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Double Variable Importance Matching to Estimate Distinct Causal Effects on Event Probability and Timing

双重变量重要性匹配:区分事件概率与发生时间的因果效应

In many clinical contexts, estimating effects of treatment in time-to-event data is complicated not only by confounding, censoring, and heterogeneity, but also by the presence of a cured subpopulation in which the event of interest never occurs. In such settings, treatment may have distinct effects on (1) the probability of being cured and (2) the event timing among non-cured individuals. Standard survival analysis and causal inference methods typically do not separate cured…

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Assessing Omitted Variable Bias when the Controls are Endogenous

控制变量存在内生关联时的遗漏变量偏误评估

Omitted variables are one of the most important threats to the identification of causal effects. Several widely used methods assess the impact of omitted variables on empirical conclusions by comparing measures of selection on observables with measures of selection on unobservables. The recent literature has discussed various limitations of these existing methods, however. This includes challenges that arise when the omitted variables are endogenous, meaning that they are…

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Guardrailed Uplift Targeting: A Causal Optimization Playbook for Marketing Strategy

带业务约束的增量效应定向:营销策略的因果优化框架

This paper introduces a marketing decision framework that optimizes customer targeting by integrating heterogeneous treatment effect estimation with explicit business guardrails. The objective is to maximize revenue and retention while adhering to constraints such as budget, revenue protection, and customer experience. The framework first estimates Conditional Average Treatment Effects (CATE) using uplift learners, then solves a constrained allocation problem to decide whom…

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Covariate Selection for Joint Latent Space Modeling of Sparse Network Data

稀疏网络联合潜空间建模中的协变量选择

Network data are increasingly common in the social sciences and infectious disease epidemiology. Analyses often link network structure to node-level covariates, but existing methods falter with sparse networks and high-dimensional node features. We propose a joint latent space modeling framework for sparse networks with high-dimensional binary node covariates that performs covariate selection while accounting for uncertainty in estimated latent positions. Building on joint…

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Validating Causal Message Passing Against Network-Aware Methods on Real Experiments

在真实实验中将因果消息传递与网络感知方法比较验证

Estimating total treatment effects in the presence of network interference typically requires knowledge of the underlying interaction structure. However, in many practical settings, network data is either unavailable, incomplete, or measured with substantial error. We demonstrate that causal message passing, a methodology that leverages temporal structure in outcome data rather than network topology, can recover total treatment effects comparable to network-aware approaches.…

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Mixture Quantiles Estimated by Constrained Linear Regression

用约束线性回归估计混合分位数

We study the problem of modeling univariate distributions via their quantile functions. We introduce a flexible family of distributions whose quantile function is a linear combination of basis quantiles. Because the model is linear in its parameters, estimation reduces to constrained linear regression, yielding a convex optimization problem that readily accommodates cardinality constraints as well as L1 or smoothness regularization. For Lq-type objectives we show the…

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Count Data Models with Heterogeneous Peer Effects under Rational Expectations

理性预期下具有异质同伴效应的计数数据模型

This paper develops a peer effect model for count responses under rational expectations. The model accounts for heterogeneity in peer effects across groups based on observed characteristics. Identification is based on the linear model condition that requires the presence of friends of friends who are not direct friends. I show that this identification condition extends to a broad class of nonlinear models. Parameters are estimated using a nested pseudo-likelihood approach.…

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Global Testing in Multivariate Regression Discontinuity Designs

多维断点回归设计中的全局检验

Regression discontinuity (RD) designs with multiple running variables arise in a growing number of empirical applications, including geographic boundaries and multi-score assignment rules. Although recent methodological work has extended estimation and inference tools to multivariate settings, far less attention has been devoted to developing global testing methods that formally assess whether a discontinuity exists anywhere along a multivariate treatment boundary. Existing…

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Bias-Reduced Estimation of Finite Mixtures: An Application to Latent Group Structures in Panel Data

