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Semiparametric Causal Inference for Right-Censored Outcomes with Many Weak Invalid Instruments

大量弱无效工具变量下右删失结局的半参数因果推断

We propose a semiparametric framework for causal inference with right-censored survival outcomes and many weak invalid instruments, motivated by Mendelian randomization in biobank studies where classical methods may fail. We adopt an accelerated failure time model and construct a moment condition based on augmented inverse probability of censoring weighting, incorporating both uncensored and censored observations. Under a heteroscedasticity-based condition on the treatment…

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Adaptive Data-Borrowing for Improving Treatment Effect Estimation using External Controls

利用外部对照改进处理效应估计的自适应数据借用

Randomized controlled trials (RCTs) often exhibit limited inferential efficiency in estimating treatment effects due to small sample sizes. In recent years, the combination of external controls has gained increasing attention as a means of improving the efficiency of RCTs. However, external controls are not always comparable to RCTs, and direct borrowing without careful evaluation can introduce substantial bias and reduce the efficiency of treatment effect estimation. In…

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"Post" Pre-Analysis Plans: Valid Inference for Non-Preregistered Specifications

“事后”预分析计划:未预注册规格的有效推断

Pre-analysis plans (PAPs) have become standard in experimental economics research, but it is nevertheless common to see researchers deviating from their PAPs to supplement preregistered estimates with non-prespecified findings. While such ex-post analysis can yield valuable insights, there is broad uncertainty over how to interpret -- or whether to even acknowledge -- non-preregistered results. In this paper, we consider the case of a truth-seeking researcher who, after…

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Breakdown Analysis for Instrumental Variables with Binary Outcomes

二元结果工具变量模型的崩溃分析

This paper studies the partial identification of treatment effects in Instrumental Variables (IV) settings with binary outcomes under violations of independence. I derive the identified sets for the treatment parameters of interest in the setting, as well as breakdown values for conclusions regarding the true treatment effects. I derive $\sqrt{N}$-consistent nonparametric estimators for the bounds of treatment effects and for breakdown values. These results can be used to…

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Transfer Estimates for Causal Effects across Heterogeneous Sites

异质地点间因果效应的迁移估计

We consider the problem of extrapolating treatment effects across heterogeneous populations (``sites"/``contexts"). We consider an idealized scenario in which the researcher observes cross-sectional data for a large number of units across several ``experimental" sites in which an intervention has already been implemented to a new ``target" site for which a baseline survey of unit-specific, pre-treatment outcomes and relevant attributes is available. Our approach treats the…

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A Likelihood Based Approach to Distribution Regression Using Conditional Deep Generative Models

基于似然的分布回归:条件深度生成模型

In this work, we explore the theoretical properties of conditional deep generative models under the statistical framework of distribution regression where the response variable lies in a high-dimensional ambient space but concentrates around a potentially lower-dimensional manifold. More specifically, we study the large-sample properties of a likelihood-based approach for estimating these models. Our results lead to the convergence rate of a sieve maximum likelihood…

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On Causal Inference for the Survivor Function

生存函数的因果推断

In this expository paper, we consider the problem of causal inference and efficient estimation for the counterfactual survivor function. This problem has previously been considered in the literature in several papers, each relying on the imposition of conditions meant to identify the desired estimand from the observed data. These conditions, generally referred to as either implying or satisfying coarsening at random, are inconsistently imposed across this literature and, in…

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Generalized Bayes in Conditional Moment Restriction Models

条件矩限制模型中的广义贝叶斯方法

This paper develops a generalized (quasi-) Bayes framework for conditional moment restriction models, where the parameter of interest is a nonparametric structural function of endogenous variables. We establish contraction rates for a class of Gaussian process priors and provide conditions under which a Bernstein-von Mises theorem holds for the quasi-Bayes posterior. Consequently, we show that optimally weighted quasi-Bayes credible sets achieve exact asymptotic frequentist…

