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不膨胀协变量不平衡方差的临床试验自适应随机化AI 解读

Covariate adaptive randomization (CAR) procedures are extensively used to reduce the likelihood of covariate imbalances occurring in clinical trials. In literatures, a lot of CAR procedures have been proposed so that the specified covariates are balanced well between treatments. However, the variance of the imbalance of the unspecified covariates may be inflated comparing to the one under the simple randomization. The inflation of the variance causes the usual test of…

扩散引导平滑的几何自适应反事实分布学习AI 解读

We study counterfactual distribution learning for high-dimensional outcomes whose laws may concentrate near lower-dimensional structure. Standard isotropic smoothing ignores this geometry, leading to unfavorable scaling and unstable local inference. We propose semiparametrically debiased, diffusion-guided estimators for smoothed counterfactual densities and their scores. These estimators combine causal nuisance adjustment with geometry-adaptive localization driven by a…

用于个体化治疗规则的结局加权学习神经网络AI 解读

Individualized treatment rules (ITRs) formalize precision medicine by assigning treatments according to patient covariates, with the goal of maximizing expected clinical outcomes. Such rules are especially important when treatment effects vary across patients, as in chronic diseases where demographic, clinical, genetic, imaging, or biomarker information may modify the relative benefits of available therapies. Individualized treatment rules (ITRs) formalize precision medicine…

简约、灵活、忠实：通过 Frengression 模拟因果数据AI 解读

Machine learning has revitalized causal inference by combining flexible models and principled estimators, yet robust benchmarking and evaluation remain challenging with real-world data. In this work, we introduce frengression, a deep generative realization of the frugal parameterization that models the joint distribution of covariates, treatments and outcomes around the causal margin of interest. Frengression provides accurate estimation and flexible, faithful simulation of…

种族的哪一种效应？不固定其他特征的因果推断AI 解读

Empirical studies of racial discrimination vary race while holding nonracial traits fixed, a design the literature defends as what credible inference requires. This defense bundles two claims: which effect of race a study should target, and whether its design can recover that effect. I separate them. The same randomization that secures credible estimation and inference recovers a family of race estimands, from the all-else-equal effect to a within-race effect that lets…

B-CALM：协变量不匹配下以随机试验为锚的偏差受限贝叶斯信息借用AI 解读

Randomized controlled trials (RCTs) identify treatment effects in the randomized trial population but are often too small for reliable heterogeneity estimation; observational studies (OS) are larger but confounded and measured on only partially overlapping covariates. We develop Bayesian Calibrated ALignment under covariate Mismatch (B-CALM), a Bayesian borrowing method for RCT-defined conditional average treatment effect (CATE) estimation. B-CALM maps source-specific…

条件校准下潜在组别效应的识别AI 解读

We study identification of a structural group effect when the group indicator $G\in\{0,1\}$ is unobserved, but the analyst observes a calibrated probability score $p$ satisfying $E[G\mid p,X]=p$. Under a constant-coefficient structural mean model, the latent-group coefficient $τ$ is point-identified by a closed-form ratio of observable moments whose denominator is the residual score variance $V^{*}=E[(p-E[p\mid X])^2]$. Identification fails exactly when the score is a…

部分观测动态网络上的传染病过程完全数据似然AI 解读

Inference for infectious disease transmission on dynamic contact networks is complicated by latent infection times, partially observed network evolution, measurement error in contact data, and infection originating from outside the observed population. Existing likelihood-based approaches typically address these challenges separately and often rely on restrictive assumptions such as fully observed networks, closed populations, or symptom onset as a surrogate for infection…

评估带符号脑网络的不平衡性AI 解读

Many complex systems - be they financial, natural, or social - are composed of units - such as stocks, neurons, or agents - whose joint activity can be represented as a multivariate time series. An issue of both practical and theoretical importance concerns the possibility of inferring the presence of a static relationship between any two units solely from their dynamic behaviour. The present contribution aims at tackling such an issue within the framework of traditional…

大型多维网络中的统计推断AI 解读

We propose the Polyads estimator, a new method to estimate structural parameters in weighted multi-way networks while controlling for rich, arbitrary structures of fixed effects. The method is based on a series of classification tasks and is agnostic to both the number and structure of fixed effects. Unlike full maximum likelihood, our estimator does not suffer from the incidental parameter problem: it is consistent and satisfies a Central Limit Theorem with no asymptotic…

让事件研究图支持诚实推断：因果分析的函数型数据方法AI 解读

Event study plots are the centerpiece of Difference-in-Differences (DiD) analysis, but current plotting methods cannot provide honest causal inference when the parallel trends and/or no-anticipation assumptions fail. We introduce a novel functional data approach to DiD that directly enables honest causal inference via event study plots. Our DiD estimator converges to a Gaussian process in the Banach space of continuous functions, enabling powerful simultaneous confidence…

单调处理响应下，处理效应超过给定阈值的概率AI 解读

Experiments may, by design, prevent one from observing on a single subject both the response to a treatment and to its absence. Because of this, marginal distributions for both cases may be observable but not their joint distribution, thus obscuring the distribution of the treatment effect. We examine the case where we impose that the treatment effect is nonnegative, also called monotone treatment response, a common assumption relevant to many practical applications. We…

