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局部稳健政策学习：不平等、机会不平等与代际流动AI 解读

Policy makers need to decide whether to treat or not to treat heterogeneous individuals. The optimal treatment choice depends on the welfare function that the policy maker has in mind and it is referred to as the policy learning problem. I study a general setting for policy learning with semiparametric Social Welfare Functions (SWFs) that can be estimated by locally robust/orthogonal moments based on U-statistics. This rich class of SWFs substantially expands the setting in…

关于处理效应异质性序贯验证与随机实验机器学习推断评论的回应AI 解读

We warmly thank Kosuke Imai, Michael Lingzhi Li, and Stefan Wager for their gracious and insightful comments. We are particularly encouraged that both pieces recognize the importance of the research agenda the lecture laid out, which we see as critical for applied researchers. It is also great to see that both underscore the potential of the basic approach we propose - targeting summary features of the CATE after proxy estimation with sample splitting. We are also happy that…

通过尺度参数发现重尾线性结构方程模型中的因果关系AI 解读

Causal dependence modelling of multivariate extremes is intended to improve our understanding of the relationships amongst variables associated with rare events. Regular variation provides a standard framework in the study of extremes. This paper concerns the linear structural equation model with regularly varying noise variables. We focus on extreme observations generated from such a model and propose a causal discovery method based on the scaling parameters of its extremal…

协变量自适应随机化下的多回归变量调整AI 解读

Our paper discovers a new trade-off of using regression adjustments (RAs) in causal inference under covariate-adaptive randomizations (CARs). On one hand, RAs can improve the efficiency of causal estimators by incorporating information from covariates that are not used in the randomization. On the other hand, RAs can degrade estimation efficiency due to their estimation errors, which are not asymptotically negligible when the number of regressors is of the same order as the…

对照始终不可观测时的时间序列处理效应分析AI 解读

Estimating treatment effects in time series data presents a significant challenge, especially when the control group is always unobservable. For example, in analyzing the effects of Christmas on retail sales, we lack direct observation of what would have occurred in late December without the Christmas impact. To address this, we try to recover the control group in the event period while accounting for confounders and temporal dependencies. Experimental results on the M5…

网络干扰下的因果推断：回归调整与最优性AI 解读

In randomized controlled trials without interference, regression adjustment is widely used to enhance the efficiency of treatment effect estimation. This paper extends this efficiency principle to settings with network interference, where a unit's response may depend on the treatments assigned to its neighbors in a network. We make three key contributions: (1) we establish a central limit theorem for a linear regression-adjusted estimator and prove its optimality in…

从时间序列因果图的抽象表示识别总效应AI 解读

We study the problem of identifiability of the total effect of an intervention from observational time series in the situation, common in practice, where one only has access to abstractions of the true causal graph. We consider here two abstractions: the extended summary causal graph, which conflates all lagged causal relations but distinguishes between lagged and instantaneous relations, and the summary causal graph which does not give any indication about the lag between…

学习可识别结构以避免深度神经网络监督因果学习的偏差AI 解读

Causal discovery is a structured prediction task that aims to predict causal relations among variables based on their data samples. Supervised Causal Learning (SCL) is an emerging paradigm in this field. Existing Deep Neural Network (DNN)-based methods commonly adopt the "Node-Edge approach", in which the model first computes an embedding vector for each variable-node, then uses these variable-wise representations to concurrently and independently predict for each directed…

残差化处理强度与平均偏效应估计AI 解读

This paper introduces R-OLS, an estimator for the average partial effect (APE) of a continuous treatment variable on an outcome variable in the presence of non-linear and non-additively separable confounding of unknown form. Identification of the APE is achieved by generalising Stein's Lemma (Stein, 1981), leveraging an exogenous error component in the treatment along with a flexible functional relationship between the treatment and the confounders. The identification…

无需平滑参数的多变量根号 n 一致匹配与逆密度加权期望估计AI 解读

Expected values weighted by the inverse of a multivariate density or, equivalently, Lebesgue integrals of regression functions with multivariate regressors occur in various areas of applications, including estimating average treatment effects, nonparametric estimators in random coefficient regression models or deconvolution estimators in Berkson errors-in-variables models. The frequently used nearest-neighbor and matching estimators suffer from bias problems in multiple…

多粒度因果效应的综合机器学习AI 解读

Uncovering causal effects in multiple treatment setting at various levels of granularity provides substantial value to decision makers. Comprehensive machine learning approaches to causal effect estimation allow to use a single causal machine learning approach for estimation and inference of causal mean effects for all levels of granularity. Focusing on selection-on-observables, this paper compares three such approaches, the modified causal forest (mcf), the generalized…

经中介路径传导的因果归因概率AI 解读

We propose a set of causal estimands that we call the "mediated probabilities of causation." These estimands quantify the probabilities that an observed negative outcome was induced via a mediating pathway versus a direct pathway in a stylized setting involving a binary exposure or intervention, a single binary mediator, and a binary outcome. We outline a set of conditions sufficient to identify these effects given observed data, and propose a doubly-robust projection based…

