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Multiple conditional randomization tests for lagged and spillover treatment effects

滞后与溢出处理效应的多个条件随机化检验

We consider the problem of constructing multiple independent conditional randomization tests using a single dataset. Because the tests are independent, the randomization p-values can be interpreted individually and combined using standard methods for multiple testing. We give a simple, sequential construction of such tests, and then discuss its application to three problems: Rosenbaum's evidence factors for observational studies, lagged treatment effect in stepped-wedge…

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Federated Offline Policy Learning

联邦离线策略学习

We consider the problem of learning personalized decision policies from observational bandit feedback data across multiple heterogeneous data sources. In our approach, we introduce a novel regret analysis that establishes finite-sample upper bounds on distinguishing notions of global regret for all data sources on aggregate and of local regret for any given data source. We characterize these regret bounds by expressions of source heterogeneity and distribution shift.…

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Robust Offline Policy Learning with Observational Data from Multiple Sources

利用多来源观察数据开展鲁棒离线策略学习

We consider the problem of using observational bandit feedback data from multiple heterogeneous data sources to learn a personalized decision policy that robustly generalizes across diverse target settings. To achieve this, we propose a minimax regret optimization objective to ensure uniformly low regret under general mixtures of the source distributions. We develop a policy learning algorithm tailored to this objective, combining doubly robust offline policy evaluation…

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A causal inference framework for spatial confounding

空间混杂的因果推断框架

Over the past few decades, addressing "spatial confounding" has become a major topic in spatial statistics. However, the literature has provided conflicting definitions, and many proposed solutions are tied to specific analysis models and do not address the issue of confounding as it is understood in causal inference. We offer an analysis-model-agnostic definition of spatial confounding as the existence of an unmeasured causal confounder variable with a spatial structure. We…

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Addressing selection bias in cluster randomized experiments via weighting

通过加权处理整群随机试验中的选择偏差

In cluster randomized experiments, individuals are often recruited after the cluster treatment assignment, and data are typically only available for the recruited sample. Post-randomization recruitment can lead to selection bias, inducing systematic differences between the overall and the recruited populations, and between the recruited intervention and control arms. In this setting, we define causal estimands for the overall and the recruited populations. We prove, under…

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General Covariance-Based Conditions for Central Limit Theorems with Dependent Triangular Arrays

依赖三角阵中心极限定理的一般协方差条件

We present a general central limit theorem with simple, easy-to-check covariance-based sufficient conditions for triangular arrays of random vectors when all variables could be interdependent. The result is constructed from Stein's method, but the conditions are distinct from related work. We show that these covariance conditions nest standard assumptions studied in the literature such as $M$-dependence, mixing random fields, non-mixing autoregressive processes, and…

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Causal Inference for Continuous Multiple Time Point Interventions

连续多时点干预的因果推断

There are limited options to estimate the treatment effects of variables which are continuous and measured at multiple time points, particularly if the true dose-response curve should be estimated as closely as possible. However, these situations may be of relevance: in pharmacology, one may be interested in how outcomes of people living with -- and treated for -- HIV, such as viral failure, would vary for time-varying interventions such as different drug concentration…

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Modeling Causal Mechanisms with Diffusion Models for Interventional and Counterfactual Queries

利用扩散模型刻画因果机制并回答干预与反事实问题

We consider the problem of answering observational, interventional, and counterfactual queries in a causally sufficient setting where only observational data and the causal graph are available. Utilizing the recent developments in diffusion models, we introduce diffusion-based causal models (DCM) to learn causal mechanisms, that generate unique latent encodings. These encodings enable us to directly sample under interventions and perform abduction for counterfactuals.…

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Local Effects of Continuous Instruments without Positivity

无需正值性假设的连续工具变量局部效应

Instrumental variables are a popular study design for the estimation of treatment effects in the presence of unobserved confounders. In the canonical instrumental variables design, the instrument is a binary variable. In many settings, however, the instrument is continuous. Standard estimation methods can be applied with continuous instruments, but they require strong assumptions. While recent work has introduced more flexible estimation approaches, these methods require a…

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Finitely Heterogeneous Treatment Effect in Event-study

事件研究中的有限类型异质性处理效应

A key assumption of the differences-in-differences designs is that the average evolution of untreated potential outcomes is the same across different treatment cohorts: a parallel trends assumption. In this paper, we relax the parallel trend assumption by assuming a latent type variable and developing a type-specific parallel trend assumption. With a finite support assumption on the latent type variable and long pretreatment time periods, we show that an extremum classifier…

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Direct Estimation for Commonly Used Pattern-Mixture Models in Clinical Trials

临床试验常用模式混合模型的直接估计

Pattern-mixture models have received increasing attention as they are commonly used to assess treatment effects in primary or sensitivity analyses for clinical trials with nonignorable missing data. Pattern-mixture models have traditionally been implemented using multiple imputation, where the variance estimation may be a challenge because the Rubin's approach of combining between- and within-imputation variance may not provide consistent variance estimation while bootstrap…

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Separable pathway effects of semi-competing risks using multi-state models

利用多状态模型分解半竞争风险中的可分离路径效应

Semi-competing risks refer to the phenomenon where a primary event (such as mortality) can ``censor'' an intermediate event (such as relapse of a disease), but not vice versa. Under the multi-state model, the primary event consists of two specific types: the direct outcome event and an indirect outcome event developed from intermediate events. Within this framework, we show that the total treatment effect on the cumulative incidence of the primary event can be decomposed…

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A Non-parametric Direct Learning Approach to Heterogeneous Treatment Effect Estimation under Unmeasured Confounding

