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允许工具变量潜在无效的可能性理论回归AI 解读

Instrumental variable regression is a common approach for causal inference in the presence of unobserved confounding. However, identifying valid instruments is often difficult in practice. In this paper, we propose a novel method based on possibility theory that performs posterior inference on the treatment effect, conditional on a user-specified set of potential violations of the instrument exogeneity assumption. Our method can provide valid results even when only a single,…

高维伊辛模型中的迁移学习AI 解读

In high-dimensional Ising model estimation, target sample sizes are often limited, and effectively using auxiliary binary datasets of unknown relevance remains challenging. To address this, we propose Trans-Ising, a transfer learning method that combines a loss-based source screening rule with a two-stage estimation procedure. The method first identifies informative auxiliary sources using held-out target pseudolikelihood to prevent negative transfer. It then computes an…

存在未测量处理诱发混杂的近端中介分析AI 解读

Mediation analysis provides a central framework for elucidating causal mechanisms, yet its application is often impeded by treatment-induced confounding, under which the widely used natural mediation effects are generally unidentifiable. Interventional effects have been proposed as an alternative when these confounders are observable; however, identifying and estimating interventional effects remains challenging when confounders are unmeasured. In this paper, we address this…

结局子抽样纵向两阶段设计的目标最大似然估计AI 解读

We consider efficient estimation of causal parameters in longitudinal two-stage designs with outcome subsampling, motivated by resampling designs in HIV-related mortality studies. In these studies, many participants become lost to follow-up; resampling designs address this by tracing a subset of lost individuals to ascertain their outcomes. Analyses often use inverse-probability-weighted Kaplan-Meier (wKM) estimators that discard longitudinal covariate information and suffer…

平行趋势假设下的结构嵌套均值模型AI 解读

We link and extend two approaches to estimating time-varying treatment effects on repeated continuous outcomes--time-varying Difference in Differences (DiD; see Roth et al. (2023) and Chaisemartin et al. (2023) for reviews) and Structural Nested Mean Models (SNMMs; see Vansteelandt and Joffe (2014) for a review). In particular, we show that SNMMs, previously known to be nonparametrically identified under a no unobserved confounding assumption, are also identified under a…

用库存生命周期价值衡量机会成本AI 解读

Measuring the long-term opportunity cost of interventions remains a critical challenge in e-commerce A/B testing. While strategic levers (such as dynamic pricing, ranking algorithms, and promotional campaigns) trigger shifts in consumer behaviour that persist over months, operational constraints necessitate fast decision-making cycles that are typically limited to weekly experimental windows. Standard metrics like revenue and conversion are inherently short-sighted, biasing…

随机临床试验中协变量调整 g-computation 的偏差减少AI 解读

G-computation is a powerful method for estimating unconditional treatment effects with covariate adjustment in randomized clinical trials. It typically relies on fitting canonical generalized linear models. However, this could be problematic when the sample size or event number is small relative to the number of covariates. Common issues include the underestimation of the variance and the potential nonexistence of maximum likelihood estimators. Bias reduction methods are…

倾向得分传播：未知倾向得分下基于设计的推断框架AI 解读

Design-based inference, also known as randomization-based or finite-population inference, provides a principled framework for trustworthy statistical inference. It attributes randomness solely to the design mechanism, such as treatment assignment, survey sampling, or missingness, without imposing super-population distributional or modeling assumptions on the outcome data. From the seminal work of Fisher and Neyman to its recent resurgence, design-based inference has played a…

带结构化收缩先验的连续时间贝叶斯网络：大规模电子健康记录中的多病轨迹建模AI 解读

Multiple long-term conditions (MLTCs) arise through complex, time-dependent interactions among diseases, yet existing methods often struggle to jointly model disease progression, multimorbidity networks, and high-dimensional risk factors. We propose a structured Bayesian continuous-time Bayesian network (CTBN) framework for learning directed disease-dependency networks from longitudinal electronic health records. The model allows disease transition intensities to depend on…

测量误差诱发的混杂AI 解读

A critical assumption of observational studies is that all confounding variables must be known and sufficiently adjusted for to estimate causal effects. An implicit, and often overlooked, aspect of this assumption is that all confounding variables have been measured without error. In the social and medical sciences, latent traits such as motivation, self-efficacy, and ability measures are likely confounding variables. Because latent traits are not directly observable,…

序贯实验的半参数效率：基于平均倾向得分的刻画与设计AI 解读

Modern experiments, including evaluations of AI-enabled services and platform interventions, often depart from independent and identically distributed (i.i.d.) sampling because assignments may be adaptive, balanced across covariates, or subject to rollout constraints such as exposure, fairness, and budget limits. This paper studies the efficiency benchmark for estimating causal targets in such sequential experiments. We show that every non-anticipating design induces an…

真实世界证据中信息性治疗切换的工具变量方法AI 解读

Reproducible and generalizable assessment of treatment decisions requires principled handling of subsequent treatment switching that may inform expected outcomes and shift across cohorts and over time. To effectively account for informative treatment switching, we propose an instrumental variable approach that characterizes the poorly documented expected outcomes at switching as unmeasured confounding. After establishing the baseline treatment as a viable instrumental…

