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静态面板数据估计量的动态偏差AI 解读

This paper identifies an important bias - termed dynamic bias - in fixed effects panel estimators that arises when dynamic feedback is ignored in the estimating equation. Dynamic feedback occurs if past outcomes impact current outcomes, a feature of many settings ranging from economic growth to agricultural and labor markets. When estimating equations omit past outcomes, dynamic bias can lead to significantly inaccurate treatment effect estimates, even with randomly assigned…

异质性处理效应估计中的缺失协变量问题AI 解读

Many applications of causal inference require using treatment effects estimated on a study population to make decisions in a separate target population. We consider the challenging setting where there are covariates that are observed in the target population that were not seen in the original study. Our goal is to estimate the tightest possible bounds on heterogeneous treatment effects conditioned on such newly observed covariates. We introduce a novel partial identification…

基于结构因果关系的可泛化概念发现模型AI 解读

The rising need for explainable deep neural network architectures has utilized semantic concepts as explainable units. Several approaches utilizing disentangled representation learning estimate the generative factors and utilize them as concepts for explaining DNNs. However, even though the generative factors for a dataset remain fixed, concepts are not fixed entities and vary based on downstream tasks. In this paper, we propose a disentanglement mechanism utilizing a…

评估临床试验与观察数据中处理效应异质性的现代方法AI 解读

In this paper we review recent advances in statistical methods for the evaluation of the heterogeneity of treatment effects (HTE), including subgroup identification and estimation of individualized treatment regimens, from randomized clinical trials and observational studies. We identify several types of approaches using the features introduced in Lipkovich, Dmitrienko and D'Agostino (2017) that distinguish the recommended principled methods from basic methods for HTE…

基于贝叶斯方法的倾向得分分层估计器AI 解读

Subclassification estimators are one of the methods used to estimate causal effects of interest using the propensity score. This method is more stable compared to other weighting methods, such as inverse probability weighting estimators, in terms of the variance of the estimators. In subclassification estimators, the number of strata is traditionally set at five, and this number is not typically chosen based on data information. Even when the number of strata is selected,…

利用 HeartSteps 微随机试验的纵向函数数据建模移动健康干预的时变效应AI 解读

To optimize mobile health interventions and advance domain knowledge on intervention design, it is critical to understand how the intervention effect varies over time and with contextual information. This study aims to assess how a push notification suggesting physical activity influences individuals' step counts using data from the HeartSteps micro-randomized trial (MRT). The statistical challenges include the time-varying treatments and longitudinal functional step count…

基于异质环境优化的因果估计AI 解读

This paper presents a new optimization approach to causal estimation. Given data that contains covariates and an outcome, which covariates are causes of the outcome, and what is the strength of the causality? In classical machine learning (ML), the goal of optimization is to maximize predictive accuracy. However, some covariates might exhibit a non-causal association with the outcome. Such spurious associations provide predictive power for classical ML, but they prevent us…

利用共享神经元 RBF 网络估计个体化多处理响应曲线AI 解读

Heterogeneous treatment effect estimation is an important problem in precision medicine. Specific interests lie in identifying the differential effect of different treatments based on some external covariates. We propose a novel non-parametric treatment effect estimation method in a multi-treatment setting. Our non-parametric modeling of the response curves relies on radial basis function (RBF)-nets with shared hidden neurons. Our model thus facilitates modeling commonality…

利用多个工具变量识别离散、有序及连续处理的因果效应AI 解读

Inferring causal relationships from observational data is often challenging due to endogeneity. This paper provides new identification results for causal effects of discrete, ordered and continuous treatments using multiple binary instruments. The key contribution is the identification of a new causal parameter that has a straightforward interpretation with a positive weighting scheme and is applicable in many settings due to a mild monotonicity assumption. This paper…

缺失数据下因果效应的可恢复性：一项纵向案例研究AI 解读

Missing data in multiple variables is a common issue. We investigate the applicability of the framework of graphical models for handling missing data to a complex longitudinal pharmacological study of children with HIV treated with an efavirenz-based regimen as part of the CHAPAS-3 trial. Specifically, we examine whether the causal effects of interest, defined through static interventions on multiple continuous variables, can be recovered (estimated consistently) from the…

利用工具变量识别稀疏因果效应AI 解读

Exogenous heterogeneity, for example, in the form of instrumental variables can help us learn a system's underlying causal structure and predict the outcome of unseen intervention experiments. In this paper, we consider linear models in which the causal effect from covariates $X$ on a response $Y$ is sparse. We provide conditions under which the causal coefficient becomes identifiable from the observed distribution. These conditions can be satisfied even if the number of…

异质性处理效应的数据驱动估计AI 解读

Estimating how a treatment affects different individuals, known as heterogeneous treatment effect estimation, is an important problem in empirical sciences. In the last few years, there has been a considerable interest in adapting machine learning algorithms to the problem of estimating heterogeneous effects from observational and experimental data. However, these algorithms often make strong assumptions about the observed features in the data and ignore the structure of the…