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Aggregation Trees

聚合树

Uncovering the heterogeneous effects of particular policies or "treatments" is a key concern for researchers and policymakers. A common approach is to report average treatment effects across subgroups based on observable covariates. However, the choice of subgroups is crucial as it poses the risk of $p$-hacking and requires balancing interpretability with granularity. This paper proposes a nonparametric approach to construct heterogeneous subgroups. The approach enables a…

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Partial Identification Approach to Counterfactual Fairness Assessment

反事实公平评估的部分识别方法

The wide adoption of AI decision-making systems in critical domains such as criminal justice, loan approval, and hiring processes has heightened concerns about algorithmic fairness. As we often only have access to the output of algorithms without insights into their internal mechanisms, it was natural to examine how decisions would alter when auxiliary sensitive attributes (such as race) change. This led the research community to come up with counterfactual fairness…

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Computationally and statistically efficient estimation of time-smoothed counterfactual curves

时间平滑反事实曲线的计算与统计高效估计

Longitudinal causal inference is concerned with defining, identifying, and estimating the effect of a time-varying intervention on a time-varying outcome that is indexed by a follow-up time. In an observational study, Robins's generalized g-formula can identify causal effects induced by a broad class of time-varying interventions. Various methods for estimating the generalized g-formula have been posed for different outcome types, such as a failure event indicator by a…

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Persuasion Effects in Regression Discontinuity Designs

回归不连续设计中的说服效应

We develop a framework for identifying and estimating persuasion effects in regression discontinuity (RD) designs. The RD persuasion rate measures the probability that individuals at the threshold would take the action if exposed to a persuasive message, given that they would not take the action without exposure. We present identification results for both sharp and fuzzy RD designs, derive sharp bounds under various data scenarios, and extend the analysis to local compliers.…

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Triadic Network Formation

三元网络形成

We study estimation and inference for triadic link formation with dyad-level fixed effects in a nonlinear binary choice logit framework. Dyad-level effects provide a richer and more realistic representation of heterogeneity across pairs of dimensions (e.g. importer-exporter, importer-product, exporter-product), yet their sheer number creates a severe incidental parameter problem. We propose a novel ``hexad logit'' estimator and establish its consistency and asymptotic…

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A Statistical Framework for Co-Mediators of Zero-Inflated Single-Cell RNA-Seq Data

零膨胀单细胞 RNA 测序数据的共同中介统计框架

Single-cell RNA sequencing (scRNA-seq) has revolutionized the study of cellular heterogeneity, enabling detailed molecular profiling at the individual cell level. However, integrating high-dimensional single-cell data into causal mediation analysis remains challenging due to zero inflation and complex mediator structures. We propose a novel mediation framework leveraging zero-inflated negative binomial models to characterize cell-level mediator distributions and beta…

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Staged Event Trees for Transparent Treatment Effect Estimation

用于透明治疗效应估计的分阶段事件树

Average and conditional treatment effects are fundamental causal quantities used to evaluate the effectiveness of treatments in various critical applications, including clinical settings and policy-making. Beyond the gold-standard estimators from randomized trials, numerous methods have been proposed to estimate treatment effects using observational data. In this paper, we provide a novel characterization of widely used causal inference techniques within the framework of…

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Leveraging LLMs to Improve Experimental Design: A Generative Stratification Approach

利用大语言模型改善实验设计:生成式分层方法

Pre-experiment stratification, or blocking, is a well-established technique for designing more efficient experiments and increasing the precision of the experimental estimates. However, when researchers have access to many covariates at the experiment design stage, they often face challenges in effectively selecting or weighting covariates when creating their strata. This paper proposes a Generative Stratification procedure that leverages Large Language Models (LLMs) to…

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On the Use of Weighting for Personalized and Transparent Evidence Synthesis