有限混合模型的偏差缩减估计及面板潜在组结构应用

Finite mixture models are widely used in econometric analyses to capture unobserved heterogeneity. This paper shows that maximum likelihood estimation of finite mixtures of parametric densities can suffer from substantial finite-sample bias in all parameters under mild regularity conditions. The bias arises from the influence of outliers in component densities with unbounded or large support and increases with the degree of overlap among mixture components. I show that…

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Bayesian Estimation of Causal Effects Using Proxies of a Latent Interference Network

利用潜在干扰网络代理进行因果效应的贝叶斯估计

Network interference occurs when treatments assigned to some units affect the outcomes of others. Traditional approaches often assume that the observed network correctly specifies the interference structure. However, in practice, researchers frequently only have access to proxy measurements of the interference network due to limitations in data collection or potential mismatches between measured networks and actual interference pathways. In this paper, we introduce a…

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Conformal Prediction for Causal Effects of Continuous Treatments

连续治疗因果效应的共形预测

Uncertainty quantification of causal effects is crucial for safety-critical applications such as personalized medicine. A powerful approach for this is conformal prediction, which has several practical benefits due to model-agnostic finite-sample guarantees. Yet, existing methods for conformal prediction of causal effects are limited to binary/discrete treatments and make highly restrictive assumptions such as known propensity scores. In this work, we provide a novel…

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Causal Inference on Networks under Misspecified Exposure Mappings: A Partial Identification Framework

暴露映射误设下网络因果推断的部分识别框架

Estimating treatment effects in networks is challenging, as each potential outcome depends on the treatments of all other nodes in the network. To overcome this difficulty, existing methods typically impose an exposure mapping that compresses the treatment assignments in the network into a low-dimensional summary. However, if this mapping is misspecified, standard estimators for direct and spillover effects can be severely biased. We propose a novel partial identification…

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Causal inference for calibrated scaling interventions on time-to-event processes

事件时间过程中校准缩放干预的因果推断

This work develops a flexible inferential framework for nonparametric causal inference in time-to-event settings, based on stochastic interventions defined through multiplicative scaling of the intensity governing an intermediate event process. These interventions induce a family of estimands indexed by a scalar parameter α, representing effects of modifying event rates while preserving the temporal and covariate-dependent structure of the observed data generating mechanism.…

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Factorial Difference-in-Differences

析因双重差分

We formulate factorial difference-in-differences (FDID), a research design that extends canonical difference-in-differences (DID) to settings in which an event affects all units. In many panel data applications, researchers exploit cross-sectional variation in a baseline factor alongside temporal variation in the event, but the corresponding estimand is often implicit and the justification for applying the DID estimator remains unclear. We frame FDID as a factorial design…

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Disentangling spatial interference and spatial confounding biases in causal inference

区分因果推断中的空间干扰与空间混杂偏差

Spatial interference and spatial confounding are two major issues inhibiting precise causal estimates when dealing with observational spatial data. Moreover, the definition and interpretation of spatial confounding remain arguable in the literature. In this paper, our goal is to provide clarity in a novel way on misconception and issues around spatial confounding from Directed Acyclic Graph (DAG) perspective and to disentangle both direct, indirect spatial confounding and…

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Selective Information Borrowing for Region-Specific Treatment Effect Inference under Covariate Mismatch in Multi-Regional Clinical Trials

多区域临床试验中协变量不匹配下的区域治疗效应推断

Multi-regional clinical trials (MRCTs) are central to global drug development, enabling evaluation of treatment effects across diverse populations. A key challenge is valid and efficient inference for a region-specific estimand when the target region is small and differs from auxiliary regions in baseline covariates or unmeasured factors. We adopt an estimand-based framework and focus on the region-specific average treatment effect (RSATE) in a prespecified target region,…

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Nonparametric Inference with an Instrumental Variable under a Separable Binary Treatment Choice Model

