论文检索

BaCaDI：干预目标未知时的贝叶斯因果发现AI 解读

Inferring causal structures from experimentation is a central task in many domains. For example, in biology, recent advances allow us to obtain single-cell expression data under multiple interventions such as drugs or gene knockouts. However, the targets of the interventions are often uncertain or unknown and the number of observations limited. As a result, standard causal discovery methods can no longer be reliably used. To fill this gap, we propose a Bayesian framework…

多臂试验中的患者分层：贝叶斯画像回归两阶段方法AI 解读

Precision medicine is an emerging field that takes into account individual heterogeneity to inform better clinical practice. In clinical trials, the evaluation of treatment effect heterogeneity is an important component, and recently, many statistical methods have been proposed for stratifying patients into different subgroups based on such heterogeneity. However, the majority of existing methods developed for this purpose focus on the case with a dichotomous treatment and…

分层计数数据的安全序贯检验与效应估计AI 解读

Sequential decision making significantly speeds up research and is more cost-effective compared to fixed-n methods. We present a method for sequential decision making for stratified count data that retains Type-I error guarantee or false discovery rate under optional stopping, using e-variables. We invert the method to construct stratified anytime-valid confidence sequences, where cross-talk between subpopulations in the data can be allowed during data collection to improve…

基于线性高斯状态空间混合模型与 EM 算法的时间序列聚类AI 解读

In this paper, we consider the task of clustering a set of individual time series while modeling each cluster, that is, model-based time series clustering. The task requires a parametric model with sufficient flexibility to describe the dynamics in various time series. To address this problem, we propose a novel model-based time series clustering method with mixtures of linear Gaussian state space models, which have high flexibility. The proposed method uses a new…

基于经验福利更新的随机处理选择AI 解读

This paper proposes a novel method to estimate individualised treatment assignment rules. The method is designed to find rules that are stochastic, reflecting uncertainty in estimation of an assignment rule and about its welfare performance. Our approach is to form a prior distribution over assignment rules, not over data generating processes, and to update this prior based upon an empirical welfare criterion, not likelihood. The social planner then assigns treatment by…

图模型的 Lauritzen–Chen 似然AI 解读

Graphical models such as Markov random fields (MRFs) that are associated with undirected graphs, and Bayesian networks (BNs) that are associated with directed acyclic graphs, have proven to be a very popular approach for reasoning under uncertainty, prediction problems and causal inference. Parametric MRF likelihoods are well-studied for Gaussian and categorical data. However, in more complicated parametric and semi-parametric settings, likelihoods specified via clique…

基于单样本 Mantel–Haenszel 方法的篮式试验频率学派分析AI 解读

Recent substantial advances of molecular targeted oncology drug development is requiring new paradigms for early-phase clinical trial methodologies to enable us to evaluate efficacy of several subtypes simultaneously and efficiently. The concept of the basket trial is getting of much attention to realize this requirement borrowing information across subtypes, which are called baskets. Bayesian approach is a natural approach to this end and indeed the majority of the existing…

线性不等式约束下未观测成分模型的参数估计AI 解读

We propose a new \textit{quadratic programming-based} method of approximating a nonstandard density using a multivariate Gaussian density. Such nonstandard densities usually arise while developing posterior samplers for unobserved components models involving inequality constraints on the parameters. For instance, Chan et al. (2016) provided a new model of trend inflation with linear inequality constraints on the stochastic trend. We implemented the proposed quadratic…

时间序列图上的变点检测AI 解读

When analysing multiple time series that may be subject to changepoints, it is sometimes possible to specify a priori, by means of a graph, which pairs of time series are likely to be impacted by simultaneous changepoints. This article proposes an informative prior for changepoints which encodes the information contained in the graph, inducing a changepoint model for multiple time series that borrows strength across clusters of connected time series to detect weak signals…

含缺失数据的高维条件高斯状态空间模型AI 解读

We develop an efficient sampling approach for handling complex missing data patterns and a large number of missing observations in conditionally Gaussian state space models. Two important examples are dynamic factor models with unbalanced datasets and large Bayesian VARs with variables in multiple frequencies. A key insight underlying the proposed approach is that the joint distribution of the missing data conditional on the observed data is Gaussian. Moreover, the inverse…

mbsts 包：R 中的多变量贝叶斯结构时间序列模型AI 解读

The multivariate Bayesian structural time series (MBSTS) model is a general machine learning model that deals with inference and prediction for multiple correlated time series, where one also has the choice of using a different candidate pool of contemporaneous predictors for each target series. The MBSTS model has wide applications and is ideal for feature selection, time series forecasting, nowcasting, inferring causal impact, and others. This paper demonstrates how to use…

使用路径签名的近似贝叶斯计算AI 解读

Simulation models often lack tractable likelihood functions, making likelihood-free inference methods indispensable. Approximate Bayesian computation generates likelihood-free posterior samples by comparing simulated and observed data through some distance measure, but existing approaches are often poorly suited to time series simulators, for example due to an independent and identically distributed data assumption. In this paper, we propose to use path signatures in…

