论文检索

nph2ph 变换及其在已完成临床试验统计分析中的应用AI 解读

We present several illustrations from completed clinical trials on a statistical approach that allows us to gain useful insights regarding the time dependency of treatment effects. Our approach leans on a simple proposition: all non-proportional hazards (NPH) models are equivalent to a proportional hazards model. The nph2ph transform brings an NPH model into a PH form. We often find very simple approximations for this transform, enabling us to analyze complex NPH…

利用表征平衡学习聚类数据中的条件平均剂量反应AI 解读

Estimating a unit's responses to interventions with an associated dose, the "conditional average dose response" (CADR), is relevant in a variety of domains, from healthcare to business, economics, and beyond. Such a response typically needs to be estimated from observational data, which introduces several challenges. That is why the machine learning (ML) community has proposed several tailored CADR estimators. Yet, the proposal of most of these methods requires strong…

因果推断中的结构方程模型与贝叶斯网络整合：积极青少年发展案例AI 解读

In this study, the combined use of structural equation modeling (SEM) and Bayesian network modeling (BNM) in causal inference analysis is revisited. The perspective highlights the debate between proponents of using BNM as either an exploratory phase or even as the sole phase in the definition of structural models, and those advocating for SEM as the superior alternative for exploratory analysis. The individual strengths and limitations of SEM and BNM are recognized, but this…

样本选择下异质性治疗效应的界：社交媒体与政治极化应用AI 解读

We propose a method for estimation and inference for bounds for heterogeneous causal effect parameters in general sample selection models where the treatment can affect whether an outcome is observed and no exclusion restrictions are available. The method provides conditional effect bounds as functions of policy relevant pre-treatment variables. It allows for conducting valid statistical inference on the unidentified conditional effects. We use a flexible debiased/double…

从小样本开始：利用精确有限样本似然在随机试验中优先考虑安全性AI 解读

We use the exact finite sample likelihood and statistical decision theory to answer questions of ``why?'' and ``what should you have done?'' using data from randomized experiments and a utility function that prioritizes safety over efficacy. We propose a finite sample Bayesian decision rule and a finite sample maximum likelihood decision rule. We show that in finite samples from 2 to 50, it is possible for these rules to achieve better performance according to established…

单人移动设备非平稳时间序列中的时变因果效应：目标量与识别AI 解读

Mobile technology (mobile phones and wearable devices) generates continuous data streams encompassing outcomes, exposures and covariates, presented as intensive longitudinal or multivariate time series data. The high frequency of measurements enables granular and dynamic evaluation of treatment effect, revealing their persistence and accumulation over time. Existing methods predominantly focus on the contemporaneous effect, temporal-average, or population-average effects,…

用于肿瘤免疫治疗临床试验的半参数分段加速失效时间模型AI 解读

Effectiveness of immune-oncology chemotherapies has been presented in recent clinical trials. The Kaplan-Meier estimates of the survival functions of the immune therapy and the control often suggested the presence of the lag-time until the immune therapy began to act. It implies the use of hazard ratio under the proportional hazards assumption would not be appealing, and many alternatives have been investigated such as the restricted mean survival time. In addition to such…

随机对照试验中的地球观测与效应异质性：数据、模型及评价指标的选择AI 解读

Many social and environmental phenomena are associated with macroscopic changes in the built environment, captured by satellite imagery on a global scale and with daily temporal resolution. While widely used for prediction, these images and especially image sequences remain underutilized for causal inference, especially in the context of randomized controlled trials (RCTs), where causal identification is established by design. In this paper, we develop and compare a set of…

分箱散点回归与 Binsreg 软件包AI 解读

We introduce the package Binsreg, which implements the binscatter methods developed by Cattaneo, Crump, Farrell, and Feng (2024b,a). The package includes seven commands: binsreg, binslogit, binsprobit, binsqreg, binstest, binspwc, and binsregselect. The first four commands implement binscatter plotting, point estimation, and uncertainty quantification (confidence intervals and confidence bands) for least squares linear binscatter regression (binsreg) and for nonlinear…

随机系数结构方程模型中的最优最坏风险最小化AI 解读

The insight that causal parameters are particularly suitable for out-of-sample prediction has sparked a lot development of causal-like predictors. However, the connection with strict causal targets, has limited the development with good risk minimization properties, but without a direct causal interpretation. In this manuscript we derive the optimal out-of-sample risk minimizing predictor of a certain target $Y$ in a non-linear system $(X,Y)$ that has been trained in several…

面向多个二元结局的 W-method 与 A-learner 扩展AI 解读

In this study, we compared two groups, in which subjects were assigned to either the treatment or the control group. In such trials, if the efficacy of the treatment cannot be demonstrated in a population that meets the eligibility criteria, identifying the subgroups for which the treatment is effective is desirable. Such subgroups can be identified by estimating heterogeneous treatment effects (HTE). In recent years, methods for estimating HTE have increasingly relied on…

一般干预下结局条件化偏效应的识别与推断AI 解读

This paper proposes a new class of distributional causal quantities, referred to as the \textit{outcome conditioned partial policy effects} (OCPPEs), to measure the \textit{average} effect of a general counterfactual intervention of a target covariate on the individuals in different quantile ranges of the outcome distribution. The OCPPE approach is valuable in several aspects: (i) Unlike the unconditional quantile partial effect (UQPE) that is not $\sqrt{n}$-estimable, an…

