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存在溢出效应时的合成控制：一项比较研究AI 解读

Iterative Synthetic Control Method is introduced in this study, a modification of the Synthetic Control Method (SCM) designed to improve its predictive performance by utilizing control units affected by the treatment in question. This method is then compared to other SCM modifications: SCM without any modifications, SCM after removing all spillover-affected units, Inclusive SCM, and the SP SCM model. For the comparison, Monte Carlo simulations are utilized, generating…

理解自适应实验后的统计推断AI 解读

Adaptive experiments such as multi-arm bandits adapt the treatment-allocation policy and/or the decision to stop the experiment to the data observed so far. This has the potential to improve outcomes for study participants within the experiment, to improve the chance of identifying best treatments after the experiment, and to avoid wasting data. Seen as an experiment (rather than just a continually optimizing system) it is still desirable to draw statistical inferences with…

利用距离秩的信息不平衡推断高维动态过程的因果关系AI 解读

We introduce an approach which allows detecting causal relationships between variables for which the time evolution is available. Causality is assessed by a variational scheme based on the Information Imbalance of distance ranks, a statistical test capable of inferring the relative information content of different distance measures. We test whether the predictability of a putative driven system Y can be improved by incorporating information from a potential driver system X,…

使用纵向数据研究多种治疗的因果效应：一项模拟研究AI 解读

Many clinical questions involve estimating the effects of multiple treatments using observational data. When using longitudinal data, the interest is often in the effect of treatment strategies that involve sustaining treatment over time. This requires causal inference methods appropriate for handling multiple treatments and time-dependent confounding. Robins Generalised methods (g-methods) are a family of methods which can deal with time-dependent confounding and some of…

局部同时推断AI 解读

Selective inference is the problem of giving valid answers to statistical questions chosen in a data-driven manner. A standard solution to selective inference is simultaneous inference, which delivers valid answers to the set of all questions that could possibly have been asked. However, simultaneous inference can be unnecessarily conservative if this set includes many questions that were unlikely to be asked in the first place. We introduce a less conservative solution to…

通过代理变量条件独立检验进行因果发现AI 解读

Distinguishing causal connections from correlations is important in many scenarios. However, the presence of unobserved variables, such as the latent confounder, can introduce bias in conditional independence testing commonly employed in constraint-based causal discovery for identifying causal relations. To address this issue, existing methods introduced proxy variables to adjust for the bias caused by unobserveness. However, these methods were either limited to categorical…

利用整群 SMART 数据比较整群自适应干预的有限样本校正AI 解读

Adaptive interventions, aka dynamic treatment regimens, are sequences of pre-specified decision rules that guide the provision of treatment for an individual given information about their baseline and evolving needs, including in response to prior intervention. Clustered adaptive interventions (cAIs) extend this idea by guiding the provision of intervention at the level of clusters (e.g., clinics), but with the goal of improving outcomes at the level of individuals within…

利用双重机器学习估计因果效应：方法评估AI 解读

The estimation of causal effects with observational data continues to be a very active research area. In recent years, researchers have developed new frameworks which use machine learning to relax classical assumptions necessary for the estimation of causal effects. In this paper, we review one of the most prominent methods - "double/debiased machine learning" (DML) - and empirically evaluate it by comparing its performance on simulated data relative to more traditional…

纵向实验的混杂校正：基于潜在条件可交换性的非线性混合效应标准化AI 解读

Non-linear mixed effects modeling and simulation (NLME M&S) is evaluated to be used for standardization with longitudinal data in presence of confounders. Standardization is a well-known method in causal inference to correct for confounding by analyzing and combining results from subgroups of patients. We show that non-linear mixed effects modeling is a particular implementation of standardization that conditions on individual parameters described by the random effects of…

线性估计量的敏感性分析AI 解读

We propose a novel sensitivity analysis framework for linear estimators with identification failures that can be viewed as seeing the wrong outcome distribution. Our approach measures the degree of identification failure through the change in measure between the observed distribution and a hypothetical target distribution that would identify the causal parameter of interest. The framework yields a sensitivity analysis that generalizes existing bounds for Average Potential…

异质因果效应估计中模型选择的实证分析AI 解读

We study the problem of model selection in causal inference, specifically for conditional average treatment effect (CATE) estimation. Unlike machine learning, there is no perfect analogue of cross-validation for model selection as we do not observe the counterfactual potential outcomes. Towards this, a variety of surrogate metrics have been proposed for CATE model selection that use only observed data. However, we do not have a good understanding regarding their…

约束条件下的最优处理分配AI 解读

In optimal policy problems where treatment effects vary at the individual level, optimally allocating treatments to recipients is complex even when potential outcomes are known. We present an algorithm for multi-arm treatment allocation problems that is guaranteed to find the optimal allocation in strongly polynomial time, and which is able to handle arbitrary potential outcomes as well as constraints on treatment requirement and capacity. Further, starting from an arbitrary…

