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Improving uplift model evaluation on RCT data

改进随机对照试验数据中的增益模型评估

Estimating treatment effects is one of the most challenging and important tasks of data analysts. In many applications, like online marketing and personalized medicine, treatment needs to be allocated to the individuals where it yields a high positive treatment effect. Uplift models help select the right individuals for treatment and maximize the overall treatment effect (uplift). A major challenge in uplift modeling concerns model evaluation. Previous literature suggests…

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Tree-based exploratory identification of predictive biomarkers in observational data

基于树的观察性数据预测性生物标志物探索识别

The idea of "stratified medicine" is an important driver of methodological research on the identification of predictive biomarkers. Most methods proposed so far for this purpose have been developed for the use on randomized data only. However, especially for rare cancers, data from clinical registries or observational studies might be the only available data source. For such data, methods for an unbiased estimation of the average treatment effect are well established.…

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On sample size determination for restricted mean survival time-based tests in randomized clinical trials

随机临床试验中基于限制平均生存时间检验的样本量确定

Restricted mean survival time (RMST) is gaining attention as a measure to quantify the treatment effect on survival outcomes in randomized clinical trials. Several methods to determine sample size based on the RMST-based tests have been proposed. However, to the best of our knowledge, there is no discussion about the power and sample size regarding the augmented version of RMST-based tests, which utilize baseline covariates for a gain in estimation efficiency and in power…

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Nonparametric estimators of interventional (transported) direct and indirect effects that accommodate multiple mediators and multiple intermediate confounders

容许多个中介与多个中间混杂因素的干预型及可迁移直接、间接效应非参数估计

Mediation analysis is appealing for its ability to improve understanding of the mechanistic drivers of causal effects, but real-world data complexities challenge its successful implementation, including: 1) the existence of post-exposure variables that also affect mediators and outcomes (thus, confounding the mediator-outcome relationship), that may also be 2) multivariate, and 3) the existence of multivariate mediators. Interventional direct and indirect effects (IDE/IIE)…

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One Instrument to Rule Them All: The Bias and Coverage of Just-ID IV

一个工具变量统领全局:恰好识别工具变量估计的偏差与覆盖率

We revisit the finite-sample behavior of single-variable just-identified instrumental variables (just-ID IV) estimators, arguing that in most microeconometric applications, the usual inference strategies are likely reliable. Three widely-cited applications are used to explain why this is so. We then consider pretesting strategies of the form $t_{1}>c$, where $t_{1}$ is the first-stage $t$-statistic, and the first-stage sign is given. Although pervasive in empirical practice,…

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The finite sample performance of instrumental variable-based estimators of the Local Average Treatment Effect when controlling for covariates

控制协变量时工具变量局部平均处理效应估计量的有限样本表现

This paper investigates the finite sample performance of a range of parametric, semi-parametric, and non-parametric instrumental variable estimators when controlling for a fixed set of covariates to evaluate the local average treatment effect. Our simulation designs are based on empirical labor market data from the US and vary in several dimensions, including effect heterogeneity, instrument selectivity, instrument strength, outcome distribution, and sample size. Among the…

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Entropy Balancing for Causal Generalization with Target Sample Summary Information

利用目标样本汇总信息进行因果推广的熵平衡

In this paper, we focus on estimating the average treatment effect (ATE) of a target population when individual-level data from a source population and summary-level data (e.g., first or second moments of certain covariates) from the target population are available. In the presence of heterogeneous treatment effect, the ATE of the target population can be different from that of the source population when distributions of treatment effect modifiers are dissimilar in these two…

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Doubly Robust Calibration of Prediction Sets under Covariate Shift

协变量漂移下预测集的双重稳健校准

Conformal prediction has received tremendous attention in recent years and has offered new solutions to problems in missing data and causal inference; yet these advances have not leveraged modern semiparametric efficiency theory for more robust and efficient uncertainty quantification. In this paper, we consider the problem of obtaining distribution-free prediction regions accounting for a shift in the distribution of the covariates between the training and test data. Under…

