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二元结果混合对照试验的稳健估计与推断：非小细胞肺癌案例AI 解读

Hybrid controlled trials (HCTs), which augment randomized controlled trials (RCTs) with external controls (ECs), are increasingly receiving attention as a way to address limited power, slow accrual, and ethical concerns in clinical research. However, borrowing from ECs raises critical statistical challenges in estimation and inference, especially for binary outcomes where hidden bias is harder to detect and estimands such as risk difference, risk ratio, and odds ratio are of…

矩阵自回归模型的脉冲响应推断AI 解读

Matrix autoregressive (MAR) models offer a parsimonious framework for modeling matrix-valued time series, yet tools for estimation and inference for their impulse response functions are lacking. We develop asymptotic and bootstrap-based inference for impulse responses of stable MAR($p$) models. We derive the joint asymptotic distribution of the coefficient and covariance estimators, which permits closed-form delta-method standard errors. To address finite-sample bias, we…

协变量密度有界条件下期望条件协方差的极小极大估计AI 解读

In many scientific studies, evaluating the association between two responses requires adjusting for shared covariates. The expected conditional covariance measures this adjusted association and is used in conditional independence testing and treatment effect estimation. Researchers often estimate it using fitted conditional means, but removing the bias caused by the estimation errors of these conditional means remains a difficult task. This difficulty can increase when the…

随机分配回归变量的自助法推断：协方差过滤与边际重抽样的局限AI 解读

Random assignment can make ordinary least squares (OLS) inference insensitive to outcome dependence, yet iid resampling can still fail because assignment and resampling need not remove the same covariance terms. With binary treatment, the iid variance target differs from the sampling variance by exactly minus aggregate cross-unit covariance of treatment effects. Under a Gaussian first-order limit, positive covariance leads to over-rejection and negative covariance to…

预测比较中的不确定性量化AI 解读

Skill scores, which measure the relative improvement of a forecasting method over a benchmark via consistent scoring functions and proper scoring rules, are a standard tool in forecast evaluation, yet their sampling uncertainty is rarely rigorously quantified. With modern forecasting applications being increasingly multivariate and involving evaluations across multiple horizons, variables, spatial locations, and forecasting methods, standard tools like the pairwise…

多源整合因子模型中共同与个体成分的检验及分离AI 解读

Disentangling shared (joint) structures from source-specific (individual) variations is a fundamental task in multi-source data integration. Existing joint-individual models often rely on computationally intensive optimization or loose spectral bounds, leading to suboptimal separation accuracy and poor scalability. In this paper, we propose the Multi-Source Sequential Alignment Test (MSSAT). MSSAT leverages the geometric observation that true joint components manifest as…

The bootstrap is widely used to construct confidence intervals but may perform poorly for some estimators. We consider semiparametric estimators that use cross-validation to estimate nuisance pa- rameters and can be computationally expensive in large datasets. We illustrate potential problems with bootstrapping with replacement when cross-validation is used and extend the cheap bootstrap confidence interval to subsampling without replacement for asymptotically linear…

Wearable devices for continuous electronic health monitoring often capture data at frequent intervals under a dense functional design. The focal point is the analysis of longitudinal functional data, wherein functional trajectories are observed repeatedly over time. This work is motivated by the interest in assessing the efficacy of a noninflammatory medication, meloxicam, on the daily activity levels of household cats with a pre-existing condition of osteoarthritis under a…

数据驱动亚组发现后标准试验估计量的推断AI 解读

Data-driven subgroup identification is increasingly used in clinical trials, yet the effect reported for a discovered subgroup is typically the standard analysis: a Cox or generalized-linear-model treatment coefficient fitted within that subgroup. Selection by an effect-driven rule --- rewarding large estimated effects subject to screening and size criteria --- inflates the reported coefficient: a winner's curse invalidating naive intervals whether or not the identifier's…

SPARK：基于残差投影的通用拟合优度评估AI 解读

Goodness-of-fit testing is a basic tool for assessing whether a fitted procedure has captured the systematic information contained in the covariates. While traditional theory has largely focused on parametric regression models, modern data analysis increasingly relies on flexible black-box learners, whose predictive success alone is insufficient to assess model accuracy. In this paper, we propose SPARK, a general framework for goodness-of-fit testing that applies to…

多控制变量下工资不平等界的去偏推断AI 解读

We study estimation and inference for a partially identified parameter whose identified set depends on a first-stage nuisance parameter that must itself be estimated. Combining the criterion-function approach with the theory of Neyman-orthogonal moments that underlies double/debiased machine learning, we propose a two-step procedure: the point-identified nuisance is estimated by flexible machine-learning methods, and the set-identified target is recovered as a level set of a…

基于残差化 Walsh–Hadamard 得分的异质析因效应修饰因子去偏与同时推断AI 解读

In factorial randomized experiments with $K$ binary treatment components, we study which baseline covariates modify component main effects and interactions. We define effect-modifier cells $(j,S)$, $j\in[p]$ and $\emptyset\neq S\subseteq[K]$, through the coefficients $θ^\ast_{jS}$ of population linear projections of conditional Walsh--Hadamard contrasts $τ_{S}$ onto standardized covariates. Using baseline-robust direct scores, we develop frequentist inference for all $p(2^K-1)$…

