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Comparative Study of Causal Discovery Methods for Cyclic Models with Hidden Confounders

含隐蔽混杂的循环模型因果发现方法比较

Nowadays, the need for causal discovery is ubiquitous. A better understanding of not just the stochastic dependencies between parts of a system, but also the actual cause-effect relations, is essential for all parts of science. Thus, the need for reliable methods to detect causal directions is growing constantly. In the last 50 years, many causal discovery algorithms have emerged, but most of them are applicable only under the assumption that the systems have no feedback…

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Optimizing Returns from Experimentation Programs

实验项目收益的优化

Experimentation in online digital platforms is used to inform decision making. Specifically, the goal of many experiments is to optimize a metric of interest. Null hypothesis statistical testing can be ill-suited to this task, as it is indifferent to the magnitude of effect sizes and opportunity costs. Given access to a pool of related past experiments, we discuss how experimentation practice should change when the goal is optimization. We survey the literature on empirical…

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Causal discovery with endogenous context variables

具有内生情境变量的因果发现

Causal systems often exhibit variations of the underlying causal mechanisms between the variables of the system. Often, these changes are driven by different environments or internal states in which the system operates, and we refer to context variables as those variables that indicate this change in causal mechanisms. An example are the causal relations in soil moisture-temperature interactions and their dependence on soil moisture regimes: Dry soil triggers a dependence of…

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Quantile Granger Causality in the Presence of Instability

存在不稳定性时的分位数格兰杰因果检验

We propose a new framework for assessing Granger causality in quantiles in unstable environments, for a fixed quantile or over a continuum of quantile levels. Our proposed test statistics are consistent against fixed alternatives, they have nontrivial power against local alternatives, and they are pivotal in certain important special cases. In addition, we show the validity of a bootstrap procedure when asymptotic distributions depend on nuisance parameters. Monte Carlo…

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Marginal Causal Flows for Validation and Inference

用于验证与推断的边际因果流模型

Investigating the marginal causal effect of an intervention on an outcome from complex data remains challenging due to the inflexibility of employed models and the lack of complexity in causal benchmark datasets, which often fail to reproduce intricate real-world data patterns. In this paper we introduce Frugal Flows, a novel likelihood-based machine learning model that uses normalising flows to flexibly learn the data-generating process, while also directly inferring the…

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Moment-based Random-effects Meta-analysis Equipped with Huber's M-Estimation

结合 Huber M 估计的矩方法随机效应元分析

Meta-analyses are commonly used to provide solid evidence across numerous studies. Traditional moment methods, such as the DerSimonian-Laird method, remain popular in spite of the availability of more accurate alternatives. While moment estimators are simple and intuitive, they are known to underestimate the variance of the overall treatment effect, particularly when the number of studies is small. This underestimation can lead to excessively narrow confidence intervals that…

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The R.O.A.D. to clinical trial emulation

R.O.A.D.:通向临床试验模拟的框架

Observational studies provide the only evidence on the effectiveness of interventions when randomized controlled trials (RCTs) are impractical due to cost, ethical concerns, or time constraints. While many methodologies aim to draw causal inferences from observational data, there is a growing trend to model observational study designs after RCTs, a strategy known as "target trial emulation." Despite its potential, causal inference through target trial emulation cannot fully…

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Controlling Counterfactual Harm in Decision Support Systems Based on Prediction Sets

控制基于预测集的决策支持系统中的反事实伤害

Decision support systems based on prediction sets help humans solve multiclass classification tasks by narrowing down the set of potential label values to a subset of them, namely a prediction set, and asking them to always predict label values from the prediction sets. While this type of systems have been proven to be effective at improving the average accuracy of the predictions made by humans, by restricting human agency, they may cause harm$\unicode{x2014}$a human who…

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Removing Spurious Correlation from Neural Network Interpretations

消除神经网络解释中的伪相关

The existing algorithms for identification of neurons responsible for undesired and harmful behaviors do not consider the effects of confounders such as topic of the conversation. In this work, we show that confounders can create spurious correlations and propose a new causal mediation approach that controls the impact of the topic. In experiments with two large language models, we study the localization hypothesis and show that adjusting for the effect of conversation…

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SpaCE: The Spatial Confounding Environment

SpaCE:空间混杂评测环境

Spatial confounding poses a significant challenge in scientific studies involving spatial data, where unobserved spatial variables can influence both treatment and outcome, possibly leading to spurious associations. To address this problem, we introduce SpaCE: The Spatial Confounding Environment, the first toolkit to provide realistic benchmark datasets and tools for systematically evaluating causal inference methods designed to alleviate spatial confounding. Each dataset…

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Nature versus nurture in galaxy formation: the effect of environment on star formation with causal machine learning

星系形成中的先天与后天因素:用因果机器学习研究环境对恒星形成的影响

Understanding how galaxies form and evolve is at the heart of modern astronomy. With the advent of large-scale surveys and simulations, remarkable progress has been made in the last few decades. Despite this, the physical processes behind the phenomena, and particularly their importance, remain far from known, as correlations have primarily been established rather than the underlying causality. We address this challenge by applying the causal inference framework.…

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Endogenous Interference in Randomized Experiments

随机实验中的内生干扰

This paper investigates the identification and inference of treatment effects in randomized controlled trials with social interactions. Two key network features characterize the setting and introduce endogeneity: (1) latent variables may affect both network formation and outcomes, and (2) the intervention may alter network structure, mediating treatment effects. I make three contributions. First, I define parameters within a post-treatment network framework, distinguishing…

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Interventional Causal Discovery in a Mixture of DAGs

