- a stable bias assumption -- which generalizes the conditional parallel trends assumption in DiD, leading to the proposed…

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BayesDAG: Gradient-Based Posterior Inference for Causal Discovery

BayesDAG:面向因果发现的梯度后验推断

Bayesian causal discovery aims to infer the posterior distribution over causal models from observed data, quantifying epistemic uncertainty and benefiting downstream tasks. However, computational challenges arise due to joint inference over combinatorial space of Directed Acyclic Graphs (DAGs) and nonlinear functions. Despite recent progress towards efficient posterior inference over DAGs, existing methods are either limited to variational inference on node permutation…

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Causal normalizing flows: from theory to practice

因果归一化流:从理论到实践

In this work, we deepen on the use of normalizing flows for causal reasoning. Specifically, we first leverage recent results on non-linear ICA to show that causal models are identifiable from observational data given a causal ordering, and thus can be recovered using autoregressive normalizing flows (NFs). Second, we analyze different design and learning choices for causal normalizing flows to capture the underlying causal data-generating process. Third, we describe how to…

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A simple sensitivity analysis method for unmeasured confounders via linear programming with estimating equation constraints

利用估计方程约束与线性规划开展未测混杂敏感性分析

In estimating the average treatment effect in observational studies, the influence of confounders should be appropriately addressed. To this end, the propensity score is widely used. If the propensity scores are known for all the subjects, bias due to confounders can be adjusted by using the inverse probability weighting (IPW) by the propensity score. Since the propensity score is unknown in general, it is usually estimated by the parametric logistic regression model with…

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Independent-Set Design of Experiments for Estimating Treatment and Spillover Effects under Network Interference

网络干扰下估计处理效应与溢出效应的独立集实验设计

Interference is ubiquitous when conducting causal experiments over networks. Except for certain network structures, causal inference on the network in the presence of interference is difficult due to the entanglement between the treatment assignments and the interference levels. In this article, we conduct causal inference under interference on an observed, sparse but connected network, and we propose a novel design of experiments based on an independent set. Compared to…

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Algorithm as Experiment: Machine Learning, Market Design, and Policy Eligibility Rules

算法即实验:机器学习、市场设计与政策资格规则

Algorithms make a growing portion of policy and business decisions. We develop a treatment-effect estimator using algorithmic decisions as instruments for a class of stochastic and deterministic algorithms. Our estimator is consistent and asymptotically normal for well-defined causal effects. A special case of our setup is multidimensional regression discontinuity designs with complex boundaries. We apply our estimator to evaluate the Coronavirus Aid, Relief, and Economic…

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A Theory Guide to Using Control Functions to Instrument Hazard Models

使用控制函数为风险率模型引入工具变量的理论指南

I develop the theory around using control functions to instrument hazard models, allowing the inclusion of endogenous (e.g., mismeasured) regressors. Simple discrete-data hazard models can be expressed as binary choice panel data models, and the widespread Prentice and Gloeckler (1978) discrete-data proportional hazards model can specifically be expressed as a complementary log-log model with time fixed effects. This allows me to recast it as GMM estimation and its…

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On the instrumental variable estimation with many weak and invalid instruments

大量弱且无效工具变量下的工具变量估计

We discuss the fundamental issue of identification in linear instrumental variable (IV) models with unknown IV validity. With the assumption of the "sparsest rule", which is equivalent to the plurality rule but becomes operational in computation algorithms, we investigate and prove the advantages of non-convex penalized approaches over other IV estimators based on two-step selections, in terms of selection consistency and accommodation for individually weak IVs. Furthermore,…

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A Graphical Approach to Treatment Effect Estimation with Observational Network Data

观测网络数据中治疗效应估计的图方法

We propose an easy-to-use adjustment estimator for the effect of a treatment based on observational data from a single (social) network of units. The approach allows for interactions among units within the network, called interference, and for observed confounding. We define a simplified causal graph that does not differentiate between units, called generic graph. Using valid adjustment sets determined in the generic graph, we can identify the treatment effect and build a…

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Multiply robust estimators in longitudinal studies with missing data under control-based imputation

基于对照组插补的纵向缺失数据多重稳健估计

Longitudinal studies are often subject to missing data. The ICH E9(R1) addendum addresses the importance of defining a treatment effect estimand with the consideration of intercurrent events. Jump-to-reference (J2R) is one classically envisioned control-based scenario for the treatment effect evaluation using the hypothetical strategy, where the participants in the treatment group after intercurrent events are assumed to have the same disease progress as those with identical…

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A Class of Directed Acyclic Graphs with Mixed Data Types in Mediation Analysis

中介分析中适用于混合数据类型的一类有向无环图

We propose a unified class of generalized structural equation models (GSEMs) with data of mixed types in mediation analysis, including continuous, categorical, and count variables. Such models extend substantially the classical linear structural equation model to accommodate many data types arising from the application of mediation analysis. Invoking the hierarchical modeling approach, we specify GSEMs by a copula joint distribution of outcome variable, mediator and exposure…

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Policy Evaluation for Temporal and/or Spatial Dependent Experiments

时间或空间依赖实验中的策略评估

The aim of this paper is to establish a causal link between the policies implemented by technology companies and the outcomes they yield within intricate temporal and/or spatial dependent experiments. We propose a novel temporal/spatio-temporal Varying Coefficient Decision Process (VCDP) model, capable of effectively capturing the evolving treatment effects in situations characterized by temporal and/or spatial dependence. Our methodology encompasses the decomposition of the…

