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个体患者数据有限时相容间接治疗比较的参数化 G 计算AI 解读

Population adjustment methods such as matching-adjusted indirect comparison (MAIC) are increasingly used to compare marginal treatment effects when there are cross-trial differences in effect modifiers and limited patient-level data. MAIC is based on propensity score weighting, which is sensitive to poor covariate overlap and cannot extrapolate beyond the observed covariate space. Current outcome regression-based alternatives can extrapolate but target a conditional…

模型不确定性下的稳健数据驱动决策AI 解读

When sample data are governed by an unknown sequence of independent but possibly non-identical distributions, the data-generating process (DGP) in general cannot be perfectly identified from the data. For making decisions facing such uncertainty, this paper presents a novel approach by studying how the data can best be used to robustly improve decisions. That is, no matter which DGP governs the uncertainty, one can make a better decision than without using the data. I show…

即时预测中计量经济学与机器学习方法的基准比较AI 解读

Nowcasting can play a key role in giving policymakers timelier insight to data published with a significant time lag, such as final GDP figures. Currently, there are a plethora of methodologies and approaches for practitioners to choose from. However, there lacks a comprehensive comparison of these disparate approaches in terms of predictive performance and characteristics. This paper addresses that deficiency by examining the performance of 12 different methodologies in…

通过随机优化进行估计与推断AI 解读

In non-linear estimations, it is common to assess sampling uncertainty by bootstrap inference. For complex models, this can be computationally intensive. This paper combines optimization with resampling: turning stochastic optimization into a fast resampling device. Two methods are introduced: a resampled Newton-Raphson (rNR) and a resampled quasi-Newton (rqN) algorithm. Both produce draws that can be used to compute consistent estimates, confidence intervals, and standard…

未知软干预下贝叶斯因果推断的干预型高斯等价评分AI 解读

Describing the causal relations governing a system is a fundamental task in many scientific fields, ideally addressed by experimental studies. However, obtaining data under intervention scenarios may not always be feasible, while discovering causal relations from purely observational data is notoriously challenging. In certain settings, such as genomics, we may have data from heterogeneous study conditions, with soft (partial) interventions only pertaining to a subset of the…

利用灵活局部投影估计脉冲响应AI 解读

This paper introduces a flexible local projection that generalizes the model by Jordá (2005) to a non-parametric setting using Bayesian Additive Regression Trees. Monte Carlo experiments show that our BART-LP model is able to capture non-linearities in the impulse responses. Our first application shows that the fiscal multiplier is stronger in recession than in expansion only in response to contractionary fiscal shocks, but not in response to expansionary fiscal shocks. We…

逆问题的贝叶斯时空建模AI 解读

Inverse problems with spatiotemporal observations are ubiquitous in scientific studies and engineering applications. In these spatiotemporal inverse problems, observed multivariate time series are used to infer parameters of physical or biological interests. Traditional solutions for these problems often ignore the spatial or temporal correlations in the data (static model), or simply model the data summarized over time (time-averaged model). In either case, the data…

面向收缩估计的实验设计AI 解读

We consider how increasingly available observational data can be used to improve the design of randomized controlled trials (RCTs). We seek to design a prospective RCT, with the intent of using an Empirical Bayes estimator to shrink the causal estimates from our trial toward causal estimates obtained from an observational study. We ask: how might we design the experiment to better complement the observational study in this setting? We propose using an estimator that shrinks…

含缺失数据的多条多元时间序列无限隐马尔可夫模型AI 解读

Exposure to air pollution is associated with increased morbidity and mortality. Recent technological advancements permit the collection of time-resolved personal exposure data. Such data are often incomplete with missing observations and exposures below the limit of detection, which limit their use in health effects studies. In this paper we develop an infinite hidden Markov model for multiple asynchronous multivariate time series with missing data. Our model is designed to…

马尔可夫范畴、因果理论与 do 演算AI 解读

We give a category-theoretic treatment of causal models that formalizes the syntax for causal reasoning over a directed acyclic graph (DAG) by associating a free Markov category with the DAG in a canonical way. This framework enables us to define and study important concepts in causal reasoning from an abstract and "purely causal" point of view, such as causal independence/separation, causal conditionals, and decomposition of intervention effects. Our results regarding these…

带变量选择的贝叶斯非齐次隐马尔可夫模型：癫痫发作风险周期的驱动因素AI 解读

A major issue in the clinical management of epilepsy is the unpredictability of seizures. Yet, traditional approaches to seizure forecasting and risk assessment in epilepsy rely heavily on raw seizure frequencies, which are a stochastic measurement of seizure risk. We consider a Bayesian non-homogeneous hidden Markov model for unsupervised clustering of zero-inflated seizure count data. The proposed model allows for a probabilistic estimate of the sequence of seizure risk…

后验预测倾向得分与 p 值AI 解读

\citet{Rosenbaum83ps} introduced the notion of the propensity score and discussed its central role in causal inference with observational studies. Their paper, however, caused a fundamental incoherence with an early paper by \citet{Rubin78}, which showed that the propensity score does not play any role in the Bayesian analysis of unconfounded observational studies if the priors on the propensity score and outcome models are independent. Despite the serious efforts made in…