BRP-GABLE：适用于多种结果类型的可解释规则预测框架AI 解读

Interpretable prediction models are important in biomedical research, where predictive accuracy must often be balanced against the ability to examine predictor-outcome relationships. Automatic Binary Logistic Estimation (ABLE) provides interpretable rule-based representations by constructing additive models using threshold rules. However, the original method is restricted to binary outcomes, and its greedy forward construction follows a search path, making candidate rules…

删失持续时间模型中的未观测异质性检验：EM方法AI 解读

Ignoring unobserved heterogeneity in duration models biases parameter estimates and invalidates inference, but testing for it is non-regular: the null hypothesis lies on the boundary of the parameter space and some parameters are unidentified under the null. These features render standard asymptotic theory inapplicable. This paper develops an EM test for unobserved heterogeneity in censored Weibull duration models, building on the EM approach of Li, Chen, and Marriott…

交替处理实验中的随机化检验AI 解读

Switchback experiments assign an experimental unit, such as a market or a platform, to treatment or control over successive blocks of time. Inference can be challenging because these experiments often contain only a small number of randomized blocks, while outcomes may exhibit serial dependence, seasonality, and treatment effects that persist across periods. We develop a conditional randomization test for the null of no total treatment effect that is finite-sample valid…

工具变量回归中维度自适应的自助法 Anderson–Rubin 检验AI 解读

Weak-identification-robust tests for instrumental variable (IV) regressions are typically developed separately depending on whether the number of IVs is treated as fixed or increasing with the sample size, forcing researchers to make a stance on the asymptotic behavior, which is often ambiguous in practice. This paper proposes a bootstrap-based, dimension-agnostic Anderson-Rubin (AR) test that achieves correct asymptotic size regardless of whether the number of IVs is fixed…

LOCO-AdaMP：兼顾预测与内置变量重要性推断的自适应小块集成AI 解读

As black-box machine learning models become increasingly common, extracting interpretations with uncertainty quantification has become a critical challenge. One popular type of interpretation is leave-one-covariate-out (LOCO) feature importance, while prior LOCO inference methods often require data-splitting or model-refitting. A recent ensemble framework, LOCO-MP, addresses these challenges using minipatches that subsample both observations and features, but massive feature…

核设定检验的数据驱动调参：选择渐近理论、有效性与功效AI 解读

We develop model checks for conditional moment restrictions whose tuning parameters, the kernel bandwidth and the regularization level, are selected by cross-validation. The tests regress the estimated residuals on the covariates via kernel ridge regression (KRR), yielding a coefficient function in a reproducing kernel Hilbert space (RKHS) that vanishes under the null and is nonzero for any misspecification not annihilated by the Neyman projection. Our central contribution…

双重差分与合成控制的结合：双重稳健识别和估计AI 解读

Difference-in-Differences (DiD) and Synthetic Control (SC) are widely used methods for causal inference in panel data, each with distinct strengths and limitations. We propose a novel method for short-panel causal inference that integrates the advantages of both approaches. Our method delivers a doubly robust identification strategy for the average treatment effect on the treated (ATT) under either of two non-nested assumptions: parallel trends or a group-level SC condition.…

高维白噪声的自适应 L2 型检验AI 解读

We propose a new $L_2$-type test for white noise which allows the dimension $p$ of the time series to either (i) be a fixed constant, or (ii) diverge with the sample size $n$. The proposed test statistic exhibits an interesting phase transition, following two different regimes of behavior: $p$ is fixed, and $p\rightarrow\infty$. Because identification of the operable regime is difficult, if not impossible in practice, we devise a novel adaptive bootstrap method to construct…

表格基础模型能否摊销统计推断成本？AI 解读

For decades, statistical inference has largely been developed one problem at a time. Given a scientific target, such as a treatment effect or a regression function, statisticians design a problem-specific estimator together with a procedure for quantifying its uncertainty. This paper proposes a different paradigm. We focus on a classical problem in statistical inference, confidence interval construction, and develop TabCon, an amortized inference system built on a tabular…

弱依赖估计方程的两点依赖野生自助法AI 解读

This paper develops a general two-point dependent wild bootstrap (DWB) for weakly dependent estimating equations. Its key feature is that the two-point marginal distribution and the latent serial dependence specification can be chosen separately. The construction combines a normalized two-point distribution with a stationary latent Gaussian process via a Gaussian copula transformation, includes dependent Rademacher and Mammen multipliers, and nests the classical iid…

测度线性表示模型中识别、计算与推断的对抗方法AI 解读

We develop a framework for identification, computation, and inference in econometric models with a linear-in-measures representation. These models express maintained restrictions as moment conditions linear in the joint probability measure of observed and latent inputs, and map that measure linearly to the distribution of outputs, even with nonlinear outcome equations. We construct an adversarial discrepancy function whose zeros characterize the identified set for structural…

基于时延嵌入置信界的拓扑周期性检验AI 解读

Time-delay embedding is a fundamental technique in Topological Data Analysis (TDA) for reconstructing phase-space dynamics of time-series data, where persistent homology can reveal loops associated with periodicity. However, rigorous statistical uncertainty quantification for these features remains underdeveloped. First, we analyze the topology of time-delay embeddings, showing that the embedded trajectory is homotopy equivalent to a circle ($S^1$) for periodic signals and…