线性工具变量回归中的稳健置换检验AI 解读

This paper develops permutation versions of identification-robust tests in linear instrumental variables (IV) regression. Unlike the existing randomization and rank-based tests in which independence between the instruments and the error terms is assumed, the permutation Anderson- Rubin (AR), Lagrange Multiplier (LM) and Conditional Likelihood Ratio (CLR) tests are asymptotically similar and robust to conditional heteroskedasticity under standard exclusion restriction i.e.…

随机实验中分布处理效应的估计：利用机器学习降低方差AI 解读

We propose a novel regression adjustment method designed for estimating distributional treatment effect parameters in randomized experiments. Randomized experiments have been extensively used to estimate treatment effects in various scientific fields. However, to gain deeper insights, it is essential to estimate distributional treatment effects rather than relying solely on average effects. Our approach incorporates pre-treatment covariates into a distributional regression…

分层实验中的协变量调整AI 解读

This paper studies covariate adjusted estimation of the average treatment effect in stratified experiments. We work in a general framework that includes matched tuples designs, coarse stratification, and complete randomization as special cases. Regression adjustment with treatment-covariate interactions is known to weakly improve efficiency for completely randomized designs. By contrast, we show that for stratified designs such regression estimators are generically…

时间序列的局部神经网络建模：美国货币政策案例AI 解读

In this paper, we investigate a semiparametric regression model under the context of treatment effects via a localized neural network (LNN) approach. Due to a vast number of parameters involved, we reduce the number of effective parameters by (i) exploring the use of identification restrictions; and (ii) adopting a variable selection method based on the group-LASSO technique. Subsequently, we derive the corresponding estimation theory and propose a dependent wild bootstrap…

存在试验参与效应时随机试验因果推断的推广与迁移AI 解读

Trial engagement effects are effects of trial participation on the outcome that are not mediated by treatment assignment. Most work on extending (generalizing or transporting) causal inferences from a randomized trial to a target population has, explicitly or implicitly, assumed that trial engagement effects are absent, allowing evidence about the effects of the treatments examined in trials to be applied to non-experimental settings. Here, we define novel causal estimands…

利用工具变量时间序列识别因果效应：辅助变量与历史依赖调整AI 解读

Instrumental variable (IV) regression relies on instruments to infer causal effects from observational data with unobserved confounding. We consider IV regression in time series models, such as vector auto-regressive (VAR) processes. Direct applications of i.i.d. techniques are generally inconsistent as they do not correctly adjust for dependencies in the past. In this paper, we outline the difficulties that arise due to time structure and propose methodology for…

用于学习断点回归异质性效应的改进 BARTAI 解读

This paper introduces BART-RDD, a sum-of-trees regression model built around a novel regression tree prior, which incorporates the special covariate structure of regression discontinuity designs. Specifically, the tree splitting process is constrained to ensure overlap within a narrow band surrounding the running variable cutoff value, where the treatment effect is identified. It is shown that unmodified BART-based models estimate RDD treatment effects poorly, while our…

复杂处理下的因果推断：综述AI 解读

Causal inference plays an important role in explanatory analysis and decision making across various fields like statistics, marketing, health care, and education. Its main task is to estimate treatment effects and make intervention policies. Traditionally, most of the previous works typically focus on the binary treatment setting that there is only one treatment for a unit to adopt or not. However, in practice, the treatment can be much more complex, encompassing…

纳入非同期对照的平台试验治疗比较AI 解读

Shared controls in platform trials comprise concurrent and non-concurrent controls. For a given experimental arm, non-concurrent controls refer to data from patients allocated to the control arm before the arm enters the trial. The use of non-concurrent controls in the analysis is attractive because it may increase the trial's power of testing treatment differences while decreasing the sample size. However, since arms are added sequentially in the trial, randomization occurs…

基于有效连接的癫痫发作脑层级变化拓扑分析AI 解读

Traditional Topological Data Analysis (TDA) methods, such as Persistent Homology (PH), rely on distance measures (e.g., cross-correlation, partial correlation, coherence, and partial coherence) that are symmetric by definition. While useful for studying topological patterns in functional brain connectivity, the main limitation of these methods is their inability to capture the directional dynamics - which is crucial for understanding effective brain connectivity. We propose…

利用凝聚型层次聚类选择有效工具变量AI 解读

We propose a procedure which combines hierarchical clustering with a test of overidentifying restrictions for selecting valid instrumental variables (IV) from a large set of IVs. Some of these IVs may be invalid in that they fail the exclusion restriction. We show that if the largest group of IVs is valid, our method achieves oracle properties. Unlike existing techniques, our work deals with multiple endogenous regressors. Simulation results suggest an advantageous…

整合多项多变量结局观察研究的因果元分析AI 解读

Integrating multiple observational studies to make unconfounded causal or descriptive comparisons of group potential outcomes in a large natural population is challenging. Moreover, retrospective cohorts, being convenience samples, are usually unrepresentative of the natural population of interest and have groups with unbalanced covariates. We propose a general covariate-balancing framework based on pseudo-populations that extends established weighting methods to the…