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Interpretable Causal Graphical Models for Equilibrium Systems with Confounding

存在混杂的均衡系统:可解释因果图模型

In applications, quantities of interest are often modelled in equilibrium or an equilibrium solution is sought. The presence of confounding makes causal inference in this setting challenging. We provide interpretable graphical models for equilibrium systems with confounding using anterial graphs (Lauritzen and Sadeghi, 2018), a class of graphs containing directed acyclic graphs, ancestral graphs, and chain graphs. In this setting, we provide valid graphical representations…

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Robust Matrix Estimation with Side Information

利用辅助信息的稳健矩阵估计

We introduce a flexible framework for high-dimensional matrix estimation to incorporate side information for both rows and columns. Existing approaches, such as inductive matrix completion, often impose restrictive structure-for example, an exact low-rank covariate interaction term, linear covariate effects, and limited ability to exploit components explained only by one side (row or column) or by neither-and frequently omit an explicit noise component. To address these…

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Causal Discovery on Dependent Mixed Data with Applications to Gene Regulatory Network Inference

相依混合数据的因果发现及其在基因调控网络推断中的应用

Causal discovery aims to infer causal relationships among variables from observational data, typically represented by a directed acyclic graph (DAG). Most existing methods assume independent and identically distributed observations, an assumption often violated in modern applications. In addition, many datasets contain a mixture of continuous and discrete variables, which further complicates causal modeling when dependence across samples is present. To address these…

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Identification and Bayesian Inference for Synthetic Control Methods with Spillover Effects

存在溢出效应的合成控制方法:识别与贝叶斯推断

The synthetic control method (SCM) is widely used for causal inference with panel data, particularly when the number of treated units is small. It relies on the stable unit treatment value assumption (SUTVA), ruling out spillover effects. However, interventions often affect not only treated but also untreated units. This study proposes a novel panel data method that extends standard SCM to account for spillovers and estimate both treatment and spillover effects. The approach…

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Discovering Causal Relationships Between Time Series With Spatial Structure

发现具有空间结构的时间序列之间的因果关系

Causal discovery is the subfield of causal inference concerned with estimating the structure of cause-and-effect relationships in a system of interrelated variables, as opposed to quantifying the strength or describing the form of causal effects. As interest in causal discovery builds in fields such as ecology, public health, and environmental sciences where data are regularly collected with spatial and temporal structures, approaches must evolve to manage autocorrelation…

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Bayesian Nonparametrics for Principal Stratification with Continuous Post-Treatment Variables

连续处理后变量主层分析的贝叶斯非参数方法

Principal stratification provides a causal inference framework for investigating treatment effects in the presence of a post-treatment variable. Principal strata play a key role in characterizing the treatment effect by identifying groups of units with the same or similar values for the potential post-treatment variable at all treatment levels. The literature has focused mainly on binary post-treatment variables. Few papers considered continuous post-treatment variables. In…

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An Exponential-Polynomial Divergence-based Robust Information Criterion for Linear Panel Data Models and Neural Networks

用于线性面板模型与神经网络的指数多项式散度稳健信息准则

Model selection is a cornerstone of statistical inference, where information criteria are widely employed to balance model fit and complexity. However, classical likelihood-based criteria are often highly sensitive to contamination, outliers, and model misspecification. In this paper, we develop a robust alternative based on the Exponential-Polynomial Divergence, a flexible extension of existing divergence measures that enhances adaptability to diverse data irregularities.…

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Identification and estimation of causal mechanisms in cluster-randomized trials with post-treatment confounding using Bayesian nonparametrics

处理后混杂下集群随机试验因果机制的贝叶斯非参数识别与估计

Causal mediation analysis in cluster-randomized trials (CRTs) is essential for explaining how cluster-level interventions affect individual outcomes, yet it is complicated by interference, post-treatment confounding, and hierarchical covariate adjustment. We develop a Bayesian nonparametric framework that simultaneously accommodates interference and a post-treatment confounder that precedes the mediator. Identification is achieved through a multivariate Gaussian copula that…

