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Randomized Controlled Trials Under Influence: Covariate Factors and Graph-Based Network Interference

影响下的随机对照试验:协变量因素与图网络干扰

Randomized controlled trials are not only the golden standard in medicine and vaccine trials but have spread to many other disciplines like behavioral economics, making it an important interdisciplinary tool for scientists. When designing randomized controlled trials, how to assign participants to treatments becomes a key issue. In particular in the presence of covariate factors, the assignment can significantly influence statistical properties and thereby the quality of the…

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Causal Representation Learning for Context-Aware Face Transfer

面向情境感知人脸迁移的因果表征学习

Human face synthesis involves transferring knowledge about the identity and identity-dependent face shape (IDFS) of a human face to target face images where the context (e.g., facial expressions, head poses, and other background factors) may change dramatically. Human faces are non-rigid, so facial expression leads to deformation of face shape, and head pose also affects the face observed in 2D images. A key challenge in face transfer is to match the face with unobserved new…

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Translating questions to estimands in randomized clinical trials with intercurrent events

将伴发事件下的随机临床试验问题转化为目标估计量

Intercurrent (post-treatment) events occur frequently in randomized trials, and investigators often express interest in treatment effects that suitably take account of these events. A naive conditioning on intercurrent events does not have a straight-forward causal interpretation, and the practical relevance of other commonly used approaches is debated. In this work, we discuss how to formulate and choose an estimand, beyond the marginal intention to treat effect, from the…

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A Two-Sample Robust Bayesian Mendelian Randomization Method Accounting for Linkage Disequilibrium and Idiosyncratic Pleiotropy with Applications to the COVID-19 Outcome

兼顾连锁不平衡与特异性多效性的两样本稳健贝叶斯孟德尔随机化

Mendelian randomization (MR) is a statistical method exploiting genetic variants as instrumental variables to estimate the causal effect of modifiable risk factors on an outcome of interest. Despite wide uses of various popular two-sample MR methods based on genome-wide association study summary level data, however, those methods could suffer from potential power loss or/and biased inference when the chosen genetic variants are in linkage disequilibrium (LD), and also have…

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Shrinkage Bayesian Causal Forests for Heterogeneous Treatment Effects Estimation

用于异质性处理效应估计的收缩贝叶斯因果森林

This paper develops a sparsity-inducing version of Bayesian Causal Forests, a recently proposed nonparametric causal regression model that employs Bayesian Additive Regression Trees and is specifically designed to estimate heterogeneous treatment effects using observational data. The sparsity-inducing component we introduce is motivated by empirical studies where not all the available covariates are relevant, leading to different degrees of sparsity underlying the surfaces…

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An Outcome Test of Discrimination for Ranked Lists

排序名单中的歧视结果检验

This paper extends Becker (1957)'s outcome test of discrimination to settings where a (human or algorithmic) decision-maker produces a ranked list of candidates. Ranked lists are particularly relevant in the context of online platforms that produce search results or feeds, and also arise when human decisionmakers express ordinal preferences over a list of candidates. We show that non-discrimination implies a system of moment inequalities, which intuitively impose that one…

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Dynamic Network Quantile Regression Model

动态网络分位数回归模型

We propose a dynamic network quantile regression model to investigate the quantile connectedness using a predetermined network information. We extend the existing network quantile autoregression model of Zhu et al. (2019b) by explicitly allowing the contemporaneous network effects and controlling for the common factors across quantiles. To cope with the endogeneity issue due to simultaneous network spillovers, we adopt the instrumental variable quantile regression (IVQR)…

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Scalable Intervention Target Estimation in Linear Models

线性模型中可扩展的干预目标估计

This paper considers the problem of estimating the unknown intervention targets in a causal directed acyclic graph from observational and interventional data. The focus is on soft interventions in linear structural equation models (SEMs). Current approaches to causal structure learning either work with known intervention targets or use hypothesis testing to discover the unknown intervention targets even for linear SEMs. This severely limits their scalability and sample…

