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Restricted mean time lost for survival and competing risks data using mets in R

使用 R 包 mets 分析生存与竞争风险数据的限制平均损失时间

This paper introduces software implemented in the mets R-package for calculating non-parametric and regression estimates of Restricted Mean Survival Time (RMST) and Restricted Mean Time Lost (RMTL), including RMTL due to specific causes. A unique feature is the ability to compute the non-parametric estimates of RMST and RMTL, as well as their standard errors, for all time horizons simultaneously. Regression modeling in mets is based on Inverse Probability of Censoring…

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Improved Guarantees for Heterogeneous Treatment-Effect Estimation via Matrix Completion

通过矩阵补全改进异质性处理效应估计的理论保证

A central goal of modern causal inference is estimating heterogeneous treatment effects to answer questions like "how does an intervention affect each unit," rather than only on average. We study this problem with panel-data where we observe $n$ units across $m$ times under unknown, non-uniform treatment assignments. The data in this setting is naturally represented as a matrix of all unit--time treatment effects. Estimating heterogeneous treatment effects can then be…

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Semiparametric Inference for Causal Effects on Functional Outcomes

函数型结局因果效应的半参数推断

Difference-in-differences (DiD) is a cornerstone of causal inference, yet extending it to functional outcomes is not a routine scalar generalization; rather, it entails three fundamental challenges in identification, inference, and observation. This paper develops a comprehensive semiparametric inference framework for functional DiD with discretely observed data. First, we define the functional average treatment effect under parallel trends and derive its efficient influence…

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Modifying causal models to distinguish between transient and lasting causal effects

修改因果模型以区分暂时与持久的因果效应

This paper considers how to classify the effects of interventions in causal models for outcomes and exposures observed over time. First, we demonstrate the limitations of the most common uses of potential outcomes and causal directed acyclic graphs for capturing all possible interventions in a time varying framework, particularly in problems where the key question concerns interventions to maintain or change equilibrium behaviour. Second, we adopt a system and state based…

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A Doubly Robust GMM Estimator for Sequential Non-monotone Missingness

序贯非单调缺失下的双重稳健 GMM 估计量

We study moment-based estimation with two sequentially collected variables subject to non-monotone missingness. The commonly used Missing at Random (MAR) assumption requiring all missingness mechanisms to depend on the same fully observed covariates often fails in such cases. We introduce a sequential MAR assumption that allows asymmetric missingness mechanisms across stages. Based on this assumption, we construct an Augmented Inverse-Probability-Weighted GMM (AIPW-GMM)…

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rd2d: Causal Inference in Boundary Discontinuity Designs

rd2d:边界断点设计中的因果推断软件

Boundary Discontinuity (BD) designs are used in empirical research to learn about causal treatment effects along a continuous assignment boundary defined by a bivariate score. These designs are also known as multi-score regression discontinuity (RD) designs, and include geographic RD designs as a prominent example. This article introduces \pkg{rd2d}, a statistical software package for \proglang{R}, \proglang{Python}, and \proglang{Stata} that implements local polynomial…

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Bridging Maximum Likelihood and Optimal Transport for Efficient Inference and Model Selection in Stochastic Block Models

连接最大似然与最优传输:随机块模型的高效推断与模型选择

We study inference in stochastic block models (SBMs) through the lens of optimal transport (OT). We first establish that maximum likelihood variational inference (MLVI) can be interpreted as a semi-relaxed Gromov-Wasserstein (srGW) projection with entropic regularization. While this formulation yields accurate clustering, the entropic regularization prevents transport plans to be sparse, hindering intrinsic model selection. Consequently, we investigate unregularized srGW…

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Estimating Continuous Treatment Effects with Two-Stage Kernel Ridge Regression

利用两阶段核岭回归估计连续处理效应

We study the problem of estimating the effect function for a continuous treatment, which maps each treatment value to a population-averaged outcome. A central challenge in this setting is confounding: treatment assignment often depends on covariates, creating selection bias that makes direct regression of the response on treatment unreliable. To address this issue, we propose a two-stage kernel ridge regression method. In the first stage, we learn a model for the response as…