Multi-CATE：对未知协变量分布变化稳健的多重准确条件平均处理效应估计AI 解读

Estimating heterogeneous treatment effects is important to tailor treatments to those individuals who would most likely benefit. However, conditional average treatment effect predictors may often be trained on one population but possibly deployed on different, possibly unknown populations. We use methodology for learning multi-accurate predictors to post-process CATE T-learners (differenced regressions) to become robust to unknown covariate shifts at the time of deployment.…

存在治疗中止的肿瘤随机试验中事件时间结局的因果效应评估AI 解读

In clinical trials, patients may discontinue treatments prematurely, breaking the initial randomization and, thus, challenging inference. Stakeholders in drug development are generally interested in going beyond the Intention-To-Treat (ITT) analysis, which provides valid causal estimates of the effect of treatment assignment but does not inform on the effect of the actual treatment receipt. Our study is motivated by an RCT in oncology, where patients assigned the…

条件结果等价：条件平均处理效应的分位数替代方案AI 解读

Conditional quantile treatment effect (CQTE) can provide insight into the effect of a treatment beyond the conditional average treatment effect (CATE). This ability to provide information over multiple quantiles of the response makes CQTE especially valuable in cases where the effect of a treatment is not well-modelled by a location shift, even conditionally on the covariates. Nevertheless, the estimation of CQTE is challenging and often depends upon the smoothness of the…

多臂处理规则的 Qini 曲线AI 解读

Qini curves have emerged as an attractive and popular approach for evaluating the benefit of data-driven targeting rules for treatment allocation. We propose a generalization of the Qini curve to multiple costly treatment arms, that quantifies the value of optimally selecting among both units and treatment arms at different budget levels. We develop an efficient algorithm for computing these curves and propose bootstrap-based confidence intervals that are exact in large…

检验参数可分模型的识别假设：条件矩不等式方法AI 解读

In this paper, we propose a simple method for testing identifying assumptions in parametric separable models, namely treatment exogeneity, instrument validity, and/or homoskedasticity. We show that the testable implications can be written in the intersection bounds framework, which is easy to implement using the inference method proposed in Chernozhukov, Lee, and Rosen (2013), and the Stata package of Chernozhukov et al. (2015). Monte Carlo simulations confirm that our test…

支持随时有效因果推断的多臂老虎机实验设计AI 解读

Experimentation is crucial for managers to rigorously quantify the value of a change and determine if it leads to a statistically significant improvement over the status quo. As companies increasingly mandate that all changes undergo experimentation before widespread release, two challenges arise: (1) minimizing the proportion of customers assigned to the inferior treatment and (2) increasing experimentation velocity by enabling data-dependent stopping. This paper addresses…

识别高维结果空间中的稀疏处理效应AI 解读

Based on technological advances in sensing modalities, randomized trials with primary outcomes represented as high-dimensional vectors have become increasingly prevalent. For example, these outcomes could be week-long time-series data from wearable devices or high-dimensional neuroimaging data, such as from functional magnetic resonance imaging. This paper focuses on randomized treatment studies with such high-dimensional outcomes characterized by sparse treatment effects,…

大规模纵向实验：估计与推断AI 解读

Large-scale randomized experiments are seldom analyzed using panel regression methods because of computational challenges arising from the presence of millions of nuisance parameters. We leverage Mundlak's insight that unit intercepts can be eliminated by using carefully chosen averages of the regressors to rewrite several common estimators in a form that is amenable to weighted-least squares estimation with frequency weights. This renders regressions involving arbitrary…

多变量中间区间随机化设计AI 解读

In a tie-breaker design (TBD), subjects with high values of a running variable are given some (usually desirable) treatment, subjects with low values are not, and subjects in the middle are randomized. TBDs are intermediate between regression discontinuity designs (RDDs) and randomized controlled trials (RCTs). TBDs allow a tradeoff between the resource allocation efficiency of an RDD and the statistical efficiency of an RCT. We study a model where the expected response is…

N-of-1 试验中个体因果效应的工具变量估计：ISTOP 应用AI 解读

An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide evidence to directly inform personalized treatment decisions. Advancements in wearable devices greatly improved the feasibility of adopting these trials to identify optimal individual treatment plans, particularly when treatments differ among individuals and responses are highly heterogeneous. Our work was motivated by the I-STOP-AFib Study, which examined the impact of different…

生存分析中空间定义环境暴露的测量误差校正AI 解读

Environmental exposures are often defined using buffer zones around geocoded home addresses, but these static boundaries can miss dynamic daily activity patterns, leading to biased results. This paper presents a novel measurement error correction method for spatially defined environmental exposures within a survival analysis framework using the Cox proportional hazards model. The method corrects high-dimensional surrogate exposures from geocoded residential data at multiple…

适用于随机阶梯楔形与观察性交错采用的广义双重差分估计AI 解读

Staggered treatment adoption arises in the evaluation of policy impact and implementation in many settings, including both randomized stepped-wedge trials and non-randomized quasi-experiments with panel data. In both settings, getting an interpretable, unbiased effect estimate requires careful consideration of the target estimand and possible treatment effect heterogeneities. This paper proposes a novel non-parametric approach to this estimation for either setting. By…