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Causal Inference on Win Ratio for Observational Data with Dependent Subjects

存在个体依赖的观察数据中胜比的因果推断

Composite endpoints are commonly used with an anticipation that clinically relevant endpoints as a whole would yield meaningful treatment benefits. The win ratio is a rank-based statistic to summarize composite endpoints, allowing prioritizing the important components of the composite endpoints. Recent development in statistical inference for the win ratio statistic has been focusing on independent subjects without any potential confounding. When analyzing composite…

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Instrumental Variables in Causal Inference and Machine Learning: A Survey

因果推断与机器学习中的工具变量:综述

Causal inference is the process of using assumptions, study designs, and estimation strategies to draw conclusions about the causal relationships between variables based on data. This allows researchers to better understand the underlying mechanisms at work in complex systems and make more informed decisions. In many settings, we may not fully observe all the confounders that affect both the treatment and outcome variables, complicating the estimation of causal effects. To…

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Hybrid Censored Quantile Regression Forest to Assess the Heterogeneous Effects

用于评估异质性效应的混合删失分位数回归森林

In many applications, heterogeneous treatment effects on a censored response variable are of primary interest, and it is natural to evaluate the effects at different quantiles (e.g., median). The large number of potential effect modifiers, the unknown structure of the treatment effects, and the presence of right censoring pose significant challenges. In this paper, we develop a hybrid forest approach called Hybrid Censored Quantile Regression Forest (HCQRF) to assess the…

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Double Robustness for Complier Parameters and a Semiparametric Test for Complier Characteristics

服从者参数的双重稳健性与服从者特征的半参数检验

We propose a semiparametric test to evaluate (i) whether different instruments induce subpopulations of compliers with the same observable characteristics on average, and (ii) whether compliers have observable characteristics that are the same as the full population on average. The test is a flexible robustness check for the external validity of instruments. We use it to reinterpret the difference in LATE estimates that Angrist and Evans (1998) obtain when using different…

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Robust Inference in High Dimensional Linear Model with Cluster Dependence

聚类依赖下高维线性模型的稳健推断

Cluster standard error (Liang and Zeger, 1986) is widely used by empirical researchers to account for cluster dependence in linear model. It is well known that this standard error is biased. We show that the bias does not vanish under high dimensional asymptotics by revisiting Chesher and Jewitt (1987)'s approach. An alternative leave-cluster-out crossfit (LCOC) estimator that is unbiased, consistent and robust to cluster dependence is provided under high dimensional setting…

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Estimation and Inference on Heterogeneous Treatment Effects in High-Dimensional Dynamic Panels under Weak Dependence

弱依赖下高维动态面板异质处理效应的估计与推断

This paper provides estimation and inference methods for a conditional average treatment effects (CATE) characterized by a high-dimensional parameter in both homogeneous cross-sectional and unit-heterogeneous dynamic panel data settings. In our leading example, we model CATE by interacting the base treatment variable with explanatory variables. The first step of our procedure is orthogonalization, where we partial out the controls and unit effects from the outcome and the…

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Bivariate Causal Discovery for Categorical Data via Classification with Optimal Label Permutation

通过最优标签置换分类进行类别数据的二元因果发现

Causal discovery for quantitative data has been extensively studied but less is known for categorical data. We propose a novel causal model for categorical data based on a new classification model, termed classification with optimal label permutation (COLP). By design, COLP is a parsimonious classifier, which gives rise to a provably identifiable causal model. A simple learning algorithm via comparing likelihood functions of causal and anti-causal models suffices to learn…

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Individual causal effects from observational longitudinal studies with time-varying exposures

时变暴露观测性纵向研究中的个体因果效应

Causal effects may vary among individuals and can even be of opposite signs. When significant effect heterogeneity exists, the population average causal effect might be uninformative for an individual. Due to the fundamental problem of causality, individual causal effects (ICEs) cannot be retrieved from cross-sectional data. However, in crossover studies, it is accepted that ICEs can be estimated under the assumptions of no carryover effects and time invariance of potential…