混杂调整的贝叶斯非参数方法AI 解读

Analysis of observational studies increasingly confronts the challenge of determining which of a possibly high-dimensional set of available covariates are required to satisfy the assumption of ignorable treatment assignment for estimation of causal effects. We propose a Bayesian nonparametric approach that simultaneously 1) prioritizes inclusion of adjustment variables in accordance with existing principles of confounder selection; 2) estimates causal effects in a manner…

标准与参照组条件均值插补AI 解读

Clinical trials with longitudinal outcomes typically include missing data due to missed assessments or structural missingness of outcomes after intercurrent events handled with a hypothetical strategy. Approaches based on Bayesian random multiple imputation and Rubin's rule for pooling results across multiple imputed datasets are increasingly used in order to align the analysis of these trials with the targeted estimand. We propose and justify deterministic conditional mean…

基于正交随机线性混合模型的高维时间序列贝叶斯推断AI 解读

Many modern time-series datasets contain large numbers of output response variables sampled for prolonged periods of time. For example, in neuroscience, the activities of 100s-1000's of neurons are recorded during behaviors and in response to sensory stimuli. Multi-output Gaussian process models leverage the nonparametric nature of Gaussian processes to capture structure across multiple outputs. However, this class of models typically assumes that the correlations between…

利用网络元回归综合跨研究设计证据与跨格式数据AI 解读

In network meta-analysis (NMA), we synthesize all relevant evidence about health outcomes with competing treatments. The evidence may come from randomized controlled trials (RCT) or non-randomized studies (NRS) as individual participant data (IPD) or as aggregate data (AD). We present a suite of Bayesian NMA and network meta-regression (NMR) models allowing for cross-design and cross-format synthesis. The models integrate a three-level hierarchical model for synthesizing IPD…

用于基因表达数据因果推断的贝叶斯 Copula 方向依赖AI 解读

Modelling and understanding directional gene networks is a major challenge in biology as they play an important role in the architecture and function of genetic systems. Copula Directional Dependence (CDD) can measure the directed connectivity among variables without any strict requirements of distributional and linearity assumptions. Furthermore, copulas can achieve that by isolating the dependence structure of a joint distribution. In this work, a novel extension of the…

Metropolis-Hastings 采样器的方差缩减AI 解读

We introduce a general framework that constructs estimators with reduced variance for random walk Metropolis and Metropolis-adjusted Langevin algorithms. The resulting estimators require negligible computational cost and are derived in a post-process manner utilising all proposal values of the Metropolis algorithms. Variance reduction is achieved by producing control variates through the approximate solution of the Poisson equation associated with the target density of the…

最小消息长度准则下的 ARMA 模型阶数选择AI 解读

This paper derives a Minimum Message Length (MML) criterion for the model selection of the Autoregressive Moving Average (ARMA) time series model. The MML87 performances on the ARMA model compared with other well known model selection criteria, Akaike Information Criterion (AIC), Corrected AIC (AICc), Bayesian Information Criterion (BIC), and Hannan Quinn (HQ). The experimental results show that the MML87 is outperformed the other model selection criteria as it select most…

动态系统时变参数的流形约束高斯过程推断AI 解读

Identification of parameters in ordinary differential equations (ODEs) is an important and challenging task when modeling dynamic systems in biomedical research and other scientific areas, especially with the presence of time-varying parameters. This article proposes a fast and accurate method, TVMAGI (Time-Varying MAnifold-constrained Gaussian process Inference), to estimate both time-constant and time-varying parameters in the ODE using noisy and sparse observation data.…

清晰与模糊断点及折点设计中的层级高斯过程模型AI 解读

We propose nonparametric Bayesian estimators for causal inference exploiting Regression Discontinuity/Kink (RD/RK) under sharp and fuzzy designs. Our estimators are based on Gaussian Process (GP) regression and classification. The GP methods are powerful probabilistic machine learning approaches that are advantageous in terms of derivative estimation and uncertainty quantification, facilitating RK estimation and inference of RD/RK models. These estimators are extended to…

利用贝叶斯非参数模型预测美国通胀AI 解读

The relationship between inflation and predictors such as unemployment is potentially nonlinear with a strength that varies over time, and prediction errors error may be subject to large, asymmetric shocks. Inspired by these concerns, we develop a model for inflation forecasting that is nonparametric both in the conditional mean and in the error using Gaussian and Dirichlet processes, respectively. We discuss how both these features may be important in producing accurate…

有能力共同基金的筛选：依赖结构下的错误发现控制AI 解读

Selecting skilled mutual funds through the multiple testing framework has received increasing attention from finance researchers and statisticians. The intercept $α$ of Carhart four-factor model is commonly used to measure the true performance of mutual funds, and positive $α$'s are considered as skilled. We observe that the standardized OLS estimates of $α$'s across the funds possess strong dependence and nonnormality structures, indicating that the conventional multiple…

状态空间模型中变分贝叶斯的推断与预测准确性AI 解读

Using theoretical and numerical results, we document the accuracy of commonly applied variational Bayes methods across a range of state space models. The results demonstrate that, in terms of accuracy on fixed parameters, there is a clear hierarchy in terms of the methods, with approaches that do not approximate the states yielding superior accuracy over methods that do. We also document numerically that the inferential discrepancies between the various methods often yield…