迁移学习与自适应 LASSO 分位数回归AI 解读

We propose for a quantile regression an estimation method for transferring knowledge using two $L_1$ penalties based on an estimator obtained from a source database. The proposed transfer learning estimator satisfies the properties of consistency and sparsity. Its convergence rate and asymptotic behavior are studied in several scenarios. This knowledge transfer results in a shorter computation time than that of the standard adaptive LASSO estimator. Another advantage of our…

针对排除限制与外生性违背的广义证伪适应集AI 解读

The falsification adaptive set (FAS) as proposed by Masten and Poirier (2021) provides an identified set for a treatment effect when the baseline model is falsified, assuming invalid instruments violate exclusion only. We show that whether an invalid instrument is a confounder or collider has important consequences: incorrect treatment can cause the FAS to exclude the true parameter. We derive pattern-specific falsification adaptive sets for each combination of violations…

边际处理效应函数的一致置信带AI 解读

This paper presents a method for constructing uniform confidence bands for the marginal treatment effect (MTE) function. The shape of the MTE function provides insight into how the unobserved propensity to receive treatment relates to the treatment effect. Our approach visualizes the statistical uncertainty of an estimated function, facilitating inferences about the function's shape. The proposed method is computationally inexpensive and requires only minimal information:…

存在个体间干扰时的因果推断敏感性分析框架AI 解读

In many applications of causal inference, the treatment received by one unit may influence the outcome of another, a phenomenon referred to as interference. Although there are several frameworks for conducting causal inference in the presence of interference, practitioners often lack the data necessary to adjust for its effects. In this paper, we propose a weighting-based sensitivity analysis framework that can be used to assess the systematic bias arising from ignoring…

面向全体人群的因果推断：死亡截断结局的边际估计目标AI 解读

In longitudinal studies, outcomes of interest are often truncated by death, meaning that they are only observed or well-defined conditional on intercurrent events such as survival. Existing strategies face a trade-off: causally interpretable estimands, such as survivor average causal effects, target a latent subgroup, whereas while-alive and composite summaries apply to the full population but are difficult to interpret as causal effects on the non-mortality outcome. We…

基于经验分位数的估计量的渐近性质AI 解读

We consider inference for parameters of the form $θ_0 = E[F_Y^{-1}\circ F_Z(X)]$ for some variables $X$, $Y$ and $Z$. Such parameters appear, in particular, in the ``changes-in-changes'' model of \cite{AtheyImbens2006}. We first establish that $\widehatθ$, a plug-in estimator of $θ_0$, is root-$n$ consistent and asymptotically normal under weaker conditions than those previously available, allowing in particular for unbounded variables. Next, we propose a new estimator of…

含测量误差的分位数回归AI 解读

We devise a novel estimator for a general quantile regression model with normal measurement errors in the covariates. The method is applicable to both linear and nonlinear quantile regressions and does not impose the quantile requirement on multiple quantile levels simultaneously. We circumvent the difficulties caused by discontinuity in quantile regression through kernel smoothing, and overcome the nonlinearity inherent in quantile regression via considering extension to…

数字孪生的相似性预测：面板数据、理论与应用AI 解读

Prediction from sequential panel data is central to digital-twin modeling, where new panels arrive over time and the predictive system is updated sequentially. Existing methods often rely on temporal proximity, which can fail when similar input-output patterns recur at nonadjacent times or when recent panels differ from the target panel. We propose State-Local Prediction (StaLoP), a nonparametric dynamic panel prediction framework that utilizes information through…

因果泛函中变量离散化导致的粗化偏差AI 解读

Causal identification functionals often require integration over conditional densities of continuous variables, such as those arising in nonparametric identification theory of total and mediated causal effects in DAGs with hidden variables. Estimating these densities and evaluating the resulting integrals can be statistically and computationally demanding. A common workaround is to discretize the continuous variable and replace integrals with finite sums. Although…

利用辅助外部数据识别治疗受益者的共形筛选框架AI 解读

Identifying patients who are likely to benefit from a treatment is central to precision medicine and can guide follow-up trials, enrichment designs, and individualized decisions. Although randomized controlled trials (RCTs) provide evidence on efficacy, they are usually powered to estimate average treatment effects rather than patient-level benefit. Meanwhile, artificial intelligence and machine learning methods offer flexible tools for estimating heterogeneous treatment…

测地空间中的因果推断AI 解读

Adjusting for confounding and imbalance when establishing statistical relationships is an increasingly important task, and causal inference methods have emerged as the most popular tool to achieve this. Existing methodology has been developed primarily for outcomes that lie in Euclidean spaces. We introduce here a general framework for causal inference when outcomes reside in general geodesic metric spaces, where we draw on a novel geodesic calculus that facilitates scalar…

断点回归设计中的灵活协变量调整AI 解读

Empirical regression discontinuity (RD) studies often include covariates in their specifications to increase the precision of their estimates. In this paper, we propose a novel class of estimators that use such covariate information more efficiently than existing methods and can accommodate many covariates. Our estimators are simple to implement and involve running a standard RD analysis after subtracting a function of the covariates from the original outcome variable. We…