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Efficient estimation of weighted cumulative treatment effects by double/debiased machine learning

用双重/去偏机器学习有效估计加权累积治疗效应

In empirical studies with time-to-event outcomes, investigators often leverage observational data to conduct causal inference on the effect of exposure when randomized controlled trial data is unavailable. Model misspecification and lack of overlap are common issues in observational studies, and they often lead to inconsistent and inefficient estimators of the average treatment effect. Estimators targeting overlap weighted effects have been proposed to address the challenge…

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On the pitfalls of Gaussian likelihood scoring for causal discovery

高斯似然评分用于因果发现的陷阱

We consider likelihood score-based methods for causal discovery in structural causal models. In particular, we focus on Gaussian scoring and analyze the effect of model misspecification in terms of non-Gaussian error distribution. We present a surprising negative result for Gaussian likelihood scoring in combination with nonparametric regression methods.

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Identifying an Earnings Process With Dependent Contemporaneous Income Shocks

允许同期收入冲击相依的收入过程识别

This paper proposes a novel approach for identifying coefficients in an earnings dynamics model with arbitrarily dependent contemporaneous income shocks. Traditional methods relying on second moments fail to identify these coefficients, emphasizing the need for nongaussianity assumptions that capture information from higher moments. Our results contribute to the literature on earnings dynamics by allowing models of earnings to have, for example, the permanent income shock of…

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Defining and Estimating Effects in Cluster Randomized Trials: A Methods Comparison

整群随机试验中的效应定义与估计:方法比较

Across research disciplines, cluster randomized trials (CRTs) are commonly implemented to evaluate interventions delivered to groups of participants, such as communities and clinics. Despite advances in the design and analysis of CRTs, several challenges remain. First, there are many possible ways to specify the causal effect of interest (e.g., at the individual-level or at the cluster-level). Second, the theoretical and practical performance of common methods for CRT…

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Validation of massively-parallel adaptive testing using dynamic control matching

利用动态对照匹配验证大规模并行自适应测试

A/B testing is a widely-used paradigm within marketing optimization because it promises identification of causal effects and because it is implemented out of the box in most messaging delivery software platforms. Modern businesses, however, often run many A/B/n tests at the same time and in parallel, and package many content variations into the same messages, not all of which are part of an explicit test. Whether as the result of many teams testing at the same time, or as…

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Propensity score regression for causal inference with treatment heterogeneity

用于异质性治疗效应因果推断的倾向得分回归

Understanding how treatment effects vary on individual characteristics is critical in the contexts of personalized medicine, personalized advertising and policy design. When the characteristics are of practical interest are only a subset of full covariate, non-parametric estimation is often desirable; but few methods are available due to the computational difficult. Existing non-parametric methods such as the inverse probability weighting methods have limitations that hinder…

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Leveraging covariate adjustments at scale in online A/B testing

大规模在线A/B测试中的协变量调整

Companies offering web services routinely run randomized online experiments to estimate the causal impact associated with the adoption of new features and policies on key performance metrics of interest. These experiments are used to estimate a variety of effects: the increase in click rate due to the repositioning of a banner, the impact on subscription rate as a consequence of a discount or special offer, etc. In these settings, even effects whose sizes are very small can…

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Frameworks for Estimating Causal Effects in Observational Settings: Comparing Confounder Adjustment and Instrumental Variables

观察性研究中的因果效应估计框架:混杂调整与工具变量比较

To estimate causal effects, analysts performing observational studies in health settings utilize several strategies to mitigate bias due to confounding by indication. There are two broad classes of approaches for these purposes: use of confounders and instrumental variables (IVs). Because such approaches are largely characterized by untestable assumptions, analysts must operate under an indefinite paradigm that these methods will work imperfectly. In this tutorial, we…

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A universal model for the Lorenz curve with novel applications for datasets containing zeros and/or exhibiting extreme inequality

洛伦兹曲线的通用模型:含零值与极端不平等数据的应用

Given that the existing parametric functional forms for the Lorenz curve do not fit all possible size distributions, a universal parametric functional form is introduced. By using the empirical data from different scientific disciplines and also the hypothetical data, this study shows that, the proposed model fits not only the data whose actual Lorenz plots have a typical convex segment but also the data whose actual Lorenz plots have both horizontal and convex segments…

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A Bayesian Joint Model for Compositional Mediation Effect Selection in Microbiome Data

微生物组数据中组成型中介效应选择的贝叶斯联合模型

Analyzing multivariate count data generated by high-throughput sequencing technology in microbiome research studies is challenging due to the high-dimensional and compositional structure of the data and overdispersion. In practice, researchers are often interested in investigating how the microbiome may mediate the relation between an assigned treatment and an observed phenotypic response. Existing approaches designed for compositional mediation analysis are unable to…

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Estimation of Characteristics-based Quantile Factor Models

基于个体特征的分位数因子模型估计

This paper studies the estimation of characteristic-based quantile factor models where the factor loadings are unknown functions of observed individual characteristics while the idiosyncratic error terms are subject to conditional quantile restrictions. We propose a three-stage estimation procedure that is easily implementable in practice and has nice properties. The convergence rates, the limiting distributions of the estimated factors and loading functions, and a…

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Common Correlated Effects Estimation of Nonlinear Panel Data Models

非线性面板数据模型的共同相关效应估计

This paper focuses on estimating the coefficients and average partial effects of observed regressors in nonlinear panel data models with interactive fixed effects, using the common correlated effects (CCE) framework. The proposed two-step estimation method involves applying principal component analysis to estimate latent factors based on cross-sectional averages of the regressors in the first step, and jointly estimating the coefficients of the regressors and factor loadings…