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Tail-Calibrated Estimation of Extreme Quantile Treatment Effects

极端分位数处理效应的尾部校准估计

Extreme quantile treatment effects (eQTEs) measure the causal impact of a treatment on the tails of an outcome distribution and are central for studying rare, high-impact events. Standard QTE methods often fail in extreme regimes due to data sparsity, while existing eQTE methods rely on restrictive tail assumptions or on interior-quantile theory. We propose the Tail-Calibrated Inverse Estimating Equation (TIEE) framework, which combines information across quantile levels and…

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On the inclusion of non-concurrent controls in platform trials with an interim analysis

含期中分析的平台试验如何纳入非同期对照

The analysis of platform trials can be enhanced by utilizing non-concurrent controls. Since including this data might also introduce bias in the treatment effect estimators if time trends are present, methods for incorporating non-concurrent controls adjusting for time have been proposed. However, so far their behavior has not been systematically investigated in platform trials that include interim analyses. To evaluate the impact of an interim analysis in trials utilizing…

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Bayesian variable selection in sample selection models using spike-and-slab priors

样本选择模型中的贝叶斯变量选择:spike-and-slab 先验

Sample selection models are a widely used approach for correcting bias caused by data that are missing not at random. Their formulation requires specifying the variables that influence the outcome and those that drive the selection process. This specification is often based on expert knowledge, which can result in the inclusion of irrelevant variables or the omission of important ones. Moreover, to avoid inferential problems such as practical non-identifiability,…

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Riesz Regression As Direct Density Ratio Estimation

将 Riesz 回归理解为直接密度比估计

This study clarifies the relationship between Riesz regression [Chernozhukov et al., 2021] and density ratio estimation (DRE) in causal inference problems, such as average treatment effect estimation. We first show that the Riesz representer can be written as a signed density ratio and then demonstrate that the Riesz regression objective coincides with the least-squares importance fitting criterion [Kanamori et al., 2009]. Although Riesz regression applies to a broad class…

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An Improved Inference for IV Regressions

工具变量回归的改进推断:结合低维与多工具变量检验

Empirical instrumental variables (IV) studies often report separate results based on low-dimensional instruments and many base instruments. This paper proposes a combination test that integrates these commonly reported statistics. The test linearly combines a cluster-robust Wald statistic based on low-dimensional IVs with leave-one-cluster-out Lagrangian Multiplier (LM) and Anderson-Rubin (AR) statistics constructed from many IVs. We establish joint asymptotic normality and…

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Optimal Design under Interference, Homophily, and Robustness Trade-offs

干扰、同质性与稳健性权衡下的最优实验设计

To minimize the mean squared error (MSE) in global average treatment effect (GATE) estimation under network interference, a popular approach is to use a cluster-randomized design. However, in the presence of homophily, which is common in social networks, cluster randomization can instead increase the MSE. We develop a novel potential outcomes model that accounts for interference, homophily, and heterogeneous variation. In this setting, we establish a framework for optimizing…

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Variable Selection in Functional Linear Quantile Regression for Identifying Associations between Daily Patterns of Physical Activity and Cognitive Function

函数型线性分位数回归的变量选择:识别日常体力活动模式与认知功能的关联

Quantile regression is useful for characterizing the conditional distribution of a response variable and understanding heterogeneity in the covariate effects at different quantiles. The rise of high-dimensional physiological data in biomedical research through wearable and sensor devices underscores the need for effective variable selection methods for interpretable and accurate quantile regression, which can offer robust insights into heterogeneous and dynamic covariate…

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Consistent Bayesian causal discovery for structural equation models with equal error variances

等误差方差结构方程模型的一致贝叶斯因果发现

We consider the problem of recovering the true causal structure among a set of variables, generated by a linear acyclic structural equation model (SEM) with the error terms being independent, not necessarily Gaussian, and having equal variances. It is well-known that the true underlying directed acyclic graph (DAG) encoding the causal structure is uniquely identifiable under this assumption. Interestingly, in this setting, it further holds that the sum of minimum expected…

