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删失数据下纵向替代标志物的稳健评估AI 解读

The development of statistical methods to evaluate surrogate markers is an active area of research. In many clinical settings, the surrogate marker is not simply a single measurement but is instead a longitudinal trajectory of measurements over time, e.g., fasting plasma glucose measured every 6 months for 3 years. In general, available methods developed for the single-surrogate setting cannot accommodate a longitudinal surrogate marker. Furthermore, many of the methods have…

治疗方案响应曲线估计量的非参数评估AI 解读

Marginal structural models have been widely used in causal inference to estimate mean outcomes under either a static or a prespecified set of treatment decision rules. This approach requires imposing a working model for the mean outcome given a sequence of treatments and possibly baseline covariates. In this paper, we introduce a dynamic marginal structural model that can be used to estimate an optimal decision rule within a class of parametric rules. Specifically, we will…

早期疫苗试验中个体处理效应的随机化推断AI 解读

Randomization inference is a powerful tool in early phase vaccine trials when estimating the causal effect of a regimen against a placebo or another regimen. Randomization-based inference often focuses on testing either Fisher's sharp null hypothesis of no treatment effect for any participant or Neyman's weak null hypothesis of no sample average treatment effect. Many recent efforts have explored conducting exact randomization-based inference for other summaries of the…

基于变分自编码器的多层神经格兰杰因果连接学习框架AI 解读

Granger causality has been widely used in various application domains to capture lead-lag relationships amongst the components of complex dynamical systems, and the focus in extant literature has been on a single dynamical system. In certain applications in macroeconomics and neuroscience, one has access to data from a collection of related such systems, wherein the modeling task of interest is to extract the shared common structure that is embedded across them, as well as…

孕期身体活动对生活质量的影响：因果机器学习方法AI 解读

The concept of Quality of Life (QoL) refers to a holistic measurement of an individual's well-being, incorporating psychological and social aspects. Pregnant women, especially those with obesity and stress, often experience lower QoL. Physical activity (PA) has shown the potential to enhance the QoL. However, pregnant women who are overweight and obese rarely meet the recommended level of PA. Studies have investigated the relationship between PA and QoL during pregnancy…

GENIUS-MAWII：应对大量弱且无效工具变量的稳健孟德尔随机化AI 解读

Mendelian randomization (MR) has become a popular approach to study causal effects by using genetic variants as instrumental variables. We propose a new MR method, GENIUS-MAWII, which simultaneously addresses the two salient phenomena that adversely affect MR analyses: many weak instruments and widespread horizontal pleiotropy. Similar to MR GENIUS (Tchetgen Tchetgen et al., 2021), we achieve identification of the treatment effect by leveraging heteroscedasticity of the…

右删失下利用实验数据检验观察性研究AI 解读

Drawing causal inferences from observational studies (OS) requires unverifiable validity assumptions; however, one can falsify those assumptions by benchmarking the OS with experimental data from a randomized controlled trial (RCT). A major limitation of existing procedures is not accounting for censoring, despite the abundance of RCTs and OSes that report right-censored time-to-event outcomes. We consider two cases where censoring time (1) is independent of time-to-event…

算法辅助人类决策的最优策略AI 解读

We consider optimal regimes for algorithm-assisted human decision-making. Such regimes are decision functions of measured pre-treatment variables and, by leveraging natural treatment values, enjoy a "superoptimality" property whereby they are guaranteed to outperform conventional optimal regimes. When there is unmeasured confounding, the benefit of using superoptimal regimes can be considerable. When there is no unmeasured confounding, superoptimal regimes are identical to…

厘清整群随机试验中的估计目标AI 解读

Estimands can help clarify the interpretation of treatment effects and ensure that estimators are aligned to the study's objectives. Cluster randomised trials require additional attributes to be defined within the estimand compared to individually randomised trials, including whether treatment effects are marginal or cluster specific, and whether they are participant or cluster average. In this paper, we provide formal definitions of estimands encompassing both these…

干扰为何使定价实验产生假阳性结论AI 解读

It is standard practice in online retail to run pricing experiments by randomizing at the article-level, i.e. by changing prices of different products to identify treatment effects. Due to customers' cross-price substitution behavior, such experiments suffer from interference bias: the observed difference between treatment groups in the experiment is typically significantly larger than the global effect that could be expected after a roll-out decision of the tested pricing…

迈向自动化因果发现：5G 电信数据案例AI 解读

We introduce the concept of Automated Causal Discovery (AutoCD), defined as any system that aims to fully automate the application of causal discovery and causal reasoning methods. AutoCD's goal is to deliver all causal information that an expert human analyst would and answer a user's causal queries. We describe the architecture of such a platform, and illustrate its performance on synthetic data sets. As a case study, we apply it on temporal telecommunication data. The…

利用 Bootstrap 集成与置信度度量改进时间序列因果发现AI 解读

Learning causal graphs from multivariate time series is a ubiquitous challenge in all application domains dealing with time-dependent systems, such as in Earth sciences, biology, or engineering, to name a few. Recent developments for this causal discovery learning task have shown considerable skill, notably the specific time-series adaptations of the popular conditional independence-based learning framework. However, uncertainty estimation is challenging for conditional…