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Non-agency interventions for causal mediation in the presence of intermediate confounding

存在中间混杂时用于因果中介分析的非行动主体干预

Recent approaches to causal inference have focused on causal effects defined as contrasts between the distribution of counterfactual outcomes under hypothetical interventions on the nodes of a graphical model. In this article we develop theory for causal effects defined with respect to a different type of intervention, one which alters the information propagated through the edges of the graph. These information transfer interventions may be more useful than node…

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Selecting invalid instruments to improve Mendelian randomization with two-sample summary data

选择无效工具变量以改进双样本汇总数据的孟德尔随机化

Mendelian randomization (MR) is a widely-used method to estimate the causal relationship between a risk factor and disease. A fundamental part of any MR analysis is to choose appropriate genetic variants as instrumental variables. Genome-wide association studies often reveal that hundreds of genetic variants may be robustly associated with a risk factor, but in some situations investigators may have greater confidence in the instrument validity of only a smaller subset of…

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The Ordinary Least Eigenvalues Estimator

普通最小特征值估计量

We propose a rate optimal estimator for the linear regression model on network data with interacted (unobservable) individual effects. The estimator achieves a faster rate of convergence $N$ compared to the standard estimators' $\sqrt{N}$ rate and is efficient in cases that we discuss. We observe that the individual effects alter the eigenvalue distribution of the data's matrix representation in significant and distinctive ways. We subsequently offer a correction for the…

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The impact of directly observed therapy on the efficacy of Tuberculosis treatment: A Bayesian multilevel approach

直接督导治疗对结核病疗效的影响:贝叶斯多层方法

We propose and discuss a Bayesian procedure to estimate the average treatment effect (ATE) for multilevel observations in the presence of confounding. We focus on situations where the confounders may be latent (e.g., spatial latent effects). This work is motivated by an interest in determining the causal impact of directly observed therapy (DOT) on the successful treatment of Tuberculosis (TB); the available data correspond to individual-level information observed across…

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CIMLA: Interpretable AI for inference of differential causal networks

CIMLA:用于差异因果网络推断的可解释人工智能

The discovery of causal relationships from high-dimensional data is a major open problem in bioinformatics. Machine learning and feature attribution models have shown great promise in this context but lack causal interpretation. Here, we show that a popular feature attribution model estimates a causal quantity reflecting the influence of one variable on another, under certain assumptions. We leverage this insight to implement a new tool, CIMLA, for discovering…

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Causal Semantic Communication for Digital Twins: A Generalizable Imitation Learning Approach

数字孪生的因果语义通信:可泛化的模仿学习方法

A digital twin (DT) leverages a virtual representation of the physical world, along with communication (e.g., 6G), computing (e.g., edge computing), and artificial intelligence (AI) technologies to enable many connected intelligence services. In order to handle the large amounts of network data based on digital twins (DTs), wireless systems can exploit the paradigm of semantic communication (SC) for facilitating informed decision-making under strict communication constraints…

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Functional Causal Inference with Time-to-Event Data

事件发生时间数据的函数型因果推断

Functional data is a powerful tool for capturing and analyzing complex patterns and relationships in a variety of fields, allowing for more precise modeling, visualization, and decision-making. For example, in healthcare, functional data such as medical images can help doctors make more accurate diagnoses and develop more effective treatment plans. However, understanding the causal relationships between functional predictors and time-to-event outcomes remains a challenge. To…

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Nonparametric Estimation of Conditional Incremental Effects

条件增量效应的非参数估计

Conditional effect estimation has great scientific and policy importance because interventions may impact subjects differently depending on their characteristics. Most research has focused on estimating the conditional average treatment effect (CATE). However, identification of the CATE requires all subjects have a non-zero probability of receiving treatment, or positivity, which may be unrealistic in practice. Instead, we propose conditional effects based on incremental…

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Causal Effect Estimation with Variational AutoEncoder and the Front Door Criterion

结合变分自编码器与前门准则的因果效应估计

An essential problem in causal inference is estimating causal effects from observational data. The problem becomes more challenging with the presence of unobserved confounders. When there are unobserved confounders, the commonly used back-door adjustment is not applicable. Although the instrumental variable (IV) methods can deal with unobserved confounders, they all assume that the treatment directly affects the outcome, and there is no mediator between the treatment and the…

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Identification of Auction Models Using Order Statistics

利用次序统计量识别拍卖模型

Auction data often contain information on only the most competitive bids as opposed to all bids. The usual measurement error approaches to unobserved heterogeneity are inapplicable due to dependence among order statistics. We bridge this gap by providing a set of positive identification results. First, we show that symmetric auctions with discrete unobserved heterogeneity are identifiable using two consecutive order statistics and an instrument. Second, we extend the results…

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Policy Learning under Biased Sample Selection

有偏样本选择下的政策学习

Practitioners often use data from a randomized controlled trial to learn a treatment assignment policy that can be deployed on a target population. A recurring concern in doing so is that, even if the randomized trial was well-executed (i.e., internal validity holds), the study participants may not represent a random sample of the target population (i.e., external validity fails)--and this may lead to policies that perform suboptimally on the target population. We consider a…

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A Conditional Linear Combination Test with Many Weak Instruments

大量弱工具变量下的条件线性组合检验

We consider a linear combination of jackknife Anderson-Rubin (AR), jackknife Lagrangian multiplier (LM), and orthogonalized jackknife LM tests for inference in IV regressions with many weak instruments and heteroskedasticity. Following I.Andrews (2016), we choose the weights in the linear combination based on a decision-theoretic rule that is adaptive to the identification strength. Under both weak and strong identifications, the proposed test controls asymptotic size and is…

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