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含处理与协变量交互项的两阶段最小二乘及处理效应异质性AI 解读

Treatment effect heterogeneity with respect to covariates is common in instrumental variable (IV) analyses. An intuitive approach, which we call the interacted two-stage least squares (2sls), is to postulate a working linear model of the outcome on the treatment, covariates, and treatment-covariate interactions, and instrument it using the IV, covariates, and IV-covariate interactions. We clarify the causal interpretation of the interacted 2sls under the local average…

异质性处理效应变量重要性的目标学习AI 解读

Quantifying the heterogeneity of treatment effect is important for understanding how a commercial product or medical treatment affects different population subgroups. While much of treatment effect heterogeneity analysis focuses on the conditional average treatment effect, an alternative parameter that captures treatment effect heterogeneity is the variance of treatment effect across different covariate groups. One can also derive variable importance parameters that measure…

DoFlow：用于时间序列干预与反事实预测的流生成模型AI 解读

Time-series forecasting increasingly demands not only accurate observational predictions but also causal forecasting under interventional and counterfactual queries in multivariate systems. We present DoFlow, a flow-based generative model defined over a causal Directed Acyclic Graph (DAG) that delivers coherent observational and interventional predictions, as well as counterfactuals through the natural encoding-decoding mechanism of continuous normalizing flows (CNFs). We…

工具变量回归中的弱工具稳健子向量推断：LM 检验与 AR 置信集性质AI 解读

We propose a weak-instrument-robust subvector Lagrange multiplier test for instrumental variables regression. We show that it is asymptotically size-correct under a technical condition or as the number of instruments grows to infinity. This is the first weak-instrument-robust subvector test for instrumental variables regression to recover the degrees of freedom of the commonly used non-weak-instrument-robust Wald test. Additionally, we provide a closed-form solution for…

如何解释净生存率：实际估计目标与通常理解的差异AI 解读

Net survival is conventionally defined as ``survival if cancer were the only possible cause of death'', an estimand corresponding to cancer-specific mortality alone. The Pohar Perme estimator targets this by removing general population other-cause mortality from observed total mortality, but achieves it only when cancer patients experience the same other-cause mortality as the general population. However, cancer patients often experience elevated other-cause mortality due to…

测量误差下凹分布函数的推断AI 解读

We propose an estimator of a concave cumulative distribution function under the measurement error model, where the non-negative variables of interest are perturbed by additive independent random noise. The estimator is defined as the least concave majorant on the positive half-line of the deconvolution estimator of the distribution function. We show its uniform consistency and its square root convergence in law in $\ell_\infty(\mathbb R)$. To assess the validity of the…

随机占优的修正 Wilcoxon–Mann–Whitney 检验AI 解读

Given independent samples from two univariate distributions, the one-sided Wilcoxon-Mann-Whitney statistic may be used to conduct a rank-based test of first-order stochastic dominance. We broaden the scope of applicability of such tests by showing that the bootstrap may be used to conduct valid inference in a matched pairs sampling framework permitting dependence between the two samples. Further, we show that a modified bootstrap incorporating an implicit estimate of a…

用于因果中介与溢出效应的网络结构方程模型AI 解读

Social network interference induces complex dependencies where a unit's outcome is influenced not only by its own exposure and mediator but also by those of connected neighbors. In such settings, a significant challenge lies in distinguishing direct exposure effects from interference-driven spillover effects, and further separating these from indirect effects mediated by intermediate variables. To address this, we propose a theoretical framework utilizing structural…

隐藏在眼前：不可折叠性如何使网络元分析的处理效应产生偏差AI 解读

Network meta-analysis (NMA) is widely used to compare multiple interventions simultaneously by synthesizing direct and indirect evidence. The general fixed or random effects contrast-based NMA model can be applied to different outcomes and data structures by opting for either an arm-based or contrast-based likelihood depending on the data available. Depending on the outcome and link-function, we estimate either collapsible or non-collapsible effect measures. Using an…

重症监护中的锚回归域泛化与域适应AI 解读

The performance of predictive models in clinical settings often degrades when deployed in new hospitals due to distribution shifts. This paper presents a large-scale study of causality-inspired domain generalization on heterogeneous multi-center intensive care unit (ICU) data. We apply anchor regression and introduce anchor boosting, a novel, tree-based nonlinear extension, to a large dataset comprising 400,000 patients from nine distinct ICU databases. We find that anchor…

估计长期处理效应的替代指标指数法：敏感性分析AI 解读

This paper develops a sensitivity analysis of the surrogacy assumption for the surrogate index approach in Athey et al. [2025b]. We introduce "Weighted Surrogate Indices (WSIs)," the analog of the surrogate index under the surrogacy assumption. We show that under comparability, the ATE on WSI identifies the ATE on the long-term outcome when a copula of the treatment and the long-term outcome conditional on baseline covariates and surrogates is known. When the copula is…

自遮蔽非随机缺失混杂变量下的因果推断：分层偏移插补倾向估计AI 解读

In observational studies, causal inference becomes difficult when confounders are missing-not-at-random (MNAR), particularly where the missingness depends on the confounder's own unreported value (self-masking). Existing methods for handling MNAR confounders often rely on strong, unverifiable assumptions, leading to biased estimates. We propose a simple approach with Stratified Delta-Imputed Propensity Estimator (SDIPE) in the presence of self-masking confounders. SDIPE…