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Identification and Inference for Structural Accelerated Failure Time Models via Instrument Interactions

利用工具变量交互识别与推断结构加速失效时间模型

We study causal inference for time-to-event outcomes under right censoring in the presence of unmeasured confounding. Focusing on structural accelerated failure time models, we develop an identification and inference framework that exploits interactions among instrumental variables. The proposed approach does not rely on classical instrumental variable validity and yields valid causal inference under both valid and invalid instruments, provided that the interaction-based…

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Graph Neural Networks for Generalized Mundlak Estimator under Network Confounding

网络混杂下基于图神经网络的广义 Mundlak 估计量

This paper proposes a generalized Mundlak estimator based on graph neural networks (GME-GNN). The estimator is designed to mitigate bias arising from group-level heterogeneity and to accommodate within-group dependence among individuals. Traditional fixed-effects models handle group heterogeneity via group-specific intercepts, but require overly strict linear additivity and intra-group independence assumptions, and are confined to within-group comparisons. Rather than…

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Estimating within-cluster and between-cluster spillover effects in randomized saturation designs

随机饱和度设计中簇内与簇间溢出效应的估计

Randomized saturation designs are two-stage experiments: they first randomly assign treatment probabilities over the clusters and then randomly assign the treatment to the units within the clusters. The existing literature on randomized saturation designs focuses on estimating within-cluster spillover effects by assuming away between-cluster spillover effects. However, the units may interact across clusters in many practical randomized saturation designs. A leading example…

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Bayesian Structured Mediation Analysis With Unobserved Confounders

含未观测混杂因素的贝叶斯结构化中介分析

We explore methods to reduce the impact of unobserved confounders on the causal mediation analysis of high-dimensional mediators with spatially smooth structures, such as brain imaging data. The key approach is to incorporate the latent individual effects, which influence the structured mediators, as unobserved confounders in the outcome model, thereby potentially debiasing the mediation effects. We develop BAyesian Structured Mediation analysis with Unobserved confounders…

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Beyond Exchangeability: Distribution-Shift-Aware Integration of External Control Data in Randomized Trials

超越可交换性:随机试验中考虑分布偏移的外部对照整合

Randomized controlled trials (RCTs) are the gold standard for evaluating causal effects but are often costly and difficult to scale; consequently, they are frequently augmented with auxiliary external controls in many applications. Prior approaches for borrowing such data typically rely on exchangeability, under which the external controls are readily usable for inference in the trial population. In practice, however, differences in eligibility criteria, standard of care,…

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IV regression with distribution-valued outcomes

分布值结局的工具变量回归

We develop IV Fréchet regression (IVFR), an instrumental-variable (IV) method for settings where the outcome is an entire distribution. Framing the problem as an IV regression in 2-Wasserstein space, IVFR extends global Fréchet regression to the case with endogenous covariates. IVFR projects IV-weighted quantile curves onto the space of valid distributions and then recovers the corresponding regression coefficient functions. The projection provably reduces the estimation…

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Heterogeneity-robust granular instruments

对异质性稳健的颗粒工具变量

Granular instrumental variables (GIV) has experienced sharp growth in empirical macro-finance. The methodology's rise showcases granularity's potential for identification across many economic environments, like the estimation of spillovers and demand systems. I propose a new estimator--called robust granular instrumental variables (RGIV)--that enables studying unit-level heterogeneity in spillovers. Unlike existing methods that assume heterogeneity is a function of…

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The Modified Egger Intercept Tests for Detecting Horizontal Pleiotropy in Two-Sample Summary-Data Mendelian Randomization

检测两样本汇总数据孟德尔随机化水平多效性的修正 Egger 截距检验

The Egger intercept (EI) test is a widely used tool to detect horizontal pleiotropy in two-sample summary-data Mendelian randomization. A significant EI test suggests that either the average pleiotropic effect differs from zero (i.e., directional pleiotropy) or the InSIDE (Instrument Strength Independent of Direct Effect) assumption is violated (i.e., correlated pleiotropy) or both. As such, the EI test provides an assessment of the validity of the instrumental variable…