利用非混杂预测协变量提高双重稳健估计效率AI 解读

In observational studies, covariates with substantial missing data are often omitted, despite their strong predictive capabilities. These excluded covariates are generally believed not to simultaneously affect both treatment and outcome, indicating that they are not genuine confounders and do not impact the identification of the average treatment effect (ATE). In this paper, we introduce an alternative doubly robust (DR) estimator that fully leverages non-confounding…

结合 Group LASSO 扩展 Bagging MARS 的异质性处理效应估计AI 解读

Recent years, large scale clinical data like patient surveys and medical record data are playing an increasing role in medical data science. These large-scale clinical data, collectively referred to as "real-world data (RWD)". It is expected to be widely used in large-scale observational studies of specific diseases, personal medicine or precise medicine, finding the responder of drugs or treatments. Applying RWD for estimating heterogeneous treat ment effect (HTE) has…

存在治疗不依从时构造最优策略的敏感性分析AI 解读

The current body of research on developing optimal treatment strategies often places emphasis on intention-to-treat analyses, which fail to take into account the compliance behavior of individuals. Methods based on instrumental variables have been developed to determine optimal treatment strategies in the presence of endogeneity. However, these existing methods are not applicable when there are two active treatment options and the average causal effects of the treatments…

连接两种方法论：Angrist 与 Imbens 对因果识别的贡献AI 解读

In the 1990s, Joshua Angrist and Guido Imbens studied the causal interpretation of Instrumental Variable estimates (a widespread methodology in economics) through the lens of potential outcomes (a classical framework to formalize causality in statistics). Bridging a gap between those two strands of literature, they stress the importance of treatment effect heterogeneity and show that, under defendable assumptions in various applications, this method recovers an average…

在存在干扰的因果推断中引入主动学习：在线实验的新方法AI 解读

In the domain of causal inference research, the prevalent potential outcomes framework, notably the Rubin Causal Model (RCM), often overlooks individual interference and assumes independent treatment effects. This assumption, however, is frequently misaligned with the intricate realities of real-world scenarios, where interference is not merely a possibility but a common occurrence. Our research endeavors to address this discrepancy by focusing on the estimation of direct…

面向定向政策的非线性三重变化估计量AI 解读

The renowned difference-in-differences (DiD) estimator relies on the assumption of 'parallel trends,' which does not hold in many practical applications. To address this issue, the econometrics literature has turned to the triple difference estimator. Both DiD and triple difference are limited to assessing average effects exclusively. An alternative avenue is offered by the changes-in-changes (CiC) estimator, which provides an estimate of the entire counterfactual…

理解错位实施政策的双重差分：Medicaid 与 HIV 的应用AI 解读

While a randomized control trial is considered the gold standard for estimating causal treatment effects, there are many research settings in which randomization is infeasible or unethical. In such cases, researchers rely on analytical methods for observational data to explore causal relationships. Difference-in-differences (DID) is one such method that, most commonly, estimates a difference in some mean outcome in a group before and after the implementation of an…

通过逆协方差矩阵的稀疏分解学习大型因果结构AI 解读

Learning causal structures from observational data is a fundamental problem facing important computational challenges when the number of variables is large. In the context of linear structural equation models (SEMs), this paper focuses on learning causal structures from the inverse covariance matrix. The proposed method, called ICID for Independence-preserving Decomposition from Inverse Covariance matrix, is based on continuous optimization of a matrix decomposition model…

选择相关遗传变异后的比例共定位频率学检验AI 解读

Colocalization analyses assess whether two traits are affected by the same or distinct causal genetic variants in a single gene region. A class of Bayesian colocalization tests are now routinely used in practice; for example, for genetic analyses in drug development pipelines. In this work, we consider an alternative frequentist approach to colocalization testing that examines the proportionality of genetic associations with each trait. The proportional colocalization…

利用核 Stein 差异估计反事实密度AI 解读

Causal effects are usually studied in terms of the means of counterfactual distributions, which may be insufficient in many scenarios. Given a class of densities known up to normalizing constants, we propose to model counterfactual distributions by minimizing kernel Stein discrepancies in a doubly robust manner. This enables the estimation of counterfactuals over large classes of distributions while exploiting the desired double robustness. We present a theoretical analysis…

超越玩具模型的可信因果推断AI 解读

Causal inference with observational data critically relies on untestable and extra-statistical assumptions that have (sometimes) testable implications. Well-known sets of assumptions that are sufficient to justify the causal interpretation of certain estimators are called identification strategies. These templates for causal analysis, however, do not perfectly map into empirical research practice. Researchers are often left in the disjunctive of either abstracting away from…

观察性研究方案：回归不连续设计的应用AI 解读

In his 2022 IMS Medallion Lecture delivered at the Joint Statistical Meetings, Prof. Dylan S. Small eloquently advocated for the use of protocols in observational studies. We discuss his proposal and, inspired by his ideas, we develop a protocol for the regression discontinuity design.