未测量混杂下异质性处理效应的非参数直接学习方法

In many social, behavioral, and biomedical sciences, treatment effect estimation is a crucial step in understanding the impact of an intervention, policy, or treatment. In recent years, an increasing emphasis has been placed on heterogeneity in treatment effects, leading to the development of various methods for estimating Conditional Average Treatment Effects (CATE). These approaches hinge on a crucial identifying condition of no unmeasured confounding, an assumption that…

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Robust Domain Generalisation with Causal Invariant Bayesian Neural Networks

利用因果不变贝叶斯神经网络实现稳健域泛化

Deep neural networks can obtain impressive performance on various tasks under the assumption that their training domain is identical to their target domain. Performance can drop dramatically when this assumption does not hold. One explanation for this discrepancy is the presence of spurious domain-specific correlations in the training data that the network exploits. Causal mechanisms, in the other hand, can be made invariant under distribution changes as they allow…

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Efficient Asymmetric Causality Tests

高效的非对称因果关系检验

Asymmetric causality tests are increasingly gaining popularity in different scientific fields. This approach corresponds better to reality since logical reasons behind asymmetric behavior exist and need to be considered in empirical investigations. Hatemi-J (2012) introduced the asymmetric causality tests via partial cumulative sums for positive and negative components of the variables operating within the vector autoregressive (VAR) model. However, since the residuals…

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Comparing HIV Vaccine Immunogenicity across Trials with Different Populations and Study Designs

跨人群与研究设计比较 HIV 疫苗免疫原性

Safe and effective preventive vaccines have the potential to help stem the HIV epidemic. The efficacy of such vaccines is typically measured in randomized, double-blind phase IIb/III trials and described as a reduction in newly acquired HIV infections. However, such trials are often expensive, time-consuming, and/or logistically challenging. These challenges lead to a great interest in immune responses induced by vaccination, and in identifying which immune responses predict…

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Neural Networks Decoded: Targeted and Robust Analysis of Neural Network Decisions via Causal Explanations and Reasoning

解码神经网络:基于因果解释与推理的针对性稳健分析

Despite their success and widespread adoption, the opaque nature of deep neural networks (DNNs) continues to hinder trust, especially in critical applications. Current interpretability solutions often yield inconsistent or oversimplified explanations, or require model changes that compromise performance. In this work, we introduce TRACER, a novel method grounded in causal inference theory designed to estimate the causal dynamics underpinning DNN decisions without altering…

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$\texttt{rdid}$ and $\texttt{rdidstag}$: Stata commands for robust difference-in-differences

rdid 与 rdidstag:稳健双重差分的 Stata 命令

This article provides a Stata package for the implementation of the robust difference-in-differences (RDID) method developed in Ban and Kédagni (2023). It contains three main commands: $\texttt{rdid}$, $\texttt{rdid_dy}$, $\texttt{rdidstag}$, which we describe in the introduction and the main text. We illustrate these commands through simulations and empirical examples.

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Nonparametric Jackknife Instrumental Variable Estimation and Confounding Robust Surrogate Indices

非参数刀切工具变量估计与抗混杂替代指标

Jackknife instrumental variable estimation (JIVE) is a classic method to leverage many weak instrumental variables (IVs) to estimate linear structural models, overcoming the bias of standard methods like two-stage least squares. In this paper, we extend the jackknife approach to nonparametric IV (NPIV) models with many weak IVs. Since NPIV characterizes the structural regression as having residuals projected onto the IV being zero, existing approaches minimize an estimate of…

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A Bayesian Method for Adverse Effects Estimation in Observational Studies with Truncation by Death

死亡截断下观察性研究不良事件效应的贝叶斯估计

Death among subjects is common in observational studies evaluating the causal effects of interventions among geriatric or severely ill patients. High mortality rates complicate the comparison of the prevalence of adverse events (AEs) between interventions. This problem is often referred to as outcome "truncation" by death. A possible solution is to estimate the survivor average causal effect (SACE), an estimand that evaluates the effects of interventions among those who…

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Causal Message Passing for Experiments with Unknown and General Network Interference

未知一般网络干扰实验中的因果消息传递

Randomized experiments are a powerful methodology for data-driven evaluation of decisions or interventions. Yet, their validity may be undermined by network interference. This occurs when the treatment of one unit impacts not only its outcome but also that of connected units, biasing traditional treatment effect estimations. Our study introduces a new framework to accommodate complex and unknown network interference, moving beyond specialized models in the existing…

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Confidence Sets for Causal Orderings

因果排序的置信集合

Causal discovery procedures aim to deduce causal relationships among variables in a multivariate dataset. While various methods have been proposed for estimating a single causal model or a single equivalence class of models, less attention has been given to quantifying uncertainty in causal discovery in terms of confidence statements. A primary challenge in causal discovery of directed acyclic graphs is determining a causal ordering among the variables, and our work offers a…

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Local Projections Inference with High-Dimensional Covariates without Sparsity

无需稀疏性假设的高维协变量局部投影推断

This paper presents a comprehensive local projections (LP) framework for estimating future responses to current shocks, robust to high-dimensional controls without relying on sparsity assumptions. The approach is applicable to various settings, including impulse response analysis and difference-in-differences (DiD) estimation. While methods like LASSO exist, they often assume most parameters are exactly zero, limiting their effectiveness in dense data generation processes. I…

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Partially Identified Heterogeneous Treatment Effect with Selection: An Application to Gender Gaps

样本选择下异质性处理效应的部分识别:性别差距应用

This paper addresses the sample selection model within the context of the gender gap problem, where even random treatment assignment is affected by selection bias. By offering a robust alternative free from distributional or specification assumptions, we bound the treatment effect under the sample selection model with an exclusion restriction, an assumption whose validity is tested in the literature. This exclusion restriction allows for further segmentation of the…

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