混合有向无环图中的干预式因果发现

Causal interactions among a group of variables are often modeled by a single causal graph. In some domains, however, these interactions are best described by multiple co-existing causal graphs, e.g., in dynamical systems or genomics. This paper addresses the hitherto unknown role of interventions in learning causal interactions among variables governed by a mixture of causal systems, each modeled by one directed acyclic graph (DAG). Causal discovery from mixtures is…

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Inference on LATEs with covariates

含协变量的局部平均处理效应推断

In theory, two-stage least squares (TSLS) identifies a weighted average of covariate-specific local average treatment effects (LATEs) from a saturated specification, without making parametric assumptions on how available covariates enter the model. In practice, TSLS is severely biased as saturation leads to a large number of control dummies and an equally large number of, arguably weak, instruments. This paper derives asymptotically valid tests and confidence intervals for…

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Environment Invariant Linear Least Squares

环境不变线性最小二乘

This paper considers a multi-environment linear regression model in which data from multiple experimental settings are collected. The joint distribution of the response variable and covariates may vary across different environments, yet the conditional expectations of $y$ given the unknown set of important variables are invariant. Such a statistical model is related to the problem of endogeneity, causal inference, and transfer learning. The motivation behind it is…

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Adjusting auxiliary variables under approximate neighborhood interference

近似邻域干扰下的辅助变量调整

Randomized experiments are the gold standard for causal inference. However, traditional assumptions, such as the Stable Unit Treatment Value Assumption (SUTVA), often fail in real-world settings where interference between units is present. Network interference, in particular, has garnered significant attention. Structural models, like the linear-in-means model, are commonly used to describe interference; but they rely on the correct specification of the model, which can be…

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Difference-in-differences Design with Outcomes Missing Not at Random

结局非随机缺失下的双重差分设计

This paper addresses one of the most prevalent problems encountered by political scientists working with difference-in-differences (DID) design: missingness in panel data. A common practice for handling missing data, known as complete case analysis, is to drop cases with any missing values over time. A more principled approach involves using nonparametric bounds on causal effects or applying inverse probability weighting based on baseline covariates. Yet, these methods are…

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A Bayesian semi-parametric approach to causal mediation for longitudinal mediators and time-to-event outcomes with application to a cardiovascular disease cohort study

纵向中介与事件时间结局的贝叶斯半参数因果中介分析

Causal mediation analysis of observational data is an important tool for investigating the potential causal effects of medications on disease-related risk factors, and on time-to-death (or disease progression) through these risk factors. However, when analyzing data from a cohort study, such analyses are complicated by the longitudinal structure of the risk factors and the presence of time-varying confounders. Leveraging data from the Atherosclerosis Risk in Communities…

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Causal and Local Correlations Based Network for Multivariate Time Series Classification

基于因果与局部相关性的多元时间序列分类网络

Recently, time series classification has attracted the attention of a large number of researchers, and hundreds of methods have been proposed. However, these methods often ignore the spatial correlations among dimensions and the local correlations among features. To address this issue, the causal and local correlations based network (CaLoNet) is proposed in this study for multivariate time series classification. First, pairwise spatial correlations between dimensions are…

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Regularized Multi-LLMs Collaboration for Enhanced Score-based Causal Discovery

正则化多大语言模型协作辅助基于评分的因果发现

As the significance of understanding the cause-and-effect relationships among variables increases in the development of modern systems and algorithms, learning causality from observational data has become a preferred and efficient approach over conducting randomized control trials. However, purely observational data could be insufficient to reconstruct the true causal graph. Consequently, many researchers tried to utilise some form of prior knowledge to improve causal…

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Bayesian Variable Selection for High-Dimensional Mediation Analysis: Application to Metabolomics Data in Epidemiological Studies

高维中介分析的贝叶斯变量选择:流行病学代谢组数据应用

In epidemiological research, causal models incorporating potential mediators along a pathway are crucial for understanding how exposures influence health outcomes. This work is motivated by integrated epidemiological and blood biomarker studies, investigating the relationship between long-term adherence to a Mediterranean diet and cardiometabolic health, with plasma metabolomes as potential mediators. Analyzing causal mediation in such high-dimensional omics data presents…

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Valid Bayesian Inference based on Variance Weighted Projection for High-Dimensional Logistic Regression with Binary Covariates

基于方差加权投影的高维二元协变量 Logistic 回归有效贝叶斯推断

We address the challenge of conducting inference for a categorical treatment effect related to a binary outcome variable while taking into account high-dimensional baseline covariates. The conventional technique used to establish orthogonality for the treatment effect from nuisance variables in continuous cases is inapplicable in the context of binary treatment. To overcome this obstacle, an orthogonal score tailored specifically to this scenario is formulated which is based…

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Causally Sound Priors for Binary Experiments

二元随机实验中符合因果结构的先验

We introduce the BREASE framework for the Bayesian analysis of randomized controlled trials with a binary treatment and a binary outcome. Approaching the problem from a causal inference perspective, we propose parameterizing the likelihood in terms of the baselinerisk, efficacy, and adverse side effects of the treatment, along with a flexible, yet intuitive and tractable jointly independent beta prior distribution on these parameters, which we show to be a generalization of…

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Estimating the Cost of Informal Care with a Novel Two-Stage Approach to Individual Synthetic Control

利用新两阶段个体合成控制方法估计非正式照护成本

Informal carers provide the majority of care for people living with challenges related to older age, long-term illness, or disability. However, the care they provide often results in a significant income penalty for carers, a factor largely overlooked in the economics literature and policy discourse. Leveraging data from the UK Household Longitudinal Study, this paper provides the first robust causal estimates of the caring income penalty using a novel individual synthetic…

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