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Spline Quantile Regression with Cubic and Linear Smoothing Splines

三次与线性平滑样条的分位数回归

Spline quantile regression (SQR) is a method introduced recently by Li and Megiddo (2026) for linear quantile regression where the regression coefficients are treated as smooth functions of the quantile level. With the coefficients represented by cubic splines with fixed knots on a given set of quantiles, the SQR method produces an estimate for the functional coefficients by solving a penalized quantile regression problem. The $\ell_1$-norm of the second derivatives of the…

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Cost-Aware Optimized Front-Door Experimental Design

考虑成本的最优前门实验设计

Causal effect estimation often succeeds cost-constrained sequential data collection. This work considers multivariate linear front-door models with arbitrary unobserved confounding on treatment and response. We optimize the experimental design by balancing the statistical efficiency and measurement costs through partial data. The full-data efficient influence function for the causal effect is derived, together with the geometry of all observed-data influence functions. This…

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Learning about Treatment Effects with Prior Studies: A Bayesian Model Averaging Approach

利用既有研究学习处理效应:贝叶斯模型平均方法

We establish concentration rates for estimation of treatment effects in experiments that incorporate prior sources of information -- such as past pilots, related studies, or expert assessments -- whose external validity is uncertain. Each source is modeled as a Gaussian prior with its own mean and precision, and sources are combined using Bayesian model averaging (BMA), allowing data from the new experiment to update posterior weights. To capture empirically relevant…

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On the Number of Conditional Independence Tests in Constraint-based Causal Discovery

基于约束的因果发现所需条件独立检验数量

Learning causal relations from observational data is a fundamental problem with wide-ranging applications across many fields. Constraint-based methods infer the underlying causal structure by performing conditional independence tests. However, existing algorithms such as the prominent PC algorithm need to perform a large number of independence tests, which in the worst case is exponential in the maximum degree of the causal graph. Despite extensive research, it remains…

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Rethinking the Win Ratio: A Causal Framework for Hierarchical Outcome Analysis

重新审视胜率比:层级结局分析的因果框架

Quantifying causal effects in the presence of complex and multivariate outcomes remains a key challenge in treatment evaluation. For hierarchical multivariate outcomes, the FDA recommends the Win Ratio and Generalized Pairwise Comparisons approaches \citep{Pocock2011winratio,Buyse2010}. However, commonly used estimators can yield treatment recommendations that target a population-level estimand (the probability that a randomly sampled patient under treatment fares better…

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Cumulative Marginal Mean Model for Assessing Sequential Effects Using Digital Health Data

利用数字健康数据评估序贯效应的累积边际均值模型

Mobile health (mHealth) leverages digital technologies, such as mobile phones, to capture objective, frequent, and real-world digital phenotypes from individuals, enabling the delivery of tailored interventions to accommodate substantial between-subject and temporal heterogeneity. However, evaluating heterogeneous treatment effects (HTEs) using digital phenotype data is challenging because treatments are delivered dynamically over time and may generate carryover effects that…

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Double machine learning to estimate the effects of multiple treatments and their interactions

用双重机器学习估计多种处理及其交互效应

Causal inference literature has extensively focused on binary treatments, with relatively fewer methods developed for multi-valued treatments. In particular, methods for multiple simultaneously assigned treatments remain understudied despite their practical importance. This paper introduces two settings: (1) estimating the effects of multiple treatments of different types (binary, categorical, and continuous) and the effects of treatment interactions, and (2) estimating the…

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Sequential Transport for Causal Mediation Analysis

用于因果中介分析的序贯传输

We propose sequential transport (ST), a distributional framework for mediation analysis that combines optimal transport (OT) with a mediator directed acyclic graph (DAG). Instead of relying on cross-world counterfactual assumptions, ST constructs unit-level mediator counterfactuals by minimally transporting each mediator, either marginally or conditionally, toward its distribution under an alternative treatment while preserving the causal dependencies encoded by the DAG. For…

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