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以校准的 g 先验混合层级模型估计荟萃分析中的处理效应调节AI 解读

Assessing treatment effect moderation is critical in biomedical research and many other fields, as it guides personalized intervention strategies to improve participant's outcomes. Individual participant-level data meta-analysis (IPD-MA) offers a robust framework for such assessments by leveraging data from multiple trials. However, its performance is often compromised by challenges such as high between-trial variability. Traditional Bayesian shrinkage methods have gained…

结局与协变量信息不完整时 HIV 照护留存的贝叶斯反事实预测AI 解读

Like many chronic diseases, human immunodeficiency virus (HIV) is managed over time at regular clinic visits. At each visit, patient features are assessed, treatments are prescribed, and a subsequent visit is scheduled. There is a need for data-driven methods for both predicting retention and recommending scheduling decisions that optimize retention. Prediction models can be useful for estimating retention rates across a range of scheduling options. However, training such…

利用干预样本高效开展因果图的贝叶斯学习AI 解读

Causal discovery is a fundamental problem with applications spanning various areas in science and engineering. It is well understood that solely using observational data, one can only orient the causal graph up to its Markov equivalence class, necessitating interventional data to learn the complete causal graph. Most works in the literature design causal discovery policies with perfect interventions, i.e., they have access to infinite interventional samples. This study…

新型处理效应估计模型的消融研究AI 解读

Ablation studies are essential for understanding the contribution of individual components within complex models, yet their application in nonparametric treatment effect estimation remains limited. This paper emphasizes the importance of ablation studies by examining the Bayesian Causal Forest (BCF) model, particularly the inclusion of the estimated propensity score $\hatπ(x_i)$ intended to mitigate regularization-induced confounding (RIC). Through a partial ablation study…

最大得分问题的贝叶斯视角AI 解读

This paper presents a Bayesian inference framework for a linear index threshold-crossing binary choice model that satisfies a median independence restriction. The key idea is that the model is observationally equivalent to a probit model with nonparametric heteroskedasticity. Consequently, Gibbs sampling techniques from Albert and Chib (1993) and Chib and Greenberg (2013) lead to a computationally attractive Bayesian inference procedure in which a Gaussian process forms a…

含共同因子的动态时空与网络 ARCH 模型AI 解读

We introduce a dynamic spatiotemporal volatility model that extends traditional approaches by incorporating spatial, temporal, and spatiotemporal spillover effects, along with volatility-specific observed and latent factors. The model offers a more general network interpretation, making it applicable for studying various types of network spillovers. The primary innovation lies in incorporating volatility-specific latent factors into the dynamic spatiotemporal volatility…

利用负向对照调整未测量混杂的贝叶斯非参数方法AI 解读

Unmeasured confounding bias threatens the validity of observational studies. While sensitivity analyses and study designs have been proposed to address this issue, they often overlook the growing availability of auxiliary data. Using negative controls from these data is a promising new approach to reduce unmeasured confounding bias. In this article, we develop a Bayesian nonparametric method to estimate a causal exposure-response function (CERF) leveraging information from…

基于贝叶斯方法的倾向得分分层估计器AI 解读

Subclassification estimators are one of the methods used to estimate causal effects of interest using the propensity score. This method is more stable compared to other weighting methods, such as inverse probability weighting estimators, in terms of the variance of the estimators. In subclassification estimators, the number of strata is traditionally set at five, and this number is not typically chosen based on data information. Even when the number of strata is selected,…

利用共享神经元 RBF 网络估计个体化多处理响应曲线AI 解读

Heterogeneous treatment effect estimation is an important problem in precision medicine. Specific interests lie in identifying the differential effect of different treatments based on some external covariates. We propose a novel non-parametric treatment effect estimation method in a multi-treatment setting. Our non-parametric modeling of the response curves relies on radial basis function (RBF)-nets with shared hidden neurons. Our model thus facilitates modeling commonality…

ARFIMA 长记忆过程的新贝叶斯算法：MCMC 与 ABC 的比较AI 解读

This paper presents a comparative study of two Bayesian approaches - Markov Chain Monte Carlo (MCMC) and Approximate Bayesian Computation (ABC) - for estimating the parameters of autoregressive fractionally-integrated moving average (ARFIMA) models, which are widely used to capture long-memory in time series data. We propose a novel MCMC algorithm that filters the time series into distinct long-memory and ARMA components, and benchmarked it against standard approaches.…

存在治疗中止的肿瘤随机试验中事件时间结局的因果效应评估AI 解读

In clinical trials, patients may discontinue treatments prematurely, breaking the initial randomization and, thus, challenging inference. Stakeholders in drug development are generally interested in going beyond the Intention-To-Treat (ITT) analysis, which provides valid causal estimates of the effect of treatment assignment but does not inform on the effect of the actual treatment receipt. Our study is motivated by an RCT in oncology, where patients assigned the…

实证博弈中的反事实分析AI 解读

We address counterfactual analysis in empirical models of games with partially identified parameters, and multiple equilibria and/or randomized strategies, by constructing and analyzing the counterfactual predictive distribution set (CPDS). This framework accommodates various outcomes of interest, including behavioral and welfare outcomes. It allows a variety of changes to the environment to generate the counterfactual, including modifications of the utility functions, the…