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Marginal Density Ratio for Off-Policy Evaluation in Contextual Bandits

情境老虎机离线策略评估中的边际密度比

Off-Policy Evaluation (OPE) in contextual bandits is crucial for assessing new policies using existing data without costly experimentation. However, current OPE methods, such as Inverse Probability Weighting (IPW) and Doubly Robust (DR) estimators, suffer from high variance, particularly in cases of low overlap between target and behavior policies or large action and context spaces. In this paper, we introduce a new OPE estimator for contextual bandits, the Marginal Ratio…

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Linking convolutional kernel size to generalization bias in face analysis CNNs

卷积核大小与人脸分析 CNN 泛化偏差的联系

Training dataset biases are by far the most scrutinized factors when explaining algorithmic biases of neural networks. In contrast, hyperparameters related to the neural network architecture have largely been ignored even though different network parameterizations are known to induce different implicit biases over learned features. For example, convolutional kernel size is known to affect the frequency content of features learned in CNNs. In this work, we present a causal…

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A unified framework for covariate adjustment under stratified randomization

分层随机化下协变量调整的统一框架

Randomization, as a key technique in clinical trials, can eliminate sources of bias and produce comparable treatment groups. In randomized experiments, the treatment effect is a parameter of general interest. Researchers have explored the validity of using linear models to estimate the treatment effect and perform covariate adjustment and thus improve the estimation efficiency. However, the relationship between covariates and outcomes is not necessarily linear, and is often…

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Identification and Inference for Synthetic Controls with Confounding

存在混杂时合成控制的识别与推断

This paper studies inference on treatment effects in panel data settings with unobserved confounding. We model outcome variables through a factor model with random factors and loadings. Such factors and loadings may act as unobserved confounders: when the treatment is implemented depends on time-varying factors, and who receives the treatment depends on unit-level confounders. We study the identification of treatment effects and illustrate the presence of a trade-off between…

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Assessing treatment effect heterogeneity in the presence of missing effect modifier data in cluster-randomized trials

整群随机试验中效应修饰变量缺失时的治疗效应异质性评估

Understanding whether and how treatment effects vary across subgroups is crucial to inform clinical practice and recommendations. Accordingly, the assessment of heterogeneous treatment effects (HTE) based on pre-specified potential effect modifiers has become a common goal in modern randomized trials. However, when one or more potential effect modifiers are missing, complete-case analysis may lead to bias and under-coverage. While statistical methods for handling missing…

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Bayesian causal discovery from unknown general interventions

未知一般干预下的贝叶斯因果发现

We consider the problem of learning causal Directed Acyclic Graphs (DAGs) using combinations of observational and interventional experimental data. Current methods tailored to this setting assume that interventions either destroy parent-child relations of the intervened (target) nodes or only alter such relations without modifying the parent sets, even when the intervention targets are unknown. We relax this assumption by proposing a Bayesian method for causal discovery from…

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Applying the estimands framework to non-inferiority trials: guidance on choice of hypothetical estimands for non-adherence and comparison of estimation methods

非劣效试验中的估计目标框架:不依从的假想目标与估计方法比较

A common concern in non-inferiority (NI) trials is that non adherence due, for example, to poor study conduct can make treatment arms artificially similar. Because intention to treat analyses can be anti-conservative in this situation, per protocol analyses are sometimes recommended. However, such advice does not consider the estimands framework, nor the risk of bias from per protocol analyses. We therefore sought to update the above guidance using the estimands framework,…

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A Policy Gradient Method for Confounded POMDPs

混杂部分可观测马尔可夫决策过程的策略梯度方法

In this paper, we propose a policy gradient method for confounded partially observable Markov decision processes (POMDPs) with continuous state and observation spaces in the offline setting. We first establish a novel identification result to non-parametrically estimate any history-dependent policy gradient under POMDPs using the offline data. The identification enables us to solve a sequence of conditional moment restrictions and adopt the min-max learning procedure with…

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The Functional Average Treatment Effect

泛函平均处理效应

This paper establishes the functional average as an important estimand for causal inference. The significance of the estimand lies in its robustness against traditional issues of confounding. We prove that this robustness holds even when the probability distribution of the outcome, conditional on treatment or some other vector of adjusting variables, differs almost arbitrarily from its counterfactual analogue. This paper also examines possible estimators of the functional…

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Identification in Endogenous Sequential Treatment Regimes

内生序贯处理方案中的识别

This paper develops a novel nonparametric identification method for treatment effects in settings where individuals self-select into treatment sequences. I propose an identification strategy which relies on a dynamic version of standard Instrumental Variables (IV) assumptions and builds on a dynamic version of the Marginal Treatment Effects (MTE) as the fundamental building block for treatment effects. The main contribution of the paper is to relax assumptions on the support…

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Local causal effects with continuous exposures: A matching estimator for the average causal derivative effect

连续暴露的局部因果效应:平均因果导数效应的匹配估计

The estimation of causal effects is a fundamental goal in the field of causal inference. However, it is challenging for various reasons. One reason is that the exposure (or treatment) is naturally continuous in many real-world scenarios. When dealing with continuous exposure, dichotomizing the exposure variable based on a pre-defined threshold may result in a biased understanding of causal relationships. In this paper, we propose a novel causal inference framework that can…

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