预测限价订单簿中间价动态的贝叶斯双线性神经网络AI 解读

The prediction of financial markets is a challenging yet important task. In modern electronically-driven markets, traditional time-series econometric methods often appear incapable of capturing the true complexity of the multi-level interactions driving the price dynamics. While recent research has established the effectiveness of traditional machine learning (ML) models in financial applications, their intrinsic inability to deal with uncertainties, which is a great concern…

通过贝叶斯线性规划控制信号发现与定位AI 解读

Scientists often must simultaneously localize and discover signals. For instance, in genetic fine-mapping, high correlations between nearby genetic variants make it hard to identify the exact locations of causal variants. So the statistical task is to output as many disjoint regions containing a signal as possible, each as small as possible, while controlling false positives. Similar problems arise in any application where signals cannot be perfectly localized, such as…

环境流行病学中因果暴露反应曲线的贝叶斯高斯过程估计AI 解读

Motivated by environmental policy questions, we address the challenges of estimation, change point detection, and uncertainty quantification of a causal exposure-response function (CERF). Under a potential outcome framework, the CERF describes the relationship between a continuously varying exposure (or treatment) and its causal effect on an outcome. We propose a new Bayesian approach that relies on a Gaussian process (GP) model to estimate the CERF nonparametrically. To…

边际结构模型中的自动化目标贝叶斯与目标最小损失估计推断AI 解读

Two of the principle tasks of causal inference are to define and estimate the effect of a treatment on an outcome of interest. Formally, such treatment effects are defined as a possibly functional summary of the data generating distribution, and are referred to as target parameters. Estimation of the target parameter can be difficult, especially when it is high-dimensional. Marginal Structural Models (MSMs) provide a way to summarize such target parameters in terms of a…

隐半马尔可夫模型的序贯贝叶斯学习AI 解读

In this paper, we explore the class of the Hidden Semi-Markov Model (HSMM), a flexible extension of the popular Hidden Markov Model (HMM) that allows the underlying stochastic process to be a semi-Markov chain. HSMMs are typically used less frequently than their basic HMM counterpart due to the increased computational challenges when evaluating the likelihood function. Moreover, while both models are sequential in nature, parameter estimation is mainly conducted via batch…

通过 MCMC 实现经典估计的方法AI 解读

This paper studies computationally and theoretically attractive estimators called the Laplace type estimators (LTE), which include means and quantiles of Quasi-posterior distributions defined as transformations of general (non-likelihood-based) statistical criterion functions, such as those in GMM, nonlinear IV, empirical likelihood, and minimum distance methods. The approach generates an alternative to classical extremum estimation and also falls outside the parametric…

事件时间结局的主分层分析AI 解读

Post-randomization events, also known as intercurrent events, such as treatment noncompliance and censoring due to a terminal event, are common in clinical trials. Principal stratification is a framework for causal inference in the presence of intercurrent events. Despite the extensive existing literature, there lacks generally applicable and accessible methods for principal stratification analysis with time-to-event outcomes. In this paper, we specify two causal estimands…

阶段树模型的评分等价性AI 解读

Staged trees are a recently-developed, powerful family of probabilistic graphical models. An equivalence class of staged trees has now been characterised, and two fundamental statistical operators have been defined to traverse the equivalence class of a given staged tree. Here, two staged trees are said to be statistically equivalent when they represent the same set of distributions. Probabilistic graphical models such as staged trees are increasingly being used for causal…

因子数量未知时的稀疏贝叶斯因子分析AI 解读

There has been increased research interest in the subfield of sparse Bayesian factor analysis with shrinkage priors, which achieve additional sparsity beyond the natural parsimonity of factor models. In this spirit, we estimate the number of common factors in the highly implemented sparse latent factor model with spike-and-slab priors on the factor loadings matrix. Our framework leads to a natural, efficient and simultaneous coupling of model estimation and selection on one…

基于广义下三角结构的基本因子模型识别与计数规则AI 解读

Despite the popularity of factor models with sparse loading matrices, little attention has been given to formally address identifiability of these models beyond standard rotation-based identification such as the positive lower triangular (PLT) constraint. To fill this gap, we review the advantages of variance identification in sparse factor analysis and introduce the generalized lower triangular (GLT) structures. We show that the GLT assumption is an improvement over PLT…

融合预测变量的多受试者动态功能连接贝叶斯方法AI 解读

Time Varying Functional Connectivity (TVFC) investigates how the interactions among brain regions vary over the course of an fMRI experiment. The transitions between different individual connectivity states can be modulated by changes in underlying physiological mechanisms that drive functional network dynamics, e.g., changes in attention or cognitive effort as measured by pupil dilation. In this paper, we develop a multi-subject Bayesian framework for estimating dynamic…

序列相关误差下删失回归的贝叶斯方法AI 解读

The problem of estimating censored linear regression models with autocorrelated errors arises in many environmental and social studies. The present work proposes a Bayesian approach to estimate censored regression models with AR(p) errors. The algorithm developed here considers the Gibbs sampler with data augmentation(GDA), in which, at each iteration, both the model parameters and the latent variables are sampled. The data augmentation is achieved from multiple sampling of…