高维矩阵值自回归模型的正则化估计AI 解读

Matrix-variate time series data are increasingly popular in economics, statistics, and environmental studies, among other fields. This paper develops regularized estimation methods for analyzing high-dimensional matrix-variate time series using bilinear matrix-variate autoregressive models. The bilinear autoregressive structure is widely used for matrix-variate time series, as it reduces model complexity while capturing interactions between rows and columns. However, when…

多变量中间区间随机化设计AI 解读

In a tie-breaker design (TBD), subjects with high values of a running variable are given some (usually desirable) treatment, subjects with low values are not, and subjects in the middle are randomized. TBDs are intermediate between regression discontinuity designs (RDDs) and randomized controlled trials (RCTs). TBDs allow a tradeoff between the resource allocation efficiency of an RDD and the statistical efficiency of an RCT. We study a model where the expected response is…

由随机线性扩展推断偏序：十二世纪王室文书中的权力关系AI 解读

In the eleventh and twelfth centuries in England, Wales and Normandy, Royal Acta were legal documents in which witnesses were listed in order of social status. Any bishops present were listed as a group. For our purposes, each witness-list is an ordered permutation of bishop names with a known date or date-range. Changes over time in the order bishops are listed may reflect changes in their authority. Historians would like to detect and quantify these changes. There is no…

N-of-1 试验中个体因果效应的工具变量估计：ISTOP 应用AI 解读

An N-of-1 trial is a multiple crossover trial conducted in a single individual to provide evidence to directly inform personalized treatment decisions. Advancements in wearable devices greatly improved the feasibility of adopting these trials to identify optimal individual treatment plans, particularly when treatments differ among individuals and responses are highly heterogeneous. Our work was motivated by the I-STOP-AFib Study, which examined the impact of different…

利用因果不变贝叶斯神经网络实现稳健域泛化AI 解读

Deep neural networks can obtain impressive performance on various tasks under the assumption that their training domain is identical to their target domain. Performance can drop dramatically when this assumption does not hold. One explanation for this discrepancy is the presence of spurious domain-specific correlations in the training data that the network exploits. Causal mechanisms, in the other hand, can be made invariant under distribution changes as they allow…

死亡截断下观察性研究不良事件效应的贝叶斯估计AI 解读

Death among subjects is common in observational studies evaluating the causal effects of interventions among geriatric or severely ill patients. High mortality rates complicate the comparison of the prevalence of adverse events (AEs) between interventions. This problem is often referred to as outcome "truncation" by death. A possible solution is to estimate the survivor average causal effect (SACE), an estimand that evaluates the effects of interventions among those who…

用于非对称贝叶斯小波收缩的一类先验AI 解读

This paper proposes a class of asymmetric priors to perform Bayesian wavelet shrinkage in the standard nonparametric regression model with Gaussian error. The priors are composed by mixtures of a point mass function at zero and one of the following distributions: asymmetric beta, Kumaraswamy, asymmetric triangular or skew normal. Statistical properties of the associated shrinkage rules such as squared bias, variance and risks are obtained numerically and discussed. Monte…

非线性遗憾下的处理选择AI 解读

The literature focuses on the mean of welfare regret, which can lead to undesirable treatment choice due to sensitivity to sampling uncertainty. We propose to minimize the mean of a nonlinear transformation of regret and show that singleton rules are not essentially complete for nonlinear regret. Focusing on mean square regret, we derive closed-form fractions for finite-sample Bayes and minimax optimal rules. Our approach is grounded in decision theory and extends to limit…

Cox 比例风险模型中未测混杂的非参数贝叶斯调整AI 解读

In observational studies, unmeasured confounders present a crucial challenge in accurately estimating desired causal effects. To calculate the hazard ratio (HR) in Cox proportional hazard models for time-to-event outcomes, two-stage residual inclusion and limited information maximum likelihood are typically employed. However, these methods are known to entail difficulty in terms of potential bias of HR estimates and parameter identification. This study introduces a novel…

利用多重先验强化随机对照试验并学习外部有效性AI 解读

This paper introduces a framework for incorporating prior information into the design of sequential experiments. These sources may include past experiments, expert opinions, or the experimenter's intuition. We model the problem using a multi-prior Bayesian approach, mapping each source to a Bayesian model and aggregating them based on posterior probabilities. Policies are evaluated on three criteria: learning the parameters of payoff distributions, the probability of…

大型 Probit 模型的高效计算估计AI 解读

Probit models are useful for modeling correlated discrete responses in many disciplines, including consumer choice data in economics and marketing. However, the Gaussian latent variable feature of probit models coupled with identification constraints pose significant computational challenges for its estimation and inference, especially when the dimension of the discrete response variable is large. In this paper, we propose a computationally efficient Expectation-Maximization…

混合类型时间序列广义线性模型的 Granger 因果性：多模态脑连接案例AI 解读

This paper is motivated by studies in neuroscience experiments to understand interactions between nodes in a brain network using different types of data modalities that capture different distinct facets of brain activity. To assess Granger-causality, we introduce a flexible framework through a general class of models that accommodates mixed types of data (binary, count, continuous, and positive components) formulated in a generalized linear model (GLM) fashion. Statistical…