可分二元治疗选择模型下的工具变量非参数推断

Instrumental variable (IV) methods are widely used to infer treatment effects in the presence of unmeasured confounding. In this paper, we study nonparametric inference with an IV under a separable binary treatment choice model, which posits that the odds of the probability of taking the treatment, conditional on the instrument and the treatment-free potential outcome, factor into separable components for each variable. While nonparametric identification of smooth…

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Causal Inference for Preprocessed Outcomes with an Application to Functional Connectivity

预处理结局的因果推断及其在功能连接中的应用

In biomedical research, repeated measurements within each subject are often processed to remove artifacts and unwanted sources of variation. The resulting data are used to construct derived outcomes that act as proxies for scientific outcomes that are not directly observable. Although intra-subject processing is widely used, its impact on inter-subject statistical inference has not been systematically studied, and a principled framework for causal analysis in this setting is…

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Posterior Uncertainty for Targeted Parameters in Bayesian Bootstrap Procedures

贝叶斯自助法中目标参数的后验不确定性

We propose a general method to carry out a valid Bayesian analysis of a finite-dimensional `targeted' parameter in the presence of a finite-dimensional nuisance parameter. We apply our methods to causal inference based on estimating equations. While much of the literature in Bayesian causal inference has relied on the conventional 'likelihood times prior' framework, a recently proposed method, the 'Linked Bayesian Bootstrap', deviated from this classical setting to obtain…

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Performance of prior event rate ratio method in the presence of differential mortality or dropout

差异性死亡或退出下既往事件率比方法的表现

Purpose: Prior event rate ratio (PERR) method was proposed to control for measured or unmeasured confounders in real-world evaluation of effectiveness and safety of medical treatments using electronic medical records data. A widely cited simulation study showed that PERR estimate of treatment effect was biased in the presence of differential morality/dropout. However, the study only considered one specific PERR estimator of treatment effect and one specific scenario of…

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Designing Time Series Experiments in A/B Testing with Transformer Reinforcement Learning

利用 Transformer 强化学习设计时间序列 A/B 实验

A/B testing has become a gold standard for modern technological companies to conduct policy evaluation. Yet, its application to time series experiments, where policies are sequentially assigned over time, remains challenging. Existing designs suffer from two limitations: (i) they do not fully leverage the entire history for treatment allocation; (ii) they rely on strong assumptions to approximate the objective function (e.g., the mean squared error of the estimated treatment…

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The Innovation Tax: Generative AI Adoption, Productivity Paradox, and Systemic Risk in the U.S. Banking Sector

创新税:生成式人工智能采用、生产率悖论与美国银行业系统性风险

This paper evaluates the causal impact of Generative Artificial Intelligence (GenAI) adoption on productivity and systemic risk in the U.S. banking sector. Using a novel dataset linking SEC 10-Q filings to Federal Reserve regulatory data for 809 financial institutions over 2018--2025, we employ two complementary identification strategies: Dynamic Spatial Durbin Models (DSDM) to capture network spillovers and Synthetic Difference-in-Differences (SDID) for causal inference…

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Counterfactual Forecasting for Panel Data

面板数据的反事实预测

We address the challenge of forecasting counterfactual outcomes in a panel data with missing entries and temporally dependent latent factors -- a common scenario in causal inference, where estimating unobserved potential outcomes ahead of time is essential. We propose Forecasting Counterfactuals under Stochastic Dynamics (FOCUS), a method that extends traditional matrix completion methods by leveraging time series dynamics of the factors, thereby enhancing the prediction…

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Demystify Doubly-Robust Estimation: The Role of Overlap

理解双重稳健估计:协变量重叠的作用

The doubly-robust (DR) estimator is popular for evaluating causal effects in observational studies and is often perceived as more desirable than inverse probability weighting (IPW) or outcome modeling alone because it provides extra protection against model misspecification. However, double robustness is an asymptotic property that may not hold in finite samples. We investigate how the finite sample performance of the DR estimator depends on the degree of covariate overlap…

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