作为潜变量的处理响应AI 解读

Scientists often need to analyze the samples in a study that responded to treatment in order to refine their hypotheses and find potential causal drivers of response. Natural variation in outcomes makes teasing apart responders from non-responders a statistical inference problem. To handle latent responses, we introduce the causal two-groups (C2G) model, a causal extension of the classical two-groups model. The C2G model posits that treated samples may or may not experience…

利用时间背景信息的评分式因果发现AI 解读

Temporal background information can improve causal discovery algorithms by orienting edges and identifying relevant adjustment sets. We develop the Temporal Greedy Equivalence Search (TGES) algorithm and terminology essential for score-based causal discovery with tiered background knowledge. TGES learns a restricted Markov equivalence class of directed acyclic graphs (DAGs) using observational data and tiered background knowledge. To construct TGES we formulate a scoring…

连续处理匹配观察研究的偏差缓解：卡尺非二分匹配与偏差修正推断AI 解读

In matched observational studies with continuous treatments, individuals with different treatment doses but the same or similar covariate values are paired for causal inference. While inexact covariate matching (i.e., covariate imbalance after matching) is common in practice, previous matched studies with continuous treatments have often overlooked this issue as long as post-matching covariate balance meets certain criteria. Through re-analyzing a matched observational study…

变分因果推断AI 解读

Estimating an individual's potential outcomes under counterfactual treatments is a challenging task for traditional causal inference and supervised learning approaches when the outcome is high-dimensional (e.g. gene expressions, impulse responses, human faces) and covariates are relatively limited. In this case, to construct one's outcome under a counterfactual treatment, it is crucial to leverage individual information contained in its observed factual outcome on top of the…

结合变分因果推断与细化关系信息预测细胞响应AI 解读

Predicting the responses of a cell under perturbations may bring important benefits to drug discovery and personalized therapeutics. In this work, we propose a novel graph variational Bayesian causal inference framework to predict a cell's gene expressions under counterfactual perturbations (perturbations that this cell did not factually receive), leveraging information representing biological knowledge in the form of gene regulatory networks (GRNs) to aid individualized…

利用多个结果变量改进合成控制方法AI 解读

When there are multiple outcome series of interest, Synthetic Control analyses typically proceed by estimating separate weights for each outcome. In this paper, we instead propose estimating a common set of weights across outcomes, by balancing either a vector of all outcomes or an index or average of them. Under a low-rank factor model, we show that these approaches lead to lower bias bounds than separate weights, and that averaging leads to further gains when the number of…

事件史分析与高效调整的无模型方法：博士论文AI 解读

This thesis contains a series of independent contributions to statistics, unified by a model-free perspective. The first chapter elaborates on how a model-free perspective can be used to formulate flexible methods that leverage prediction techniques from machine learning. Mathematical insights are obtained from concrete examples, and these insights are generalized to principles that permeate the rest of the thesis. The second chapter studies the concept of local…

随机试验亚组处理效应的协调估计：外部对照数据的使用AI 解读

Subgroup analyses of randomized controlled trials (RCTs) constitute an important component of the drug development process in precision medicine. In particular, subgroup analyses of early-stage trials often influence the design and eligibility criteria of subsequent confirmatory trials and ultimately influence which subpopulations will receive the treatment after regulatory approval. However, subgroup analyses are often complicated by small sample sizes, which leads to…

基于纵向秩和检验的多变量纵向试验功效与样本量计算AI 解读

Neurodegenerative diseases such as Alzheimer's and Parkinson's often exhibit complex, multivariate longitudinal outcomes that require advanced statistical methods to comprehensively evaluate treatment efficacy. The Longitudinal Rank Sum Test (LRST) offers a nonparametric framework to assess global treatment effects across multiple longitudinal endpoints without requiring multiplicity corrections. This study develops a robust methodology for power and sample size estimation…

肿瘤试验处理交叉的增强两阶段估计：利用外部数据提高精度AI 解读

Randomized controlled trials (RCTs) in oncology often allow control group participants to crossover to experimental treatments, a practice that, while often ethically necessary, complicates the accurate estimation of long-term treatment effects. When crossover rates are high or sample sizes are limited, commonly used methods for crossover adjustment (such as the rank-preserving structural failure time model, inverse probability of censoring weights, and two-stage estimation…

Shapley-PC：受 Shapley 值启发的约束型因果结构学习AI 解读

Causal Structure Learning (CSL), also referred to as causal discovery, amounts to extracting causal relations among variables in data. CSL enables the estimation of causal effects from observational data alone, avoiding the need to perform real life experiments. Constraint-based CSL leverages conditional independence tests to perform causal discovery. We propose Shapley-PC, a novel method to improve constraint-based CSL algorithms by using Shapley values over the possible…

网络干扰下带聚类的两阶段逐步投放实验设计分析AI 解读

Estimating causal effects under interference is pertinent to many real-world settings. Recent work with low-order potential outcomes models uses a rollout design to obtain unbiased estimators that require no interference network information. However, the required extrapolation can lead to prohibitively high variance. To address this, we propose a two-stage experiment that selects a sub-population in the first stage and restricts treatment rollout to this sub-population in…