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Power and Sample Size Calculations for Rerandomization

再随机化实验的功效与样本量计算

Power analyses are an important aspect of experimental design, because they help determine how experiments are implemented in practice. It is common to specify a desired level of power and compute the sample size necessary to obtain that power. Such calculations are well-known for completely randomized experiments, but there can be many benefits to using other experimental designs. For example, it has recently been established that rerandomization, where subjects are…

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Optimal Model Selection in RDD and Related Settings Using Placebo Zones

利用安慰剂区域优化断点回归及相关方法的模型选择

We propose a new model-selection algorithm for Regression Discontinuity Design, Regression Kink Design, and related IV estimators. Candidate models are assessed within a 'placebo zone' of the running variable, where the true effects are known to be zero. The approach yields an optimal combination of bandwidth, polynomial, and any other choice parameters. It can also inform choices between classes of models (e.g. RDD versus cohort-IV) and any other choices, such as…

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Semiparametric Distribution Regression with Instruments and Monotonicity

带工具变量与单调性约束的半参数分布回归

This paper proposes IV-based estimators for the semiparametric distribution regression model in the presence of an endogenous regressor, which are based on an extension of IV probit estimators. We discuss the causal interpretation of the estimators and two methods (monotone rearrangement and isotonic regression) to ensure a monotonically increasing distribution function. Asymptotic properties and simulation evidence are provided. An application to wage equations reveals…

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Learning Instrumental Variable from Data Fusion for Treatment Effect Estimation

从数据融合中学习工具变量以估计处理效应

The advent of the big data era brought new opportunities and challenges to draw treatment effect in data fusion, that is, a mixed dataset collected from multiple sources (each source with an independent treatment assignment mechanism). Due to possibly omitted source labels and unmeasured confounders, traditional methods cannot estimate individual treatment assignment probability and infer treatment effect effectively. Therefore, we propose to reconstruct the source label and…

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Robust Orthogonal Machine Learning of Treatment Effects

处理效应的稳健正交机器学习

Causal learning is the key to obtaining stable predictions and answering \textit{what if} problems in decision-makings. In causal learning, it is central to seek methods to estimate the average treatment effect (ATE) from observational data. The Double/Debiased Machine Learning (DML) is one of the prevalent methods to estimate ATE. However, the DML estimators can suffer from an \textit{error-compounding issue} and even give extreme estimates when the propensity scores are…

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Adaptive Sequential Surveillance with Network and Temporal Dependence

具有网络与时间依赖的自适应序贯监测

Strategic test allocation plays a major role in the control of both emerging and existing pandemics (e.g., COVID-19, HIV). Widespread testing supports effective epidemic control by (1) reducing transmission via identifying cases, and (2) tracking outbreak dynamics to inform targeted interventions. However, infectious disease surveillance presents unique statistical challenges. For instance, the true outcome of interest - one's positive infectious status, is often a latent…

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A Data Fusion Approach for Ride-sourcing Demand Estimation: A Discrete Choice Model with Sampling and Endogeneity Corrections

网约车需求估计的数据融合方法:带抽样和内生性校正的离散选择模型

Ride-sourcing services offered by companies like Uber and Didi have grown rapidly in the last decade. Understanding the demand for these services is essential for planning and managing modern transportation systems. Existing studies develop statistical models for ride-sourcing demand estimation at an aggregate level due to limited data availability. These models lack foundations in microeconomic theory, ignore competition of ride-sourcing with other travel modes, and cannot…

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Generalized Varying Coefficient Mediation Models

广义变系数中介模型

Motivated by an analysis of causal mechanism from economic stress to entrepreneurial withdrawals through depressed affect, we develop a two-layer generalized varying coefficient mediation model. This model captures the bridging effects of mediators that may vary with another variable, by treating them as smooth functions of this variable. It also allows various response types by introducing the generalized varying coefficient model in the first layer. The varying direct and…

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