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Analysis of stepped wedge cluster randomized trials in the presence of a time-varying treatment effect

处理效应随暴露时间变化时的阶梯楔形整群随机试验分析

Stepped wedge cluster randomized controlled trials are typically analyzed using models that assume the full effect of the treatment is achieved instantaneously. We provide an analytical framework for scenarios in which the treatment effect varies as a function of exposure time (time since the start of treatment) and define the "effect curve" as the magnitude of the treatment effect on the linear predictor scale as a function of exposure time. The "time-averaged treatment…

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Interquantile Shrinkage in Spatial Quantile Autoregressive Regression models

空间分位数自回归模型中的跨分位数收缩

Spatial dependent data frequently occur in many fields such as spatial econometrics and epidemiology. To deal with the dependence of variables and estimate quantile-specific effects by covariates, spatial quantile autoregressive models (SQAR models) are introduced. Conventional quantile regression only focuses on the fitting models but ignores the examination of multiple conditional quantile functions, which provides a comprehensive view of the relationship between the…

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Normalized Augmented Inverse Probability Weighting with Neural Network Predictions

结合神经网络预测的归一化增广逆概率加权

The estimation of Average Treatment Effect (ATE) as a causal parameter is carried out in two steps, where in the first step, the treatment and outcome are modeled to incorporate the potential confounders, and in the second step, the predictions are inserted into the ATE estimators such as the Augmented Inverse Probability Weighting (AIPW) estimator. Due to the concerns regarding the nonlinear or unknown relationships between confounders and the treatment and outcome, there…

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Beware of the Simulated DAG! Causal Discovery Benchmarks May Be Easy To Game

警惕模拟有向无环图:因果发现基准可能容易被取巧

Simulated DAG models may exhibit properties that, perhaps inadvertently, render their structure identifiable and unexpectedly affect structure learning algorithms. Here, we show that marginal variance tends to increase along the causal order for generically sampled additive noise models. We introduce varsortability as a measure of the agreement between the order of increasing marginal variance and the causal order. For commonly sampled graphs and model parameters, we show…

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Generalized Kernel Ridge Regression for Causal Inference with Missing-at-Random Sample Selection

随机缺失样本选择下用于因果推断的广义核岭回归

I propose kernel ridge regression estimators for nonparametric dose response curves and semiparametric treatment effects in the setting where an analyst has access to a selected sample rather than a random sample; only for select observations, the outcome is observed. I assume selection is as good as random conditional on treatment and a sufficiently rich set of observed covariates, where the covariates are allowed to cause treatment or be caused by treatment -- an extension…

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Assessing Outcome-to-Outcome Interference in Sibling Fixed Effects Models

评估兄弟姐妹固定效应模型中的结局间干扰

Sibling fixed effects (FE) models are useful for estimating causal treatment effects while offsetting unobserved sibling-invariant confounding. However, treatment estimates are biased if an individual's outcome affects their sibling's outcome. We propose a robustness test for assessing the presence of outcome-to-outcome interference in linear two-sibling FE models. We regress a gain-score--the difference between siblings' continuous outcomes--on both siblings' treatments and…

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An Online Sequential Test for Qualitative Treatment Effects

定性处理效应的在线序贯检验

Tech companies (e.g., Google or Facebook) often use randomized online experiments and/or A/B testing primarily based on the average treatment effects to compare their new product with an old one. However, it is also critically important to detect qualitative treatment effects such that the new one may significantly outperform the existing one only under some specific circumstances. The aim of this paper is to develop a powerful testing procedure to efficiently detect such…

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Causal Mediation and Sensitivity Analysis for Mixed-Scale Data

混合尺度数据的因果中介与敏感性分析

The goal of causal mediation analysis, often described within the potential outcomes framework, is to decompose the effect of an exposure on an outcome of interest along different causal pathways. Using the assumption of sequential ignorability to attain non-parametric identification, Imai et al. (2010) proposed a flexible approach to measuring mediation effects, focusing on parametric and semiparametric normal/Bernoulli models for the outcome and mediator. Less attention…