用于个性化与透明证据综合的加权方法

Over the past few decades, statistical methods for causal inference have made impressive strides, enabling progress across a range of scientific fields. However, much of this methodological development has been confined to individual studies, limiting its ability to draw more generalizable conclusions. Achieving a thorough understanding of cause and effect typically relies on the integration, reconciliation, and synthesis from diverse study designs and multiple data sources.…

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Calibrated Counterfactual Conformal Fairness ($C^3F$): Post-hoc, Shift-Aware Coverage Parity via Conformal Prediction and Counterfactual Regularization

校准反事实共形公平性:分布偏移下的覆盖率平等

We present Calibrated Counterfactual Conformal Fairness ($C^3F$), a post-hoc procedure that targets group-conditional coverage parity under covariate shift. $C^3F$ combines importance-weighted conformal calibration with a counterfactual regularizer based on path-specific effects in a structural causal model. The method estimates group-specific nonconformity quantiles using likelihood-ratio weights so that coverage degrades gracefully with the second moment of the weights. We…

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Difference-in-Differences Under Network Interference

网络干扰下的双重差分

This paper develops doubly robust estimators for direct (DATT) and spillover (SATT) average treatment effects on the treated in network-based difference-in-differences (DiD) designs. Unlike standard DiD methods, the proposed approach explicitly accommodates treatment spillovers and high-dimensional network confounding arising from complex inter-unit dependencies. Identification relies on a conditional parallel-trends assumption that holds after adjusting for high-dimensional…

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Combining Experimental and Observational Data for Identification and Estimation of Long-Term Causal Effects

结合实验与观察数据识别和估计长期因果效应

We study identifying and estimating the causal effect of a treatment variable on a long-term outcome using data from an observational and an experimental domain. The observational data are subject to unobserved confounding. Furthermore, subjects in the experiment are only followed for a short period; thus, long-term effects are unobserved, though short-term effects are available. Consequently, neither data source alone suffices for causal inference on the long-term outcome,…

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Off-Policy Evaluation in Markov Decision Processes under Weak Distributional Overlap

弱分布重叠下马尔可夫决策过程的离策略评估

Doubly robust methods hold considerable promise for off-policy evaluation in Markov decision processes (MDPs) under sequential ignorability: They have been shown to converge as $1/\sqrt{T}$ with the horizon $T$, to be statistically efficient in large samples, and to allow for modular implementation where preliminary estimation tasks can be executed using standard reinforcement learning techniques. Existing results, however, make heavy use of a strong distributional overlap…

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Cohort-Anchored Robust Inference for Event-Study with Staggered Adoption

交错处理事件研究中以处理队列为锚的稳健推断

This paper proposes a cohort-anchored framework for robust inference in event studies with staggered adoption, building on Rambachan and Roth (2023). Robust inference based on event-study coefficients aggregated across cohorts can be misleading due to the dynamic composition of treated cohorts, especially when pre-trends differ across cohorts. My approach avoids this problem by operating at the cohort-period level. To address the additional challenge posed by time-varying…

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Causal inference for the expected number of recurrent events in the presence of a terminal event

存在终末事件时复发事件期望次数的因果推断

While recurrent event analyses have been extensively studied, limited attention has been given to causal inference within the framework of recurrent event analysis. We develop a multiply robust estimation framework for causal inference in recurrent event data with a terminal failure event. We define our estimand as the vector comprising both the expected number of recurrent events and the failure survival function evaluated along a sequence of landmark times. We show that…

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Collaborative Indirect Treatment Comparisons with Multiple Distributed Single-arm Trials

多个分布式单臂试验的协作间接治疗比较

When randomized controlled trials are impractical or unethical to simultaneously compare multiple treatments, indirect treatment comparisons using single-arm trials offer valuable evidence for health technology assessments, especially for rare diseases and early-phase drug development. In practice, each sponsor conducts a single-arm trial on its own drug with restricted data-sharing and targets effects in its trial population, which can lead to unfair comparisons. This…

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