利用处理后变量研究预测性处理效应异质性的经验分层AI 解读

Post-treatment variables (PVs), such as intercurrent events, treatment noncompliance, and behavioral responses to treatment, provide information about individuals' post-treatment responses and may help characterize heterogeneity in treatment effects on the primary outcome. This paper develops an empirical stratification framework to study the treatment effect heterogeneity across baseline-predicted PV response profiles. Specifically, we construct empirical scores from…

处理状态缺失时，如何学习应该干预谁AI 解读

Policy learning methods are increasingly used to inform treatment allocation under budget constraints. Most proposed methods assume complete treatment data, yet applications frequently suffer from missingness that can bias estimates and lead to suboptimal policies. We address this gap by extending efficient estimators for average treatment effect (ATE) estimation to policy value and conditional average treatment effect (CATE) estimation under missing at random (MAR) and…

用于因果推断的生成式合成数据：陷阱、补救与机会AI 解读

Synthetic tabular data are often evaluated by distributional similarity, privacy distance, or train-on-synthetic-test-on-real predictive performance, but these criteria do not ensure validity for causal inference. We show that fully generative tabular synthesizers, including GAN- and LLM-based models, can preserve predictive utility while distorting average treatment effect (ATE) estimates. The failure is structural: ATE preservation requires both a realistic covariate law…

部分可观测的结构因果模型AI 解读

Here we introduce Partially Observed Structural Causal Models (POSCMs) as an extension of structural causal models (SCMs) to settings where upstream contexts co-determine both the interaction structure and downstream mechanisms on observed variables. POSCMs thus provide a self-contained causal modeling framework for endogenous graphs, allowing for an intervention hierarchy spanning node- and edge-level contexts and endogenous variable interventions. To define edge…

干预分布公式的验证AI 解读

We formalize verification in causal graphical models: deciding whether a given observational formula identifies a target interventional distribution. This opens a problem complementary to identification, asking not whether any identifying formula exists, but whether the given formula is identifying. We show that even sound and complete solutions to identification do not solve verification. We propose a falsifier as a first practical route forward, prove that it induces an…

利用高维工具变量筛选估计潜在双重网络并开展推断AI 解读

We develop a novel methodology for estimation and inference in high-dimensional panel network models with latent dual structures. The framework allows outcomes to be affected simultaneously by positive and negative interaction channels, accommodating settings in which some interactions reinforce outcomes while others generate competition and displacement effects. The proposed method identifies and estimates the network directly from the structural model using observed data…

多商品多期库存控制的实验设计AI 解读

Randomized experiments, or A/B testing, are the gold standard for evaluating interventions, yet they remain underutilized in inventory management. This study addresses this gap by analyzing A/B testing strategies in multi-item, multi-period inventory systems with lost sales and capacity constraints. We examine two canonical experimental designs--switchback experiments and item-level randomization--and show that both suffer from systematic bias due to interference: temporal…

智能体经济建模AI 解读

We introduce Agentic Economic Modeling (AEM), a framework that aligns synthetic LLM choices with small-sample human evidence for econometric inference. AEM first generates task-conditioned synthetic choices via LLMs, then learns a bias-correction mapping from task features and raw LLM choices to human-aligned choices, upon which standard econometric estimators perform inference to recover demand elasticities and treatment effects. We validate AEM in two experiments. In a…

聚类处理分配下的遗漏变量偏差敏感性分析AI 解读

Cinelli and Hazlett (2020) develops a sensitivity analysis method for the linear regression model that parameterizes omitted variable bias in terms of two partial $R^2$ parameters capturing the residual variation explained by an omitted confounder in the treatment and outcome respectively. This method is often applied to regressions fit to unit-level data when treatment is assigned at a higher level of aggregation -- as in clustered observational designs. This paper shows…

连续处理随机政策变动下的双重差分AI 解读

Treatment effects of stochastic policy shifts quantify differences in outcomes across counterfactual scenarios with varying treatment distributions. Stochastic policy shifts may be of interest in settings where it is unrealistic or infeasible to deterministically manipulate treatments. In this paper, methods are developed to draw inference about stochastic policy effects under difference-in-differences (DiD) designs with a continuous treatment. The proposed causal estimand…

含交互效应的动态面板模型的全局识别AI 解读

We investigate the problem of global identification in dynamic panel models with interactive effects, in the large-N, fixed-T setting. While local identification, typically established via the Jacobian matrix, is well understood, global identification has remained a more elusive and challenging issue. It is commonly believed to be unachievable in this context. However, we demonstrate that the model is, in fact, globally identified for almost all configurations of the…

显著性优先分裂：协调处理效应异质性检测与诚实估计AI 解读

Estimating heterogeneous treatment effects (CATE) requires simultaneously detecting effect modification and quantifying estimation uncertainty. Existing tree-based methods make an uneasy trade-off: significance-based approaches (Radcliffe and Surry 2011) identify subgroup interactions directly but lack valid inference; honest causal trees (Athey and Imbens 2016) deliver nominal confidence interval coverage but use outcome-agnostic splitting criteria that sacrifice…