中国土地市场中的反腐执法与出让机制选择AI 解读

Upon taking office in late 2012, Chinese President Xi Jinping launched one of the most intensive anticorruption campaigns in the history of the People's Republic of China. Prior to the campaign, China's land market suffered from corruption, particularly surrounding sale method selection (auction versus listing). Listing is a two-stage sale mechanism that prior research has identified as more susceptible to corruption, leading to lower prices. This paper examines the…

利用潜因子模型的个体化动态中介分析AI 解读

Mediation analysis plays a crucial role in causal inference as it can investigate the pathways through which treatment influences outcome. Most existing mediation analysis assumes that mediation effects are static and homogeneous within populations. However, mediation effects usually change over time and exhibit significant heterogeneity among individuals in many real-world applications. Additionally, the mediation mechanism can be complicated and involves non-sparse, making…

因果工具变量模型中的贝叶斯模型平均AI 解读

Instrumental variables are a popular tool to infer causal effects under unobserved confounding, but choosing suitable instruments is challenging in practice. We propose gIVBMA, a Bayesian model averaging procedure that addresses this challenge by averaging across different sets of instrumental variables and covariates in a structural equation model. This allows for data-driven selection of valid and relevant instruments and provides additional robustness against invalid…

使用双重机器学习的双重差分中介分析AI 解读

We propose a difference-in-differences (DiD) framework with mediation for possibly multivalued discrete or continuous treatments and mediators, aimed at identifying the direct effect of the treatment on the outcome (net of effects operating through the mediator), the indirect effect via the mediator, and the joint effects of treatment and mediator, consistent with the framework of dynamic treatment effects. Identification relies on a conditional parallel trends assumption…

现实工作流程约束下的纵向因果发现AI 解读

Causal discovery has achieved substantial theoretical progress, yet its deployment in large-scale longitudinal systems remains limited. A key obstacle is that operational data are generated under institutional workflows whose induced partial orders are rarely formalized, enlarging the admissible graph space in ways inconsistent with the recording process. We characterize a workflow-induced constraint class for longitudinal causal discovery that restricts the admissible…

拥抱离散搜索：因果结构学习的一种可行方法AI 解读

We present FLOP (Fast Learning of Order and Parents), a score-based causal discovery algorithm for linear models. It pairs fast parent selection with iterative Cholesky-based score updates, cutting run-times over prior algorithms. This makes it feasible to fully embrace discrete search, enabling iterated local search with principled order initialization to find graphs with scores at or close to the global optimum. The resulting structures are highly accurate across…

现代因果推断与数据整合中的局部过度识别及效率增益AI 解读

This paper studies nonparametric local (over-)identification and the semiparametric efficiency in modern causal frameworks. We develop a unified approach that begins by translating structural models with latent variables into their induced statistical models of observables and then analyzes local overidentification through conditional moment restrictions. We apply this approach to three popular classes of causal models: (1) the general treatment model under unconfoundedness;…

没有工具变量时的边际处理效应AI 解读

We propose a method for defining, identifying, and estimating the marginal treatment effect (MTE) without imposing the instrumental variable (IV) assumptions of independence, exclusion, and separability (or monotonicity). Under a new definition of the MTE based on reduced-form treatment error that is statistically independent of the covariates, we find that the relationship between the MTE and standard treatment parameters holds in the absence of IVs. We provide a set of…

对假设进行压力测试：因果推断中的贝叶斯敏感性分析指南AI 解读

While observational data are routinely used to estimate causal effects of biomedical treatments, doing so requires special methods to adjust for observed confounding. These methods invariably rely on untestable statistical and causal identification assumptions. When these assumptions do not hold, sensitivity analysis methods can be used to characterize how different violations may change our inferences. The Bayesian approach to sensitivity analyses in causal inference has…

因果生存分析中的处理效应估计：实践建议AI 解读

The restricted mean survival time (RMST) difference offers an interpretable causal contrast to estimate the treatment effect for time-to-event outcomes, yet a wide range of available estimators leaves limited guidance for practice. We provide a unified review of RMST estimators for randomized trials and observational studies, establish identification and asymptotic properties, and supply new derivations where needed. Our extensive simulation study compares simple…

存在未观测空间变化混杂时处理效应的可识别性AI 解读

The study of causal effects in the presence of unmeasured spatially varying confounders has garnered increasing attention. However, a general framework for identifiability, which is critical for reliable causal inference from observational data, has yet to be advanced. In this paper, we study a linear model with various parametric model assumptions on the covariance structure between the unmeasured confounder and the exposure of interest. We establish identifiability of the…

加权估计敏感性模型中混杂强度的校准：比较综述与新方法AI 解读

Causal inference is only valid when its underlying assumptions are satisfied, one of the most central being the ignorability or unconfoundedness assumption. However, this hypothesis is often unrealistic in observational studies, as some confounding variables may remain unobserved. To address this limitation, sensitivity models for Inverse Probability Weighting (IPW) estimators, known as Marginal Sensitivity Models, have been introduced, allowing for a controlled relaxation…