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Bootstrap inference for panel data quantile regression

面板数据分位数回归的自助法推断

This paper develops bootstrap methods for practical statistical inference in panel data quantile regression models with fixed effects. We consider random-weighted bootstrap resampling and formally establish its validity for asymptotic inference. The bootstrap algorithm is simple to implement in practice by using a weighted quantile regression estimation for fixed effects panel data. We provide results under conditions that allow for temporal dependence of observations within…

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Multistage Estimators for Missing Covariates and Incomplete Outcomes

协变量缺失与结局不完整的多阶段估计方法

We study problems with multiple missing covariates and partially observed responses. We develop a new framework to handle complex missing covariate scenarios via inverse probability weighting, regression adjustment, and a multiply-robust procedure. We apply our framework to three classical problems: the Cox model from survival analysis, missing response, and binary treatment from causal inference. We also discuss how to handle missing covariates in these scenarios, and…

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Leveraging Population Outcomes to Improve the Generalization of Experimental Results

利用总体结果数据提升实验结论的推广效率

Generalizing causal estimates in randomized experiments to a broader target population is essential for guiding decisions by policymakers and practitioners in the social and biomedical sciences. While recent papers developed various weighting estimators for the population average treatment effect (PATE), many of these methods result in large variance because the experimental sample often differs substantially from the target population, and estimated sampling weights are…

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A framework for causal segmentation analysis with machine learning in large-scale digital experiments

大型数字实验中基于机器学习的因果分群分析框架

We present an end-to-end methodological framework for causal segment discovery that aims to uncover differential impacts of treatments across subgroups of users in large-scale digital experiments. Building on recent developments in causal inference and non/semi-parametric statistics, our approach unifies two objectives: (1) the discovery of user segments that stand to benefit from a candidate treatment based on subgroup-specific treatment effects, and (2) the evaluation of…

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Towards Principled Causal Effect Estimation by Deep Identifiable Models

利用深度可识别模型开展有原则的因果效应估计

As an important problem in causal inference, we discuss the estimation of treatment effects (TEs). Representing the confounder as a latent variable, we propose Intact-VAE, a new variant of variational autoencoder (VAE), motivated by the prognostic score that is sufficient for identifying TEs. Our VAE also naturally gives representations balanced for treatment groups, using its prior. Experiments on (semi-)synthetic datasets show state-of-the-art performance under diverse…

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Partially Intervenable Causal Models

仅允许部分变量干预的因果模型

Graphical causal models led to the development of complete non-parametric identification theory in arbitrary structured systems, and general approaches to efficient inference. Nevertheless, graphical approaches to causal inference have not been embraced by the statistics and public health communities. In those communities causal assumptions are instead expressed in terms of potential outcomes, or responses to hypothetical interventions. Such interventions are generally…

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Efficient Online Estimation of Causal Effects by Deciding What to Observe

通过选择观测内容高效在线估计因果效应

Researchers often face data fusion problems, where multiple data sources are available, each capturing a distinct subset of variables. While problem formulations typically take the data as given, in practice, data acquisition can be an ongoing process. In this paper, we aim to estimate any functional of a probabilistic model (e.g., a causal effect) as efficiently as possible, by deciding, at each time, which data source to query. We propose online moment selection (OMS), a…

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Cause-effect inference through spectral independence in linear dynamical systems: theoretical foundations

线性动态系统中谱独立性因果推断的理论基础

Distinguishing between cause and effect using time series observational data is a major challenge in many scientific fields. A new perspective has been provided based on the principle of Independence of Causal Mechanisms (ICM), leading to the Spectral Independence Criterion (SIC), postulating that the power spectral density (PSD) of the cause time series is uncorrelated with the squared modulus of the frequency response of the filter generating the effect. Since SIC rests on…

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