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Automated, efficient and model-free inference for randomized clinical trials via data-driven covariate adjustment

通过数据驱动协变量调整实现随机临床试验的自动化高效无模型推断

In 2023, the U.S. Food and Drug Administration issued guidance for adjustment of covariates in randomized clinical trials, emphasizing its role in enhancing precision and power through prognostic baseline variables. Despite its potential, many trials underutilize this method partly due to challenges in pre-specifying optimal baseline covariates and their functional forms. We explore the potential of automated, data-adaptive methods-including stepwise regression, Lasso and…

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Identifying Direct Causal Effects in Latent Factor Models by Accounting for Unidentified Parents

考虑尚未识别的父节点效应以识别潜因子模型中的直接因果效应

We consider linear structural equation models with explicitly modelled latent variables. In such models, observed and latent variables solve linear equations including stochastic noise terms. The goal of our work is to identify the direct causal effects between the observed variables of interest by providing (rational) formulas in the observed covariances. Most prior identification approaches operate in the latent projection framework, where latent variables are projected…

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Learning Correlated Reward Models: Statistical Barriers and Opportunities

学习相关奖励模型:统计障碍与机会

Random Utility Models (RUMs) are a classical framework for modeling user preferences and play a key role in reward modeling for Reinforcement Learning from Human Feedback (RLHF). However, a crucial shortcoming of many of these techniques is the Independence of Irrelevant Alternatives (IIA) assumption, which collapses \emph{all} human preferences to a universal underlying utility function, yielding a coarse approximation of the range of human preferences. On the other hand,…

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Causal Machine Learning: A Survey and Open Problems

因果机器学习:综述与开放问题

Causal Machine Learning (CausalML) is an umbrella term for machine learning methods that formalize the data-generation process as a structural causal model (SCM). This perspective enables us to reason about the effects of changes to this process (interventions) and what would have happened in hindsight (counterfactuals). We categorize work in CausalML into five groups according to the problems they address: (1) causal supervised learning, (2) causal generative modeling, (3)…

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Causally-interpretable meta-analysis using aggregate data

利用汇总数据开展具有因果解释的元分析

Evidence syntheses and meta-analyses are used to inform clinical practice guidelines and health economic evaluations. However, heterogeneity of treatment effects poses a significant challenge. Conventional meta-analysis addresses heterogeneity through random-effect assumptions, which are not supported by design and lead to estimates that may not apply to any real-world population. Causally-interpretable meta-analysis (CIMA) offers a rigorous framework for specification,…

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A Simple Measure of Robustness for External Validity under Covariate Shifts

协变量分布偏移下外部有效性的简明稳健性度量

This paper studies the robustness of estimated policy effects to changes in the distribution of covariates, a key determinant of the external validity of (quasi)-experimental results. I propose a novel robustness metric $δ^*$ which measures the smallest covariate shift needed to invalidate an empirical claim about the policy effect (e.g., $ATE > 0$). I estimate $δ^*$ via de-biased GMM, achieving a parametric rate of convergence while accommodating machine-learning estimators…

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Auditing and Fixing Economic Validity in Tabular Foundation Models for Discrete Choice

审计并修复表格基础模型在离散选择中的经济有效性

Tabular foundation models achieve strong accuracy on choice prediction tasks, but their predictions often violate the economic logic those tasks require: raising a price sometimes increases predicted demand, and implied willingness-to-pay estimates are frequently negative or implausible. We propose a two-stage adapter that embeds foundation model predictions within a utility-maximization framework. In the first stage, we estimate a standard choice model whose parameters are…

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Global Average Treatment Effects for Individualized Randomization Experiments with Aggregate Data

仅用聚合数据识别个体随机化实验的全局平均处理效应

Individualized randomized experiments are central to online platforms for optimizing personalized decisions in complex environments. In two-sided markets, however, standard treatment effect estimation is often invalid due to strong temporal and cross-unit interference, a challenge compounded when only aggregated data are available because of privacy or system constraints. To address these issues, we identify the Global Average Treatment Effect (GATE) using only group-level…

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