横截面观测数据的通用因果推断框架AI 解读

Causal inference methods for observational data are highly regarded due to their wide applicability. While there are already numerous methods available for de-confounding bias, these methods generally assume that covariates consist solely of confounders or make naive assumptions about the covariates. Such assumptions face challenges in both theory and practice, particularly when dealing with high-dimensional covariates. Relaxing these naive assumptions and identifying the…

不公平背后是什么？强化学习中的动态公平性AI 解读

In sequential decision-making problems involving sensitive attributes like race and gender, reinforcement learning (RL) agents must carefully consider long-term fairness while maximizing returns. Recent works have proposed many different types of fairness notions, but how unfairness arises in RL problems remains unclear. In this paper, we address this gap in the literature by investigating the sources of inequality through a causal lens. We first analyse the causal…

马氏平衡：近似协变量平衡的多变量视角AI 解读

In the past decade, various exact balancing-based weighting methods were introduced to the causal inference literature. Exact balancing alleviates the extreme weight and model misspecification issues that may incur when one implements inverse probability weighting. It eliminates covariate imbalance by imposing balancing constraints in an optimization problem. The optimization problem can nevertheless be infeasible when there is bad overlap between the covariate distributions…

始终存活者及其他人群因果效应界限的统一框架AI 解读

We investigate the bounding problem of causal effects in experimental studies in which the outcome is truncated by death, meaning that the subject dies before the outcome can be measured. Causal effects cannot be point identified without instruments and/or tight parametric assumptions but can be bounded under mild restrictions. Previous work on partial identification under the principal stratification framework has primarily focused on the `always-survivor' subpopulation. In…

Riesz 表示元的对抗式估计AI 解读

Many causal parameters are linear functionals of an underlying regression. The Riesz representer is a key component in the asymptotic variance of a semiparametrically estimated linear functional. We propose an adversarial framework to estimate the Riesz representer using general function spaces. We prove a nonasymptotic mean square rate in terms of an abstract quantity called the critical radius, then specialize it for neural networks, random forests, and reproducing kernel…

没有外生变异时反向因果关系的可检验性AI 解读

This paper shows that testability of reverse causality is possible even in the absence of exogenous variation, such as in the form of instrumental variables. Instead of relying on exogenous variation, we achieve testability by imposing relatively weak model restrictions and exploiting that a dependence of residual and purported cause is informative about the causal direction. Our main assumption is that the true functional relationship is nonlinear and that error terms are…

份额—冲击设计中的过度识别AI 解读

This paper studies the testability of identifying restrictions commonly employed to assign a causal interpretation to two stage least squares (TSLS) estimators based on Bartik instruments. For homogeneous effects models applied to short panels, our analysis yields testable implications previously noted in the literature for the two major available identification strategies. We propose overidentification tests for these restrictions that remain valid in high dimensional…

Neyman 与因果机器学习：个体化处理规则的实验评估AI 解读

A century ago, Neyman showed how to evaluate the efficacy of treatment using a randomized experiment under a minimal set of assumptions. This classical repeated sampling framework serves as a basis of routine experimental analyses conducted by today's scientists across disciplines. In this paper, we demonstrate that Neyman's methodology can also be used to experimentally evaluate the efficacy of individualized treatment rules (ITRs), which are derived by modern causal…

通过幂似然结合实验与观察数据AI 解读

Randomized controlled trials are the gold standard for causal inference and play a pivotal role in modern evidence-based medicine. However, the sample sizes they use are often too limited to draw significant causal conclusions for subgroups that are less prevalent in the population. In contrast, observational data are becoming increasingly accessible in large volumes but can be subject to bias as a result of hidden confounding. Given these complementary features, we propose…

跨研究异质性处理效应估计的多研究 R-learnerAI 解读

Estimating heterogeneous treatment effects (HTEs) is crucial for precision medicine. While multiple studies can improve the generalizability of results, leveraging them for estimation is statistically challenging. Existing approaches often assume identical HTEs across studies, but this may be violated due to various sources of between-study heterogeneity, including differences in study design, study populations, and data collection protocols, among others. To this end, we…

研究治疗启动时间窗时克隆—删失—加权法的复杂估计对象AI 解读

Clone-censor-weighting (CCW) is an analytic method for studying treatment regimens that are indistinguishable from one another at baseline without relying on landmark dates or creating immortal person time. One particularly interesting CCW application is estimating outcomes when starting treatment within specific time windows in observational data (e.g., starting a treatment within 30 days of hospitalization). In such cases, CCW estimates something fairly complex. We show…

异方差下一般析因设计的协方差分析：多重对比检验AI 解读

A common goal in clinical trials is to conduct tests on estimated treatment effects adjusted for covariates such as age or sex. Analysis of Covariance (ANCOVA) is often used in these scenarios to test the global null hypothesis of no treatment effect using an $F$-test. However, in several samples, the $F$-test does not provide any information about individual null hypotheses and has strict assumptions such as variance homoscedasticity. We extend the method proposed by…